FAS
HGNC:11920 · 26 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | FAS | “Gene expression analysis showed upregulation of COX-2, iNOS, TNF-α, FAS, and BAX and downregulation of PIK3CD and BCL-2, indicating inflammation and impaired survival signaling.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Adipose tissue, skeletal muscle, and liver tissue samples were collected to determine mRNA expression, of pro-inflammatory cytokines [tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6)] and genes involved in lipid metabolism [peroxisome proliferator-activated receptor α (PPARα), peroxisome proliferator-activated receptor γ (PPARγ), fatty acid synthase (FAS), and sterol regulatory element-binding protein-1c (SREBP-1c)].” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Furthermore, cell free metabolites from L. brevis FS1 (CMLB) treatment reduced fat deposition and the genes related to adipogenesis and lipogenesis such as C/EBP-β (CCAAT/ enhancer-binding protein- β), PPAR-γ (Peroxisome proliferator activated receptor- γ), acetyl CoA carboxylase (ACC), Fatty acid synthase (FAS), adipocyte binding protein (aP2), Serum regulatory element binding protein-1 (SREBP-1) and increased insulin sensitizing protein adiponectin expression compared to control cells.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Also increased mRNA expression of lipogenic genes as FAS and SREBP-1c and gluconeogenic genes as pepck and g6pc while downregulated, pparα, cpt1, acox1.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Accompanying LZ-induced modulations in the expression levels of GHR, IGF-1, leptin, CCK, FAS, and ACC genes in both quail varieties were reported.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Adipogenesis was assessed through Oil-Red O staining, gene expression analysis (PPAR-γ, C/EBPα, Adiponectin, Glut-4, FAS), and glucose uptake assays on 3T3-L1 cells.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Canagliflozin improved hepatic lipogenesis via the downregulation of fatty acid synthase (FAS) and transcriptional regulatory element binding protein 1c (SREBP1c) genes leading to an improved serum lipid profile.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Likewise, the relative gene expression levels of (GHr-1, IGF-1, FAS and LPL) were notably (p < 0.05) upregulated by phytase enzyme, associated with DCP and control groups.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Fatty acid synthase (FAS) in rat liver and its in vitro activity were suppressed by ARB, which also upregulated the LDL receptor (LDL-R) and ABCA1, and had no effect on ABCG5 and ABCG8 mRNA.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “In addition, bacoside-A showed a potent reduction in genes precise to adipocytes such as lipoprotein lipase (LPL), fatty acid synthase (FAS), adipocyte fatty acid-binding protein (FABP4), and leptin expressions.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “FEN exposure significantly upregulated the pyroptosis-related genes, including GSDMD, Casp-1, Casp-3, Casp-8, IL-18, TNF-α, IL-1β, and NF-κB and altered the expression of lipogenesis-related genes including SREBP-1c, PPAR-α, MCP1, and FAS in the hepatic tissues.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Moreover, HFD and PE-MP exposure upregulated genes related to lipogenesis (SREBP1, FAS, and C/EBPα) and inflammation (tnfα, il1β, and il-6) in the liver.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “TLR4 activation in turn caused c-JUN-dependent and STAT3-dependent translocations of MYC loci to suppress transactivation of CD95/FAS.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “The ability of N5 and N7 to reduce total regulating lipogenic specific genes C/EBP-α, SREBP-1 and FAS were evaluated using relative gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Both quantitative Real-time PCR (RT-PCR) and western blotting revealed that MP seeds oil significantly decreased the expression of lipogenesis-associated genes such as peroxisome proliferator-activated receptors gamma (PPARγ) and fatty acid synthase (FAS) and significantly elevated the expression of lipolysis-associated genes (acetyl-CoA carboxylase1, ACCl).” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Sanger sequencing of the FAS gene did not reveal any causal mutation.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “METHODS: In this study, we performed a mutational analysis by sequencing the entire coding regions in four key apoptotic genes FAS, FASLG, CASP8 and CASP10 in 92 independent families belonging to French and Tunisian populations and diagnosed with several forms of familial hematological malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-α were observed in experimental rats.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Cancer is associated with mutations in genes controlling proliferation and apoptosis, oxidative stress, fatty acid synthase (FAS) expression, and other mechanisms.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Juice administration downregulated the increment of FAS and SERBP-1c mRNA expression in liver and upregulated HSL and GLUT-2 expressions.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Also, the M. quadrangula extract significantly reduced the expression of fatty acid synthase (FAS) and increased the expression of LDL receptor in the liver of HCD-fed rats.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Intriguingly, EFLC treatment also reversed the mRNA expression of fatty acid oxidative genes, such as peroxisome proliferator activated receptor-α (PPAR-α), carnitine palmitoyltransferase-1 (CPT-1), and acetyl-CoA carboxylase (ACO), and fatty acid synthesis genes such as fatty acid synthase (FAS), sterol-regulatory-element-binding protein-1c (SREBP-1c), and acetyl-CoA carboxylase (ACC).” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “These increases were associated with up-regulation of PPAR-γ2, C/EBP-α, adiponectin, FAS, and leptin mRNA and protein expressions.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Subsequently, CA treatment decreased the expression of sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthase (FAS), acetyl CoA carboxylase (ACC) and adiponectin.” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “The mRNA and protein expression of PPAR-γ2, C/EBP‑α, adiponectin, fatty acid synthase (FAS), and SREBP-1 were increased by PLA treatment as compared with control adipocytes (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | FAS | “Whereas, FCGA studies have identified some candidate genes which are associated with vitiligo, such as HLA, AIRE, VIT1, CAT, FOXD3, ESR1, COMT, PTPN22, NALP1, PDGFRA, MYG1, MITF, CD117, XBP1, FAS, COX2, EDN1 and ACE, but few of them reports now appear to be false-positive.” | 0.98 | hgnc_dict_v1 |