atopic dermatitis
SaudiVarKB evidence summary derived from retained literature mentions.
121Phenotype mentions
100Publications
48Associated gene records
42Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| DOCK8 | HGNC:19191 | 11 | 11 |
| STAT3 | HGNC:11364 | 7 | 7 |
| CCL17 | HGNC:10615 | 5 | 5 |
| FLG | HGNC:3748 | 4 | 4 |
| CCL5 | HGNC:10632 | 2 | 2 |
| STAT6 | HGNC:11368 | 2 | 2 |
| TYK2 | HGNC:12440 | 2 | 2 |
| TGM1 | HGNC:11777 | 2 | 2 |
| IMPACT | HGNC:20387 | 2 | 2 |
| FOXP3 | HGNC:6106 | 1 | 1 |
| CD4 | HGNC:1678 | 1 | 1 |
| IL2RA | HGNC:6008 | 1 | 1 |
| CD19 | HGNC:1633 | 1 | 1 |
| DNMT3A | HGNC:2978 | 1 | 1 |
| CARD11 | HGNC:16393 | 1 | 1 |
| ADA | HGNC:186 | 1 | 1 |
| PEPD | HGNC:8840 | 1 | 1 |
| LIPA | HGNC:6617 | 1 | 1 |
| STAT1 | HGNC:11362 | 1 | 1 |
| HLA-DRB1 | HGNC:4948 | 1 | 1 |
| SOCS3 | HGNC:19391 | 1 | 1 |
| CLEC7A | HGNC:14558 | 1 | 1 |
| IL7R | HGNC:6024 | 1 | 1 |
| TNFRSF1B | HGNC:11917 | 1 | 1 |
| HLA-DRA | HGNC:4947 | 1 | 1 |
| IL2RG | HGNC:6010 | 1 | 1 |
| POU2AF1 | HGNC:9211 | 1 | 1 |
| PLEC | HGNC:9069 | 1 | 1 |
| CTLA4 | HGNC:2505 | 1 | 1 |
| ABCA12 | HGNC:14637 | 1 | 1 |
| SDR9C7 | HGNC:29958 | 1 | 1 |
| HLA-DRB3 | HGNC:4951 | 1 | 1 |
| HLA-DRB4 | HGNC:4952 | 1 | 1 |
| HLA-DRB5 | HGNC:4953 | 1 | 1 |
| CXCL8 | HGNC:6025 | 1 | 1 |
| PGM3 | HGNC:8907 | 1 | 1 |
| TSLP | HGNC:30743 | 1 | 1 |
| BTD | HGNC:1122 | 1 | 1 |
| CCL22 | HGNC:10621 | 1 | 1 |
| EGFR | HGNC:3236 | 1 | 1 |
| EGF | HGNC:3229 | 1 | 1 |
| CCL27 | HGNC:10626 | 1 | 1 |
| CXCL10 | HGNC:10637 | 1 | 1 |
| CCL26 | HGNC:10625 | 1 | 1 |
| OSMR | HGNC:8507 | 1 | 1 |
| CD68 | HGNC:1693 | 1 | 1 |
| MRGPRX2 | HGNC:17983 | 1 | 1 |
| CD63 | HGNC:1692 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| I50V | I50V | 2 | 2 |
| c.166delC | c.166delC | 1 | 1 |
| c.923G>T | c.923G>T | 1 | 1 |
| p.Gly308Val | p.Gly308Val | 1 | 1 |
| A56V | A56V | 1 | 1 |
| 1G>T | 1G>T | 1 | 1 |
| 1G>C | 1G>C | 1 | 1 |
| c.1612C>T | c.1612C>T | 1 | 1 |
| p.Arg538Cys | p.Arg538Cys | 1 | 1 |
| rs61816761 | rs61816761 | 1 | 1 |
| rs12130219 | rs12130219 | 1 | 1 |
| rs77199844 | rs77199844 | 1 | 1 |
| rs558269137 | rs558269137 | 1 | 1 |
| rs4363385 | rs4363385 | 1 | 1 |
| rs12144049 | rs12144049 | 1 | 1 |
| rs471144 | rs471144 | 1 | 1 |
| rs6661961 | rs6661961 | 1 | 1 |
| rs10888499 | rs10888499 | 1 | 1 |
| rs3126085 | rs3126085 | 1 | 1 |
| rs12130219 | rs12130219 | 1 | 1 |
| rs61816761 | rs61816761 | 1 | 1 |
| rs558269137 | rs558269137 | 1 | 1 |
| rs12144049 | rs12144049 | 1 | 1 |
| rs3126085 | rs3126085 | 1 | 1 |
| rs471144 | rs471144 | 1 | 1 |
| rs6661961 | rs6661961 | 1 | 1 |
| rs10192157 | rs10192157 | 1 | 1 |
| 1646C>T | 1646C>T | 1 | 1 |
| rs2899642 | rs2899642 | 1 | 1 |
| 27C>G | 27C>G | 1 | 1 |
| 1625G>A | 1625G>A | 1 | 1 |
| 1534C>G | 1534C>G | 1 | 1 |
| p.R501X | p.R501X | 1 | 1 |
| p.S3316X | p.S3316X | 1 | 1 |
| p.R826X | p.R826X | 1 | 1 |
| c.1498C>T | c.1498C>T | 1 | 1 |
| G2964A | G2964A | 1 | 1 |
| G2946A | G2946A | 1 | 1 |
| Q576R | Q576R | 1 | 1 |
| V282M | V282M | 1 | 1 |
| p.Tyr398Cys | p.Tyr398Cys | 1 | 1 |
| p.Asn75Ile | p.Asn75Ile | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Average volumes of cow's milk formula in the nursery are a potential risk for childhood atopy.Nutrition (Burbank, Los Angeles County, Calif.)1 mentions
- 2026Immunoassay-based biomarkers in atopic dermatitis.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2026The expression of pruritus-associated genes in seven skin diseases: Evidence from microarray.Journal of the European Academy of Dermatology and Venereology : JEADV1 mentions
- 2026Expanding the clinical spectrum of interleukin-2 receptor alpha chain deficiency: two novel cases with long-term hematopoietic stem cell transplantation outcome and literature review.Frontiers in immunology1 mentions
- 2026Comparative effectiveness and safety of phototherapy, cytotoxic agents, and biologics in adults with atopic dermatitis: real-world multicenter cohort data.The Journal of dermatological treatment1 mentions
- 2026Geraniol alleviates DNCB-induced atopic dermatitis in mice by downregulating IL-4/IL-13 and reducing inflammation.Biomolecules & biomedicine1 mentions
- 2026Topical acacia gum reshapes staphylococcal dysbiosis and inflammation in atopic dermatitis.NPJ biofilms and microbiomes1 mentions
- 2026Factors Associated with Symptomatic Dermographism: Findings from the UCARE PREVALENCE-D Study.American journal of clinical dermatology1 mentions
- 2026Tapinarof Versus Crisaborole for Pediatric Atopic Dermatitis: A Systematic Review and Meta-Analysis.Dermatology practical & conceptual1 mentions
- 2026Breastfeeding, Family Stress, and Climate as Key Determinants of Atopic Dermatitis Severity in Children: A Cross-Sectional Study.Clinical, cosmetic and investigational dermatology1 mentions
- 2026Nanotechnology in Dermatology: A Comprehensive Narrative Review of Performance, Safety, and Clinical Translation.Health science reports1 mentions
- 2026A Real-world Meta-analysis Study of Disease Severity in European Patients Who Received Baricitinib for Atopic Dermatitis: Data from BioDay, SCRATCH and TREATgermany.Acta dermato-venereologica1 mentions
- 2026Human germline biallelic loss-of-function OSMR variants cause severe allergic disease.Journal of human immunity1 mentions
- 2026Indole-3-carbinol attenuates DNCB-induced atopic dermatitis in mice by reducing inflammation and IL-4/IL-13 expression.Biomolecules & biomedicine1 mentions
- 2025Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence.Pediatric research1 mentions
- 2025An evaluation of the recently approved drugs for treating atopic dermatitis in the context of their safety and efficacy: a systematic review and meta-analysis.Expert review of clinical immunology1 mentions
- 2025A real-world study to assess the disease control of moderate to severe atopic dermatitis in patients receiving dupilumab therapy, with atopic dermatitis control tool in Gulf countries.The Journal of dermatological treatment1 mentions
- 2025Topical Anti-Inflammatory Effects of Quercetin Glycosides on Atopic Dermatitis-Like Lesions: Influence of the Glycone Type on Efficacy and Skin Absorption.Inflammation1 mentions
- 2025Examining the Prevalence, Characteristics, and Potential Links Between Skin Disorders and Autism Spectrum Disorder (ASD).Journal of clinical medicine1 mentions
- 2025Association of Genetic Liability to Allergic Diseases with Overall and Early-Onset Colorectal Cancer Risk: A Mendelian Randomization Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology1 mentions
- 2025Melano-erythrodermic folliculotropic mycosis fungoides misdiagnosed as a case of recalcitrant atopic dermatitis: A case report.SAGE open medical case reports1 mentions
- 2025Exploring Attention-Deficit/Hyperactivity Disorder Symptoms in Patients With Atopic Dermatitis by Disease Severity: Cross-Sectional Analysis.JMIR dermatology1 mentions
- 2025Microbiome modulation in dermatological disorders: Current insights and therapeutic prospects - A narrative review.Microbial pathogenesis1 mentions
- 2025Exploring dupilumab for asthma: from mechanistic insights to clinical outcomes, safety, and cost-effectiveness.Frontiers in pharmacology1 mentions
- 2025Immunogenetic investigation of WAS patients revealing impaired IL-6/STAT3 signaling in T cells.Frontiers in immunology1 mentions
- 2025The efficacy and safety of upadacitinib in atopic dermatitis: A systematic review and meta-analysis.Medicine1 mentions
- 2025Real-world outcomes of dupilumab therapy in moderate-to-severe atopic dermatitis patients: an observational retrospective study in Gulf countries.The Journal of dermatological treatment1 mentions
- 2025Dupilumab for atopic manifestations in pediatric patients with inborn errors of immunity: efficacy and safety in a genetically diverse cohort.Frontiers in immunology1 mentions
- 2025Tatton-Brown-Rahman Syndrome Due to a Novel DNMT3A Variant Presenting With Autism, Attention-Deficit/Hyperactivity Disorder (ADHD), and Regression: A Saudi Case Report.Cureus1 mentions
- 2025Probiotics and human health: biological activities, nutritional aspects, immunomodulatory properties, applications, and future perspectives - a comprehensive review.Frontiers in immunology1 mentions
- 2024Profiling of secondary metabolite and evaluation of anti-diabetic potency of Crotalaria quinquefolia (L): In-vitro, in-vivo, and in-silico approaches.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2024Skin delivery of synthetic benzoyl pterostilbenes suppresses atopic dermatitis-like inflammation through the inhibition of keratinocyte and macrophage activation.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie1 mentions
- 2024Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency.The Journal of allergy and clinical immunology1 mentions
- 2024Knowledge, Attitude, and Practice of Probiotics Among Saudi Health Care Students-A Cross-Sectional Study From Saudi University in Riyadh Saudi Arabia.Inquiry : a journal of medical care organization, provision and financing1 mentions
- 2024Strategic Approaches to Reducing the Burden of Atopic Dermatitis in the Middle East and Africa Region.Value in health regional issues1 mentions
- 2024Patient-reported burden in adults with atopic dermatitis: an international qualitative study.Archives of dermatological research1 mentions
- 2024Awareness of Side Effects of Corticosteroids among Users and Nonusers in Saudi Arabia.Journal of pharmacy & bioallied sciences1 mentions
- 2024Prevalence of Autoimmune Diseases Among Patients With Psoriasis: A Single Tertiary Center Experience.Cureus1 mentions
- 2024Combining treat-to-target principles and shared decision-making: International expert consensus-based recommendations with a novel concept for minimal disease activity criteria in atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV1 mentions
- 2024Correction: Examining the association between autism spectrum disorder and atopic eczema: meta-analysis of current evidence.Pediatric research1 mentions
- 2024Topical delivery of bioactive compounds from Cortex Dictamni alleviates atopic dermatitis-like lesion by inhibiting the activation of keratinocytes, macrophages, and basophils: Dictamnine versus fraxinellone.International immunopharmacology1 mentions
- 2024Exploring food-specific IgG responses in pediatric allergic disorders: A retrospective cross-sectional study.Allergologia et immunopathologia1 mentions
- 2024Tacrolimus versus hydrocortisone in management of atopic dermatitis in children, a randomized controlled double-blind study: New insights on TARC, CTACK, TSLP, and E-selectin.Immunity, inflammation and disease1 mentions
- 2023Bronchial Asthma Exacerbation in the Emergency Department in a Saudi Pediatric Population: An Insight From a Tertiary Hospital in Riyadh, Saudi Arabia.Cureus1 mentions
- 2023Multi-Omics Profiling in PGM3 and STAT3 Deficiencies: A Tale of Two Patients.International journal of molecular sciences1 mentions
- 2023Prevalence and Risk Factors of Allergic Diseases Among School Students in Tabuk: A Cross-Sectional Study.Cureus1 mentions
- 2023Drug permeation enhancement, efficacy, and safety assessment of azelaic acid loaded SNEDDS hydrogel to overcome the treatment barriers of atopic dermatitis.Environmental research1 mentions
- 2023Design, optimization, and characterization of Althaea officinalis-loaded transliposomes for the treatment of atopic dermatitis: a Box Behnken Design, in vitro, and ex vivo study.Journal of biomaterials science. Polymer edition1 mentions
- 2023Atopic dermatitis: a brief review of recent advances in its management.Dermatology reports1 mentions
- 2023Pimecrolimus 1% cream for mild-to-moderate atopic dermatitis: a systematic review and meta-analysis with a focus on children and sensitive skin areas.European journal of dermatology : EJD1 mentions
- 2022Attenuation of experimentally induced atopic dermatitis in mice by sulforaphane: effect on inflammation and apoptosis.Toxicology mechanisms and methods1 mentions
- 2022Polymorphisms of the filaggrin gene are associated with atopic dermatitis in the Caucasian population of Central Russia.Gene1 mentions
- 2022Targeting therapeutic approaches and highlighting the potential role of nanotechnology in atopic dermatitis.Environmental science and pollution research international1 mentions
- 2022Atopic dermatitis and the atopic march: Considering racial and ethnic diversity in atopic disease progression.The Journal of allergy and clinical immunology1 mentions
- 2022The role of cytokines in atopic dermatitis: a breakthrough in immunopathogenesis and treatment.Acta dermatovenerologica Alpina, Pannonica, et Adriatica1 mentions
- 2022L. Cucurbita pepo modulates contact dermatitis in depressed rats through downregulation of proinflammatory cytokines and upregulation of antioxidant status.Postepy dermatologii i alergologii1 mentions
- 2022IL-4/13 Blockade and sleep-related adverse drug reactions in over 37,000 Dupilumab reports from the World Health Organization Individual Case Safety reporting pharmacovigilance database (VigiBase™): a big data and machine learning analysis.European review for medical and pharmacological sciences1 mentions
- 2022Successful Treatment of an Adult with Atopic Dermatitis and Lamellar Ichthyosis Using Dupilumab.Biologics : targets & therapy1 mentions
- 2022Anti-Inflammatory microRNAs for Treating Inflammatory Skin Diseases.Biomolecules1 mentions
- 2022Pharmacological basis of the putative therapeutic effect of Topical Vitamin D3 on the experimental model of atopic dermatitis in mice.European review for medical and pharmacological sciences1 mentions
- 2022Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist.Frontiers in immunology1 mentions
- 2022Eczema herpeticum vs dermatitis herpetiformis as a clue of dedicator of cytokinesis 8 deficiency diagnosis: A case report.World journal of clinical cases1 mentions
- 2022The humanistic and economic burden of atopic dermatitis among adults and adolescents in Saudi Arabia.Journal of medical economics1 mentions
- 2022Diagnostic challenge in a series of eleven patients with hyper IgE syndromes.Frontiers in immunology1 mentions
- 2021Biologicals in atopic disease in pregnancy: An EAACI position paper.Allergy1 mentions
- 2021Oral Administration of Live and Dead Cells of Lactobacillus sakei proBio65 Alleviated Atopic Dermatitis in Children and Adolescents: a Randomized, Double-Blind, and Placebo-Controlled Study.Probiotics and antimicrobial proteins1 mentions
- 2021Staphylococcus aureus second immunoglobulin-binding protein drives atopic dermatitis via IL-33.The Journal of allergy and clinical immunology1 mentions
- 2021Atopic dermatitis in the pediatric population: A cross-sectional, international epidemiologic study.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology1 mentions
- 2021Missense, silent, non-sense and frame-shift mutations in exon 3 of the filaggrin gene in patients with bronchial asthma, atopic dermatitis, allergic rhinitis and mixed atopy.Nucleosides, nucleotides & nucleic acids1 mentions
- 2021Gut microbiome skin axis in the development of atopic dermatitis.JPMA. The Journal of the Pakistan Medical Association1 mentions
- 2021Bronchopleural fistula in a 5- years old child with novel CARMIL 2 mutation: A rare disease and a rare case.Annals of medicine and surgery (2012)1 mentions
- 2021Filaggrin gene polymorphisms are associated with atopic dermatitis in women but not in men in the Caucasian population of Central Russia.PloS one1 mentions
- 2021Whole-Exome Sequencing Reveals a Missense Variant c.1612C>T (p.Arg538Cys) in the BTD Gene Leading to Neuromyelitis Optica Spectrum Disorder in Saudi Families.Frontiers in pediatrics1 mentions
- 2021Proteomics Profiling to Distinguish DOCK8 Deficiency From Atopic Dermatitis.Frontiers in allergy1 mentions
- 2020Whole exome sequencing detects novel variants in Saudi children diagnosed with eczema.Journal of infection and public health1 mentions
- 2020Atopy and allergic diseases among Saudi young adults: A cross-sectional study.The Journal of international medical research1 mentions
- 2020Clinical, molecular, and biochemical delineation of asparagine synthetase deficiency in Saudi cohort.Genetics in medicine : official journal of the American College of Medical Genetics1 mentions
- 2019A practical algorithm for topical treatment of atopic dermatitis in the Middle East emphasizing the importance of sensitive skin areas.The Journal of dermatological treatment1 mentions
- 2019Quantitative profiling of cytokines and chemokines in DOCK8-deficient and atopic dermatitis patients.Allergy1 mentions
- 2019Hematopoietic Stem Cell Transplantation as Treatment for Patients with DOCK8 Deficiency.The journal of allergy and clinical immunology. In practice1 mentions
- 2019Pattern of skin diseases in a university hospital in Jeddah, Saudi Arabia: age and sex distribution.Annals of Saudi medicine1 mentions
- 2019Tachykinin upregulation in atopic dermatitis.Immunopharmacology and immunotoxicology1 mentions
- 2019Prevalence of herbal medicines in patients with chronic allergic disorders in Western Saudi Arabia.Saudi medical journal1 mentions
- 2019Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children.Nutrients1 mentions
- 2019Prevalence of skin disorders and associated socio-economic factors among primary school children in the Eastern region of Saudi Arabia.JPMA. The Journal of the Pakistan Medical Association1 mentions
- 2019Metabolomics Distinguishes DOCK8 Deficiency from Atopic Dermatitis: Towards a Biomarker Discovery.Metabolites1 mentions
- 2018Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans.The Journal of investigative dermatology1 mentions
- 2018Blocking TGF-β type 1 receptor partially reversed skin tissue damage in experimentally induced atopic dermatitis in mice.Cytokine1 mentions
- 2018Association of Severe Atopic Dermatitis with month of birth in Armenian pediatric patients.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology1 mentions
- 2018Cytokine Gene Polymorphisms in Saudi Patients With Atopic Dermatitis: A Case-Control Study.Biomarker insights1 mentions
- 2018Hyaluronic acid decorated tacrolimus-loaded nanoparticles: Efficient approach to maximize dermal targeting and anti-dermatitis efficacy.Carbohydrate polymers1 mentions
- 2018A Systematic Review of the Prevalence of Atopic Diseases in Children on the Arabian Peninsula.Medical principles and practice : international journal of the Kuwait University, Health Science Centre1 mentions
- 2018The atopic dermatitis-like lesion and the associated MRSA infection and barrier dysfunction can be alleviated by 2,4-dimethoxy-6-methylbenzene-1,3-diol from Antrodia camphorata.Journal of dermatological science1 mentions
- 2018Basidiomycetes-X, an edible mushroom, alleviates the development of atopic dermatitis in NC/Nga mouse model.Experimental and molecular pathology1 mentions
- 2017Honey is potentially effective in the treatment of atopic dermatitis: Clinical and mechanistic studies.Immunity, inflammation and disease1 mentions
- 2017Hydrogen water ameliorates the severity of atopic dermatitis-like lesions and decreases interleukin-1β, interleukin-33, and mast cell infiltration in NC/Nga mice.Saudi medical journal1 mentions
- 2017DOCK8 Deficiency Presenting as an IPEX-Like Disorder.Journal of clinical immunology1 mentions
- 2016What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model.International journal of pharmaceutics1 mentions
- 2016Gene Polymorphism of Interleukin-4, Interleukin-4 Receptor and STAT6 in Children with Atopic Dermatitis in Taif, Saudi Arabia.Immunological investigations1 mentions
- 2016Formulation and clinical evaluation of silymarin pluronic-lecithin organogels for treatment of atopic dermatitis.Drug design, development and therapy1 mentions