VKORC1
HGNC:23663 · SaudiVarKB evidence summary derived from retained literature mentions.
15Gene mentions
15Publications
18Linked variants
5Associated phenotypes
Associated phenotypes
Co-mentioned in VKORC1 publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| diabetes mellitus | — | 1 | 1 |
| sickle cell disease | HP:0001878 | 1 | 1 |
| familial hypercholesterolemia | HP:0003124 | 1 | 1 |
| renal failure | — | 1 | 1 |
| stroke | — | 1 | 1 |
Linked variants
Variants normalized to VKORC1| Variant | HGVS / rsID | Articles | Mentions |
|---|---|---|---|
| rs9923231 | rs9923231 | 2 | 2 |
| -1173C>T | — | 2 | 2 |
| p.Asp36Tyr | p.Asp36Tyr | 1 | 1 |
| rs61742245 | rs61742245 | 1 | 1 |
| rs98332238 | rs98332238 | 1 | 1 |
| rs9332172 | rs9332172 | 1 | 1 |
| rs1057910 | rs1057910 | 1 | 1 |
| rs9332230 | rs9332230 | 1 | 1 |
| rs1799853 | rs1799853 | 1 | 1 |
| rs1057911 | rs1057911 | 1 | 1 |
| rs9332119 | rs9332119 | 1 | 1 |
| rs28399511 | rs28399511 | 1 | 1 |
| rs3758581 | rs3758581 | 1 | 1 |
| rs11572080 | rs11572080 | 1 | 1 |
| rs10509681 | rs10509681 | 1 | 1 |
| rs9934438 | rs9934438 | 1 | 1 |
| rs7294 | rs7294 | 1 | 1 |
| C1173T | — | 1 | 1 |
Population context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | — | 4 |
| Not specified | — | 0 | 1 |
| Saudi Arabia | — | 100 | 1 |
| Saudi Arabia | — | 22 | 1 |
| Not specified | — | 2,000 | 1 |
| Not specified | — | 107 | 1 |
| Saudi Arabia · Central Province | — | 111 | 1 |
| Saudi Arabia | — | 193 | 1 |
| Not specified | — | 54 | 1 |
| Saudi Arabia | — | 786 | 1 |
| Saudi Arabia | — | 936 | 1 |
Supporting publications
15 records- 2026Clinical Pharmacogenomic Variants Among the Saudi Population and Their Impact on Drug Response: A Review of Saudi-Based Evidence.CureusPubMed ↗
- 2025The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients.Frontiers in pharmacologyPubMed ↗
- 2025The Genetic Polymorphisms of CYP2C9 and VKORC1 in the Saudi Population and Their Impact on Anticoagulant Management.Medicina (Kaunas, Lithuania)PubMed ↗
- 2023Targeted next-generation sequencing of genes involved in Warfarin Pharmacodynamics and pharmacokinetics pathways using the Saudi Warfarin Pharmacogenetic study (SWAP).The pharmacogenomics journalPubMed ↗
- 2023The Association Between Bone Remodeling Markers, genes polymorphisms with Incidence of Osteopenia Among Young Saudi Female.Cellular and molecular biology (Noisy-le-Grand, France)PubMed ↗
- 2022Identification of pharmacogenetic variants from large scale next generation sequencing data in the Saudi population.PloS onePubMed ↗
- 2022Association of VKORC1 and CYP2C9 single-nucleotide polymorphisms with warfarin dose adjustment in Saudi patients.Drug metabolism and personalized therapyPubMed ↗
- 2022Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement.Frontiers in cardiovascular medicinePubMed ↗
- 2022Association of VKORC1 and CYP2C9 single-nucleotide polymorphisms with warfarin dose adjustment in Saudi patients.Drug metabolism and personalized therapyPubMed ↗
- 2021Pharmacogenetic determinants of warfarin in the Indian population.Pharmacological reports : PRPubMed ↗
- 2020The effect of the VKORC1 promoter variant on warfarin responsiveness in the Saudi WArfarin Pharmacogenetic (SWAP) cohort.Scientific reportsPubMed ↗
- 2019Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals.Clinical pharmacology and therapeuticsPubMed ↗
- 2018Utilizing Whole-Exome Sequencing to Characterize the Phenotypic Variability of Sickle Cell Disease.Genetic testing and molecular biomarkersPubMed ↗
- 2016A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.PloS onePubMed ↗
- 2016VKORC1 gene (vitamin K epoxide reductase) polymorphisms are associated with cardiovascular disease in chronic kidney disease patients on hemodialysis.Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi ArabiaPubMed ↗