SOD1
HGNC:11179 · 46 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | SOD1 | “Several key genetic factors have been identified, particularly mutations in C9orf72, SOD1, TARDBP, and FUS, which serve as important targets for novel treatments, such as Tofersen, a recently approved SOD1-specific antisense oligonucleotide (ASO) gene therapy.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Prespecified variables included demographics, family history, initial phenotype, MRI/EMG, genetics, treatments (riluzole, edaravone, SPT, tofersen for SOD1), times to noninvasive ventilation (NIV), gastrostomy and invasive ventilation.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Assessing the Association Between Genetic Variants in ACE, SOD1, and PER3 and their Role in Breast Cancer Risk among Jordanian Women.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Investigating the impact of SOD1 mutations on amyotrophic lateral sclerosis progression and potential drug repurposing through in silico analysis.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Biological testing confirmed the ability of 1 to induce a mixed, non-lethal stress response in human U87-MG glioblastoma cells; analysis of stress markers by qRT-PCR revealed early upregulation of superoxide dismutase 1 (SOD1) and C/EBP-homologous protein (CHOP) relative to the control.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Nearly 20 gene mutations are associated with ALS, with SOD1, FUS, TARDBP, and C9orf72 mutations being more common.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Gene expression analysis of SOD1, CAT, NF-κB, TNF-α, IL-1β, BCL2, BAX, MBP, and Syn2a provided molecular evidence of disrupted antioxidant defenses, impaired myelin formation, altered synaptic function in the brain, inflammatory responses, and increased apoptosis in the ovaries.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Additionally, this review summarizes contemporary understandings of the biology of Cu/Zn superoxide dismutase 1 (SOD1) from SOD1 genetics and its therapeutic potential.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Aggregation-Prone Pathogenic SOD1 Variants in Amyotrophic Lateral Sclerosis: Insights from Computational Genomics and Evolutionary Conservation.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Molecular analysis confirmed upregulation of oxidative stress genes (SOD1, CAT) and inflammatory markers (HSP70, IL- 1β).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Six liver-metabolism-related DEGs, SOD2, SOD1, CD19, IGF1, HK2, and PFKFB3, were expressed differently among the three sheep groups.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “RES was shown to mitigate the effect of PA on macrophages bioenergetics and the oxidative damage and counteracted PA effect on genes linked to oxidative damage, such as Nrf2, Ho-1, NF-κB p65, SOD1, and SOD2.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Analysis of gene expression demonstrated significant dysregulation in genes associated with oxidative stress (SOD1, CAT), inflammatory markers (TNF-α, IL-1β), apoptotic regulators (p53, bcl2), and neurobiological genes (brain-derived neurotrophic factor, bdnf).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “NanoBiT-based Analysis of Canine SOD1 Protein Dynamics: Understanding the Role of CCS and Ebselen Derivatives as Potential Therapeutics for Canine Degenerative Myelopathy.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Neurodegeneration refers to the gradual loss of neurons and extensive changes in glial cells like tau inclusions in astrocytes and oligodendrocytes, α-synuclein inclusions in oligodendrocytes and SOD1 aggregates in astrocytes along with deterioration in the motor, cognition, learning, and behavior.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Gene expression analysis revealed downregulation of SOD1 and CAT genes, upregulation of inflammatory genes TNF-α and IL-1β, and increased expression of the apoptotic gene p53 with decreased expression of Bcl-2 and BDNF.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “The BPA administration also induces ROS production, which decreases the expression of antioxidant genes Superoxide dismutase 1 (SOD1), Superoxide dismutase 2 (SOD2), Catalase (CAT), Glutathione peroxidase 1 (GPX1), and Forkhead box O3 (FOXO3) in ovarian cells.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Up regulation (p ≤ 0.001) of the expressions of catalase, GPX1, and SOD1 were in LGX200 group compared to other groups.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Relative expression levels of genes associated with energy (ACADM, PEPCK, GOT2, GLUT1, and CS), ROS modulation (SIRT1), mitochondrial free-radical scavengers (SOD1, PRX4, NOS2, GPX1, and GPX4), anti-apoptotic genes (NF-κβ), apoptotic (CASP7), and tissue damage using histology, during migration were assessed.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “This review summarizes the molecular genetics of fALS, highlighting key mutations that contribute to its pathogenesis, such as mutations in SOD1, FUS, and C9orf72.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Dietary inclusion of LC and or B. subtilis supplementation significantly (P < 0.001) up-regulated hepatic growth-related genes (growth hormone receptor (GHR) and insulin growth factor1 (IGF-1)) and antioxidant-related genes (superoxide dismutase 1 (SOD1), glutathione peroxidase (GPX1) and uncoupling protein (UCP) and down-regulated (P < 0.001) splenic toll-like receptor 4 (TLRP) gene expression while had no significant effect on splenic interleukin 8 (IL8) and tumor necrosis factor (TNF) with the best-obtained results with 1.0% followed by 0.5% LC with B. subtilis supplementation.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Oxidative stress was induced after ND exposure indicated by a reduction in GSH and SOD1 level, with increased MDA level.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Notably, the expression of three important aging-related genes, SIR2, SOD1, and SOD2, showed a significant difference following PLME treatment.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Unveiling promising inhibitors of superoxide dismutase 1 (SOD1) for therapeutic interventions.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “The qPCR quantification showed the upregulation of caspase 3, caspase 9, bax, and SOD1 genes in GRO-NLs-treated cells.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “The disease is either sporadic or familial with SOD1, C9orf72, FUS, and TDP-43 constituting the majority of familial ALS.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Broiler chickens fed diets supplemented with 150 mg/kg of diet had higher (P < 0.05) mRNA expressions of jejunal SOD1 and interleukins 6 and 10 (IL-6, IL-10).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Familial ALS, including superoxide dismutase 1 (SOD1) mutation, accounts for 5-10% of all cases of ALS.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “This review compares the temporal disease progression with severity of disease at the NMJ in mouse models with the most commonly mutated genes in ALS patients (SOD1, C9ORF72, TARDBP and FUS).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Evaluation of each group was via histopathological examination, assessment of gene and/or protein expression concerned with oxidative stress (SOD1, SOD2, Nox2, Nox4, iNOS), inflammation (TNF-α, ICAM-1, NF-κB) and angiogenesis (VEGF, VE-cadherin).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Gene expression of catalase, superoxide dismutase (SOD1, SOD2), and glutathione peroxidase (GPx) are changed twice, thrice, and quadruplet, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Additionally, several markers of oxidative stress (MDA/H2O2/GSH/SOD1/CAT/GPx4) and inflammation (IL-1β/IL-6/TNF-α/IL-10) together with renal cell apoptosis and expression of caspase-3 (Casp-3) were measured.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Additionally, the levels of markers of oxidative stress (MDA/H2O2/protein adducts) and inflammation (TNF-α/IL-1β/IL-6/IL-18/TLR/HSP25) were substantially higher in the PC renal specimens, whereas the antioxidants (GSH/GPx/SOD1/CAT) and interleukin-10 decreased, relative to the NC group.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “PCR-DNA sequencing of SELL, ABCG2, SLC11A1, FEZL, SOD1, CAT, GPX1, and AhpC/TSA revealed nucleotide sequence variations in the form of SNPs associated with mastitis tolerance/susceptibility in investigated Holstein and Brown Swiss dairy cows.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “The most common familial form of ALS (fALS) has been associated with mutations in the Cu/Zn superoxide dismutase (SOD1) gene.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Six SNPs were significantly more prevalent in obese cohorts: (1) GSTM1 rs1056806*C/T; (2) SOD1 rs2234694*A; (3) SOD2 rs4880*G; (4) SOD3 rs2536512*A; (5) GPX1 rs1800668*A; (6) NOS3 rs1799983*G.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Following intervention, blood serum was examined for biochemical markers, and liver tissue was investigated for the mRNA expression of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD1) by RTPCR analysis.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “There are several genetic mutations that lead to ALS development, such as chromosome 9 hexanucleotide repeat 72 (C9ORF72), transactive response DNA-binding protein (TARDBP), superoxide dismutase 1 (SOD1) and fused in sarcoma (FUS).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Gene expression analysis showed an upregulation in CD34+ cells for antioxidant SOD1 (p < 0.05) and a downregulation in CD34- cells for IL-6 (p < 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Computing disease-linked SOD1 mutations: deciphering protein stability and patient-phenotype relations.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Analysis of the SOD1 Gene in Keratoconus Patients from Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “Association between diabetes-associated nephropathy and polymorphisms in the erythropoietin (EPO) gene, variants in the superoxide dismutase 1 (SOD1) gene and plasmacytoma variant translocation 1 (PVT1) gene have been identified.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “The cDNA sequencing revealed an open reading frame of 459 nucleotides encoding a protein of 153 amino acids which is equal to the coding region of SOD1 gene and protein from many organisms.” | 0.98 | hgnc_dict_v1 |
| gene | SOD1 | “ALS is familial in about 10% of cases, with SOD1 mutations accounting for 20% of familial cases.” | 0.98 | hgnc_dict_v1 |