CCL2
HGNC:10618 · 27 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CCL2 | “We further identified 201 common upregulated hub genes (including MMP9, CDH1, HSP90AB1, SOX2, CDKN2A, SPP1, EZH2) and 224 common downregulated hub genes (such as IL6, TNF, IL1B, JUN, CCL2, TLR4, FOS, PTGS2).” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Pilot ELISA validation confirmed significant increases in TGF-β1 (~2.05-fold), IL-6 (~2.59-fold), CCL2 (~2.10-fold), and PD-L1 (~2.56-fold) under EMT-inducing conditions (p < 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Chemotaxis and transmigration assays were measured along with transcriptional profiling of selected neutrophil inflammatory chemokines (CXCL1, CCL2 and CCL26) and chemokine receptors (IL8R and CCR4) following in vitro stimulation by saccharin through siRNA knockdown and RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “CCL2+ cells were enriched around NMJs in hTDP-43 mice, and in ALS patient skeletal muscle.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “In Group II, genes such as LIF, LBP, CSF3, IL6, CCL2, SAA1, CCL20, MMP9, CXCL10, and MMP1 were found to be involved in the transformation to adult glioblastoma.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Notably, IL-6-mediated inflammatory and PD-L1 pathways were highly active in Met cells with increased secretion of pro-inflammatory and pro-metastatic cytokines such as CCL2, CCL11, IL5, IL6, and CXCL5.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “METHODS: We utilized a set of patient-derived premalignant and malignant tissue samples to investigate the protein (Ki67 and Lamin B1) and gene (TP53, IL1A, CCL2, and MMP9) expression of several OIS-associated biomarkers using immunohistochemistry (IHC) and qRT-PCR, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Further, RT-PCR and Western blot analysis validated the expression of target genes including the overexpression of HSPA1B, FOS, and down-expression of SOD2, COL1A1, and CCL2, whereas TFs including upregulation of RELA, NFKB1, STAT3, and downregulation of SP1 and JUN in diabetic and diabetic infectious wounds.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “We used a set of patient-derived precancerous (n = 32) and noncancerous (chronic cervicitis; n = 10) tissue samples to investigate the gene expression of several OIS (LMNB1, CDKN2A, CDKN2B, and CDKN1A), and SASP (IL1A, CCL2, TGFB1, CXCL8, and MMP9) biomarkers using qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Co-treatment with MTX and resveratrol significantly reduced mRNA and chemokine expression of CCL2, CCL3, CCL4, CCL5, and CXCL10 (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Real time PCR was performed to quantify gene expression for macrophage-associated cytokines (IL-1β, TNF-α, IFN-γ) and chemokine (CCL2).” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “The immunological (IKBKG, LGALS, IL1B, CCL2, RANTES, MASP2, HMGB1, and S-LZ) genes' nucleotide sequence differences between healthy buffaloes and buffaloes affected by inflammatory reproductive diseases were found by employing PCR-DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “SLC11A1, CD-14, CCL2, TLR1, TLR7, TLR8, TLR9, β defensin, SP110, SPP1, BP1, A2M, ADORA3, CARD15, IRF3, and SCART1 SNPs that have been previously found to be associated with pneumonia resistance/susceptibility were identified via PCR-DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Toll-Like Receptor Signaling in the Pathogenesis of Chronic Dacryocystitis: Implication of c-FOS Transcription Factor and its Downstream Effector Chemokine Genes CCL2, CCL4, CXCL3, CXCR4 with a Shift of the M1/M2 Macrophage Phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “FOCAD knockout hepatocytes exhibited lowered albumin expression and signs of persistent injury accompanied by CCL2 overproduction.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Macrophages exposed to Fe3O4 NPs with a MetS-BC for 1 h or 24 h at a concentration of 25 μg/mL demonstrated enhanced gene expression of inflammatory markers: CCL2, IL-6, and TNF-α compared to Fe3O4 NPs with a healthy BC.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Convalescent plasma is rich with cytokines (IL-1β, IL-2, IL-6, IL-17, and IL-8), CCL2, and TNFα, neutralizing antibodies, and clotting factors essential for the management of SARS-CoV-2 infection.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Upregulation of LMNA in monocytic THP-1 and U937 cell lines induced CD68, TNFα, CCL2, IL-6 and NOS2.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “In addition, RA treatment resulted in elevated levels of various angiogenic factors, while inflammatory (TNF-α and IL-1β) and apoptotic markers (CXCL10 and CCL2) decreased.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Increased circulating levels of CXCL10/IP10 and CCL2/MCP-1 might also be related to the severity of MERS.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Mice were injected with 2 mg/kg AgNPs, and organs assessed for inflammatory gene expression (TNF-α, CXCL1, CXCL2, CCL2, TGF-β, HO-1, IL-4, IL-13), and Ag content.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “IL-33 markedly stimulated expression of the IL1B, CCL2, IL6, CXCL2 and CSF3 genes, but there was no effect on ADIPOQ expression.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “DHA slightly countered the actions of IL-1β on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “Two promoter constructs, TK2ST and TKTSC, were established, which have optimal low expression levels suitable for FCS studies in U2OS, HeLa CCL2, NIH 3T3, and BALB/c cells.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “RESULTS: Cross-sectional analyses showed that the LPS-induced expression of genes involved in inflammasome (NLRP3, caspase 5 and NAIP), Nod-like receptors (NLRX1 and NOD1), downstream signaling (P2RX7, RAGE, RIPk2, TIRAP and BIRC2) and effector molecules (IFN-γ, IL-12β, IL-1β, CCL2, CCL5, IL-6 and TNFα) was significantly increased in obese subjects at baseline as compared with normal weight controls.” | 0.98 | hgnc_dict_v1 |
| gene | CCL2 | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |