LEP
HGNC:6553 · SaudiVarKB evidence summary derived from retained literature mentions.
14Gene mentions
14Publications
2Linked variants
8Associated phenotypes
Associated phenotypes
Co-mentioned in LEP publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| obesity | HP:0001513 | 6 | 6 |
| breast cancer | — | 3 | 3 |
| diabetes mellitus | — | 2 | 2 |
| hypertension | — | 1 | 1 |
| pre-eclampsia | — | 1 | 1 |
| hepatocellular carcinoma | — | 1 | 1 |
| COVID-19 | — | 1 | 1 |
| hepatitis C | — | 1 | 1 |
Linked variants
Variants normalized to LEPPopulation context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | — | 1 |
| Not specified | — | — | 1 |
| Not specified | — | 71 | 1 |
| Not specified | — | 106 | 1 |
| Saudi Arabia | — | 202 | 1 |
| Not specified | — | 300 | 1 |
| Saudi Arabia | — | 206 | 1 |
| Not specified | — | 232 | 1 |
Supporting publications
14 records- 2026Adiponectin and leptin levels in mothers, fetuses, and neonates with intrauterine growth restriction compared to those with appropriate gestational age.Frontiers in endocrinology1 mentions
- 2026Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults.Frontiers in medicine1 mentions
- 2025Exploring gene expression signatures in preeclampsia and identifying hub genes through bioinformatic analysis.Placenta1 mentions
- 2025A combined transcriptomic, epigenetic, and functional analysis identifies novel biomarkers in breast cancer.Hereditas1 mentions
- 2024Integrated High-throughput Transcriptomic Data Identifies Survivin as a Potential Breast Cancer Therapeutic Biomarker.Current medicinal chemistry1 mentions
- 2023Intergenic lnc-LEP-2:6 and lnc-LEP-2:7 as novel biomarkers associated with type 2 diabetes mellitus.Archives of physiology and biochemistry1 mentions
- 2023Analysis of Potential Genes and Economic Parameters Associated with Growth and Heat Tolerance in Sheep (Ovis aries).Animals : an open access journal from MDPI1 mentions
- 2023The Impact of LEP rs7799039 Polymorphism and Obesity on the Severity of Coronavirus Disease-19.Diabetes, metabolic syndrome and obesity : targets and therapy1 mentions
- 2022-2548G>A LEP Polymorphism Is Positively Associated with Increased Leptin and Glucose Levels in Obese Saudi Patients Irrespective of Blood Pressure Status.Medicina (Kaunas, Lithuania)1 mentions
- 2020The Inter-Relation between Leptin Receptor (Q223R) Gene Polymorphism and the Risk of Egyptian Patients with HCC.Asian Pacific journal of cancer prevention : APJCP1 mentions
- 2018Meningioma transcription factors link cell lineage with systemic metabolic cues.Neuro-oncology1 mentions
- 2016Low expression of leptin and its association with breast cancer: A transcriptomic study.Oncology reports1 mentions
- 2016A Novel Homozygous Frameshift Mutation in Exon 2 of LEP Gene Associated with Severe Obesity: A Case Report.Clinical medicine insights. Pediatrics1 mentions
- 2014Toxicogenetics of lopinavir/ritonavir in HIV-infected European patients.Personalized medicine1 mentions