Literature record
Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.
PMID 39487903 | PMCID PMC11958843 | DOI 10.1007/s13730-024-00943-6 · CEN case reports · 2025
We report the case of a 39-year-old man who presented with a history of generalized fatigue, nausea, subjective fever with rigors, and renal dysfunction after receiving infliximab (IFX) therapy for Crohn's disease. A renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After other causes of acute kidney injury were excluded, steroid therapy was initiated, his fever subsided, and kidney function improved. From this case report, infliximab could be a rare cause of elevated kidney function and that it should be not considered a completely safe treatment or disregarded as potential cause of ATIN.
Source-grounded extraction
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | Crohn disease | “Acute tubulointerstitial nephritis associated with infliximab therapy in a patient with Crohn's disease: a case report.” | 0.93 | phenotype_alias_lexicon_v2 |