TLR3
HGNC:11849 · 36 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TLR3 | “Biochemical analysis revealed significantly elevated levels of the immunomodulatory cytokines IL-10, IL-12, and IFN-γ, along with other immunity-related parameters, and molecular analysis showed upregulation of genes associated with IFN-γ, IL-12, IL-10, TLR4, TLR3, and TLR1.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Subsequently, the VC2 were docked to the toll-like receptors (TLR2, TLR3, and TLR4) and showed high binding affinities of -14.2 to -23.1kcal/mol, along with H-bonds (9 to 20).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Furthermore, LSF modulated immune-related genetic markers, as evidenced by the significantly higher expression of CXC chemokine, IL-1β, IL-8, IL-6, MHC-II, TNF-alpha, TLR9, and TLR3 in fish, with maximum values observed in the LSF3 group (P < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Furthermore, GEONE mitigated HFD-induced inflammation by downregulating the expression of TLR3, TLR4, NF-κB, TNF-α, IL-6 and NLRP3.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Based on molecular docking analysis, the designed vaccine has high binding affinities with the active site of TLR3.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “TZ1391: a computationally designed circular mRNA multi-epitope vaccine candidate against Mycobacterium tuberculosis via TLR3 immunomodulation.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “In this study, we have performed population coverage analysis and molecular dynamic simulation studies which predicted that dvac could offer protection to 98.5% of world population against dengue and forms stable interactions with TLR3/TLR4 receptors, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Molecular dynamics simulations revealed that the vaccine components have the highest binding affinity for Toll-like receptor 3 (TLR3) (-318.19 kj/mol).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Molecular dynamics simulations confirmed the most stable interaction of the vaccine components with Toll-like receptor 3 (TLR3), while also demonstrating stable interactions with TLR5, TLR7, TLR8, and TLR9, eliciting a robust immunogenic response.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Molecular docking and molecular dynamics (MD) simulations evaluated the interactions of V1 with human toll-like receptors (TLR2 and TLR3).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “RESULTS: Molecular docking analysis revealed strong binding affinities between the vaccine constructs and the TLR3 receptor, with scores of -299 kcal/mol, -361 kcal/mol, -258 kcal/mol, and -312 kcal/mol for VP1, VP2, VP3, and combined vaccine-TLR3 complexes.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “The docking investigation demonstrated the strong activity of the vaccine towards the TLR2 and TLR3, having binding affinity − 10.8 kcal/mol-1 and − 15.8 kcal/mol-1, and also disclosed remarkable constancy based on the 500ns simulation period.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Molecular docking studies verified strong interactions with immune receptors, particularly toll-like receptor (TLR)2, TLR3, TLR4, TLR8, and human leukocyte antigen molecules, indicating robust immune stimulation potential.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “The predicted key genes involved in the transition from latent to active TB, including PLEKHG1, CLPB, DOK4, IL1β, and TLR3, are primarily associated with multicellular organism processes, stimulus-response, GPCR ligand binding, and immune functions.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Further, docking analysis between vaccines with TLR3 shows a strong molecular interaction with a -20.0 kcal/mol binding energy, and the stability was analysed through the MD simulation (100ns).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “The vaccine's molecular and interactions binding affinity with the human immunological receptor TLR3 were studied using MMGBSA, molecular dynamics (MD) simulations, and molecular docking analyses.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “This study investigates the TLR3 1377 C/T polymorphism's association with clinical outcomes in chronic hepatitis B patients.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “The strong binding affinity of the constructed vaccines with the human TLR3 was confirmed through molecular docking, with scores of - 333 kcal/mol for glycoprotein, - 297 kcal/mol for nucleoprotein, - 308 kcal/mol for RDRP, and - 305 kcal/mol for combined vaccines.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Molecular docking and molecular dynamics (MD) simulations were conducted to assess the binding affinity of the vaccine with Toll-like receptor 3 (TLR3).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, and TLR9 were significantly downregulated in both genotypes as compared to controls, with genotype D showing greater downregulation of TLR1, TLR5, TLR6, and TLR7 among HBV-positive patients.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “The three mutations were predicted to predispose to severe viral infections: monoallelic R488X TLR3, monoallelic His684Arg TLR3, and biallelic Val363Met IRF3.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Docking of the candidate vaccine with the toll-like receptor TLR3 was performed, and results showed a strong interaction between the immune receptor and the vaccine.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “We hypothesized that the accumulation of endogenous TLR3 ligands in the valvular leaflets may promote the generation of osteoblast-like cells through enhanced type I IFN signaling.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “With exception of the TLR3 agonist Poly IC, all TLR ligands used showed the potential to stimulate camel neutrophils resulting in increased cell size and the upregulation of CD18 and CD14 on their surface.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Furthermore, TLR3/TLR7/IRAK1 and TLR3/TLR9 were identified as independent predictors of AT SRA1 expression in individuals with obesity and T2D, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Molecular docking and molecular dynamics simulation indicated a stable and energetically favourable interaction between the constructed antigen and Toll-like receptors (TLR2, TLR3, and TLR4).” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I interferon (IFN) immunity to influenza virus in 659 patients with life-threatening COVID-19 pneumonia relative to 534 subjects with asymptomatic or benign infection.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Finally, transcriptome analysis of SNORA31-mutated neurons revealed normal responses to TLR3 and IFN-α/β stimulation but abnormal responses to HSV-1.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Interestingly, we could not see any involvement of TLR2 or TLR3 nor suppression of infection by IFN-β production.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “We investigated the effect of resveratrol treatment on TLR2, TLR3, TLR4, NF-κB, and inducible nitric oxide synthase (iNOS or NOS2) levels in CD4 spleen cells.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Toll-like receptor 3 (TLR3) plays a key role in innate immunity by recognizing pathogenic, double-stranded RNAs.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “As for the TLR3 gene (c.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “TLR3 is part of the innate immune system that recognizes double-stranded RNA (dsRNA) and provides early immune response to exogenous antigens.” | 0.98 | hgnc_dict_v1 |
| gene | TLR3 | “Autosomal recessive (AR) UNC-93B and TLR3 deficiencies and autosomal dominant (AD) TLR3 and TRAF3 deficiencies underlie HSE in some children.” | 0.98 | hgnc_dict_v1 |