ESR1
HGNC:3467 · 44 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | ESR1 | “Comprehensive genomic profiling has identified multiple resistance mechanisms, including ESR1 mutations, PI3K/AKT/mTOR pathway activation, RB1 loss, and FGFR alterations, which may co-occur and reduce sensitivity to endocrine monotherapy.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Network pharmacology and molecular docking identified AP9 as a lead chemical with high affinity for hub proteins: as AKT1, EGFR, ESR1, HIF1A, MTOR, and PARP1, implying an involvement in neurodegenerative disease pathways.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Cross-referencing polyphenol-associated targets with GBM-related genes identified 13 common targets (e.g., PTGS2, EGFR, ESR1, MMP9).” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Notably, ESR1 mutations detected in ctDNA have emerged as potential indicators of resistance to aromatase inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Network pharmacology analysis, integrating targets predicted via SwissTargetPrediction and disease-associated genes from GeneCards, identified PPARG, ESR1, and IL6 as key hub genes underlying OFSO's effects.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Then, protein-protein interaction (PPI) network analysis pinpointed seven top-ranked DEGs (GAPDH, PTEN, CCND1, APOE, ESR1, MAPK3/ERK1, and SNCA) as KGs or central modulators of PD pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Protein-protein interaction (PPI) analysis highlighted ten key genes-EGFR, ESR1, HIF1A, HSP90AA1, MAPK1, BCL2, STAT3, TP53, CASP3, and SRC-implicated in the progression of various cancers, including breast, colorectal, liver, and lung tumors.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Network analysis highlighted ESR1, HSP90AA1, SRC, HIF1A and EP300 as key hub genes within the AD-related compound-target network, suggesting critical regulatory roles.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Then, in 2012, another important study was published linking PRSS23 with proliferation of breast cancer cells by an estrogen receptor 1 (ESR1)-dependent transcriptional activation of the serine protease.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Rosemary reduced estrogen receptor (ESR1) protein mediated cycle arrest and apoptosis: A potential hormonal dependent anticancer mechanism of the plant in the MCF-7 breast cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Network pharmacology identified ESR1, CASP3, PPARG, and PTGS2 as key targets, with MQLEO components engaging apoptosis, inflammation (TNF, IL-17), and estrogen pathways.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Finally, prevalence of somatic mutations in TP53, PIK3CA, and ESR1 were higher in ADI ≥ 60.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Notably, KRAS, CUL3, TP53, ESR1, and PARP1 were influenced by both upregulated and downregulated miRNAs.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Association of ESR1, HER1, and HER2 Polymorphisms with Breast Cancer Risk in the KP Population, A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Whereas, androgen receptor (AR), epidermal growth factor receptor (EGFR), and estrogen-sensitive receptor alpha (ESR1) were the most enriched target genes.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “In patients with breast cancer, PIK3CA (35.3%), ESR1 (21.7%), and BRCA1/2 (13.3%) had the most prevalent alterations among NCCN-recommended genes.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Expression analysis of ENO1 (Enolase 1) and ESR1 (Estrogen Receptor 1) genes in relation to LDHA and ABCC1 mutations in Breast Cancer samples revealed that higher ENO1 expression is observed in mutant samples, while ESR1 expression is significantly reduced, suggesting an association with altered metabolic and hormonal pathways.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “The estrogen receptor 1 gene (ESR1) plays a crucial role in breast and mammary development in humans.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Further analysis identified 5 core/ hub targets of CN including JAK2, ERK1, ESR1, GSK3B and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Five proteins (i.e., EGFR, MAPK3, ESR1, MAPK1, and PTGS2) associated with breast cancer were selected as receptor proteins.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Survival and network analysis revealed that five genes named heat shot protein 90 AA1 (HSP90AA1), estrogen receptor 1 (ESR1), cytochrome P450 3A4 (CYP3A4), cyclin-dependent kinase 1 (CDK1), and matrix metalloproteinase-9 (MMP9) are linked with the survival of LC patients.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “In our research, we conducted a comprehensive screening using HTVS, SP, and XP, followed by an MM/GBSA computation of human-approved drugs targeting HER2/neu, BRCA1, PIK3CA, and ESR1.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Exploring the association of ESR1 and ESR2 gene SNPs with polycystic ovary syndrome in human females: a comprehensive association study.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “RESULTS: The findings revealed that Cucurbita pepo contains 18 active components and has 192 potential gene targets, including AR, EGFR, ESR1, AKT1, MAPK3, SRC, and MTOR.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “There was a positive correlation between ER expression and ESR1 mRNA expression and expression of ER-regulated genes.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Whereas, glimepiride increases BDNF by binding to KCNJ11 via AP2M1 and ESR1 proteins.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Moreover, quantitative real-time PCR (qRT-PCR) was used to detect specific genes associated with cancer, such as ESR1, Bax, Bcl-2, and p53.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Results for the three datasets included 44 unique genes and 10 unique transcription factors (SP1, HDAC1, EGR1, E2F1, AR, STAT6, RELA, SP3, NFKB1, and ESR1) which are reportedly related to pancreatic islet functions, diseases, and therapeutic targets.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Biochemical Characterization and Molecular Determination of Estrogen Receptor-α (ESR1 PvuII-rs2234693 T>C) and MiRNA-146a (rs2910164 C>G) Polymorphic Gene Variations and Their Association with the Risk of Polycystic Ovary Syndrome.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Different regions of the GPR177, ESR1 and RUNX2 genes were studied, using PCR and sequencing, in a total of forty-eight samples for each marker.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Integration of gene networking data, with additional parameters like estimation of mutation burden of tumors and cancer driver gene identification, has led to the finding of 4 hubs (JUN, VCAN, TOP2A, and COL1A1) and 8 bottleneck genes (PIK3R1, MYH11, KDR, ESR1, WT1, CCND1, EZH2, and CDKN2A), which showed a clear distinction in their distribution pattern among leiomyomas and leiomyosarcomas.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “We found that expression of ESR1, the gene encoding ERα, is directly activated by RECQ1.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “The associations between expression of hERG (KCNH2), aromatase (CYP19A1) and the oestrogen receptors (ESR1 and ESR2) and time to all-cause mortality were assessed in GBM patients within The Cancer Genome Atlas (TCGA) database. hERG expression was associated with reduced overall survival in the TCGA GBM cohort.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Estrogen Receptor 1 Gene (ESR1) rs2234693 Polymorphism and Breast Cancer Risk in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “AIM AND OBJECTIVE: To assess correlation among craniofacial proportions and genetic indicators using estrogen receptors (ESR1 and ESR2).” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Allele T of rs2234693 decreases expression of ESR1 in thyroid gland, allele T of rs2234693 and allele G of rs9340799 increase affinity to eight transcription factors (AP-4, HEN1, E2A, LBP-1, RP58, LUN, Ets and Hand).” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Association between ESR1, ESR2, HER2, UGT1A4, and UGT2B7 polymorphisms and breast Cancer in Jordan: a case-control study.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Frequent ESR1 and CDK Pathway Copy-Number Alterations in Metastatic Breast Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Estrogen Receptor Alpha (ESR1) Gene Polymorphisms in Pre-eclamptic Saudi Patients.” | 0.98 | hgnc_dict_v1 |
| gene | ESR1 | “Whereas, FCGA studies have identified some candidate genes which are associated with vitiligo, such as HLA, AIRE, VIT1, CAT, FOXD3, ESR1, COMT, PTPN22, NALP1, PDGFRA, MYG1, MITF, CD117, XBP1, FAS, COX2, EDN1 and ACE, but few of them reports now appear to be false-positive.” | 0.98 | hgnc_dict_v1 |