Population record
· 204 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| population | Population | “Stem cell collection parameters, including BM harvest volume, requirement for autologous blood transfusion postharvest, and duration of anesthesia were comparable between the 2 cohorts.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Lung cancer arises when abnormal lung cells grow uncontrollably, leading to over 2 million new cases and nearly 1.8 million deaths globally.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We performed germline whole exome sequencing (WES) on a cohort of 79 BRCA1/2 negative EOBC patients (median age 28 years, range 13-39).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: We searched five databases for studies published between 2015 and 2025 that reported BRCA1/2 mutations in BC patients across various ethnic groups.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “All tumors were immunoreactive for BRAF V600E IHC, and BRAF V600E mutations were confirmed by molecular assays, including broad next-generation sequencing on 2 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In this review, we examined current knowledge on the specific molecular mechanisms of doxorubicin resistance in HCC, including overexpression of drug efflux (ABC family) transporters, aberrations of the drug target topoisomerase IIα (TOP2A), impairments in apoptosis (p53, FOXO3, Bcl-2 family members), oncogenic activation of pro-survival signaling pathways (NF-κB, PI3K/Akt, and MAPKs), instances of tumor heterogeneity with sirtuins, and cancer stem cells.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic and Viral Characteristics and Response to Dual and Extended Antiviral Therapy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Correlation of vitamin D levels with TNF-α and IL-6 expression in insulin-resistant type 2 diabetes mellitus patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: We conducted 2 prospective birth cohort studies in Uganda from 2017 to 2023.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Phase 2 asked participants to rate the importance of each priority using a 10-point scale; exploratory factor analysis (EFA) was performed to identify underlying factors.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CONCLUSION: Our findings underscore the prolonged excretion of SARS-CoV-2 RNA in patients with antibody and combined deficiencies.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “RESULTS: The incidence of VTE varies worldwide, ranging from 2 cases per 1,000 person-years, with higher prevalence in hospitalized patients (15-30%) and critically ill patients (up to 20 %).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Correlation of TNF-α and IL-6 expression with vitamin D levels in insulin-resistant type 2 diabetes mellitus patients: exploring the role of vitamin D in inflammation and disease pathogenesis.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This study, conducted at Islamabad Diagnostic Center across Pakistan from January 2021 to August 2022, aimed to investigate hematological abnormalities among suspected SARS-CoV-2 subjects.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Diagnosis of donor-derived Malassezia restricta &Aspergillus species invasive fungal infection in renal transplant recipient using next generation sequencing - A report of 2 cases and literature review.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Based on these structural characteristics, flavonoids can exert both antioxidant or prooxidant properties, modulate the activity of ROS-scavenging enzymes and the expression and activation of proinflammatory cytokines (e.g., interleukin-1beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α)), induce apoptosis and autophagy, and target key signaling pathways, such as the nuclear factor erythroid 2-related factor 2 (Nrf2) and Bcl-2 family of proteins.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This case report describes 2 patients who developed epilepsy after exposure to explosive blasts in war zones, highlighting their clinical courses, diagnostic findings, and treatment outcomes.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Plasma Atrial Natriuretic Peptide Predicts Oxidized Low-Density Lipoprotein Levels in Type 2 Diabetes Mellitus Patients Independent of Circulating Adipokine and Cytokine.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBSERVATIONS: The authors present illustrative cases of 2 female patients (ages 70 and 39 years) with large OGMs who underwent resection via orbitozygomatic craniotomy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Plasma pTau217 declined in 2 LOAD patients after 2 years of daily use.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The role of interleukin (IL)-2 cytokine family in Parkinson's disease.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Challenges, current innovations, and opportunities for managing type 2 diabetes in frail older adults: a position paper of the European Geriatric Medicine Society (EuGMS)-Special Interest Group in Diabetes.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “MEASURES TO REDUCE RISK: Given your direct exposure to infected patients, it is imperative to establish a protocol for triaging patients with respiratory symptoms and to uphold a minimum distance of 2 meters between patients and primary care physicians.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Therefore, real-world randomized controlled trials to assess major adverse cardiac or cerebrovascular event risk reduction and reversal/prevention of type 2 diabetes among patients are needed to determine the proper interventions.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Low Plasma Levels of Contactin-Associated Protein-Like 2 in Children with Autism Spectrum Disorder: Links to Neural Development.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVES: To explore the landscape of BRCA1/2 mutations in gastric cancer patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The treatment groups had significantly greater gene expression levels of INS-1, PDX-1, IGF-1, and GLUT-2 than the positive control group (p ≤ 0.05).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This study interrogated 2 large well-characterized BC cohorts.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In-ovo treatment increased mRNA expression of JAM-2 compared to the control group.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Significant Association of Candidate Genes (AGTR1 and TGF-Β1) Polymorphism with Diabetic Nephropathy in Diabetes Mellitus Type 2 Patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Previous studies have shown that PASC impacts 10% of SARS-CoV-2 infected patients of which 50-70% are hospitalised.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “RESULTS: The seeds with the highest rutin content, NGRC03731 seeds, had 433 mg/100 g of rutin.The rutin fraction treatment and standard rutin significantly reduced cell viability in the MTT assay, and osteosarcoma cells were observed on sensitive to the IC-50 dose at a concentration of 20 g/ml after 24 h.The SAOS2 cells exposed to rutin fraction at 20 g/ml and standard rutin at 10 g/ml exhibited significant morphological alterations, cell shrinkage and decreased cell density, which indicate apoptotic cells.Rutin-fraction treated cells stained with acridine orange/ethidium bromide (AO/EtBr) dual staining cells turned yellow, orange, and red which indicatesto measure apoptosis.The anti-migration potential of rutin fraction, results prevented the migration of SAOS2 cancer cells.Rutin-fraction significantly increased the expression of pro-apoptotic proteinsBad, using real-time PCR analysis (mRNA for Bcl-2 family proteins) resulted Bcl-2's expression is negatively regulated.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The complex interplay that exists between these noncoding RNAs and apoptotic effectors, including caspases and members of the Bcl-2 family, plays a role in the precarious equilibrium that regulates cell survival and death during hepatitis.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Boosting the mRNA expression of the transporter proteins (solute carrier family 15 member 2 and solute carrier family 26 member 6) and insulin-like growth factor-1 genes with a decrease in the myostatin gene expression was noticed in the CAE-fed groups.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Role of the dynamin-related protein 2 family and SH3P2 in clathrin-mediated endocytosis in Arabidopsis thaliana.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Effects of sodium-dependent glucose transporter 2 inhibitors in patients with type 2 diabetes mellitus and asymptomatic heart failure.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We present 2 cases of MAD in previously healthy pediatric patients and highlight clinical scenarios where MAD should be suspected.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Pro-Inflammatory Characteristics of Extracellular Vesicles in the Vitreous of Type 2 Diabetic Patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: Vitreous samples from type 2 diabetic and non-diabetic subjects, collected post-mortem, were analyzed using liquid chromatography-mass spectrometry.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Neonatal Calcinosis Cutis After Treatment of Hypocalcemia with Calcium Gluconate: A Report of 2 Cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “HIV, the causative agent of acquired immunodeficiency syndrome (AIDS), infects 4,000 people daily, potentially leading to 1.2 million new cases by 2025, while HCV chronically affects 58 million people, causing cirrhosis and hepatocellular carcinoma.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVES: Investigate the morbidity and mortality associated with SARS-CoV-2 infection among pregnant individuals, considering vaccination status and variant strains.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Unlike all other known families of African origin, the Machado lineage was observed in Sudan, being shared with 86 Portuguese, 2 Spanish and 2 North-American families.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Recurrent stroke and acute necrotizing encephalopathy were described, 2 patients in each group.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CONTEXT: Bariatric surgery has been shown to be effective in inducing complete remission of type 2 diabetes in adults with obesity.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Sofosbuvir, a uridine nucleotide analog that potently inhibits viral polymerase, has been found to help treat SARS-CoV-2 patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Robust memory humoral immune response to SARS-CoV-2 in the tonsils of adults and children.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The present study aimed to investigate the efficacy of the Oxford-AstraZeneca (ChAdOx1 CoV-19) vaccine against SARS-COV-2 cases, hospital admissions, type of variants and deaths.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This molecule increased the expression levels of both p53 and Bax, and decreased the gene expression level of Bcl-2 as compared to control untreated MCF-7 carcinoma cells.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: In this study, I report a family with 2 individuals having large occipital encephalocele.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Post hoc, 2 cohorts were defined using receiver operating characteristic curves (MS less than 13 and MS greater than 12).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We used next-generation sequencing techniques to study SARS-CoV-2 genomes isolated from patients and health care workers (HCWs) across five wards of a Canadian hospital with an ongoing SARS-CoV-2 outbreak.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “BCL-2 family proteins protect cancer cells from the apoptotic effects of chemotherapeutic drugs.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: The STEMI population came from 2 retrospective cohorts with 1097 patients, cohorts A (YongChuan Hospital) and cohorts B (Taizhou First People's Hospital).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Control cases comprised of 2 cases with no significant pathological changes, and 3 cases with telencephalic leukoencephalopathy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Rats in Group 1 received saline (Sham group), Group 2 included control induced-CRS rats, Group 3 rats (CRS+ABA) included CRS rats treated with ABA and Group 4 (CRS + ABA + Verapamil + propofol) were CRS rats treated with Verapamil, propofol and ABA.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Standardized periprocedural management consisted of DOAC interruption 1 day preendoscopy with resumption 1 day after procedure at low-moderate risk of bleeding or 2 days in case of a high bleeding risk.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CONCLUSION: Our findings provide evidence to suggest negative impacts on the neurodevelopment at 2 months of preterm infants exposed to certain metals, possibly related to TPN intake and/or blood transfusions received during their NICU stay.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVE: To assess trajectory of HRQOL over 2 years in children with drug-resistant epilepsy (DRE) treated with surgery compared with medical therapy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Severity of SARS-CoV-2 infection in children with inborn errors of immunity (primary immunodeficiencies): a systematic review.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In conclusion, SARS-Cov-2 infection in children following HCT was frequently asymptomatic.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “According to WHO statistics, seasonal influenza virus epidemics are predicted to cause over 2 million severe illness cases with high death rates yearly.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Updates on Triple-Negative Breast Cancer in Type 2 Diabetes Mellitus Patients: From Risk Factors to Diagnosis, Biomarkers and Therapy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “RESULTS: Fourteenth studies were included, presenting data from 439 Crohn's disease (CD), 139 ulcerative colitis (UC) and 2 IBD-unclassified participants compared with healthy matched or unmatched groups or reference populations.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “SARS-CoV-2 infections and MIS-C among children: A narrative review.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Unfortunately, 2 patients died secondary to massive pulmonary embolism.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Familial non-medullary thyroid cancer (FNMTC) occurs in about 5% to 9% of cases, either as a part of known syndromes such as Cowden syndrome or in the form of familial clustering of 2 or more affected family members.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Analysis of OCT1, OCT2 and OCT3 gene polymorphisms among Type 2 diabetes mellitus subjects in Indian ethnicity, Malaysia.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CASE REPORT Here, we report 2 cases of delayed hemolytic transfusion reaction (DHTR) in which the patients showed evidence of alloimmunization from previous blood transfusions.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “PD-L1 immunostaining was not detected in 2/2 control specimens.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Since the first case of Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in 2019, SARS-CoV-2 infection has affected many individuals worldwide.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Molecular evidence for SARS-CoV-2 in samples collected from patients with morbilliform eruptions since late 2019 in Lombardy, northern Italy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “An isothermal lab-on-phone test for easy molecular diagnosis of SARS-CoV-2 near patients and in less than 1 hour.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “INTRODUCTION: SARS-CoV-2 belongs to the coronavirus family, a large family of viruses infecting avian and mammalian hosts.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “INTRODUCTION: A global surge in SARS-CoV-2 cases is occurring due to the emergence of new disease variants, and requires continuous adjustment of public health measures.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “SUBJECTS AND METHODS: A retrospective case-control study comprising a total of 779 type 2 diabetes patients with or without diabetic retinopathy was conducted.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Acute Kidney Injury (AKI) might develop in up to a quarter of SARS-CoV-2 patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Moreover, it estimates resistance of cancer cells by evaluating Nitric Oxide Synthase (NOS) expression and evaluate its correlation with the expression profile proteins of the apoptosis regulating Bcl-2 family.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Cardiovascular monitoring in patients with hypertrophic obstructive cardiomyopathy in a prone position: A report of 2 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The effects of PUFAs on glycemia in type 2 diabetes patients are unclear.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Blood Glucose, HbA1c Level, and its Correlation with VEGF-A (+405G/C) Polymorphism as Biomarker Predicts the Risk of Retinopathy and Nephropathy in Type 2 Diabetic Patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CONCLUSION: Overall, the findings indicate that WL15 of cysteine and glycine-rich protein 2 can act as a potential antioxidant for type 2 diabetes patients in respect of improving β-cell regeneration.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “However, results are conflicted. therefore, in this study we re-examine the relationship between MTHFR C677T in type 2 diabetes mellitus patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This report presents 2 cases of GAD65Ab-associated brain autoimmunity and their different management.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Co-infection of human immunodeficiency virus, herpes simplex virus-2 and SARS-CoV-2 in a patient with false-negative real-time polymerase chain reaction results.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Here, we try to highlight the different strategies for isolating patients with COVID-19 and point-out the evolution of such strategies over time, mainly for mildly or moderately severe SARS-CoV-2 infected patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The current study aimed at investigating the single Arg753Gln nucleotide polymorphism of the Toll-like receptor 2 gene in patients with tuberculosis infection versus a sample of healthy subjects as controls.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We found that LL-37‒induced rosacea-like inflammation was significantly reduced in mice with MC-specific deletion of β-arrestin 2 compared with that in control mice.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report 2 patients who presented with hematologic abnormalities in which 2 ADA2 gene mutations were detected.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “A few neurofibromatosis type 2 patients have been diagnosed with over 25 cervical lesions.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Congenital prothrombin deficiency is an extremely rare, autosomal recessive bleeding disorder with a prevalence of 1 in 2 million individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “DESIGN, SETTING, AND PARTICIPANTS: A 2-stage, case-control, whole-exome sequencing association study with a discovery cohort and 2 independently ascertained validation cohorts.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “One GRM7 mutation previously reported in 2 patients results in a single amino acid change, I154T, within the mGlu7 ligand-binding domain.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The use of magnetic nanoparticles is to separate nucleic acid of SARS-CoV-2 from the patient samples and apply for SARS-CoV-2 detection in an easy and more effective way.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “KRAS mutations (N = 2, 6.45%) were found in exon 1 whereas no mutations in KRAS exon 2 were detected in our patient cohort.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The newly emerged SARS-CoV-2 mutants complicated the control and mitigation strategies measures.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “AIMS: Genetic variations mediating MMP-2 expression may result in individual differences in susceptibility to particular diseases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “RESULTS: We discovered homozygous truncating and homozygous missense mutation in SYNPO2 (synaptopodin-2) (p.Lys1124∗ and p.Ala1134Thr) in 2 patients with childhood-onset NS.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “COVID-19 evolution during the pandemic - Implications of new SARS-CoV-2 variants on disease control and public health policies.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Metformin alters peripheral blood mononuclear cells (PBMC) senescence biomarkers gene expression in type 2 diabetic patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “SARS CoV-2 infection in a patient with sickle cell disease - Atypical presentation.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: To examine apoptosis in insulin resistance, we assessed the mRNA expression by qRT-PCR of several Bcl-2 family members, as well as caspase-3, -7, -8, and -9 in peripheral blood mononuclear cells (PBMCs) isolated from lean, obese, diabetic, and diabetic on metformin individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Magnetic Resonance Imaging (MRI) and neurological manifestations in SARS-CoV-2 patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVE: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CONCLUSIONS: DPNKT-like cells, IFN-γ and IL-2 patient profiles could be used as markers to predict the risk of miscarriage in patients with URM.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “PATIENT CONCERNS: This article presents 2 case reports of Oral erythema multiforme in which drugs were the precipitating factor.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Sequences of RPS16-1 and RPS16-2 in the three families of Malpighiales (Salicaceae, Passifloraceae and Euphorbiaceae) have high sequence identity suggesting that the substitution event dates to the early divergence within Malpighiales.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Thymic stromal lymphopoietin (TSLP), a member of the interleukin-2 family of cytokines, is produced by activated lung and intestinal epithelial cells, mast, and other immune cells.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This study was conducted to evaluate COX-2 expression in a large cohort of Middle Eastern papillary thyroid carcinoma (PTC), and further evaluate the prognostic significance of COX-2 expression in strata of BRAF mutation status.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “DESIGN, SETTING, AND PARTICIPANTS: A cross-sectional study of a standard germline detection method and a deep learning method in 2 convenience cohorts with prostate cancer and melanoma enrolled in the US and Europe between 2010 and 2017.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Amplicon-Based Detection and Sequencing of SARS-CoV-2 in Nasopharyngeal Swabs from Patients With COVID-19 and Identification of Deletions in the Viral Genome That Encode Proteins Involved in Interferon Antagonism.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The present study was aimed at assessing the PPAR-γ2 variant in an Asian Indian cohort of type 2 diabetes patients and its correlation with metabolic parameters.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The prognostic value of microRNA-biogenesis genes Argonaute 1 and 2 variants in breast cancer patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The complications were in 2 patients post-mitral valve (MV) repair, 3 patients post-aortic (AV) replacement, 2 pediatric patients, 1 post-aortic homograft, and the other post-repair of anomalous single coronary arising from the pulmonary artery (ASCAPA).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Association between circulating microRNAs 486, 146b and 15b and serum betatrophin levels in obese; type 2 diabetic and non-diabetic children.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: This case-control study was conducted on type 2 diabetic patients who attended Suez Canal University Hospital, Egypt, between November 2016 and October 2017.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Important ongoing tests of change included assigning a single process owner for UE reporting, ensuring proper ETT securement, and using 2 clinical staff during patient and/or ETT manipulation.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Here we present 2 pediatric cases of intracranial AFH and perform a literature review on this disease entity.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “BACKGROUND: Preexisting alteration of the immune system by factors including older age, cardiovascular diseases, morbid obesity, diabetes, and chronic obstructive pulmonary disease (COPD) have detrimental effects on SARS-CoV-2 patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The incidence of IMD is low and similar across the represented countries (<0.2 cases per 100,000 persons per year), with the predominant serogroups of Neisseria meningitidis being B, W and Y, although serogroups A and X are present in some areas.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Group 1 was treated as a normal control (NC) group and fed with saline water, Group 2 as a Diabetes Control group, Group 3 as a STZ+C. roseus ethanolic extract (CREE) group at 50 mg/kg p.o., Group 4 as a STZ+UA group orally at 50 mg/kg, Group 5 as a STZ+CREE (25 mg/kg p.o.)+UA (25 mg/kg p.o.) group, and Group 6 as a STZ+Glimepiride (0.1 mg/kg) group.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We found that the ACE1 II genotype frequency in a population was significantly negatively correlated with the number of SARS-CoV-2 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CASE REPORT We present 2 cases of 34- and 35-year-old males who presented to our tertiary care hospital because of primary infertility.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Herein, we present 2 cases of PAM in the pediatric age group, along with their clinical history, presentation, radiological studies, and histopathology findings, as well as a brief literature review.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “One extra port was inserted in 2 patients at the beginning of the series.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Two groups of infants aged 1 year or younger in 2 cohorts were included: those with malignant conditions, such as leukemia, and those with nonmalignant disorders, including immunodeficiencies.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVE: We investigated the genetic basis of recurrent sinopulmonary infections, persistent EBV viremia, and EBV-induced lymphoproliferation in 2 unrelated patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In this report, we sought to broaden the genotype-phenotype spectrum of calmodulinopathies with 2 novel calmodulin mutations and to investigate mosaicism in 2 affected families.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We aimed to evaluate a panel of circulating hyperglycemia-related lncRNAs: RNCR2, NEAT2, CDKN2B-AS1, and PVT1 in type 2 diabetes patients with/without DR and to correlate their levels with the clinical characteristics and response to aflibercept intravitreal injection in terms of visual acuity (VA) improvement, central macular thickness (CMT) decline, and macular edema resolution after 4 weeks of the initial injection.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODOLOGY: The study followed a case-control design, with 15 type 2 diabetes patients, 10 IGT subjects, and 19 control subjects.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Neurological manifestations in 2 children.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “CASE DESCRIPTION: We report the unusual manifestation of 2 adult male patients, whose recurrent posterior fossa epidermoid cysts progressively invaded the anterior surface of the pons.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In this report, we document the therapeutic importance of elucidating the specific cause of hyperammonemic encephalopathy that closely mimicked NCSE through 2 unique illustrative cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Using whole-exome or whole-genome sequencing, we identified the previously reported c.196delC and c.487C>G variants in NKX6-2 in 3 and 2 unrelated index cases, respectively; the novel c.608G>A variant was identified in a sixth patient.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “WDR45B has been identified as a potential intellectual disability gene through genomic sequencing of 2 large cohorts of affected individuals.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “To identify the cause, we performed whole exome sequencing (WES) for 2 infertile brothers and 2 fertile family members.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P < 2.2 × 10-7); of these, 16 map outside known risk-associated loci.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Real-world geographic variations in the use of cardiac implantable electronic devices-The PANORAMA 2 observational cohort study.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Differential Expression of Human Peripheral Mononuclear Cells Phenotype Markers in Type 2 Diabetic Patients and Type 2 Diabetic Patients on Metformin.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The synergistic effects of saxagliptin and metformin on CD34+ endothelial progenitor cells in early type 2 diabetes patients: a randomized clinical trial.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVE: To investigate, in 2 patient cohorts, the relationships between circulating levels of multiple forms of PCSK9 and cardiometabolic interventions or treatments known to reduce LDL cholesterol levels.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Only 2 epilepsy patients to date have been reported to have recessive mutations in SCN1B as the likely cause of their phenotype.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: The analysis was performed in 788 Type 2 diabetes cases and 1,057 controls randomly chosen from the cross-sectional Chennai Urban Rural Epidemiological Study.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Acral dermatofibrosarcoma protuberans with myoid differentiation: A report of 2 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The binding characteristics of circulating auto-antibodies in type 1 and type 2 diabetes patients against native and modified LDL were assessed.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We present 2 cases of invasive mucormycosis due to Rhizopus spp. in patients with chronic granulomatous disease (CGD) and discuss their clinical presentation, management challenges, and outcomes.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: We used data on deletions spanning the 22q11.2 locus from four independent case-control Parkinson's disease studies (UK Wellcome Trust Case Control Consortium 2, Dutch Parkinson's Disease Genetics Consortium, US National Institute on Aging, and International Parkinson's Disease Genomics Consortium studies), which were independent of the original reports of chromosome 22q11.2 deletion syndrome.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “One eye of each patient (the worse-seeing eye in five subjects) received a submacular injection of the viral vector, first at a dose of 150 µl (5.96 × 10(10)vg; 2 patients) and then 450 µl (17.88 × 10(10)vg; 4 patients).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “ARSACS is a neurodegenerative early-onset progressive disorder, originally described in French Canadians, but later observed elsewhere.(1) Whole-exome sequencing of a large group of patients with unclassified progressive myoclonus epilepsies (PMEs) identified 2 patients bearing SACS gene mutations.(2) We detail the PME clinical features associated with SACS mutations and suggest the inclusion of the SACS gene in diagnostic screening of PMEs.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In addition, 2 additional cases in our cohort demonstrated ETV6 rearrangement by FISH.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Discussion: Nrf2 genotypes in pre - and post-menopausal patients, showed significantly different distributions in the 2 patient groups, the AA genotype being significantly more common in pre-menopausal patients.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Hemorrhagic presentations of cerebellar pilocytic astrocytomas in children resulting in death: report of 2 cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Only 2 cases of coronary bypass surgery in an achondroplastic dwarf, in which the left internal mammary artery and vein grafts were used, have been reported.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We selected 50,008 unique samples: 10,002 individuals with low FEV1, 10,000 with average FEV1, and 5002 with high FEV1 from each of the heavy smoker and never smoker groups.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “BACKGROUND: BCL-xL is an anti-apoptotic BCL-2 family protein that inhibits apoptosis and is overexpressed in many cancers.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Association of 18bp insertion/deletion polymorphism, at -2549 position of VEGF gene, with diabetic nephropathy in type 2 diabetes mellitus patients of North Indian population.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Whole-exome sequencing of 2 affected individuals identified a shared homozygous, nonsense variant in the PCLO (piccolo) gene.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report 2 cases of CVST who presented with severe headache associated with neck pain and focal seizures.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Six groups of fish were treated for 2 weeks and included control group, CdCl2-treated group and groups treated with EMC or TMC alone or in combination with CdCl2.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “In this paper, we present 2 rare cases of persistent embryonic anastomoses.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Risk factors associated with diabetic retinopathy among type 2 diabetes patients at teaching hospital in Malaysia.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report these 2 cases because of the rarity of NBS, presentation of which may mimic common illnesses like sepsis and gastroenteritis.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report 2 unrelated children who presented with early-onset severe retinal dystrophy in the context of hypotonia, developmental delay, and a noticeably happy demeanor.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “METHODS: Exome sequencing was carried out on 2 family members who were both successfully resuscitated from a cardiac arrest.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “PATIENTS AND METHODS: In the CAPRI-GOIM trial, 340 KRAS exon 2 wild-type mCRC patients received first-line FOLFIRI plus cetuximab.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report 2 cases of recent onset of prolonged syncope and unrevealing cardiac work up.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “FINDINGS: Globally in 2013, there were 1·8 million new HIV infections (95% uncertainty interval 1·7 million to 2·1 million), 29·2 million prevalent HIV cases (28·1 to 31·7), and 1·3 million HIV deaths (1·3 to 1·5).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “A significantly higher incidence of TNF 2 /TNF 2 genotype was observed among patients with acute graft rejection in comparison with the control group (40.5% and 19.2% respectively, P <0.05), while no statistically significant differences were observed in the TNF 1 /TNF 1 genotype between the groups (59.4% and 80.8%, respectively, P >0.05).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The authors' main aim was to investigate biochemical parameters and the oxidative stress associated with the type 2 DR patients and to study gene expression of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) among patients with DR [DR(+)] compared with a control nondiabetic group.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We document an unusual pattern of acquired peripheral circumferential iris degeneration in 2 unrelated children with otherwise-controlled congenital glaucoma.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report recurrent visual hallucinations in 2 children with propionic acidemia.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Two- (n=17) and 8-week old (n=17) rabbits were separately divided into 2 control (n=9), and test (n=8) groups.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report here 2 cases with juvenile myoclonic epilepsy who were switched from sodium valproate to levetiracetam to avoid the cosmetic or future teratogenic effect, but this switch was associated with exaggerated myoclonus despite escalating the dose of levetiracetam but resolved completely after reintroducing sodium valproate.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Here, the authors compared the epileptological outcomes and return to work in 2 groups of patients who underwent surgery with or without hippocampectomy for paralimbic Grade II gliomas eliciting intractable epilepsy despite no tumoral involvement of the hippocampus.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We describe the successful anesthetic management of 2 children with Hurler's syndrome who underwent ventriculoperitoneal shunt surgery for acute hydrocephalus.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Thirteen G-2 patients developed chronic allograft dysfunction (CAD).” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Only 2 patients were divorced and 3 lost their job due to epilepsy.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “To evaluate correlation between infection by cagA positive strains of H. pylori and occurrence of microalbuminuria and glycemic control in type 2 diabetic patients, we prospectively studied 98 dyspeptic type 2 diabetic patients as a study group and 102 dyspeptic non-diabetic subjects as a control group.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Beginning at the age of 3 months and 2 weeks the patient had severe infantile spasms.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This is essential for preventing the transmission of HIV-1 and 2 to the infants and to the community, and for the appropriate medical treatment and counseling of affected women.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Candidate gene testing of PHOX2A, the gene for recessive CFEOM (CFEOM2), did not reveal mutation in the 2 patients or their parents.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We identified previous reports of only 2 similar cases: a woman from Alabama and a man from northern Australia.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “This report describes 2 unusual cases of congenital pouch colon and anorectal malformations.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Hemochromatosis gene (HFE) mutations in patients with type 2 diabetes and their control group in an Iranian population.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Neutrophil chemokines GCP-2 and GRO-alpha in patients with inflammatory bowel disease.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The 2 patients developed end stage renal disease.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “However, indeterminate WB reactivity to HIV-1 and HIV-2 proteins may occur in individuals who do not appear to be infected with HIV.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “These 2 cases are examples of tumorigenesis in PGD without an identifiable Y chromosome.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We present 2 interesting cases of osteomalacic myopathy secondary to celiac disease, which were treated successfully with full recovery.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Here, we describe the clinical course of 2 patients with hemophilia A who suffered bleeding in the abdomen and were treated conservatively with a successful outcome.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Apoptotic index values were higher in invasive site of tumors, and it was statistically significant in MI grade 2 OSCC cases.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “OBJECTIVE: To determine the prevalence of 3 polymorphisms in p53 gene in 3 healthy Jordanian groups and 2 cancer patient groups.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report 2 cases of CES.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We report 2 full term newborn infants who developed middle cerebral infarction.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The clinical, laboratory and cytological features of 2 Bahraini infants with Wolman's disease are described.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Ten cases have been reported in the literature, the last 2 cases were associated with Human immunodeficiency virus.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “However, structural autosomes were found to be the most prominent abnormalities and only 2 patients were demonstrated to have diagnosable syndrome.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “The active compounds exert their antiarrhythmic potency via blocking Na+ channels as in case of 5c or blocking Ca+2 channels as in case of 4a, 4c and 5c.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “There was progressive wear of acetabular articular cartilage in 2 cases, but no clinical or radiological evidence of loosening of the femoral stem.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “We documented no circadian rhythm in either AS or the GTCS, except in 2 patients who had AS and GTCS mainly when they awoke in the morning.” | 0.80 | saudi_context_rules_v1 |
| population | Population | “Determining the cause of apnea is important as treatment differs significantly and can be harmful; Caffeine given for presumed idiopathic central apnea is reported to have precipitated seizures in 2 patients with apneic seizures.” | 0.80 | saudi_context_rules_v1 |