CD68
HGNC:1693 · 33 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD68 | “Histopathologic examination confirmed CD68+/CD163+ histiocytes harboring BRAF V600E/D and NRAS mutations.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Immunohistochemical profiling revealed increased CD56⁺ natural killer cell infiltration alongside reduced CD68⁺ macrophage and TGF-β expression, indicating altered local immune regulation during chronic infection.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Immunohistochemical markers (CK20, S100, CD68, CD64, CD117, and E-cadherin) were applied as complementary tools to describe phenotypic labeling patterns.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “The CD163:CD68 Ratio Reflects Splenic Macrophage Remodelling in Murine Chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “It significantly reduced the number of CD4, CD8, CD68, CD20, and caspase-3 immunopositive cells in the studied organs.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Platelet-Rich Plasma (PRP) Mitigates Silver Nanoparticle (AgNP)-Induced Pulmonary Fibrosis via iNOS/CD68/CASP3/TWIST1 Regulation: An Experimental Study and Bioinformatics Analysis.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “We assessed nuclear factor kappa beta (NF-κB) and interleukin-1 beta (IL-1β) gene expression and evaluated immunoexpression of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), CD68, and caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Histologically, all cases showed myonecrosis infiltrated with CD68+ macrophages.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “This was in combination with significant amplification of immune response-related genes, CD68 and CD163 (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “NLRP3, caspase-1, IL-1β, CD68, and CD163 immunohistochemical staining, as well as histological alterations, were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Additionally, Nano-Gefitinib significantly increased M1 macrophage phenotype, evidenced by the upregulation in the immunoexpression of the CD68, in addition to increasing CD8 and caspase-3 and decreasing CD4, with VEGF immunoreactivity in the combination group.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Additionally, mirtazapine downregulated pro-inflammatory cytokines IL-6 and TNF-α, promoted macrophage recruitment (CD68), and shifted polarization toward an M1-like phenotype, as evidenced by increased iNOS expression.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “There was increased expression of CD8+ CD68+ M1 macrophage markers with upregulation of iNOS and co-expression of CD163+.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Aneuploidy, notably uniparental disomy (UPD), homologous recombination deficiency (HRD), epithelial-mesenchymal transition and inflammation with CD68+ monocytes were identified as tumour-intrinsic resistance factors.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Expression of CD68 and CD163 in malignant epithelial cells of oral squamous cell carcinoma: Phenotypic shift or mere cell fusion.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Additionally, we assessed macrophage polarization by examining the ratio of M2/M1 macrophages, identified through CD68+Φ (M1) and CD163+Φ (M2) cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Also, they significantly downregulated renal index, serum urea, serum creatinine, serum cystatin c, inflammatory biomarkers (C reactive protein, IL1β & TNF-α), MDA levels, HSP70/TLR4/MyD88/NF-κB p65/NLRP3 expressions, proinflammatory CD68 macrophages and caspase-3 immunoreactivity, resulting in a reversal of cis-induced renal damage.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “These image analysis pipelines are designed to quantify skeletal muscle histopathological staining for membrane damage, the abundance and size distribution of regenerating muscle fibers, inflammation via quantification of CD68+ M1 macrophages, and collagen deposition.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “The majority of CD68+ monocytes/macrophages co-expressed the M2 macrophage marker CD206.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Histopathological examination of the lacrimal sac walls using hematoxylin and eosin (H&E) stain, in addition to immunohistochemical staining of the CD68 and CD163 macrophage markers, was also performed.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Histopathological assessment of skin samples was performed and CD4 and CD68 immunoexpression was assessed.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “We examined serum creatinine, urea, lipid profile and renal cortical mRNA expression for lipogenesis marker SREBP1, inflammatory macrophage marker iNOS and fibrosis markers; TGFβ and PDGFA genes; immunohistochemical (IHC) staining for CD68; inflammatory macrophage marker and ASMA; fibrosis marker, LC3 and SQSTM1/P62; autophagy markers and western blotting (WB) for caspase-3; and, as an apoptosis marker, LC3II/I and SQSTM1/P62 in addition to staining for H&E, PAS, Sirius red and histopathological scoring.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Macrophages were examined for markers of maturation (CD14, CD68), activation (HLA-DR, CD86, IL15R), scavenger receptor (CD36), toll-like receptor (TLR4), M2 marker (CD206), immune checkpoint (PD-L1), and intracellular chemokine expression (IP-10).” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Upregulation of LMNA in monocytic THP-1 and U937 cell lines induced CD68, TNFα, CCL2, IL-6 and NOS2.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “A significant increase in serum levels of interleukin-4 along with a significant reduction of interferon-gamma, in addition to strong expression of CD68, were reported after 14 and 28 days of AMD administration reflecting Th1/Th2 cytokines imbalance and the accumulation of alveolar macrophages, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Cytokines and chemokines such as CD68, IL-1β, MCP-1, and TNF-α, as well as α-SMA were increased in the groups that were exposed to MC-LR with the high-fat diet compared to the vehicle group.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Lung tissues were used for histopathological examination or immunofluorescence staining for CD68 (pan-macrophage marker), Arginase-1 (Arg1, M2-specific marker), inducible nitric oxide synthase (iNOS, M1-specific marker) and HIF-1α.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “METHODS: Herein, we report a 23-year-old woman with severe pancytopenia diagnosed with non-LCH following presentation with pancytopenia and marrow examination showing histiocytosis positive for CD45, CD68, CD136, and lysozyme but negative for CD1a, langerin, and S100.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Large, often multinucleated, cells with features of histiocytes, including anatomical features on electron microscopy and immunostaining for major histocompatibility complex Class I and histiocyte markers (HAM56, CD68, CD163, and S100), were usually closely apposed to the surface of, or invaded, necrotic myofibers.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “We found that colitis caused a reduction of Iba-1 and CD68 immunoreactivity, microglial activation markers, in specific brain regions of the limbic system such as the medial prefrontal cortex (mPFC), while other areas remained unaffected.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Polarization markers (CD86, IL-6, TNFα, iNOS, CD36, CD11c, CD169, CD206, CD163, CD68, CD11b, CD16, and CD14) were measured by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | CD68 | “Immunohistochemical comparison of p53, Ki-67, CD68, vimentin, α-smooth muscle actin and alpha-1-antichymotry-psin in oral peripheral and central giant cell granuloma.” | 0.98 | hgnc_dict_v1 |