HLA-DQB1
HGNC:4944 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-DQB1 | “The shared genes, INSR, HLA-DQB1, and CRHR1, exhibited possible associations with T2D and DN, positioning them as key candidates for DN.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Characterisation of the Novel Allele, HLA-DQB1*06:531, Identified in a Saudi Individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Identification of the Novel Allele, HLA-DQB1*05:351, in a Saudi Individual Using Next-Generation Sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Identification of the novel allele, HLA-DQB1*03:517, in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Five patients (41.7%) had genetic susceptibility, with RNA binding motif protein 45 (RBM45/DRB1) and major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) mutations being prominent.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “We identified 17 HLA-A, 28 HLA-B, 14 HLA-C, 13 HLA-DRB1, and 5 HLA-DQB1 alleles, of which HLA-A*02 (22.2%), -B*51 (19.5%), -C*07 (20.0%), -DRB1*03 (22.2%), and -DQB1*02 (32.8%) were the most frequent allele lineages.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Moreover, the HLA-DQB1*03 allele was strongly associated with RA risk (42.2%, P = 2.2x10-8), whereas, HLA-DQB1*02 and *06 showed protective effects against RA (23.1% and 42.2%, P = 0.024 and P = 2.2x10-6, respectively).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Of these few notable known genes include, HLA-DQB1, AHSG, ALOX5AP, MUC5AC, SMPD1, SPG7, SPEG,GAS6, and SERPINA12.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Machine learning algorithms highlighted the use of the HLA-DQB1 gene as a biomarker for diabetes early detection.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “METHODS: Accordingly, we compared frequencies of five different single nucleotide polymorphisms (SNPs) in T1DM patients and healthy controls who had been typed for HLA-DRB1, HLA-DQA1, and HLA-DQB1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Additionally, PCR-based analysis of Major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1) genotyping was implemented in three study population groups as follows: group 1 (n=25) (+ve DM1 and +ve CD), group 2 (n=63) (-ve DM1 and +ve CD) and control group 3 (n=2) (+ve CD).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “We were able to identify 15 HLA-A, 20 HLA-B, 11 HLA-C, 13 HLA-DRB1, and five HLA-DQB1 homozygous alleles demonstrating a very low genetic diversity in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “RESULTS: HLA-DQB1*03:02 are significantly associated with moderate/mild cases of MERS-CoV.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Full genomic sequence of the HLA-DQB1*04:51 allele identified by next-generation sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “We analysed frequencies for 24 HLA-A alleles (3 alleles for HLA-A∗26 at four digits), 50 HLA-B alleles (11 alleles for HLA-B∗51 at four digits), 15 HLA-C alleles, 16 HLA-DRB1 alleles, 6 HLA-DQB1 alleles, and 15 HLA-DPB1 alleles.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “The novel HLA-DQB1*06:358 allele, identified by Next-Generation Sequencing in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “HLA-DQB1*06:02 allele frequency and clinic-polysomnographic features in Saudi Arabian patients with narcolepsy.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “HLA-DQA1*0201, HLA-DQB1*0201, and HLA-DRB1*0701 were the classic HLA alleles with the most significant associations with SSNS risk.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “These alleles included HLA-DRB1*15:01 (odds ratio [OR]: 3.01; 95%, confidence interval [CI]: 1.68-5.54; P = .0001), HLA-DQB1*02:01 (OR: 1.76; 95% CI: 1.20-2.58; P = .0022), HLA-DQB1*06:02 (OR: 3.52; 95% CI: 1.87-6.86; P < .0001), and HLA-DQB1*06:03 (OR: 2.42; 95% CI: 1.16-5.25; P = 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “SUBJECTS/METHODS: HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “Of which, HLA-DQB1*05 contributed the highest frequency (37.56%).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “We discovered six novel genome-wide significant signals of association with extremes of FEV1, including signals at four novel loci (KANSL1, TSEN54, TET2, and RBM19/TBX5) and independent signals at two previously reported loci (NPNT and HLA-DQB1/HLA-DQA2).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “The most frequently observed allele for HLA-A was HLA-A*02:01:01:01 (13.6%); for HLA-B, HLA-B*50:01:01 (15.8%); for HLA-C, HLA-C*06:02:01:01 (18.7%); for HLA-DRB1, HLA-DRB1*07:01:01:01 (26.6%); and for HLA-DQB1, HLA-DQB1*02:01:01 (20.3%).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “No significant differences were observed between the two groups in respect of HLA-A2, HLA-B50(21), HLA-B51(5) and HLA-Cw7 (HLA Class I), and HLA-DRB1*04, HLA-DRB1*07 and HLA-DQB1*02 (HLA Class II).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “This study is the first and largest of its kind to describe the distribution of HLA-DQB1 and HLA-DRB1 alleles in Lebanon and the region.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “In conclusion, these results show a strong association of HLA-DQB1*0201/0302 and DRB1*03/04 with T1DM.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-DQB1 | “HLA-DQB1 *02 homozygosity was present in 4/6 affected and 2/6 unaffected family members.” | 0.98 | hgnc_dict_v1 |