JAK1
HGNC:6190 · 25 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | JAK1 | “EXPERT OPINION: Oral JAK1 inhibition represents the most advanced small-molecule strategy for HS treatment.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Molybdenum induces hepatic impairments via dysregulating NLRP3, JAK1/STAT3 and NF-κB pathways: A dose dependent toxicity assessment.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Association of CpG sites to a few genes involved in active immune response (JAK1, CD1C, PIGR, TOLLIP, BLNK, CD44, IL23R, IFNLR1, SOCS2, TLR1, etc.) was seen in inhibitor-positive patients, but it did not indicate specific pathways associated with inhibitor development.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Cardioprotective potential of tectochrysin against vanadium induced heart damage via regulating NLRP3, JAK1/STAT3 and NF-κB pathway.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Prevention of fenitrothion induced hepatic toxicity by saponarin via modulating TLR4/MYD88, JAK1/STAT3 and NF-κB signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Background: Filgotinib is an emerging Janus kinase 1 (JAK1) inhibitor being investigated for inflammatory bowel disease.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Sorbitol induces sub-chronic nephrotoxicity via escalating JAK1/STAT3, oxidative stress and inflammation in Sprague Dawley rats.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “RESULTS: PPI analysis identified JAK2, MAPK3, MAPK1, JAK1, PTPN1, HSPA8, TYK2, RAF1, MAPT, and HMOX1 as key hub genes, with JAK2 emerging as a critical regulator of immune and antiviral pathways.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Leo was also found to impart STAT3 inhibition by mitigating the activation of upstream kinases such as JAK1, JAK2, and Src both in constitutive and IL-6 inducible systems.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Palliative potential of velutin against abamectin induced cardiac toxicity via regulating JAK1/STAT3, NF-κB, Nrf-2/Keap-1 signaling pathways: An insight from molecular docking.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “We identify potentially druggable targets in multiple systems, including inflammatory signalling (JAK1), monocyte-macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Our results showed that the docking affinity from 4Z16 (JAK3 wild-type model), 4E4N (JAK1), 4D1S (JAK2), and 7UYT (TYK2) from the Schrödinger software suite agreed well with the experimentally derived binding free energies with small predicted mean errors.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “At the molecular levels, the expression levels of miRNA 328, miRNA-21, TGFβ1, TGFβ1R, JAK1, STST-3, SMAD-1 and NFκβ genes were significantly up-regulated, whereas the expression levels of SMAD-7 were significantly down-regulated.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Children exposed to NSAIDs in early life and complicated by dysbiosis and AIH exhibited elevated serum levels of NLRP3, IL18, liver enzymes, ASMA, ANA, JAK1, and IL6.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “In addition, treatment with nifuroxazide significantly down-regulated serum CRP as well as the colonic expressions of MPO, IL-6, TNF-α, TLR-4, NF-κB-p65, JAK1, STAT-3, DKK1 in a dose-dependent manner.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “3FC downregulated the constitutive phosphorylation of STAT3 and non-receptor tyrosine kinases such as JAK1 and JAK2.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “We noted that LDL induced a substantial STAT3 activation and JAK1, JAK2, Src activation in diverse prostate and pancreatic tumor cells.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “USP18 down-regulates type I interferon signaling by blocking the access of Janus-associated kinase 1 (JAK1) to the type I interferon receptor.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “We further explored the mRNA and protein expression of IL-21, IL-22, IL-1β, TNF-α, NOS2, JAK1, STAT3, IL-27, and Foxp3 in brain tissue by RT-PCR, and western blotting.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “Janus kinases (JAKs) are a family of non-receptor tyrosine kinases, composed by four members, JAK1, JAK2, JAK3 and TYK2.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “CAG predominantly caused negative regulation of STAT3 phosphorylation at tyrosine 705 through the abrogation of Src and Janus-activated kinases (JAK1/2) activation.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “We also assessed the effect of resveratrol treatment on IL-6, TNF-α, IFN-γ, JAK1, and STAT3 mRNA expression levels in the brain tissue.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “We explored PBMC mRNA expression levels for IL-1β, IL-4, IFN-γ, IL-9, JAK1, and STAT5, by using real-time PCR (RT-PCR).” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “We found that GAC 17:1 can inhibit constitutive activation of STAT3 through the abrogation of upstream JAK2, Src but not of JAK1 kinases in U266 cells and also found that GAC can suppress IL-6-induced STAT3 phosphorylation in MM.1S cells.” | 0.98 | hgnc_dict_v1 |
| gene | JAK1 | “STAT3 suppression was mediated through the inhibition of activation of upstream JAK2, but not of JAK1 and Src kinases.” | 0.98 | hgnc_dict_v1 |