NQO1
HGNC:2874 · 25 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NQO1 | “Additionally, the impact of APs on regulators of mitochondrial biogenesis and antioxidant response [Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Sirtuin 1 (Sirt1), Heme Oxygenase-1 (HO-1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (PGC-1α), Adenosine Monophosphate-Activated Protein Kinase (AMPK), Uncoupling Protein 1 (UCP1), Uncoupling Protein 2 (UCP2)] was evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “GEONE also upregulated the expression of key antioxidant genes, Nrf2, HO-1 and NQO1, highlighting activation of cytoprotective pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Three hub genesCOL1A1, NQO1, and FOS-were identified, and their expression was validated using the TCGA, GEPIA, and HPA databases.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “CAEO instigated the gene expression and levels of Nrf2, HO-1, NQO1 while reduced the gene and protein expressions of JAK2, STAT3 and NF-κB.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Biochanin A Inhibits Colistin-Induced Kidney Injury in Rats via Induction of Nrf2/HO-1/NQO1 Axis.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “TMNB increased Nrf2, HO-1, and NQO1 expression (Nrf2 d = 8.21) while decreasing Keap1 (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Herein, liposomal hesperetin, especially at higher concentrations, augmented broilers FCR with upregulation of genes encoding TJP (occludin, JAM-2, MUC-2), and antioxidant attributes (GPX-1, SOD-1, CAT, HO-1, NQO1, COX2), which reflect enhancing health and welfare of broilers.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Retraction notice to "Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways" [Int.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Once in the nucleus, Nrf2 binds to antioxidant response elements (ARE) in the promoter regions of genes encoding phase II detoxifying enzymes and antioxidant proteins, including heme oxygenase-1 (HO-1), NAD(P)H quinone oxidoreductase 1 (NQO1), and glutamate-cysteine ligase.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Cypermethrin also downregulated the protein and gene expression of Nfe2l2, along with its downstream targets Hmox1, GCLC, and NQO1.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “The induction of quinone oxidoreductases NQO1 and NQO2 by clozapine: Potential implications for clozapine-induced agranulocytosis.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Intestinal redox balance was modified via decreasing H2O2 and MDA simultaneous with upregulation of catalase, SOD, GSH-Px, HO-1 and NQO1 in groups fed higher doses of QNPs.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Ameliorative effects of vanillin against pentylenetetrazole-induced epilepsy and associated memory loss in mice: The role of Nrf2/HO-1/NQO1 and HMGB1/RAGE/TLR4/NFκB pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Furthermore, γ-MN enhanced the signalling of Nrf2/HO-1 as it augmented the mRNA expression of Nrf2/downstream genes (HO-1/GCLc/NQO1/SOD).” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Of the top 15 proteins found by Cytoscape 3.6.1, 8, CAT and OGG1 (downregulated) and CASP3, COMT, CYP1B1, DPYD, NQO1, and PTGS1 (upregulated), were dysregulated in diabetes-related kidney disease.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Part of it was homogenized in sodium phosphate buffer for evaluating malondialdehyde (MDA) level, another part was used to evaluate gene (NQO1, p53, and Bcl-2) expression.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Conversely, PX treatment increased the messenger RNA expression of Nrf2, NQO1, HO-1 with an attenuated expression of 4HNE and NOX-4 levels in IHC analysis.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Virtual Screening for Potential Phytobioactives as Therapeutic Leads to Inhibit NQO1 for Selective Anticancer Therapy.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “With regard to phase II, SUN induced hepatic GSTA1 and UGT1A and renal NQO1 and UGT1A mRNA levels, whereas it inhibited renal GST1A expression.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Interestingly, the inhibition of DMBA-induced DNA adduct formation was associated with proportional decrease in CYP1A1 and in NAD(P)H: quinone oxidoreductase 1 (NQO1) gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Genetic polymorphisms in NQO1 and SOD2: interactions with smoking, schistosoma infection, and bladder cancer risk in Egypt.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “At the transcriptional levels, metformin treatment caused significant restoration in diabetic nephropathy-induced oxidative stress mRNA levels, particularly GSTα, NQO1, and CAT genes, whereas inhibited TNF-α and IL-6 pro-inflammatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | NQO1 | “Polymorphisms in five genes (CYP1A1, GSTT1, GSTP1, GSTM1, and NQO1) were characterized in 182 individuals with DLBCL and 513 normal controls using PCR-RFLP method.” | 0.98 | hgnc_dict_v1 |