Glucagon-like peptide-1 receptor agonists: a review from a cardiovascular perspective.
PMID 40342976 | PMCID PMC12060260 | DOI 10.3389/fcvm.2025.1535134 · Frontiers in cardiovascular medicine · 2025
INTRODUCTION: Glucagon-like peptide-1 receptor agonists (GLP-1 RA) are novel agents with proven cardiovascular (CV) benefits. GLP-1 RAs have been used for diabetes and found to improve CV outcomes in diabetic and nondiabetic patients. They are authorized for treating obesity. Our narrative review discussed the CV benefits of GLP-1 RAs in terms of controlling CV risk factors and improving CV outcomes in diabetic and nondiabetic patients regardless of their CV history, and the CV perspectives related to their use in clinical practice. AREAS COVERED: Literature was searched with no limits on date or language, using various combinations of keywords. Data on the CV benefits of GLP-1 RAs and their use in clinical practice were summarized. RESULTS: Several studies have discussed the CV beneficial effects of GLP-1 RAs in terms of reducing blood pressure, lipid levels, body weight, risk for arrhythmias, reducing the risk of major adverse CV events, and hospital admission for heart failure. CONCLUSION: The cardioprotective effects and low risk of hypoglycemia of GLP-1 RAs make them preferred agents in any multidisciplinary approach aiming to reduce CV disease burden and improve prognosis. Cardiologists are encouraged to strongly consider the CV benefits of GLP-1 RAs in their risk-reduction strategies.
Validated evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| phenotype | obesity | “They are authorized for treating obesity.” | 0.98 | phenotype_alias_lexicon_v2 |
| phenotype | diabetes mellitus | “GLP-1 RAs have been used for diabetes and found to improve CV outcomes in diabetic and nondiabetic patients.” | 0.93 | phenotype_alias_lexicon_v2 |
| phenotype | arrhythmia | “RESULTS: Several studies have discussed the CV beneficial effects of GLP-1 RAs in terms of reducing blood pressure, lipid levels, body weight, risk for arrhythmias, reducing the risk of major adverse CV events, and hospital admission for heart failure.” | 0.93 | phenotype_alias_lexicon_v2 |