COMT
HGNC:2228 · SaudiVarKB evidence summary derived from retained literature mentions.
16Gene mentions
16Publications
2Linked variants
6Associated phenotypes
Associated phenotypes
Co-mentioned in COMT publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| breast cancer | — | 3 | 3 |
| intellectual disability | HP:0001249 | 1 | 1 |
| diabetes mellitus | — | 1 | 1 |
| neurodevelopmental disorder | HP:0012759 | 1 | 1 |
| sickle cell disease | HP:0001878 | 1 | 1 |
| coronary artery disease | — | 1 | 1 |
Linked variants
Variants normalized to COMTPopulation context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Not specified | — | 100 | 2 |
| Saudi Arabia | — | — | 1 |
| Saudi Arabia | — | 172 | 1 |
Supporting publications
16 records- 2026Pharmacogenomics and Opioid Efficacy in Sickle Cell Disease.Medicina (Kaunas, Lithuania)PubMed ↗
- 2024Gene-gene and gene-environmental interaction of dopaminergic system genes in Pakistani children with attention deficit hyperactivity disorder.Saudi journal of biological sciencesPubMed ↗
- 2024The moderating role of COMT gene rs4680 polymorphism between maladaptive metacognitive beliefs and negative symptoms in patients with schizophrenia.BMC psychiatryPubMed ↗
- 2023Unraveling Catechol-O-Methyltransferase rs4680 SNP's Role in Patients' Response to Tramadol and Its Adverse Effects: A Pharmacogenetics Insight into Postoperative Pain Management.Journal of clinical medicinePubMed ↗
- 2022COMTVal158Met polymorphism is associated with ecstasy (MDMA)-induced psychotic symptoms in the Turkish population.Neurosciences (Riyadh, Saudi Arabia)PubMed ↗
- 2022Correlations between COMT polymorphism and brain structure and cognition in elderly subjects: An observational study.MedicinePubMed ↗
- 2022Genetic and epigenetic factors associated with depression: An updated overview.Saudi journal of biological sciencesPubMed ↗
- 2022Clinical and genetic factors associated with self-reported cognitive deficits in women with breast cancer: the "CAGE-Cog" study.BMC cancerPubMed ↗
- 2021The Antioxidative Role of Natural Compounds from a Green Coconut Mesocarp Undeniably Contributes to Control Diabetic Complications as Evidenced by the Associated Genes and Biochemical Indexes.Oxidative medicine and cellular longevityPubMed ↗
- 2018Predicted activity of UGT2B7, ABCB1, OPRM1, and COMT using full-gene haplotypes and their association with the CYP2D6-inferred metabolizer phenotype.Forensic science international. GeneticsPubMed ↗
- 2018Meta-analysis of genetic polymorphisms in xenobiotic metabolizing enzymes and their association with breast cancer risk.Journal of geneticsPubMed ↗
- 2018Potential Impact of COMT-rs4680 G > A Gene Polymorphism in Coronary Artery Disease.Journal of cardiovascular development and diseasePubMed ↗
- 2016Artificial neural network-based exploration of gene-nutrient interactions in folate and xenobiotic metabolic pathways that modulate susceptibility to breast cancer.GenePubMed ↗
- 2015Leptin influences estrogen metabolism and accelerates prostate cell proliferation.Life sciencesPubMed ↗
- 2014Genetic association of catechol-O-methyltransferase val(158)met polymorphism in Saudi schizophrenia patients.Genetics and molecular research : GMRPubMed ↗
- 2011Update on the genetics characterization of vitiligo.International journal of health sciencesPubMed ↗