CD163
HGNC:1631 · 28 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CD163 | “Histopathologic examination confirmed CD68+/CD163+ histiocytes harboring BRAF V600E/D and NRAS mutations.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “The CD163:CD68 Ratio Reflects Splenic Macrophage Remodelling in Murine Chronic Schistosomiasis.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “This was in combination with significant amplification of immune response-related genes, CD68 and CD163 (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “NLRP3, caspase-1, IL-1β, CD68, and CD163 immunohistochemical staining, as well as histological alterations, were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “In addition, Nano-Gefitinib significantly inhibited EGFR/p-AKT/ERK1/2/RIPK2/NF-κB with subsequent suppression of TGF-triggered M2 macrophage reprogramming, evidenced by the lowered protein expression of the M2 surface markers CD163 and decreased M2 protein expression (Fizz1, MMPs, and VEGF).” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Phenotypically, elevated cortisol level was associated with an expanded CD4 T-cell population, reduced γδ T cells percentage, decreased CD172a expression on neutrophils and monocytes, reduced CD14 and CD163 expression on monocytes, and enhanced CD45 and MHC I expression on lymphocytes.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Camel MDMs generated in the presence of a combined stimulation of monocytes with LPS and GM-CSF resulted in the development of an M1 macrophages phenotype with increased abundance of the antigen-presentation receptor MHCII molecules and a decreased expression of the scavenger receptor CD163.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “There was increased expression of CD8+ CD68+ M1 macrophage markers with upregulation of iNOS and co-expression of CD163+.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Functional clustering analysis in DAVID revealed dysregulation of haptoglobin-haemoglobin binding (Enrichment score 2.5, p = 0.017), confirmed using CD163 immunostaining, suggesting a neuroprotective microglial response to blood-brain barrier dysfunction in DSCLs.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “METHODS: The current study was designed to explore the effect of observing four-week, dawn to dusk IF by participants with obesity on gene expression of the anti-inflammatory CD163, oxidative stress, and bioenergetics enzymes (SOD2, Nrf2, and TFAM), as well as metabolic and cellular regulatory genes (SIRT1 and SIRT3).” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Expression of CD68 and CD163 in malignant epithelial cells of oral squamous cell carcinoma: Phenotypic shift or mere cell fusion.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Additionally, we assessed macrophage polarization by examining the ratio of M2/M1 macrophages, identified through CD68+Φ (M1) and CD163+Φ (M2) cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “We used antibodies to detect several cell surface molecules associated with camel T cells (CD4, WC1), B cells (MHCII, BAQ44A), monocytes/macrophages (CD172a, CD14, CD163), in addition to the pan-leukocyte marker CD45 and the cell adhesion molecules CD44 and CD18.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Our results indicated that Ros and D, in a dose-dependent manner, markedly restored body weight, systolic blood pressure, and renal histological architecture besides significantly upregulated SOD levels, expression of anti-inflammatory CD163 macrophages, arginase1levels, IL-10 levels,STAT3 and PCNA immunoreactivity.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “METHODS: Tumor specimens of the primary tumor from patients treated with radical cystectomy for MIBC were immunostained with the M2-macrophage-specific marker CD163 and the cell cycle protein p53.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Histopathological examination of the lacrimal sac walls using hematoxylin and eosin (H&E) stain, in addition to immunohistochemical staining of the CD68 and CD163 macrophage markers, was also performed.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Among these DEGs, a total of 10 significantly down-regulated DEGs, including cluster of differentiation 14 (CD14), beta2 Integrin Gene (ITGB2), C1q subcomponent subunit B (C1QB), Cluster of Differentiation 163 (CD163), Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1), Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP), Pleckstrin (PLEK), Complement C1q C Chain (C1QC), Fc fragment Of IgE receptor Ig (FCER1G), and tyrosine kinase binding protein (TYROBP), were shortlisted as the hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “The expression pattern of the cell markers CD172a, CD14, CD163, and MHCII molecules on BALF cells indicates a similar phenotype for camel, bovine, and porcine BALF myeloid cells.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “In addition, the higher frequency of cells expressing the M2 macrophage marker CD163 in the caudal lung tissue, with a slightly higher fraction of MHCII-positive cells (M1 phenotype) in the cranial lung tissue, may suggest the distribution of different macrophage subtypes in the different lobes of the camel lung.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “In addition, monocytes from heparin blood showed higher expression levels of the cell surface markers CD14, CD163, and MHCII when compared to cells from EDTA blood.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “The upregulation of CD163 together with the downregulation of MHC-II on monocytes from excited camels indicate a modulatory potential of animal excitement to polarize monocytes toward an anti-inflammatory phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “In addition, injection of lornoxicam resulted in decreased abundance of major histocompatibility complex (MHC) class II molecules and increased abundance of the scavenger receptor CD163 on blood monocytes, indicating an anti-inflammatory phenotype of monocytes.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Monocytes from camel blood incubated at 41°C for 4 h significantly decreased their expression level of MHC class II molecules with no change in the abundance of CD163, resulting in a CD163high MHC-IIlow M2-like macrophage phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “PURPOSE: To investigate the expression of IL-11 and its receptor IL-11Rα and to quantify density of CD163+ M2 macrophages in proliferative diabetic retinopathy (PDR).” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “The positive expression of CD163 in lung tissue is detected by IHC (immunohistochemistry), and real-time quantitative PCR (Polymerase Chain Reaction) is used to detect the expression of Ml and M2 markers in bronchoalveolar lavage fluid (BALF).” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “CD163 is a predictive biomarker for prognosis of classical Hodgkin's lymphoma in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Large, often multinucleated, cells with features of histiocytes, including anatomical features on electron microscopy and immunostaining for major histocompatibility complex Class I and histiocyte markers (HAM56, CD68, CD163, and S100), were usually closely apposed to the surface of, or invaded, necrotic myofibers.” | 0.98 | hgnc_dict_v1 |
| gene | CD163 | “Polarization markers (CD86, IL-6, TNFα, iNOS, CD36, CD11c, CD169, CD206, CD163, CD68, CD11b, CD16, and CD14) were measured by RT-qPCR.” | 0.98 | hgnc_dict_v1 |