PIK3CA
HGNC:8975 · 74 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PIK3CA | “Elacestrant improved progression-free survival in ESR1-mutated disease in the EMERALD trial, capivasertib plus fulvestrant demonstrated significant benefit in tumors harboring AKT/PIK3CA/PTEN pathway alterations in CAPItello-291, and inavolisib plus palbociclib and fulvestrant achieved both progression-free and overall survival improvement in PIK3CA-mutated patients with early relapse in INAVO120.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Multitargeted comparative evaluation suggests 2-Aoeobenoxmide shows favourable in silico binding compared to Tucatinib against ERα, HER2, AKT1, EGFR, and PIK3CA in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Clinicopathological characteristics, biomarker profiles (ER, PR, Ki-67), molecular alterations (PIK3CA, TP53, BRCA) and survival outcomes (overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and distant disease-free survival (DDFS)) were compared.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The in silico studies preliminarily revealed the potential interactions of AS09 with MI targets (JAK2, GSK3B, and PIK3CA).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Molecularly, mutations such as in PIK3CA and abnormalities in neurotransmitter signaling reveal how neurotumors communicate and adapt.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Thymol derivatives, such as 1,2,3-triazoles and carvacrol, effectively target breast cancer (BC) through PI3K/AKT/mTOR and NOTCH pathways and inhibit PIK3CA expression.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Exploring the mutational spectrum of key kinase genes PIK3CA, BRAF, EGFR, ALK and ROS1 in oral squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Four constituents of A. alba-Avicenol B, Avicenol C, Avicequinone B, and Avicequinone C-were verified, leading to the identification of 10 hub genes (i.e., EGFR, PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Finally, prevalence of somatic mutations in TP53, PIK3CA, and ESR1 were higher in ADI ≥ 60.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Effects of PIK3CA Gene Modifications on Radiosensitivity in Colorectal Cancer Cells.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “RESULTS: The combination index showed that HT-29 cells were the most responsive to the combined treatment, even with PIK3CA, B-RAF (V600E), and TP53 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Molecular testing was performed in 5 cases, where BRAF, PTPN11, and PIK3CA mutations were identified, predominantly members of the RAS-RAF-MEK-ERK pathway.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “EGFR (10.2%), FGFR1 (4.9%), and PIK3CA (4.9%) showed the most amplifications, while fusions were observed in 2.7% of patients, including ALK, FGFR2, and RET.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Dysregulation of this pathway, often due to mutations in genes such as PIK3CA, PTPN11, EGFR, and AKT1, contributes to tumorigenesis and therapy resistance.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The molecular landscape of TNBC is covered in the first section, which keeps the focus on transcriptome and genomic profiling while highlighting key molecular targets like mutations in the BRCA1/2, PIK3CA, androgen receptors (AR), epidermal growth factor receptors (EGFR), and immunological checkpoint molecules.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Unique to this case was the process of undergoing targeted genetic sequencing via the Find ITTM Panel Version 3.4 on the ACUM, looking for mutations in KRAS, PIK3CA, and FGFR2.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The KEGG enrichment analysis indicated that hsa05215: Prostate cancer is one of the most significant PCa enrichment signalling pathways which exhibited 18 protein-protein interactions including PDGFRB, PDGFRA, PPARG, GSK3B, MAP2K1, CREBBP, HSP90AA1, HSP90AB1, CHUK, PIK3CD, BRAF, PIK3CB, MTOR, AR, PIK3CA, PLAU, CDK2, and MAPK1.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Furthermore, hub genes such as IRS1, PIK3CA, CASP3, MAPK7, and PDGFRB were identified, supporting their central role in metabolic dysregulation during pregnancy.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “TERTp/EIF1AX/GNAS and TERTp/EIF1AX/PIK3CA were the least common combinations (n = 1, 3.3% each).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “In the groundwork of this research, we examined the active constituent-compound-target-pathway network and evaluated that (Guggulsterol-V, Myrrhahnone B, and Campesterol) decisively donated to the development of arthritis by affecting tumor necrosis factor (TNF), PIK3CA, and MAPK3 genes.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Variants typical for angiomatous (brain) meningioma are PIK3CA, KIT, PTPN11, CDH1, SMAD4, and SMARCB1; the variants typical for psammomatous meningioma are APC, FGFR2, HNF1A, STK11, and JAK3.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “In our research, we conducted a comprehensive screening using HTVS, SP, and XP, followed by an MM/GBSA computation of human-approved drugs targeting HER2/neu, BRCA1, PIK3CA, and ESR1.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α (PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase (PI3K) expression, Ak strain transforming phosphorylation, mTOR activity, and downstream target proteins in CRC cells with a PIK3CA mutation.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Prevalence and effect of PIK3CA H1047R somatic mutation among Indian head and neck cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Mutational Landscape and In-Silico Analysis of TP53, PIK3CA, and PTEN in Patients with Breast Cancer from Khyber Pakhtunkhwa.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “RESULTS: Three tumors were tested only by Sanger sequencing and were negative for BRAFV600E, HRAS, KRAS, NRAS, TERT promoter, PTEN, and PIK3CA mutations.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The most repeated mutations were identified in 3 of 9 examined genes, namely TP53, PIK3CA and PTEN, with highest rates of increase in Group 3.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Seven patients had single-gene TERT promoter mutations, and 17 had concurrent mutations, including BRAF V600E, HRAS, NRAS, PIK3CA, and EIF1AX.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Whole-exome sequencing of DNA extracted from a skin biopsy showed a mutation in the PIK3CA (c.3132T>G, p.ASN1044LYS).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Somatic hotspot mutations KRAS p.G12C and PIK3CA p.Q546K are associated with colorectal cancers from biallelic MUTYH carriers compared with non-carriers (p = 2 × 10-23 and p = 6 × 10-11, respectively).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Furthermore, ATR, ATM, BMI1, CCAT1, Chk1, Chk2, COX-2, FoxM1, FSCN1, Ki67, MALAT1, miR-29, miR-34a, miR-92, miR-182-5, PANDAR, PIK3CA, TIGAR over-expression revealed a robust association with CRC in Saudi Arabia (KSA).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “METHODS: We carried out targeted next-generation sequencing of six PI3K pathway genes (PIK3CA, PIK3R1, PTEN, AKT1, TSC2, and mTOR) in a total of 93 South Indian cervical cancer samples and confirmed them by sanger sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Mutational pattern of PIK3CA exon 20 in circulating DNA in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “We used TruSight Tumor 15 using Next-Generation Sequencing (NGS) to look at genetic changes in 126 Saudi women with stage I to IV breast cancer. c-MET (p = 0.001), c-KIT (p = 0.001), and PIK3CA (p = 0.0001), were shown to be substantially linked with HER2 positive patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Mutations were predominantly focused on two genes, PIK3CA and TP53, in the BC genomes of the sample set.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Mutations in TP53 and PIK3CA genes in hepatocellular carcinoma patients are associated with chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “RESULTS: Here, 41 short-term khat users carried seven somatic mutations in four out of nine cancer-related genes: 29/41(70.73%) ARID1A, 24/41(58.53%) MLH1, 34/41(82.92%) PIK3CA and 36/41(87.80%) TP53.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Across tumor types and breeds, TMB is associated with mutation of TP53 but not PIK3CA, the most mutated genes.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “851 cases of non-small cell lung cancer cases were profiled for the presence of biomarkers EGFR, KRAS, BRAF, and PIK3CA mutations by SNaPshot/sizing genotyping.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Among the genes analyzed, the highest mutation rates were found in PIK3CA (12.9%), BRCA2 (11.7%), BRCA1 (10.2%), TP53 (6.0%), MSH2 (3.8%), PMS2 (3.8%), BARD1 (3.8%), MLH1 (3.4%), CDH1 (3.0%), RAD50 (3.0%), MSH6 (3.0%), NF1 (2.6%), in addition to others.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Screening for PIK3CA mutations among Saudi women with ovarian cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Chemosensitization of HT29 and HT29-5FU Cell Lines by a Combination of a Multi-Tyrosine Kinase Inhibitor and 5FU Downregulates ABCC1 and Inhibits PIK3CA in Light of Their Importance in Saudi Colorectal Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “833 samples of non-small cell lung cancer from 799 patients who received resection of their lung cancer, were selected for molecular analysis of six known mutations, including EGFR, KRAS, BRAF, PIK3CA, HER2 and ALK.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “This genetic overgrowth syndrome is associated with mosaic gain-of-function pathogenic PIK3CA variants (OMIM #171834).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “In CTNNB1 gene a known missense mutation in c.101G>T; in TP53 a known missense mutation in c.215C>G; and two known missense variants in PIK3CA, viz., in c.1173A>G; in exon 7, and in c.3128T>C; in exon 21, were found, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “RESULTS: Sequencing analysis identified missense, nonsense and frameshift mutations in TP53 (66%), PIK3CA (27%), CDKN2A (25%), EGFR (18%), and PTEN (14%).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The diagnosis of PROS syndrome is based on the clinical features of a patient and confirmed by a pathogenic variant in one PIK3CA allele in a biopsy of the affected tissue.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “METHODS: We have investigated the association of Glu545Lys and His1047Tyr mutations of phosphatidylinositol- 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) gene with T2D.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Results: NGS analysis identified 19 variants, of which four were previously reported missense variants; c.395G>A in IDH1, c.1173A>G in PIK3CA, c.1416A>T in KDR and c.215C>G in TP53.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Whole exome sequencing (WES) recently identified frequent mutations in the genes of GPCR-mediated PI3K pathway (LPAR4, PIK3CA, and PTEN) in a Chinese population with papillary thyroid cancers (PTCs).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Structural prediction, whole exome sequencing and molecular dynamics simulation confirms p.G118D somatic mutation of PIK3CA as functionally important in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Helical and kinase domain mutations of PIK3CA, and their association with hormone receptor expression in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “PIK3CA and ARID1A mutation frequencies were higher in White and Asian patients compared with other ethnicities; TP53 and FAT1 mutation frequencies were higher in Black/African Americans; and CTNNB1 and RYR2 mutation frequencies were higher Native Hawaiians or Asian Natives.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Mutational testing of 10 of 20 tumors revealed only two PIK3CA mutations in a single tumor.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Upper limb muscle overgrowth with hypoplasia of the index finger: a new over-growth syndrome caused by the somatic PIK3CA mutation c.3140A>G.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “OBJECTIVE: Evaluate the frequency and prognostic effect of RAS, BRAF, PIK3CA, PTEN, and EGFR somatic mutations as well as mismatch repair (MMR) deficiency in Lebanese Middle Eastern patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “In some cases, resistance develops as a result of genetic or epigenetic alterations in various components of the signalling pathways, such as overexpression of her2 and erα co-activators, aberrant expression of cell-cycle regulators, and PIK3CA mutations.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The variant allele frequency of these mutations was high, while somatic mutations in other genes such as PIK3CA and NOTCH1 were low.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Absence of the frequently reported PIK3CA, CASP8, and NOTCH1 mutations in South Indian oral cancers.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “This study comprehensively investigated a large series of pediatric DTC for single point mutations in BRAF, HRAS, KRAS, NRAS, PIK3CA, PTEN, and TERT.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “In addition to confirming known genes of OSCC (TP53, CDKNA2, CASP8, PIK3CA, HRAS, FAT1, TP63, CCND1 and FADD) the analysis identified several candidate novel driver events including mutations of NOTCH3, CSMD3, CRB1, CLTCL1, OSMR and TRPM2, amplification of the proto-oncogenes FOSL1, RELA, TRAF6, MDM2, FRS2 and BAG1, and deletion of the recently described tumor suppressor SMARCC1.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “However one case with rapid clinical progression displayed mutations more commonly associated with GBM (NF1(N1054H/K63)*, PIK3CA(R38H) and ERG(A403T)).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “RESULTS: Targeted sequencing lead to the identification of frequent mutations in TP53 (65 %), APC (36 %), KRAS (35 %), PIK3CA (19 %), PTEN (13 %), EGFR (11 %), SMAD4 (11 %), and FBXW7 (7 %).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Novel mutations of PIK3CA gene in head and neck squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “METHODS: We used high-resolution array-comparative genomic hybridization to prospectively characterize copy-number changes in 150 meningiomas and then characterized these samples for mutations in AKT1, KLF4, NF2, PIK3CA, SMO, and TRAF7.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “The predictive and prognostic role of phosphatase phosphoinositol-3 (PI3) kinase (PIK3CA) mutation in HER2-positive breast cancer receiving HER2-targeted therapy: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “METHODS: K-RAS (exons 2, 3, 4) wild type colorectal cancer patients, candidates to second/third-line cetuximab with chemotherapy were prospectively allocated into 2 groups on the basis of their profile: favourable (BRAF and PIK3CA exon 20 wild type, EGFR GCN ≥ 2.6, HER-3 Rajkumar score ≤ 8, IGF-1 immunostaining < 2) or unfavourable (any of the previous markers altered or mutated).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Frequently mutated genes were: TP53 (39.6%), KRAS exons 3/4 (8.8%), NRAS exons 2/3 (7.1%), PIK3CA exons 9/20 (13.2%), BRAF (8.2%).” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Prevalence of PIK3CA mutations and the SNP rs17849079 in Arab breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “PIK3CA alterations in Middle Eastern ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.” | 0.98 | hgnc_dict_v1 |
| gene | PIK3CA | “Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population.” | 0.98 | hgnc_dict_v1 |