CD19
HGNC:1633 · 33 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD19 | “Immunological evaluation revealed hypergammaglobulinemia, impaired T-cell proliferation, reduced CD19+ B cells, inverted CD4/CD8 ratio, and absence of CD25 expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Blinatumomab, a CD3×CD19 bispecific T-cell engager, has demonstrated efficacy in relapsed/refractory (R/R) and measurable residual disease-positive (MRD+) B-cell acute lymphoblastic leukemia (B-ALL), as well as in frontline consolidation following the ECOG-ACRIN E1910 trial that established its regulatory approval in this setting.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “In vitro functional testing of CD19 + and enriched naïve B cells revealed impaired proliferation, and reduction in class-switch recombination upon CD40L and IL-21 stimulation.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “CD19 Directed CAR T Therapy for Transformed Follicular Lymphoma: A CIBMTR Analysis.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “CD19 chimeric antigen receptor T-cell (CAR-T) therapy is a pivotal part of the treatment algorithm for large B-cell lymphoma (LBCL) in the second- and third-line settings based on numerous clinical trials.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Non-synonymous and neoantigen mutation burden were no different between groups, however R-mesotheliomas were infiltrated with activated CD8+ T- and CD19+ B-lymphocytes, organised into tertiary lymphoid structures.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Chimeric antigen receptor (CAR)-T cell therapy is one of the most successful types of immunotherapy that has revolutionized cancer treatment, as evidenced by various approved products for CD19 B-cell malignancies and multiple myeloma.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Six liver-metabolism-related DEGs, SOD2, SOD1, CD19, IGF1, HK2, and PFKFB3, were expressed differently among the three sheep groups.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Protein-protein interaction (PPI) network analysis using the STRING database and Cytoscape software revealed key hub genes, including IFNA1, IL7R, CD19, IL2RA, and IFNG, crucial in antiviral defense.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Role of CD19 Chimeric Antigen Receptor T Cell Therapy in Idiopathic Inflammatory Myopathies.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Based on different T-cell depletion (TCD) approaches, four categories were identified: (1) TCRαβ+/CD19+-depletion (43.8%); (2) T-repleted with post-transplant Cyclophosphamide (PTCy, 34.0%); (3) In-vivo T-depletion with ATG/alemtuzumab (14.8%); (4) CD34+ positive selection (7.4%).” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Furthermore, the results revealed that severe COVID-19 patients had an increased frequency of CD19+ B cells, with changes in B cell subsets.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Laboratory investigations revealed low CD3+, CD4+, and CD8+ lymphocytes, along with normal CD19+ and CD16+ lymphocytes, and low serum IgM and IgA levels.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “According to different types of clusters of differentiation (CD), CD5 was positive in 84 (84%) patients, and 88 (88%) patients were positive for CD19.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “This work aimed to examine the effects of AFB1 on the expression of Notch-1, IL-6, MCP-1, iNOS, GM-CSF, and NF-κB p65 by CD19+ B cells in the spleen of the BTBR using flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Immuno-Diagnostic Interest in Monitoring CD16+CD56+ (Natural Killer) Cells and CD19+CD45+ (B Lymphocytes) in Individuals Newly Diagnosed with HIV in a Tertiary Care Center.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Flow cytometry was used to evaluate lymphocyte profiles, including CD8+ T, CD19+ B, CD3+, CD4+, natural killer (NK), NK T, T helper 1 (Th1), Th2, T cytotoxic (Tc1), and Tc2 cells, prior to and after 1 year of treatment with HU.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Most of the otoferlin-positive cells were unswitched B cells (63-99.4%), with 65-75% of them expressing plasmablast markers (CD19+, IgM+, CD38hi, CD24-).” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Severe hematotoxicity after CD19 CAR-T therapy is associated with suppressive immune dysregulation and limited CAR-T expansion.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “OBJECTIVES: To evaluate the levels of total lymphocytes, B-lymphocytes (CD19+), T-lymphocytes (CD3+), natural killer (NK) cells (CD3-/CD56+), and monocyte subsets in type 2 diabetes mellitus (T2DM) patients in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “BACKGROUND: Chimeric antigen receptor (CAR) T cells have demonstrated high clinical response rates against hematological malignancies (e.g., CD19+ cancers) but have shown limited activity in patients with solid tumors.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Peripheral blood T cells, CD3+, CD4+, CD8+, and CD19+, were analyzed in confirmed HPIV positive and healthy control group children through flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “METHODS: We measured DNA methylation in CD4+ T cells (n = 31), CD8+ T cells (n = 28), CD14+ monocytes (n = 35) and CD19+ B cells (n = 27) from relapsing-remitting (RRMS), secondary progressive (SPMS) patients and healthy controls (HC) using Infinium HumanMethylation450 arrays.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Complete blood count analyses showed significant difference in the total white cell count of neutrophils (p < 0.0001), WBC (p < 0.0001), lymphocytes (p < 0.001), monocytes (p < 0.001), eosinophils (p = 0.013) as well as the CD19 B cells (p = 0.008).” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “The pathologic features showed blastoid variant of MCL and flow cytometry showed that the tumor cells were CD5-, CD19+, CD20+, FMC-7+, CD23-, and lambda light chain restricted.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “The introduction of genes encoding artificial receptors called chimeric antigen receptors (CARs) and CAR-modified T cells targeted to the B cell-specific CD19 antigen have demonstrated promising results in multiple early clinical trials.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “Immunophenotypic analysis showed that the neoplastic cells were positive for CD4, CD123, TCL-1, and HLA-DR and were negative for CD3, CD8, CD13, CD19, CD34, and myeloperoxidase.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “All patients received a single dose of rituximab (375 mg/m(2)) and achieved complete B cell depletion as CD19 was <1% for 3 months following rituximab infusion.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “This study was designed to utilize flow cytometric immunophenotyping to characterize effects of regular blood transfusion, and high serum ferritin levels because of irregular use of iron chelation therapy on T lymphocytes (CD2, CD3, CD4 and CD8), B lymphocytes (CD19) and natural killer cells (CD56) and zinc levels in the blood of patients with thalassemia major (n = 49) and healthy normal controls (n = 60) in Kuwait.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “There was a significant difference in the total lymphocyte CD3, CD8, CD19, CD16/CD56 and natural killers (NK) cell but no significant difference in the CD4/CD8 ratio and CD4 between case (n=75) and control (n=100) groups.” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “We investigated the expression of T-cell markers (CD3, CD4, and CD8), B cells (CD19), and natural killer cells (CD16 and CD56).” | 0.98 | hgnc_dict_v1 |
| gene | CD19 | “MATERIALS AND METHODS The authors prospectively studied lymph nodes from 48 patients with the diagnosis of HD by FCM for T (CD3, CD4, and CD8) and B (CD19) lymphocytes.” | 0.98 | hgnc_dict_v1 |