HLA-A

gene

HGNC:4931 · 39 retained evidence mentions

Source-grounded findings

Supporting evidence

Type	Entity	Source evidence	Confidence	Extractor
gene	HLA-A	“Identification of the Novel HLA-A*33:03:01:29 Allele by Sequencing-Based Typing.”	0.98	hgnc_dict_v1
gene	HLA-A	“Identification of the Novel HLA-A*31:236 Allele by Sequencing-Based Typing.”	0.98	hgnc_dict_v1
gene	HLA-A	“Discovery of the Novel Allele, HLA-A*30:01:33, Identified in a Saudi Individual by Next Generation Sequencing.”	0.98	hgnc_dict_v1
gene	HLA-A	“The most frequently observed extended haplotype is HLA-A02:01∼C06:02∼B50:01∼DRB107:01∼DRB401:03∼DQA102:01∼DQB102:02∼DPA101:03∼DPB1*04:01.”	0.98	hgnc_dict_v1
gene	HLA-A	“RESULTS: in our cohort HLA-A* 02:01:01 G was associated with mild disease but was not associated with moderate and severe disease.”	0.98	hgnc_dict_v1
gene	HLA-A	“Identification of the novel HLA-A*02:829 allele by sequencing-based typing.”	0.98	hgnc_dict_v1
gene	HLA-A	“It specifically highlights genes associated with antigen processing and presentation, such as HLA-B, HLA-A and HLA-DRB1 and their possible effects on tumour progression and immune evasion.”	0.98	hgnc_dict_v1
gene	HLA-A	“Analysis of the Origin of Emiratis as Inferred from a Family Study Based on HLA-A, -C, -B, -DRB1, and -DQB1 Genes.”	0.98	hgnc_dict_v1
gene	HLA-A	“Moreover, molecular docking analysis indicated that VLMENERTL and WTYNAELLV epitopes have high binding affinity to the antigen-binding groove of the HLA-A02:01 and HLA-A68:02 molecules, respectively.”	0.98	hgnc_dict_v1
gene	HLA-A	“Identification of the novel HLA-A*74:03:03 allele by sequencing-based typing.”	0.98	hgnc_dict_v1
gene	HLA-A	“HLA-A in prostate cancer, MSR1 in familial prostate cancer, and EGFR in both castration-resistant prostate cancer and metastatic castration-resistant had the highest allele frequencies of splice-disrupt variations.”	0.98	hgnc_dict_v1
gene	HLA-A	“After sub-network analysis we identified six overlapped hub genes (RPS5, RPL37A, RPLP0, CXCL8, HLA-A, and ANXA1).”	0.98	hgnc_dict_v1
gene	HLA-A	“The selected CTL epitopes showed high affinity and stable binding with the binding groove of common human HLA class I molecules (HLA-A02:01 and HLA-B44:02) and mouse major histocompatibility complex class I molecules.”	0.98	hgnc_dict_v1
gene	HLA-A	“Host genetics impact on SARS-CoV-2 vaccine-induced immunoglobulin levels and dynamics: The role of TP53, ABO, APOE, ACE2, HLA-A, and CRP genes.”	0.98	hgnc_dict_v1
gene	HLA-A	“Among 5,000 individuals, 2,773 individuals meet inclusion criteria and were retrospectively analyzed for HLA-A, -B, -C-DRB1, and -DQB1 homozygosity at allelic and haplotype levels.”	0.98	hgnc_dict_v1
gene	HLA-A	“Distribution of HLA-A, -C, -B, -DRB1, and -DQB1 polymorphisms in the Korean minority in Kazakhstan, and relatedness to neighboring and distant populations.”	0.98	hgnc_dict_v1
gene	HLA-A	“METHODS: HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 were genotyped by polymerase chain reaction sequence-based typing.”	0.98	hgnc_dict_v1
gene	HLA-A	“We analysed frequencies for 24 HLA-A alleles (3 alleles for HLA-A∗26 at four digits), 50 HLA-B alleles (11 alleles for HLA-B∗51 at four digits), 15 HLA-C alleles, 16 HLA-DRB1 alleles, 6 HLA-DQB1 alleles, and 15 HLA-DPB1 alleles.”	0.98	hgnc_dict_v1
gene	HLA-A	“Identification of a novel HLA-A31 variant, HLA-A31:01:02:31, in a Saudi individual.”	0.98	hgnc_dict_v1
gene	HLA-A	“There was a significant difference in the HLA frequency between the two groups, with a predominance of HLA-A*01 in the low-ferritin group (19.4 vs.”	0.98	hgnc_dict_v1
gene	HLA-A	“In this study, there was a significant increase in the frequency of HLA-A01, B56 and C*01 among infected patients compared to the control group (12.1% vs.”	0.98	hgnc_dict_v1
gene	HLA-A	“Human leukocyte antigen (HLA)-B57:01, HLA-B15:02, HLA-A31:01, and HLA-B58:01 constitute established risk factors and preemptive genotyping of these HLA alleles in patients prior to the initiation of abacavir, carbamazepine, and allopurinol-based therapies can prevent toxicity and improve patient outcomes.”	0.98	hgnc_dict_v1
gene	HLA-A	“The novel allele, HLA-A*32:148, identified by next generation sequencing in a Saudi individual.”	0.98	hgnc_dict_v1
gene	HLA-A	“HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 Allele and Haplotype Frequencies of 28,927 Saudi Stem Cell Donors Typed by Next-Generation Sequencing.”	0.98	hgnc_dict_v1
gene	HLA-A	“The novel HLA-A*68:227 allele, identified by Next-Generation Sequencing in a Saudi individual.”	0.98	hgnc_dict_v1
gene	HLA-A	“A catalog of common, intermediate and well-documented (CIWD) HLA-A, -B, -C, -DRB1, -DRB3, -DRB4, -DRB5, -DQB1 and -DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries.”	0.98	hgnc_dict_v1
gene	HLA-A	“Among the genes present in the regions reported here were involved in neurotransmission (GRM3, SIGMAR1, CHAT, and SLC18A3) and members of the HLA gene family (HLA-A, HLA-DPA1, and MICC).”	0.98	hgnc_dict_v1
gene	HLA-A	“We discovered five independent risk variants for LN within the MHC region, including HLA-DRβ1 amino acid 11 (Pomnibus<0.001), HLA-DQβ1 amino acid 45 (P<0.001; odds ratio, 0.58; 95% confidence interval, 0.52 to 0.65), HLA-A amino acid 156 (Pomnibus<0.001), HLA-DPβ1 amino acid 76 (Pomnibus<0.001), and a missense variant in PRRC2A (rs114580964; P<0.001; odds ratio, 0.38; 95% confidence interval, 0.30 to 0.49) at genome-wide significance.”	0.98	hgnc_dict_v1
gene	HLA-A	“Seven HLA-A alleles accounted for more than 70% of the total alleles.”	0.98	hgnc_dict_v1
gene	HLA-A	“After controlling for the associated haplotypes in HLA-B, we observe independent associations with variants in the HLA-A, HLA-DPB1 and HLA-DRB1 loci.”	0.98	hgnc_dict_v1
gene	HLA-A	“In class I the HLA-A01 (P = 0.03, OR 2.68), A02 (P = 0.001, OR 3.02) and HLA-B*07 (P = 0.01, OR 3.27), were significantly associated with autism.”	0.98	hgnc_dict_v1
gene	HLA-A	“The haplotypes positively associated with ESRD were: HLA-A01-DRB113 and HLA-A30-DRBI03.”	0.98	hgnc_dict_v1
gene	HLA-A	“HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in Saudis using next generation sequencing technique.”	0.98	hgnc_dict_v1
gene	HLA-A	“AIMS: Being one of the most polymorphic genetic systems , the Human Leukocyte Antigen system is divided into class I (HLA-A, HLA-B and HLA-C) and class II (HLA-DP, -DQ and -DR).”	0.98	hgnc_dict_v1
gene	HLA-A	“The most common HLA-A and -B haplotypes in positive linkage disequilibrium were A24, B38; A1, B7; and A3, B52.”	0.98	hgnc_dict_v1
gene	HLA-A	“Class I HLA, HLA-A, HLA-B and HLA-C, and Class II HLA, HLA-DR and HLA-DQ, were typed for each patient and their partner.”	0.98	hgnc_dict_v1
gene	HLA-A	“Here we have analysed the frequency of HLA-A, B, DR and DQ in a group of Saudi MG patients and compared their results to a group of healthy controls.”	0.98	hgnc_dict_v1
gene	HLA-A	“Among the long list of these variables, factors that had a significant impact on outcome by univariate analysis included donor's and recipient's age, donor-recipient consanguinity, HLA-A, cytomegalovirus (CMV) and hepatitis C virus (HCV) markers, ischemia time, primary immunosuppression, ad juvant therapy, total steroid dose within the first three months, number of acute rejection episodes, time to onset of diuresis, hypertension post-transplant, serum creatinine at one year and at last follow-up besides chronic rejection.”	0.98	hgnc_dict_v1
gene	HLA-A	“Thirteen Saudi Arabian patients with Behçet's disease (BD) were typed for HLA-A and -B alleles by the conventional serologic typing and for HLA-DRB1, -DQB1 and -DPB1 alleles by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.”	0.98	hgnc_dict_v1