IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study.
PMID 39744511 | PMCID PMC11624611 | DOI 10.22099/mbrc.2024.50865.2017 · Molecular biology research communications · 2025
Genetic polymorphisms in interleukin-13 (IL13) gene have been associated with asthma susceptibility in different ethnicities. We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients. A case-control study was conducted at Al-Shaab Teaching Hospital between April and October 2022. Involving fifty asthmatic patients and fifty controls. The genotypes were determined using an allele-specific polymerase chain reaction. For rs1800925, a significant association with asthma in multivariate analysis (aOR=3.15, 95% CI: 1.13-8.76; p=0.028). The T allele was the most frequent in cases and showed a significant association with asthma (aOR=1.99, 95% CI: 1.13-3.5; p=0.016). The rs20541 did not show any association with asthma. The rs1800925 is associated with an increased risk of asthma in Sudanese patients.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IL13 | “IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study.” | 0.98 | hgnc_dict_v1 |
| phenotype | asthma | “IL13 gene polymorphisms among Sudanese patients with bronchial asthma: a case-control study.” | 0.98 | phenotype_alias_lexicon_v2 |
| variant | c.-93+487C>T | “We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients.” | 0.95 | hgvs_regex_v1 |
| variant | p.Gln144Arg | “We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients.” | 0.95 | hgvs_regex_v1 |
| variant | rs1800925 | “We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients.” | 0.90 | hgvs_regex_v1 |
| variant | rs20541 | “We investigated the association of two polymorphisms in the IL13 gene [rs1800925 (c.-93+487C>T), and rs20541 (p.Gln144Arg)] with asthma susceptibility among Sudanese patients.” | 0.90 | hgvs_regex_v1 |