STAT3
HGNC:11364 · 147 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | STAT3 | “We examined how ursolic acid affects the expression of Th1 (IFN-γ, TNF-α, STAT1, STAT4, and T-bet), Th17 (IL-17, RORγt, and STAT3), and T regulatory (Treg; IL-10, TGF-β1, and Foxp3) markers in CD4+ T cells within the spleens of BTBR and C57BL/6 mice.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “BACKGROUND: The process of cancer progression is maintained through a feedback loop whereby reactive oxygen species (ROS) induce inflammatory cytokines, which activate STAT3 and result in miRNA-21 upregulation. miRNA-21 enhances the AKT signaling pathway and suppresses PTEN, promoting the proliferation of the cancerous cells and the additional production of ROS.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Patient cells showed markedly reduced OSM-induced phosphorylation of STAT1, STAT3, and STAT5, while signaling through other IL-6 family receptor complexes remained intact.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Resveratrol as a Dual MAPK/STAT3 Inhibitor in Glioblastoma: Mutation-Dependent Therapeutic Efficacy.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Protein-protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Host immune hub genes and Salmonella virulence regulators were identified, followed by docking of curcumin to key host (AKT1, STAT3, TNF) and pathogen proteins (invA, phoP, ssrB).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “METHODS: Using a combination of protein-protein interaction prediction tools and transcriptional regulatory interaction databases, we identified JUN, FOS, ATF2, ATF4, RELA, NF-κB, SMAD3, STAT1, STAT3, and SP1 as potential candidate TFs that might be involved in Aβ1-42 related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Nano-Cilostazol significantly inhibited apoptosis and pyroptosis (NLRP3, ASC, GSDMD)-related pathways, modulated JAK2/STAT3 signaling, and downregulated miRNA-155 expression.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “However, substantial evidence implicates multiple signaling pathways in its pathogenesis, including interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), wingless/Int1 (Wnt), heme oxygenase-1 (HO-1), nuclear factor erythroid 2-related factor 2 (Nrf2), adenosine monophosphate-activated protein kinase (AMPK), mammalian target of rapamycin (mTOR), and NLR family pyrin domain-containing 3 (NLRP3).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “This was associated with the suppression of various cancer-related signaling pathways, including STAT3/NF-κB, AKT/mTOR, and ERK.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Notably, BTK-high tumors showed robust enrichment of immune pathways (interferon gamma (IFN-γ) response, interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3), tumor necrosis factor-α (TNF-α) signaling) and exhibited elevated tumor-infiltrating leukocyte and lymphocyte fractions, increased cytolytic activity, and greater abundance of myeloid and lymphoid cell populations.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Ligustilide Attenuates Neuroinflammation and Fibrosis in an Aluminum Chloride-induced Rat Model of Alzheimer's Disease via mTOR/STAT3 Signaling Inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Transcriptomic and multi-layer variant analysis identifies STAT3 and HIF1A as central regulators of regulated cell death pathways in lung squamous cell carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Specifically, the JAK2/STAT3 pathway is a key mediator of cardiac repair and defence mechanisms.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Epigenetic regulation by HDAC11-driven STAT3 activation promotes pro-inflammatory cytokine production and endothelial dysfunction upon bacterial infection in diabetes.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Molecular crosstalk between lncRNA H19, miR-29a, and JAK2/STAT3 signaling in alopecia areata: a preliminary study.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Comparative study of obeticholic acid and rosuvastatin in high-fat/fructose diet-induced metabolic dysfunction: role of AMPK, PPAR-γ, SREBP-1c, and STAT3 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Cellular signaling in heart disease is highly complex, particularly within pathways involving microRNAs (miRNAs), signal transducer and activator of transcription 3 (STAT3), and Cyclophilin D, which together form regulatory networks governing cardiomyocyte survival and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Network pharmacology analysis revealed 637 intersecting targets linking SKT-36 with dementia-associated genes such as STAT3, GSK3B, and HSP90AB1 identified as key hubs.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The model disrupted several molecular pathways, including the AMP-activated protein kinase (AMPK) pathway, and enhanced oncogenic and inflammatory markers such as Yes-associated protein/ Transcriptional coactivator with PDZ-binding motif/ Hypoxia-inducible factor 1-alpha (YAP/TAZ/ HIF-1α), nuclear factor erythroid 2-related factor 2/ Sirtuin 1(Nrf2/SIRT1), and signal transducer and activator of transcription 3 (STAT3).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Suppression of NGALR impedes TNBC cell survival, proliferation, invasion, and migration through Akt/mTOR and JAK/STAT3 pathway inhibition.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Moreover, we constructed a miRNA-mRNA regulatory network to visualize the functions of miRNAs related to IMF deposition in the yak. miR-122, miR-375, and miR-378 may play a key role in IMF deposition in the yak, and RORC, STAT3, ACACA, FTO, and FOXO1 were the core target genes.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “PROTACs can eliminate oncogenic proteins like EGFR, STAT3, c-MYC, and anti-apoptotic regulators by hijacking the ubiquitin-proteasome system, many of which are essential for OSCC pathophysiology and are considered undruggable.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “By focusing on hub genes (SRC, AKT1, MAPK1/3, STAT3, EGFR) implicated in key signaling pathways such as PI3K-Akt, MAPK, JAK-STAT, and GABAergic synapse signaling, network analysis showed that these drugs had 15-25 targets in common with epilepsy.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Of these pathways, interleukin 6 (IL-6)/signal transducer and activator of transcription 3 (STAT3), mammalian target of rapamycin and AMP-activated protein kinase (AMPK), Sphingosine kinase (SPHK)/ Sphingosine-1-phosphate, nuclear factor erythroid-2 related factor 2 (Nrf2)/heme oxygenase (HO-1).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “This review highlights xanthohumol's ability to modulate key signaling pathways, including NF-κB, STAT3, and Nrf2, which are central to inflammation, oxidative stress, and cancer progression.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “AIM OF THE STUDY: The purpose of the current study is to elucidate the defending strategies of Citrus aurantifolia (Christm.) Swingle (Rutaceae) essential oil (CAEO) in the amelioration of MTX induced hepatic and kidney toxicities focusing on the Nrf2/HO-1 and JAK2/STAT3/NF-κB pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “KEY FINDINGS: Niclosamide acts through six interconnected mechanisms: (1) mild reversible mitochondrial uncoupling, limiting ROS and cGAS-STING activation; (2) mTORC1 inhibition via lysosomal deacidification, with indirect IGF-1/IGF-1R modulation through AMPK activation; (3) restoration of autophagic flux and lysosomal biogenesis via TFEB nuclear translocation; (4) selective senolytic and senomorphic effects, suppressing NF-κB and STAT3 to neutralize the senescence-associated secretory phenotype (SASP) and reduce IL-6, IL-1β, and TNF-α; (5) blockade of canonical Wnt/β-catenin signaling to prevent tissue fibrosis; and (6) rebalancing of aged immune function by downregulating PD-1/PD-L1 and upregulating Vasorin to inhibit TGFβ‑mediated fibrosis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Severe Th2-driven atopic dermatitis and asthma are common in several IEIs, including DOCK8 deficiency, STAT3 loss-of-function, and Wiskott-Aldrich syndrome, often refractory to conventional therapies.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Genetic alterations, including mutations in STAT3, TET2, and DNMT3A, further highlight the overlap between RA pathophysiology and hematologic malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Case Report: Dual molecular diagnosis of gain-of-function STAT1 mutation and regulatory STAT3 variant in a patient with a hyper-IgE-like phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Immunogenetic investigation of WAS patients revealing impaired IL-6/STAT3 signaling in T cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “RESULTS: Network pharmacology recognized 87 overlapping targets of Rhamnolipid and Surfactin with Alzheimer's disease, with hub genes involving CASP3, SRC, CTNNB1, HSP90AA1 and STAT3.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “These variants disrupted normal PKCδ function by causing surface distortion, changing net charge, and perturbing intramolecular interactions with STAT3, which may activate PKCδ in a non-canonical manner.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Molybdenum induces hepatic impairments via dysregulating NLRP3, JAK1/STAT3 and NF-κB pathways: A dose dependent toxicity assessment.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Protein-protein interaction (PPI) analysis highlighted ten key genes-EGFR, ESR1, HIF1A, HSP90AA1, MAPK1, BCL2, STAT3, TP53, CASP3, and SRC-implicated in the progression of various cancers, including breast, colorectal, liver, and lung tumors.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Lead phytochemicals, diospyrin and galpinone, strongly targeted key hub proteins (NFκβ1, STAT3, MTOR, HSP90AA1, and HSP90AB1), demonstrating favorable binding affinities, conformational stability, and binding free energetics compared to reference inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “In the joint tissue, ALA modulated the expression of NFKB1, STAT3, GATA3, TBX21, and RORC, all of which are key transcription factors associated with arthritis pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “TAM 2.0 functional annotation supported these findings, linking the selected miRNAs to smooth muscle differentiation, cytokine signaling, and regulation by key transcription factors including SMAD4, STAT3, and AP-1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Moreover, NFX mitigated 5-FU-induced inflammation by suppressing nucleotide-binding domain, leucine-rich repeat-containing protein 3/signal transducer and activator of transcription 3 (NLRP3/STAT3) signal activation.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Additionally, HNK downregulated the expression of calcitonin gene-related peptide and the JAK/STAT3 gene.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Following that, several transcription factors (GATA2, FOXC1, SREBF1, STAT3, and NFKB1) as well as microRNA (hsa-mir-26a-5p, hsa-mir-129-2-3p, etc.) were predicted.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Multiple signaling pathways have been implicated in the pathogenesis of ulcerative colitis (UC), including Sphingosine Kinase 1 (SPHK)/Sphingosine-1-Phosphate (S1P), AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/NLR family pyrin domain-containing 3 (NLRP3), zonula occludens-1 (ZO-1), and signal transducer and activator of transcription 3 (STAT3).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “STAT3, a key protein in this pathway, has been implicated in promoting inflammation, making its inhibition a potential therapeutic strategy to mitigate disease severity.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “METHODS: Protein expression of IL-10, its α-receptor (IL10Rα), and intracellular signal transducer (STAT3) was measured by immunohistochemistry in archived paired non-cancerous and cancerous colonic specimens collected from the same patients (n = 120).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Melissa officinalis Attenuates Diclofenac-Induced Hepatorenal Toxicity via AMPK/SIRT1 and STAT3/Nrf2 Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Lysine-specific demethylase 1 controls key OSCC preneoplasia inducer STAT3 through CDK7 phosphorylation during oncogenic progression and immunosuppression.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Its role in epithelial-mesenchymal transition (EMT) further facilitates metastatic behaviour. miR-21 also modulates the tumour microenvironment by promoting angiogenesis and altering immune responses, thus enhancing cancer progression.Moreover, miRNA - 21 influences the various signalling pathways like PI3K/ AKT, TGF-β, NF-κB, and STAT3, as well as involved in the cell fate mechanisms known as Autophagy and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Cardioprotective potential of tectochrysin against vanadium induced heart damage via regulating NLRP3, JAK1/STAT3 and NF-κB pathway.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The PPAR-α selective agonist WY14643 improves lupus nephritis via the downregulation of the RORγT/STAT3 signaling pathway in MRL/lpr mice.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Prevention of fenitrothion induced hepatic toxicity by saponarin via modulating TLR4/MYD88, JAK1/STAT3 and NF-κB signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Inhibiting the MEK and STAT3 pathways disrupts key cancer-promoting mechanisms, including immune evasion, angiogenesis, and metastasis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Design, Synthesis, and Molecular Docking of Quinazolines Bearing Caffeoyl Moiety for Targeting of PGK1/PKM2/STAT3 Signaling Pathway in the Human Breast Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The Significance of STAT3 in Colonic Diseases: A Comprehensive Study of Pathological Roles and Therapeutic Implications.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “We examine how activating EGFR mutations or overexpression induce STAT3 phosphorylation and regulate transcription factors such as Snail, Twist, and ZEB1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The compound significantly reduced the percentage of phospho JAK2 and phospho STAT3 in HEL cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Highlighting an inflammatory component of TSC, TSC cell models exhibit elevated NF-κB and STAT3 activation.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Further, RT-PCR and Western blot analysis validated the expression of target genes including the overexpression of HSPA1B, FOS, and down-expression of SOD2, COL1A1, and CCL2, whereas TFs including upregulation of RELA, NFKB1, STAT3, and downregulation of SP1 and JUN in diabetic and diabetic infectious wounds.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Combination therapy of systemic and local metformin improves imiquimod-induced psoriasis-like lesions with type 2 diabetes: the role of AMPK/KGF/STAT3 axis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Targeting the p38MAPK/STAT3/NF-κB65 pathway modulates the hepatoprotective effect of pentoxifylline against sodium valproate-induced liver injury in rats; A study based on integrating network pharmacology and experiment validation.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Network pharmacology identified 24 hub targets, and molecular docking revealed strong binding affinities (-6.5 to -9.1 kcal/mol) between BRLE compounds and inflammatory proteins including EGFR, SRC, STAT3, and AKT1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “BACKGROUND: Peroxisome proliferator-activated receptor α (PPARα) has been reported to exert protective roles in immune-mediated intestinal diseases through inhibition of interleukin-6 (IL-6)-induced signal transducer and activator of transcription factor 3 (STAT3) activation.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Serum levels of C-reactive protein (CRP), nuclear factor kappa B (NF-κB), interleukin-6 (IL-6), and signal transducer and activator of transcription 3 (STAT3) were measured before and after treatment.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Sorbitol induces sub-chronic nephrotoxicity via escalating JAK1/STAT3, oxidative stress and inflammation in Sprague Dawley rats.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “JAK2/STAT3/NFκB gene expression was measured.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Mirtazapine also inhibited pro-proliferative and angiogenic markers (Ki67, Cyclin D1, VEGF, MMP-2), reactivated apoptotic pathways (Bax, caspase-3, p53), and suppressed oncogenic STAT3 and ERK1/2 signaling.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “By mapping IL 4-activated pathways and applying peptidome profiling, macrophage-derived peptide 1 (MDP1) was identified and shown to promote the phosphorylation of STAT3 and STAT6, thereby inducing the polarization of M0 macrophages toward the anti-inflammatory M2 phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Corrigendum: Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study. [This corrects the article DOI: 10.3389/fphar.2024.1381523.].” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Upon further investigation, the patient's genetic test (whole exome sequencing) demonstrated a heterozygous missense variant in the STAT3 gene.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The result showed that the conditioned medium of benzoyl pterostilbene-treated macrophages reduced the phosphorylated STAT3 in the keratinocytes, indicating the blockade of crosstalk between resident and immune cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Vinpocetine also successfully deactivated NF-κB, STAT3, and HIF-1α, along with their associated transcription proteins, thereby exerting anti-inflammatory and anti-angiogenic role.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Significant genes involved are STAT3, BCL2, and MTOR, emphasizing the chemical hazards of ICS exposure.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “STAT3 single-nucleotide variants in autoimmune thyroid disease in the Pakhtun population of Khyber Pakhtunkhwa, Pakistan.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Pathway enrichment was performed with Gene Ontology and KEGG databases; (3) Results: We identified 28 active phytoconstituents, targeting proteins such as EGFR, SRC, STAT3, AKT1, and HSP90AA1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Moreover, we discovered that Sphk1-specific small interfering RNA blocked the formation of lipid droplets, which can effectively alleviate the expression of the signal transducer and activator of the transcription 3 (STAT3)/Nf-κB pathway.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “OBJECTIVES: We aimed to explore the potential therapeutic effects of Arctiin on rats with AD by evaluating the expression of TLR4, NLRP3, STAT3, TGF-β, cyclin D1, and CDK2.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Metformin was predicted to downregulate miR-199b-5p via NFATC2 and STAT3 and reverse its downstream effects.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Notably, our findings reaffirm the relevance of lung cancer genes, such as CTNNB1, STAT3, HIF1A, HSP90AA1, and ERBB2, integral to various cellular processes and pivotal in cancer genesis and advancement.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Pharmacologic degraders (selective proteolysis-targeting chimera) and genetic (lentiviral short hairpin RNA) inhibitors were used to determine the roles of signal transducer and activator of transcription 3 (STAT3) and STAT6 in conjunction with in vivo model systems of histamine-induced hypovolemic shock.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “BACKGROUND: c-MET is a receptor tyrosine kinase which is classically activated by HGF to activate its downstream signaling cascades such as MAPK, PI3K/Akt/mTOR, and STAT3.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Several transcription factors have been identified on the regucalcin gene, including AP-1, NF1-A1, RGPR-p117, β-catenin, NF-κB, STAT3 and hypoxia-inducible factor-1α (HIF-1α).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Leonurine ameliorates the STAT3 pathway through the upregulation of SHP-1 to retard the growth of hepatocellular carcinoma cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Nifuroxazide repurposing for protection from diabetes-induced retinal injury in rats: Implication of oxidative stress and JAK/STAT3 axis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Palliative potential of velutin against abamectin induced cardiac toxicity via regulating JAK1/STAT3, NF-κB, Nrf-2/Keap-1 signaling pathways: An insight from molecular docking.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Administration of MSCs improved dyslipidemia, the altered cardiac injury biomarkers (p ≤ 0.0001), downregulated Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)/inducible Nitric oxide synthase (iNOS) and iNOS/Apoptosis signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Perindopril Ameliorates Sodium Valproate-Induced Rat Model of Autism: Involvement of Sirtuin-1, JAK2/STAT3 Axis, PI3K/Akt/GSK-3β Pathway, and PPAR-Gamma Signaling.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Thus, our research hotspot was to explore the possible renoprotective effects of rosuvastatin (Ros) and diosmetin (D) on macrophage polarization and the role of HSP70/TLR4/MyD88/NF-κB p65/NLRP3/STAT3 signaling in cis-induced AKI and study the activity of D against uropathogenic bacteria.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “In addition, we investigated the potential molecular mechanisms that underlie the impact of AFB1 on the production of Th1 (IFN-γ, STAT1, and T-bet), Th9 (IL-9 and IRF4), Th17 (IL-17A, IL-21, RORγT, and STAT3), Th22 (IL-22, AhR, and TNF-α), and T regulatory (Treg) (IL-10, TGF-β1, and FoxP3) cells in the spleen.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Multi-Omics Profiling in PGM3 and STAT3 Deficiencies: A Tale of Two Patients.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Introduction: FLLL-32, a synthetic analog of curcumin, is a potent inhibitor of STAT3's constitutive activation in a variety of cancer cells, and its anticancer properties have been demonstrated both in vitro and in vivo.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Identification of novel STAT3 inhibitors for liver fibrosis, using pharmacophore-based virtual screening, molecular docking, and biomolecular dynamics simulations.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “According to the PPI network and core targets study, the main targets against PSO were EGFR, SRC, STAT3, ERBB2, PTK2, SYK, EP300, CBL, TP53, and AR.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “From the top ten genes, STAT3, MAPK3, and SRC were selected due to their involvement in GO annotation and KEGG pathway.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “It leads to the activation of tumor suppressor genes, inhibition of angiogenesis, PI3K/AKT pathways, STAT3, transcription factor AP-1, Nrf2 and other cell signaling molecules.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “In vitro studies reveal that Guggulsterone inhibits and suppresses the proliferation of an extensive range of cancer cells by decreasing intrinsic mitochondrial apoptosis, regulating NF-kB/STAT3/β-Catenin/PI3K/Akt/CHOP pathway, modulating the expression of associated genes/proteins, and inhibiting angiogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Lung Microbiome Metabolites Inhibit STAT3 and Modulate the Immunological Network.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Adefovir Dipivoxil as a Therapeutic Candidate for Medullary Thyroid Carcinoma: Targeting RET and STAT3 Proto-Oncogenes.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Gut-derived Endotoxin-TLR4 Signaling Drives MYC-Ig Translocation to Promote Lymphoproliferation through c-JUN and STAT3 Activation.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “We then used RT-PCR to analyze IL-17A, IL-17F, IL-21, TNF-α, STAT3, and RORγ mRNA expression in the brain.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Moreover, these treatments downregulated the colonic inflammatory cascade by inhibiting NFκB, TNFα, IL-1β, IL6, IL23, IL17, COX-2, and iNOS, subsequently leading to downregulation of the JAK2/STAT3 signaling pathway and a decrease in the Th17 cell response.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “NFX has potential roles in inhibiting thyroid, breast, lung, bladder, liver, and colon cancers and osteosarcoma, melanoma, and others mediated by suppressing STAT3 as well as ALDH1, MMP2, MMP9, Bcl2 and upregulating Bax.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Different cell surface molecules like CD25, GITR, CD122, CD152, CD45RO, IL-23R, STAT3, STAT5, CD127, HLA-DR, CCR4, CCR5, CCR6 and CCR7 were studied.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The expression levels of apoptosis and autophagy markers, JAK2 and STAT3 were determined using quantitative real time-PCR (qRT-PCR) and western blotting methods.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Autosomal dominant HIES caused by loss of function mutations in Signal transducer and activator of transcription 3 (STAT3) gene is the prototype of these disorders.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “MicroRNAs and JAK/STAT3 signaling: A new promising therapeutic axis in blood cancers.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Western blot analysis revealed activation of STAT3, NF-κB, and ERK pathways due to the MetS-BC.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The key genes, including EGFR, MYC, VEGFA, and PTEN, are targeted by TF such as AR, Sp1, TP53, NF-KB1, STAT3, RELA.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “We also explored the effects of Pb on IL-17A, RORγT, STAT3, NF-κB p65, and TLR-2 mRNA expression in the brain tissue using RT-PCR analysis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “An increased level of signal transducer and activator of transcription 3 (STAT3) and a decreased level of peroxisome proliferator-activated receptor (PPAR) gamma have been linked to autism pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Gene and protein expression study revealed that Lignin and L. plantarum supplementation restored the expression of E-cad and suppressed the expression of STAT3 in DSS induced colitis model.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Researchers have identified multiple targets to specifically alter inflammation in cancer therapy to restrict malignant progression and improve the efficacy of cancer therapy. siRNA-and shRNA-loaded NPs have been observed to downregulate STAT3 signaling pathways and have been employed in studies to target tumor malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Molecular docking analysis of mutant promoter with transcription factors STAT3 and STAT6 proposed changes in protein regulation upon these reported mutations in upstream region of the gene.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Curcumin down-regulates SHH pathways, epigallocatechin-3-gallate regulates the Notch pathway and inhibits TGFβ1/SMAD signalling, and resveratrol regulates the Wnt/β-catenin pathway and carnosic acid-induced apoptosis in colon cancer cell via JAK2/STAT3 signalling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Furthermore, we demonstrate that NPM-ALK promotes NOTCH1 expression through binding of STAT3 upstream of NOTCH1.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Notably, no former studies have linked JAK2/STAT3, HMGB1/NF-κB, and Nrf2/HO-1 signaling in TNBS-evoked colitis.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Renal tissue nerve growth factor-β (NGF-β), transforming growth factor beta 1 (TGF-β1), proinflammatory cytokines, nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), nuclear factor kappa B (NF-κB) p65, signal transducer and activator of transcription 3 (STAT3), oxidative stress parameters, beclin-1 and c-Jun NH2-terminal kinase (JNK) activities were measured.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “We observed a significant decrease in CD4+COX-2, STAT3, and TNF-α cell population in whole blood after MMINA dosage.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Inhibition of JAK2 leads to decoupling of its downstream mediator, STAT3, and the subsequent inhibition of JAK/STAT signalling.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “3-Formylchromone Counteracts STAT3 Signaling Pathway by Elevating SHP-2 Expression in Hepatocellular Carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “LDL cholesterol promotes the proliferation of prostate and pancreatic cancer cells by activating the STAT3 pathway.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Therefore, this study evaluated the effects of DEHP (at 5 μM final concentration for 24 h) on inflammatory profile (NFkB, STAT3, IL-6, TNF-α, IL-1β) in monocytes of ASD subjects and typically developing control (TDC) children.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Prevention of Tobacco Carcinogen-Induced Lung Tumor Development by a Novel STAT3 Decoy Inhibitor.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Reviewed genes involved in APL variants include: ZBTB16, NPM, NuMA, STAT5b, PRKAR1A, FIP1L1, BCOR, NABP1, TBLR1, GTF2I, IRF2BP2, FNDC3B, ADAMDTS17, STAT3, and TFG.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Ectopic PD-L1 expression in JAK2 (V617F) myeloproliferative neoplasm patients is mediated via increased activation of STAT3 and STAT5.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Here, using this mouse model, we investigated the effects of AG126 administration on IL-21R, IL-21, IL-22, TNF-α, NOS2, STAT3, IL-27, and Foxp3 production by CD8+ T cells in the spleen by flow cytometry.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Mechanistic experiments disclosed that leptin activates signal transducer and activator of transcription 3 (STAT3) and mitogen-activated protein kinase (MAPK) signaling pathways in intestinal and hepatic cells, respectively, and thereby regulates divergent MTP expression.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The interplay of the inhibitory effect of nifuroxazide on NF-κB/STAT3 signaling attenuates acetic acid-induced ulcerative colitis in rats.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Since the expression of these two factors can be regulated by STAT3 signaling, we deciphered the influence of BT on modulation of this pathway.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Further, sulforaphane-treated BTBR mice had reduced Th17 immune responses (STAT3, RORC, IL-17 A and IL-23R expression in CD4 + T cells), oxidative stress parameters in neutrophils/cerebellum (NFkB, iNOS, and lipid peroxides).” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “RESULTS: WES identified somatic mutations in 4 canonical pathways (WNT, ERBB2, STAT3, and chromatin remodeling), which were validated in the TES cohort.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Cycloastragenol can negate constitutive STAT3 activation and promote paclitaxel-induced apoptosis in human gastric cancer cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Moreover, JNJ treatment and irradiation exposure in BTBR mice regulated the mRNA and protein expression levels of IL-17A, RORγT, IL-22, T-bet, STAT3, pSTAT-3, IL-10, and Foxp3 in the brain tissue.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Phloretin attenuates STAT-3 activity and overcomes sorafenib resistance targeting SHP-1-mediated inhibition of STAT3 and Akt/VEGFR2 pathway in hepatocellular carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Multiplexed detection of DOCK8, PGM3 and STAT3 proteins for the diagnosis of Hyper-Immunoglobulin E syndrome using gold nanoparticles-based immunosensor array platform.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “In addition to these active immunotherapies, inhibitors of molecular hubs with wide reaching effects, including STAT3, IDO, and TGF-β, are now in early-phase clinical trials.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Recently tested CNSTs biomarkers include VEGFR-2, EGFRvIII, IL2, PDGFR, MMPs, BRAF, STAT3, PTEN, TERT, AKT, NF2, and BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “The anticancer activity of TQ has been primarily shown by altering the expression of signal transducers and activator transcription (STAT3), PTEN and p53 genes.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “We investigated the possible role of resveratrol on IL-6+, TNF-α+, IFN-γ+, and STAT3+ in CD4+ T spleen cells in BTBR mice as compared to C57BL/6J mice.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “IPA mapped the above-mentioned hypermethylated genes to the Wnt/β-catenin, PI3k/AKT, VEGF, and JAK/STAT3 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Resveratrol inhibits STAT3 signaling pathway through the induction of SOCS-1: Role in apoptosis induction and radiosensitization in head and neck tumor cells.” | 0.98 | hgnc_dict_v1 |
| gene | STAT3 | “Seventeen patients screened for STAT3, TYK2 and DOCK8 mutations.” | 0.98 | hgnc_dict_v1 |