Literature record
Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome.
PMID 28869094 | DOI 10.1016/j.tcm.2017.07.012 · Trends in cardiovascular medicine · 2018
Age- and gender-related differences in QTc-interval are most likely the result of changes in sex-specific hormones. Although the exact mechanisms and pathophysiology of sex hormones on the QTc-interval are not known, testosterone appears to shorten the QTc-interval. In females, however, there is a more complex interaction between progesterone and estrogen. In patients with an impaired repolarization, such as long-QT syndrome (LQTS), the effect of these sex hormones on the QTc-interval is more pronounced with a differing sensitivity between the LQTS genotypes.
Source-grounded extraction
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | long QT syndrome | “Effect of age and gender on the QTc-interval in healthy individuals and patients with long-QT syndrome.” | 0.93 | phenotype_alias_lexicon_v2 |