TNF
HGNC:11892 · 72 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | TNF | “In addition, expression of the pro-inflammatory cytokines IL-6 and TNF was significantly increased.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “We further identified 201 common upregulated hub genes (including MMP9, CDH1, HSP90AB1, SOX2, CDKN2A, SPP1, EZH2) and 224 common downregulated hub genes (such as IL6, TNF, IL1B, JUN, CCL2, TLR4, FOS, PTGS2).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Host immune hub genes and Salmonella virulence regulators were identified, followed by docking of curcumin to key host (AKT1, STAT3, TNF) and pathogen proteins (invA, phoP, ssrB).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Hub genes such as TNF, IL6, CASP3, and GPX1 highlighted potential interactions among pathways affected by niclosamide.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Gene Ontology and KEGG enrichment analyses further implicated TNF, IL-17, and Toll-like receptor pathways, highlighting the broader regulatory role of indicaxanthin in hepatic stress signaling.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “RESULTS: There was a significant increase in blood glucose levels in diabetic rats, which coincided with significant increases in the skeletal muscles' mRNA expression levels of two inflammatory markers, transforming growth factor-β1 (TGF-β1) and tumor necrosis factor-α (TNF‑α), and in two biomarkers of skeletal muscle atrophy, F-boxonly protein 32 (FBXO32) and muscle RING-finger protein-1 (MuRF1).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “RESULTS: Four hub genes, IFNG, TNF, CD4, and CD8A, were identified as central immune regulators.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Gene expression analysis revealed that the tumor necrosis factor alpha (TNF), Interleukin-8 (IL-8), Mucin 2 (MUC2), claudin-1 (CLDN1), and tight junction protein 1 (TJP1) were highly upregulated in the jejunum of L. lactis MSH-08 group.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The PPI network highlighted TNF, IL2, and CD40 as central genes involved in immune-related pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The resultant protein-protein (PPI) network was analysed using the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment approaches, resulting in identification of critical pathways, ERK1, PI3K-Akt, EGRF and TNF signaling as significantly involved in DN, where, ERK1 emerging as a key node due to its involvement in cell proliferation, inflammation, and fibrosis associated with DN.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “ALA downregulated the expression of pro-inflammatory genes (IL17F, TNF) and upregulated the expression of the anti-inflammatory cytokine IL10 gene in the joint tissues.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In addition, malathion increased TNF‑α, NF‑κB, Toll‑like receptor (TLR) 2 and TLR4 expression, and malathion toxicity induced severe hepatorenal damage, including vascular congestion, inflammatory infiltration and tubular degeneration.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “PBM reduced the protein expression levels of IL-6, TNF, and apoptotic markers in alignment with their corresponding mRNA expression profiles.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Transcriptomics analysis found that ABP enriched TNF and hematopoietic pathways, with IL6 and IL1β as key pro-inflammatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Gene expression analysis revealed modulation of crucial cancer-related genes and signaling pathways, including MMP-9/NF-κB/mTOR, PD-L1 expression and PD-1 checkpoint pathway, TNF signaling pathway, and adipocytokine signaling pathway, suggesting their potential as novel therapeutics for breast cancer treatment.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The expression of TNF and SERCA2a genes and proteins was measured by real-time polymerase chain reaction (PCR) and Western blot (Wb) analysis, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Molecular docking studies focused on one hub gene, namely, tumor necrosis factor (TNF) revealing that C. tinctorius's compounds have high affinity for TNF, suggesting a potential therapeutic link to hearing loss.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In silico results identified 112 inflammation-associated gene targets, whereas tumor necrosis factor (TNF), IL6, and AKT1 were identified as top hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “This was accompanied by lower expression of TLR4, Myeloid differentiation primary response 88 (MyD88), TIR Domain-containing adaptor molecule 1 (Trif), and TNF Receptor-associated factor 3 (Traf3).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Pioglitazone pre-treatment reduced the expression of pro-inflammatory cytokine genes (IL6 and TNF).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Subsequently, the three final proposed deleterious mutants including mutations rs373838463, rs2107818892, and rs763687242, were docked with their reported binder, TNF receptor-associated factor 2 (TRAF2).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The most frequently interacting genes were HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Additionally, cigarette smoke impairs the unfolded protein response, activates the NF-κB pathway, and induces a pro-inflammatory state characterized by increased TNF and IL-18 expression.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “While, the proinflammatory genes expression (IL1B, IL6, IFNᵧ, and TNF) were down regulated (p ≤ 0.001) in the LGX200 compared to others.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “HCQ reduced the levels and the mRNA stability of poly (I:C)-induced cytokines and inflammatory mRNAs like TNF, IL-6, COX-2, and IL-8 in THP-1 and primary blood monocytes.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Our focus was to delve into the potential therapeutic impact of ZBiotic, a specially engineered strain of probiotic B. subtilis, in managing NAFP by targeting specific genes linked with necroptosis and the TNF signaling pathway, including TNF, ZBP1, HSPA1B, and MAPK3, along with their upstream epigenetic regulator, miR-5192, identified through bioinformatics.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Interestingly, fish cultured in rearing water with the mixture provided downregulated the related inflammatory genes (HSP70, TNF, IL-1β, and IL-8) partially at HGS15 mL-1.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In the groundwork of this research, we examined the active constituent-compound-target-pathway network and evaluated that (Guggulsterol-V, Myrrhahnone B, and Campesterol) decisively donated to the development of arthritis by affecting tumor necrosis factor (TNF), PIK3CA, and MAPK3 genes.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Dietary inclusion of LC and or B. subtilis supplementation significantly (P < 0.001) up-regulated hepatic growth-related genes (growth hormone receptor (GHR) and insulin growth factor1 (IGF-1)) and antioxidant-related genes (superoxide dismutase 1 (SOD1), glutathione peroxidase (GPX1) and uncoupling protein (UCP) and down-regulated (P < 0.001) splenic toll-like receptor 4 (TLRP) gene expression while had no significant effect on splenic interleukin 8 (IL8) and tumor necrosis factor (TNF) with the best-obtained results with 1.0% followed by 0.5% LC with B. subtilis supplementation.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Patient-derived IE from UM and CM clinical cases, as well as non-binding skeleton-binding protein 1 knockout parasites, were overlaid onto tumour necrosis factor (TNF)-activated HBMECs.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The study further explored the correlation between histopathological alterations and inflammatory reactions in the kidney, spleen, and liver of infected mice, alongside the immunohistochemical expression of caspase-3, proliferating cell nuclear antigen (PCNA), and tumor necrosis factor (TNF).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The level of IL17 was detected using ELISA, while the antioxidant genes Nrf2, HO-1 expression at the level of mRNA, expression of the myelin basic protein (MBP), interferon-gamma factor (INF)-γ and tumor necrosis factor (TNF)-α, and apoptotic marker (caspase-3) were measured using immunohistochemistry in the sciatic nerve.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The difference included the expression of critical genes (SKT4, SIRT1, and TNF superfamily), metabolic and signaling pathways (Hippo, Sirtuin, ARE-mediated messenger RNA degradation, MSP-RON, and Huntington), and predicted biological functions (β-cell growth and proliferation, insulin and glucose metabolism, energy balance, inflammation, and neurodegeneration).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Here, we demonstrated that upon infection/inflammation, NK cells upregulate the expression of TNF receptor 2 (TNFR2), which is associated with increased proliferation, metabolic activity, and effector function.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Likewise, the concentration of biochemical NO, GSH, and MDA improved in treatment groups concerning the diseased group. mRNA levels of different marker genes including ChAT, IL-1α, IL-1 β, TNF α, tau, and β secretase (BACE1) improved in treatment groups with respect to the disease group.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “A network pharmacology study displayed the relation between identified compounds and 136 genes, among which 84 genes related to Alzheimer's disorders, and focused on AChE, APP, BACE1, MAPT and TNF genes with interactions to all Alzheimer's disorders.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The main targets of toxicity were casp3, TNF, IL10, IL1B, BAG3, CCNB1, CCNE1, and CDC25A, and the biological pathways implicated were signal transduction involved in DNA damage checkpoints, cellular and chemical responses to oxidative stress, DNA damage response signal transduction by P53, stress-activated protein kinase signaling cascade, netrin-UNC5B signaling, PTEN gene regulation, and immune response.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “CONCLUSION: Based on our study, we conclude that the potential genes which are affected due to infection are NFKBIA, MYC, FOXO3, BIRC3, ICAM1, IL8, CXCL1/2/5, GADD45A, RELB, SGK1, AREG, BBC3, DDIT3/4, EGR1, MTHFD2, and SESN2 and the functional changes are mainly associated with these pathways: TNF, cytokine, NF-kB, TLR, TCR, BCR, Foxo, and TGF signaling pathways are among them and there are additional pathways such as hippo signaling, apoptosis, estrogen signaling, regulating pluropotency of stem cells, ErbB, Wnt, p53, cAMP, MAPK, PI3K-AKT, oxidative phosphorylation, protein processing in endoplasmic reticulum, prolactin signaling, adipocytokine, neurotrophine signaling, and longevity regulating pathways.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “This study was confirmed by in vivo experiment in which kidneys were collected for histopathology and gene expression of mitogen-activated protein kinase 4 (MKK4), MKK7, I-CAM 1, IL-6, and TNF receptor-associated factor 2 (TRAF2).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Polymorphisms of the TNF, LTA, and TNFRSF1B genes are associated with onsets of menarche and menopause in US women of European ancestry.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In this study, we compared frequencies of HLA-DRB1 alleles and single-nucleotide polymorphisms (SNPs) associated the genes coding for: toll-like receptors (TLRs), tumour necrosis factor (TNF), interleukin-1 (IL-1), interleukin-1 receptor type 1 (IL-1R1), interleukin-1 receptor antagonist (IL-1RN), interleukin-2 (IL-2) and interleukin-12B (IL-12B), between T1D patients and healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Fedratinib inhibited the expression of LIF, SOCS3, RRAD, NOTCH3, TNF, COMP, THBS2, and IL6, which are associated with various signalling pathways, including TGFβ signalling, insulin signalling, focal adhesion, Notch Signalling, IL-6 signalling, endochondral ossification, TNF-α, and cytokines and inflammatory response.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Other pivotal features of melatonin are its anti-inflammatory properties, which decrease pro-inflammatory cytokines expression and factors such as IL-8, IL-6, and TNF.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Evaluate the prognostic capacity of tumor necrosis factor (TNF), kidney injury molecule (KIM), and lactate and TNF-α-308 G > A gene polymorphism for prediction of 28 days-intensive care unit (ICU) mortality.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Cardiac toll-like receptor 4 (TLR-4), inducible nitric oxide synthase (iNOS), tumor necrosis factor (TNF)-α and interleukin (IL)-6 protein expression were up-regulated, and lipid peroxidation was increased in DOX-administered rats.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Changes in body composition, glucose, insulin resistance (IR) and lipid profiles of tissues, plasma and the pattern of gene expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and its target genes fatty-acid synthase (FAS), adipocyte protein-2 (aP2) and uncoupling protein-2 (UCP-2) and pro-inflammatory factor tumor necrosis factor (TNF)-α were observed in experimental rats.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Interestingly, these genes are known for their involvement in inflammation and immune system (signaling by interleukins, cytokine signaling in immune system, NOD-like receptor signaling, MAPK signaling, Toll-like receptor signaling, and TNF signaling) pathways connected to RA.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Also, the effect of the diets on the expression of some immune-related genes in rainbow trout head-kidney (TNF, LYZ2, IL-8 and CD-4) as well as tumour suppressor gene (WT-1a) was investigated.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Global gene expression profiling of BMS-833923-treated compared to vehicle-treated control cells, identified 348 upregulated and 540 downregulated genes with significant effects on multiple signaling pathways, including GPCR, endochondral ossification, RANK-RANKL, insulin, TNF alpha, IL6, and inflammatory response.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “OBJECTIVE: The aim of this study was to investigate the association of proinflammatory cytokine genes, tumor necrosis factor (TNF)-α (-308G/A) and TNF-β (+252A/G) polymorphisms with schizophrenia susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Impact of TNF -308 G>A (rs1800629) gene polymorphism in modulation of leprosy risk: a reappraise meta-analysis of 14 case-control studies.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “RESULTS: We silenced ATG7 in HUVECs and observed >60% decreases in tumor necrosis factor (TNF)-α-induced tissue factor (TF) transcript levels, protein expression, and activity.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “DN group also exhibited high renal expression of the pro-inflammatory cytokine; tumor necrosis factor (TNF)-α, and the apoptotic marker; caspase 3, assessed by Western blot.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Kidneys were harvested for histopathology and for the study the gene expression of c-Jun N-terminal kinases (JNK), Mitogen-activated protein kinase 4 (MKK4), MKK7, P38 mitogen-activated protein kinases (P38), tumor necrosis factors alpha (TNF-α), TNF Receptor-Associated Factor 2 (TRAF2), and interleukin-1 alpha (IL-1-α).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Tumor necrosis factor (TNF)-α -308G/A (rs1800629) polymorphism distribution in North India and its association with pemphigus: Case-control study and meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The significance and occurrence of TNF receptor polymorphisms in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “In this study, we investigated the contribution of SNPs in interleukin (IL)-1B1 (rs16944), IL1A (rs1800587), IL1B (rs1143634), toll-like receptor (TLR)-2 (rs3804099), TLR4 (rs4986790), TLR4 (rs4986791), IL1R (rs2234650), tumor necrosis factor (TNF)-α (rs1800629), TNF (rs361525), and IL1RN (rs315952) towards the development of HO in Saudi patients and compared to healthy controls.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Single nucleotide polymorphisms in tumor necrosis factor (TNF) and interleukin (IL)-10 genes have been implicated in susceptibility to BD with inconsistent results in several ethnic populations.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The purpose of this study was to investigate the association of tumor necrosis factor (TNF)-α, TNF-β and interleukin (IL)-10 gene polymorphisms with the OLP risk.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “The aim of the present study was to measure the influence of chronic infection with viral hepatitis C (CHC) genotype 1 and 4 on serum levels of activin-A, activin-B and follistatin, and to determine their correlations with viral load, liver damage, interleukin-6 (IL-6) and tumour necrosis factor (TNF)-α.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Gene and protein expression of interleukin (IL)-1β, IL-10, IL-18, tumor necrosis factor (TNF)-α and intercellular adhesion molecule (ICAM)-1 was measured.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “This study evaluates tumor necrosis factor (TNF)-alfa gene expression in patients with end-stage renal disease (ESRD) on regular hemodialysis as an expression of cardiovascular disease (CVD) risk even on a sub-clinical level and its relation to some of the parameters incriminated in the pathogenesis and the establishment of uremic arteriopathy.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Polymerase chain reaction arrays revealed the activation of several apoptotic genes by CSC, including TNF receptors, caspases, Bax and p53.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “Increased TNF α, IL-6 and ErbB2 mRNA expression in peripheral blood leukocytes from breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “A bi allelic G to A polymorphism at -308 upstream from the transcription initiation site of the promoter is associated with elevated TNF levels.” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “A significantly higher incidence of TNF 2 /TNF 2 genotype was observed among patients with acute graft rejection in comparison with the control group (40.5% and 19.2% respectively, P <0.05), while no statistically significant differences were observed in the TNF 1 /TNF 1 genotype between the groups (59.4% and 80.8%, respectively, P >0.05).” | 0.98 | hgnc_dict_v1 |
| gene | TNF | “OBJECTIVE: To assess the effect of the common polymorphisms of the tumor necrosis factor (TNF)-238G>A with hepatocellular carcinoma (HCC) risks.” | 0.98 | hgnc_dict_v1 |