PCNA
HGNC:8729 · 48 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PCNA | “Functional knockdown of circFOXN3 using specific small interfering RNAs (siRNAs) during the proliferation phase significantly enhanced myoblast proliferation, as evidenced by elevated expression of proliferation marker genes (PCNA, CCND2) and increased 5-ethynyl-2'-deoxyuridine (EdU) incorporation.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “By reversing monoubiquitination on the FANCI–FANCD2 clamp and on PCNA—preferentially when these complexes are DNA-bound—USP1–UAF1 functions as a reset valve that terminates repair-competent states and restores replisome progression.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “We assessed cell viability, proliferation markers (PCNA, cyclin B1), apoptosis markers (Bax, caspase-3, and DNA fragmentation), and the secretion of steroid (progesterone, testosterone, estradiol) and peptide (IGF-I, oxytocin) hormones via RT-qPCR, immunocytochemistry, TUNEL, and ELISA.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Additionally, co-treated groups with Vitis vinifera L. extract showed a significant decline in NF-kB p65 and increased PCNA testicular immunoreactivity with a substantial down-regulation in NF-kB p65 and PCNA epididymal immunoreactivity.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “In addition to Liver and adipose tissue histopathology, area percentage of collagen fibers, adipocytes diameter, PPAR-γ, STAT3 and PCNA immunoexpression.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Linagliptin effectively regulated the AMPK pathway, reduced markers of inflammation, restored the expression of genes with key roles in renal protection, reduced proliferating Cell Nuclear Antigen (PCNA), and elevated Caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Histological changes, serum testosterone, and dihydrotestosterone (DHT) levels, prostatic tissue content of the inflammatory biomarkers interleukin 1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α), oxidative stress biomarkers superoxide dismutase (SOD) and malondialdehyde (MDA), angiogenesis biomarker vascular endothelial growth factor (VEGF-A), cellular proliferation biomarker proliferating cell nuclear antigen (PCNA), transforming growth factor beta-1 (TGF-β1), and pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) genes were analyzed.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Tirzepatide markedly improved glucose homeostasis, restored testosterone and gonadotropin levels, enhanced antioxidant defenses via activation of the Nrf2/Keap1 pathway, normalized steroidogenic gene expression, preserved testicular architecture, increased PCNA expression, and reduced caspase-3-mediated apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Structure of the human CTF18-RFC clamp loader bound to PCNA.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “We assessed the relative expression levels of ciR-01114, cell viability, proliferation (measured by the accumulation of PCNA and cyclin B1), cytoplasmic (assessed via the accumulation of bax and caspase-3), and nuclear (DNA fragmentation) apoptosis, and the release of progesterone, testosterone, estradiol, IGF-I, and oxytocin.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Furthermore, it downregulated proliferation markers (Cyclin D1, PCNA) and activated pro-apoptotic signaling pathways (Tp53, Bax, Caspase-3) (p < 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Immunohistochemistry analysis showed that RSV reduced Proliferating Cell Nuclear Antigen (PCNA) overexpression and restored B-cell Lymphoma 2 (BCL-2) expression, suggesting a protective effect against cellular stress and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “While IL-10 treatment showed minimal effects, IL-10Rα blockade or STAT3 inhibition led to cell cycle arrest and apoptosis in HT29 and SW620 cells, associated with increased p21, p27, and Caspase-3, and decreased CCND1, CCND3, PCNA, and survivin gene and protein expression.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Additionally, these complexes trigger a chain of events that include the inhibition of proliferating cell nuclear antigen (PCNA), transforming growth factor β1 (TGF β1), and topoisomerase II, and leading to a decrease in epidermoid cell proliferation.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Proliferating cell nuclear antigen (PCNA) and connexin 43 were stained using immunohistochemistry.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Structure of the human CTF18-RFC clamp loader bound to PCNA.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The expression levels of miR-152, cell viability, cell proliferation (accumulation of proliferating cell nuclear antigen, PCNA), apoptosis (accumulation of Bax) and the release of progesterone, estradiol, and insulin-like growth factor I (IGF-I) were analyzed by real-time quantitative polymerase chain reaction (RT‒qPCR), the Trypan blue exclusion test, quantitative immunocytochemistry, and enzyme-linked immunosorbent assays (ELISAs).” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Pumpkin seed oil lessens the colchicine-induced altered sex male hormone balance, testicular oxidative status, sperm abnormalities, and collagen deposition in male rats via Caspase3/Desmin/PCNA modulation.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “A pharmacological network analysis was subsequently conducted using STITCH and Cytoscape, pinpointing six highly upregulated genes within the rutin network, including TP53, PCNA, CDK4, CCNEB1, CDKN1A, and LDHA.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Also, immunohistochemistry-based identification of Proliferating Cell Nuclear Antigen (PCNA) and zonula occludens 1 (ZO-1) is performed.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Furthermore, histology, immunohistochemical PCNA expression, and histochemical analysis of collagen, DNA, RNA, and total protein. were altered in rat testis sections, supporting the changes in biochemistry.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The expression of miR-152; viability; proliferation (cell proliferation and expression of mRNAs and accumulation of PCNA and cyclin B1); apoptosis (expression of mRNAs and accumulation of bax and caspase 3; and the proportion of cells with fragmented DNA); and release of progesterone, estradiol and IGF-I were analyzed via RT-qPCR; the Trypan blue exclusion test; quantitative immunocytochemistry; BrdU; XTT; TUNEL assays; and ELISA.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The relative expression of both circRNAs, cell viability and proliferation (accumulation of PCNA, cyclin B1, and XTT-positive cells), cytoplasmic (accumulation of bax and caspase-3) and nuclear (DNA fragmentation) apoptosis, and the release of progesterone, testosterone, estradiol, IGF-I, and oxytocin were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The immunoreactivity of PCNA and HMGB1 was examined immunohistochemically.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The expression levels of miR-105-1, viability, proliferation (accumulation of PCNA, cyclin B1, XTT-, and BrdU-positive cells), apoptosis (accumulation of bcl-2, bax, caspase 3, p53, TUNEL-positive cells), proportion of kisspeptin-positive cells, and the release of steroid hormones and IGF-I were analyzed.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “These results were augmented by an analysis of the expression of the pro-inflammatory cytokines TNFα and IL-1β, the anti-fibrogenic factor NF-κβ, the apoptotic factor caspase-3, and the proliferative indicators antigen Ki-67 and proliferating cell nuclear antigen (PCNA).” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “No apoptotic changes or cell damages were observed as indicated by proliferating cell nuclear antigen (PCNA) and caspase-3 gene expression and evidenced histopathologically.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The expression of VCL, accumulation of VCL protein, cell viability, proliferation (accumulation of PCNA and cyclin B1), proportion of proliferative active cells, apoptosis (accumulation of bax, caspase 3, p53, antiapoptotic marker bcl2, and bax/bcl-2 ratio), DNA fragmentation, and release of steroid hormones and IGF-I were analyzed by RT‒qPCR, Trypan blue exclusion test, quantitative immunocytochemistry, XTT assay, TUNEL assay, and ELISA.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “In addition, dietary 2.0-mL SEO/kg diet significantly upregulated antioxidant genes expression (CAT, SOD, GPx, GST, and GSR) with downregulation of apoptotic genes (HSP70, TLR2, caspase-3, and PCNA) in the liver.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Unveiling the therapeutic potential of thymol from Nigella sativa L. seed: selective anticancer action against human breast cancer cells (MCF-7) through down-regulation of Cyclin D1 and proliferative cell nuclear antigen (PCNA) expressions.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The study further explored the correlation between histopathological alterations and inflammatory reactions in the kidney, spleen, and liver of infected mice, alongside the immunohistochemical expression of caspase-3, proliferating cell nuclear antigen (PCNA), and tumor necrosis factor (TNF).” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Modulatory effects of Moringa oleifera leaf extract on sodium nitrate-induced experimental colitis via regulation of P53, Ki-67 and PCNA biomarkers.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Our results indicated that Ros and D, in a dose-dependent manner, markedly restored body weight, systolic blood pressure, and renal histological architecture besides significantly upregulated SOD levels, expression of anti-inflammatory CD163 macrophages, arginase1levels, IL-10 levels,STAT3 and PCNA immunoreactivity.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Notably, the excessive inflammatory response associated with CRC was prominently reduced following administration of LipoNio.BR [which decreased iterleukin (IL-B, IL-6), tumor necrosis factor-alpha (TNF-α), cyclooxygenase-2 (COX2), inducible nitric oxide synthase (iNOS), proliferating cell nuclear antigen (PCNA), follistatin, and activin BA (beta-A) expression].” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Rat jejunal sections were evaluated histologically (light and electron microscopic examination) and immunohistochemically [for tumor necrosis factor-α (TNF-α), Proliferating cell nuclear antigen (PCNA), cyclooxygenase-2 (COX2), and Bcl2].” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The gene and protein expression of apoptosis (PCNA/survivin/BAX/Cytochrome-C/Caspase-3) and cell cycle (CCND1/CCND3/p21/p27) molecules, the PI3K/mTOR/HIF1α oncogenic pathway, and glycolysis regulatory enzymes were measured by quantitative-PCR and Western blot.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The expression of proliferating cell nuclear antigen (PCNA), nuclear factor kappa B (NFkB), and caspase-3 was estimated after immunohistochemical staining.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “OBJECTIVE: The aim of this study is to determine the activity of EA on serum α-amylase and lipase titers, and on pancreatic tumor necrosis factor-α (TNF-α), proliferating cell nuclear antigen (PCNA) and interleukin-6 (IL-6) concentrations using the streptozocin-induced T2DM rodent model.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Samples of colon were used to investigate gene expression and protein levels of peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), mammalian target of rapamycin (mTOR), cyclin D1, nuclear factor erythroid 2-related factor-2 (Nrf2), heme Oxygenase-1 (HO-1) and proliferating cell nuclear antigen (PCNA).” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Moreover, the inflammatory progress mRNA and protein markers nuclear factor kappa B (NFκB), phosphatase and tensin homolog (PTEN), proliferating cell nuclear antigen (PCNA), cyclooxygenase-2 (COX-2) and occludin were significantly down-regulated by BEY treatment.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Moreover, renal tissues from the PC animals also showed substantial upregulations in NF-κB/TGF-β/KIM-1, whilst Nrf2/AMPK/AKT/PCNA declined, at the gene and protein levels in comparison to the normal rats.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “MEL-induced array of nephrotoxic morphological changes, and up-regulated immune-expression of proliferating cell nuclear antigen (PCNA) and proliferation-associated nuclear antigen Ki-67.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Semen analysis, testicular testosterone, malondialdehyde (MDA) concentrations, superoxide dismutase (SOD) activity, immunohistochemistry staining for apoptosis marker B-cell lymphoma protein 2 (Bcl-2), proliferation marker as proliferating cell nuclear antigen (PCNA), estrogen receptor α (ERα), androgen receptor (AR) were determined.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “TREM1 in the lung tissue and improved lung regenerative capacity by enhancing Ki67, PCNA and Ang-1 protein expression.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “The accumulation of ASK1, the cytoplasmic apoptosis regulators BAX and BCL2, and proliferating cell nuclear antigen (PCNA, a cell proliferation marker), as well as progesterone release, were evaluated by quantitative immunocytochemistry and radioimmunoassay.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “In immunohistochemical analysis, the xenografts from AGG-treated mice displayed a decrease in PCNA expression and an increase in caspase-3 activation as compared to the controls.” | 0.98 | hgnc_dict_v1 |
| gene | PCNA | “Furthermore, treatment of STZ-diabetic rats with SeNPs led to an elevation in the expression of PCNA (Proliferating Cell Nuclear Antigen Gene).” | 0.98 | hgnc_dict_v1 |