Mesalazine induced focal segmental glomerulosclerosis in a patient with ulcerative colitis.
PMID 32394929 | DOI 10.4103/1319-2442.284031 · Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia · 2020
Focal segmental glomerulosclerosis (FSGS) and other glomerulonephritis due to the use of 5-aminosalicylic acid derivatives have been reported in the literature. A 38-year-old male who had been using mesalazine for four years because of ulcerative colitis applied to doctor due to swelling in the lower extremities. The patient was diagnosed with nephrotic syndrome (NS). Renal biopsy was performed, and FSGS was diagnosed. Antiproteinuric treatments were initiated with steroid therapy. The patient has been followed with the normal renal function of the after treatment. 5-aminosalicylic acid derivatives affect renal functions at different levels and caused in NS.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | ulcerative colitis | “Mesalazine induced focal segmental glomerulosclerosis in a patient with ulcerative colitis.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | nephrotic syndrome | “The patient was diagnosed with nephrotic syndrome (NS).” | 0.98 | phenotype_alias_lexicon_v2 |