CD44
HGNC:1681 · 36 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD44 | “We finally constructed a three-node microRNA (miRNA) feed-forward loop (FFL) involving miR-23b-3p, CD44, and five transcription factors (TFs) [EOMES, FOS, FOSL1, GLIS3, TP63] specific to NSCLC metastasis.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “An Integrated Network Biology and Molecular Dynamics Approach Identifies CD44 as a Promising Therapeutic Target in Multiple Sclerosis.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Eleven discovery-focused studies identified specific MS-derived signatures, such as microenvironmental proteins (e.g., MTA2, CD44) and dysregulated lipid metabolites (e.g., acylcarnitines, LysoPE) that were consistently associated with PFS and OS.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “CD44 and phosphorylated ERK1/2 coexpression predicts distant metastasis in colorectal cancer based on a study of 1137 Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “RESULTS: Malignant cells showed the highest expression of MIF, which may interact with CD74 + CXCR4 + and CD74 + CD44 + receptor complexes on B cells, T cells, and myeloid cells, consistent with known MIF-mediated signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Predicted host-microbe interactions highlighted associations between key microbial biomarkers and inflammation-related genes (CD44, CXCL8, DUSP16, FOXP3, IFNGR2, IL18), all significantly overexpressed in CRC samples.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “To overcome the drawback of poor water solubility of PDT, HA/G3139/Ce6@Fe3O4 nanosystem was synthesized, which combines the benefits of G3139 antisense oligonucleotides for gene therapy and hyaluronic acid for encapsulation and targeting CD44 receptor.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Association of CpG sites to a few genes involved in active immune response (JAK1, CD1C, PIGR, TOLLIP, BLNK, CD44, IL23R, IFNLR1, SOCS2, TLR1, etc.) was seen in inhibitor-positive patients, but it did not indicate specific pathways associated with inhibitor development.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “PT also modulates epigenetic processes such as DNA methylation and histone modifications, and targets cancer stem cells by reducing the expression of stemness markers like CD44 and c-Myc.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Moreover, flow cytometric analysis revealed that amygdalin administrations were correlated with CD20 and CD44 and promoted the cell cycle and apoptosis in carcinogenic mice.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Common markers include EpCAM, used for epithelial cancers; CD44 and CD24, which are associated with cancer stem cells; and cytokeratins, such as CK8 and CK18.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “In addition, ex vivo analysis of phagocytosis and activation marker expression revealed reduced phagocytosis activity and capacity, as well as the downregulation of the activation markers CD44 and lymphocyte function-associated antigen 1 on leukocytes from the camels after cold exposure.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “The therapeutic potential of this interplay was also evaluated in vitro using MDA-MB-231 cells, a preclinical model of human triple-negative breast cancer, where treatment with PRL and Verteporfin, an FDA-approved pharmacological YAP-inhibitor, alone or their combination suppressed the expression of the mesenchymal marker vimentin and the stem cell marker CD44 as well as reduced their Ki67 proliferative marker expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “The expression pattern of the cell markers CD163, CD14, CD172a, CD44, and CD9 on MDM generated in the presence of the MERS-CoV S1 protein revealed similarity with M-CSF-induced MDM, suggesting the potential of the MERS-CoV S1 protein to induce an M2 macrophages phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Genetic Signatures: CD44 Single-Nucleotide Polymorphisms Affect Cell Surface Expression and Elevate Risk in Head and Neck Squamous Cell Carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “The cancer stem cells (CSCs) in the ovaries were identified based on staining with anti-mouse CD44 and anti-mouse CD133 antibodies and analysed by flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “The genetic background of the high prevalence red blood cell antigen AnWj has remained unresolved since its identification in 1972, despite reported associations with both CD44 and Smyd1 histone methyltransferase.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Expression of CD44 is associated with aggressiveness in seminomas.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Analysis of the expression patterns of AVP, IGF-1, and TNF-α, APP, CD44, IFN-β IFN A β-6, α-syn, and NFL and CLU genes in generalized and focal seizures.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “We used antibodies to detect several cell surface molecules associated with camel T cells (CD4, WC1), B cells (MHCII, BAQ44A), monocytes/macrophages (CD172a, CD14, CD163), in addition to the pan-leukocyte marker CD45 and the cell adhesion molecules CD44 and CD18.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “We discovered 73 common DEGs (CDEGs) and ten HubGs (ATAD2B, PPP1CB, FOXO1, AKT3, BCR, PDE4D, ITGB1, PCBP2, CD44 and SMARCA2).” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Targeting CD44 Receptor Pathways in Degenerative Joint Diseases: Involvement of Proteoglycan-4 (PRG4).” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “This induced an increase in apoptotic cells immunostained with caspase3 and decreased the CD44 immunostained HCSCs.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Ang II stimulated the expression of markers involved in monocyte/macrophage cell differentiation (e.g., CD116), as well as adhesion, cell-cell interaction, chemotaxis, and phagocytosis (CD15, CD44, CD33, and CD49F).” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Finally, core hub genes (EGR1, MMP9, and CD44) were validated using RT-PCR analysis.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “The synergic impact of lignin and Lactobacillus plantarum on DSS-induced colitis model via regulating CD44 and miR 199a alliance.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Similarly, in heparin blood, CD44 and CD172a were expressed higher on neutrophils, while CD11a was expressed higher on lymphocytes in comparison to cells from EDTA blood.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Histopathological specimens were studied with hematoxylin-eosin, Alcian blue, and immunohistochemical markers; S-100, CD44, CD117, smooth muscle actin (SMA), neurofilament, and Ki-67.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Immunocytochemistry showed a significant ratio of the KAIMRC2 cells' expressing key breast epithelial and cancer stem cells (CSCs) markers, including CD47, CD133, CD49f, CD44, and ALDH-1A1.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Loss of PRLR expression in HR+ breast cancer cells caused their dedifferentiation generating a mesenchymal-basal-like phenotype enriched in CD44+ breast cancer stem-like cells (BCSCs) showing high tumorigenic and metastatic capacities and resistance to anti-hormonal therapy.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Our DP-MSSCs were strongly positive for CD44, CD73, CD105, and CD90.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Metformin treatment decreases the expression of cancer stem cell marker CD44 and stemness related gene expression in primary oral cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “Al-Qahtani P79 Prognostic significance of CD44 expression profile in colorectal carcinoma Maryam Al-Zahrani, Sahira Lary, Sahar Hakamy, Ashraf Dallol, Mahmoud Al-Ahwal, Jaudah Al-Maghrabi, Emmanuel Dermitzakis, Adel Abuzenadah, Abdelbaset Buhmeida, Mohammed Al-Qahtani P80 Association of the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism with hypertension risk and complications Abeer A Al-refai, Mona Saleh, Rehab I Yassien, Mahmmoud Kamel, Rabab M Habeb P81 SNPs array to screen genetic variation among diabetic patients Najlaa Filimban, Ashraf Dallol, Nadia Ghannam, Mohammed Al-Qahtani, Adel Mohammed Abuzenadah P82 Detection and genotyping of Helicobacter pylori among gastric cancer patients from Saudi Arabian population Fehmida Bibi, Sana Akhtar, Esam I.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “As expected, pro-angiogenic proteins including intercellular adhesion molecule-1 (ICAM-1) and CD44 variant isoform 5 (CD44v5) are among the up-regulated proteins, whereas angio-suppressive protein, thrombospondin-1 (TSP-1) was down-regulated in C666-1 exosomes.” | 0.98 | hgnc_dict_v1 |
| gene | CD44 | “CD44 as a potential diagnostic tumor marker.” | 0.98 | hgnc_dict_v1 |