Literature record
Amyloid goiter: two cases and a review of the literature.
PMID 19318742 | PMCID PMC2813626 | DOI 10.4103/0256-4947.51808 · Annals of Saudi medicine · 2009
Although involvement of the thyroid gland by amyloid is a relatively common phenomenon, clinically significant enlargement of the thyroid owing to amyloid deposition is an extremely rare occurrence. We describe two cases of amyloid goiter and review the relevant literature. The first case was systemic amyloidosis secondary to familial Mediterranean fever. The second case was a chronic renal failure patient who presented with an enlarged thyroid and upper airway obstructive symptoms. To date, true amyloid goiter secondary to amyloidosis associated with familial Mediterranean fever has only been reported in twelve patients.
Source-grounded extraction
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | familial Mediterranean fever | “The first case was systemic amyloidosis secondary to familial Mediterranean fever.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | renal failure | “The second case was a chronic renal failure patient who presented with an enlarged thyroid and upper airway obstructive symptoms.” | 0.98 | phenotype_alias_lexicon_v2 |