CD14
HGNC:1628 · 29 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD14 | “Immunophenotypic characterization using CD14 and CD86 markers further demonstrated macrophage heterogeneity.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Here we show that in age and sex matched healthy donors, CD14+ /CD16- (classical), but not CD14+/CD16+ (non-classical and intermediate) monocytes form IFC using the CD36 scavenger pathway.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “This oxidative burden mediates villous atrophy of enterocytes and Th2-biased immune response via the induction of TMED1/CD14+ mediated IL-33 signaling cascades, as well as LITAF-induced activation of TNF-α-dependent mRNA expression of NOX2-regulating subunit NCF4 pathway.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Phenotypically, elevated cortisol level was associated with an expanded CD4 T-cell population, reduced γδ T cells percentage, decreased CD172a expression on neutrophils and monocytes, reduced CD14 and CD163 expression on monocytes, and enhanced CD45 and MHC I expression on lymphocytes.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “The expression pattern of the cell markers CD163, CD14, CD172a, CD44, and CD9 on MDM generated in the presence of the MERS-CoV S1 protein revealed similarity with M-CSF-induced MDM, suggesting the potential of the MERS-CoV S1 protein to induce an M2 macrophages phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Regarding the TLR4 expression, it was clearly up-regulated in the E. coli group in comparison to other groups, while CD14 gene decreased clearly in all treated groups compared to the positive group.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “We used antibodies to detect several cell surface molecules associated with camel T cells (CD4, WC1), B cells (MHCII, BAQ44A), monocytes/macrophages (CD172a, CD14, CD163), in addition to the pan-leukocyte marker CD45 and the cell adhesion molecules CD44 and CD18.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “With exception of the TLR3 agonist Poly IC, all TLR ligands used showed the potential to stimulate camel neutrophils resulting in increased cell size and the upregulation of CD18 and CD14 on their surface.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Among these DEGs, a total of 10 significantly down-regulated DEGs, including cluster of differentiation 14 (CD14), beta2 Integrin Gene (ITGB2), C1q subcomponent subunit B (C1QB), Cluster of Differentiation 163 (CD163), Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1), Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP), Pleckstrin (PLEK), Complement C1q C Chain (C1QC), Fc fragment Of IgE receptor Ig (FCER1G), and tyrosine kinase binding protein (TYROBP), were shortlisted as the hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “The expression pattern of the cell markers CD172a, CD14, CD163, and MHCII molecules on BALF cells indicates a similar phenotype for camel, bovine, and porcine BALF myeloid cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Based on their differential expression of the LPS receptor CD14, macrophages (CD172a+CD14high cells) were identified as the most abundant immune cell population in the camel lung tissue.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Macrophages were examined for markers of maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36), toll-like receptor (TLR4), M2 marker (CD206), immune checkpoint (PD-L1), and intracellular chemokine expression (IP-10).” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “In addition, monocytes from heparin blood showed higher expression levels of the cell surface markers CD14, CD163, and MHCII when compared to cells from EDTA blood.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “For a long time, monocytes have been considered as a homogenous cell population, characterized by the expression of CD14, the receptor of lipopolysaccharide.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “The study further aimed to assess if GCF of periodontitis patients could convert CD14+ monocytes into macrophages of destructive phenotype in an in vitro setting.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Methylmercury chloride exposure aggravates proinflammatory mediators and Notch-1 signaling in CD14+ and CD40+ cells and is associated with imbalance of neuroimmune function in BTBR T+ Itpr3tf/J mice.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Material & methods: We generated paired assay for transposase-accessible chromatin sequencing and RNA-sequencing profiles from sorted blood immune CD4+ and CD8+ T cells, CD14+ monocytes and CD19+ B cells from healthy controls (HCs) and MS patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Using flow cytometry in peripheral blood, we further examined the molecular effects of etanercept on NF-κB p65, TNF-α, IL-17A, and TLR-4 expressing CD4+, CD8+, and CD14+ cells in the peripheral blood.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “We revealed production of TIM-3 on CD3+, CD4+, CD8+, CD11a+,b+, CD14+, CD62P+, and CXCR5+ PBMCs in children with ASD and typically developing (TD) controls using immunofluorescent staining.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “We examined IL-16 expression in CD4+, CD8+, CD14+, CCR3+, and CXCR7+ cells in typically developing (TD) controls and children with ASD using flow cytometry in peripheral blood mononuclear cells (PBMCs).” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “METHODS: We measured DNA methylation in CD4+ T cells (n = 31), CD8+ T cells (n = 28), CD14+ monocytes (n = 35) and CD19+ B cells (n = 27) from relapsing-remitting (RRMS), secondary progressive (SPMS) patients and healthy controls (HC) using Infinium HumanMethylation450 arrays.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Polarization markers (CD86, IL-6, TNFα, iNOS, CD36, CD11c, CD169, CD206, CD163, CD68, CD11b, CD16, and CD14) were measured by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Treatment of BTBR mice with SCH increased the percentage of splenic CD14+TLR2+ cells, CD14+TLR3+ cells, CD14+TLR4+ cells, and decreased the percentage of CD14+IL-27+ cells, as compared to the untreated BTBR mice.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Similarly, AU cells showed decreased IL-27 production by CD14+ cells compared to that of TD control cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Expression of genes involved in the inflammasome pathway, plasma concentration of the inflammasome-associated pro-inflammatory cytokines (interleukin (IL)-1β and IL-18) and indexes of microbial translocation (lipopolysaccharide (LPS), soluble CD14 (sCD14) and intestinal fatty acid-binding protein) were analyzed at baseline in obese subjects compared with controls, and after 18 months in obese subjects.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “Platelet MPs, platelet-derived monocyte MPs (CD42a, CD61), erythrocyte MP (CD235a), monocytic MP (CD14), and platelet activity MPs (CD62P, PAC-1) were assessed by multicolor flow cytometry FACSCalibur, while platelet functions were assessed by platelet function analyzer (PFA-100).” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “On the other hand, CL2 transcriptome was enriched in immune modulatory genes, for example, CD14, CD99, NOTCH3, CXCL6, CFB, and CFI.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “CD14 tobacco gene-environment interaction in atopic children.” | 0.98 | hgnc_dict_v1 |
| gene | CD14 | “CARD15/NOD2, CD14 and toll-like 4 receptor gene polymorphisms in Saudi patients with Crohn's Disease.” | 0.98 | hgnc_dict_v1 |