BCL11A
HGNC:13221 · SaudiVarKB evidence summary derived from retained literature mentions.
23Gene mentions
23Publications
6Linked variants
6Associated phenotypes
Associated phenotypes
Co-mentioned in BCL11A publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| sickle cell disease | HP:0001878 | 12 | 12 |
| sickle cell anemia | HP:0001878 | 6 | 6 |
| thalassemia | HP:0001878 | 3 | 3 |
| stroke | — | 2 | 2 |
| leukemia | — | 1 | 1 |
| lymphoma | — | 1 | 1 |
Linked variants
Variants normalized to BCL11A| Variant | HGVS / rsID | Articles | Mentions |
|---|---|---|---|
| rs4671393 | rs4671393 | 2 | 2 |
| rs1427407 | rs1427407 | 2 | 2 |
| rs9399137 | rs9399137 | 2 | 2 |
| c.20A>T | c.20A>T | 1 | 1 |
| rs11886868 | rs11886868 | 1 | 1 |
| rs28384513 | rs28384513 | 1 | 1 |
Population context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | — | 3 |
| Saudi Arabia | — | — | 1 |
| Not specified | — | 0 | 1 |
| Not specified | — | 115 | 1 |
| Saudi Arabia · Eastern Province | — | 164 | 1 |
| Saudi Arabia | — | 139 | 1 |
| Saudi Arabia | — | 44 | 1 |
| Saudi Arabia · Western Province | — | 3 | 1 |
| Not specified | — | 166 | 1 |
| Not specified | — | 600 | 1 |
| Saudi Arabia · Jeddah | — | 132 | 1 |
Supporting publications
23 records- 2026CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials.Molecular biotechnologyPubMed ↗
- 2026miRNA-Mediated Regulation of γ-Globin to β-Globin Switching: Therapeutic Potential in β-Hemoglobinopathies.International journal of molecular sciencesPubMed ↗
- 2026Systematic Review of Non-Coding Genomic Variants in Globin and Non-Globin Clusters and Their Impact on Phenotypic Severity in Thalassemia and Sickle Cell Disease.Journal of clinical medicinePubMed ↗
- 2026A Comprehensive Review of Gene Mutations in Inherited Blood Disorders Among the Saudi Population.Human mutationPubMed ↗
- 2025BCL11A +58/+55 enhancer-editing facilitates HSPC engraftment and HbF induction in rhesus macaques conditioned with a CD45 antibody-drug conjugate.Cell stem cellPubMed ↗
- 2025Exploratory Review and In Silico Insights into circRNA and RNA-Binding Protein Roles in γ-Globin to β-Globin Switching.CellsPubMed ↗
- 2025Therapeutic promise of CRISPR-Cas9 gene editing in sickle cell disease and β-thalassemia: A current review.Current research in translational medicinePubMed ↗
- 2025Genetic patterns & public health implications of sickle cell anaemia across populations: A systematic review.The Indian journal of medical researchPubMed ↗
- 2024Targeting BCL11A through gene therapy in sickle cell disease: Will one size fit all or most?Pediatric blood & cancerPubMed ↗
- 2024Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models.CytotherapyPubMed ↗
- 2024Associations between BCL11A and HBS1L-MYB polymorphisms and thalassemia risk.Journal of Taibah University Medical SciencesPubMed ↗
- 2023Bioinformatics and genetic variants analysis of FGF10 gene promoter with their association at carcass quality and body measurement traits in Qinchuan beef cattle.Animal biotechnologyPubMed ↗
- 2023Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation.Molecular therapy. Methods & clinical developmentPubMed ↗
- 2021The Genetic and Clinical Significance of Fetal Hemoglobin Expression in Sickle Cell Disease.Medical principles and practice : international journal of the Kuwait University, Health Science CentrePubMed ↗
- 2021Haemoglobin switching modulator SNPs rs5006884 is associated with increased HbA2 in β-thalassaemia carriers.Archives of medical science : AMSPubMed ↗
- 2021CRISPR-Cas9 to induce fetal hemoglobin for the treatment of sickle cell disease.Molecular therapy. Methods & clinical developmentPubMed ↗
- 2020Detection of BCL11A and HBS1L-MYB Genotypes in Sickle Cell Anemia.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood TransfusionPubMed ↗
- 2019BCL11A rs1427407 Genotypes in Sickle Cell Anemia Patients Undergo to Stroke Problems in Sudan.Korean journal of family medicinePubMed ↗
- 2019The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching.PloS onePubMed ↗
- 2017Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients.BioMed research internationalPubMed ↗
- 2016A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.American journal of hematologyPubMed ↗
- 2015BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.Blood cells, molecules & diseasesPubMed ↗
- 2013Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype.Blood cells, molecules & diseasesPubMed ↗