C677T
· 24 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| variant | C677T | “A single nucleotide polymorphism (SNP) of MTHFR (rs1801133; C677T) is strongly associated with an increased risk of thrombophilia, heart attack, stroke, and dementia.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms are associated with major depressive disorder in the Saudi patients attending Erada complex for mental health and Erada services - Jeddah, Saudi Arabia.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “The Association Between MTHFR C677T Gene Polymorphism and Repeated Pregnancy Loss in Arabic Countries: a Systematic Review and Meta-Analysis.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Genotype distributions of the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T variant for patients were (χ2 = 22.43) and for controls were (χ2 = 0.07); for the MTHFR A1298C variant, they were (χ2 = 54.44) for patients and (χ2 = 4.58) for controls.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Detection of Methylene Tetrahydrofolate Reductase (MTHFR C677T) Mutation among Acute Lymphoblastic Leukemia in Sudanese Patients.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Biochemical Association of MTHFR C677T Polymorphism with Myocardial Infarction in the Presence of Diabetes Mellitus as a Risk Factor.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “OBJECTIVE: Type 2 Diabetes is a glucose metabolic disorder occurred by insulin insensitivity in which folate metabolism plays an important role. it is believed that polymorphism of Methylenetetrahydrofolate reductase (MTHFR) C677T linked with type 2 diabetes mellitus.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “MTHFR C677T Polymorphism and Serum Homocysteine Level as Risk Factors of Coronary Heart Disease in Patients with Androgenetic Alopecia: A Case Control Study.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Chemiluminescence technology for vitamin B12, folate and total plasma homocysteine; ELISA for estradiol and 8-oxo-2-deoxyguanosine; Ellman's method for total glutathione; and PCR-RFLP analysis for the detection of methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism were employed.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “BACKGROUND: The rationale of the current study was to test the clinical utility of the folate pathway genetic polymorphisms in predicting the risk for autism spectrum disorders (ASD) and to address the inconsistencies in the association of MTHFR C677T and hyperhomocysteinemia with ASD.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Out of the eight polymorphisms analyzed, methylenetetrahydrofolate reductase (MTHFR) C677T exhibited positive association with the breast cancer risk in both fixed effects (OR 1.14, 95 % CI 1.10-1.17) and random effects (OR 1.10, 95 % CI 1.02-1.18) models.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Allelic polymorphisms of three thrombophilic genes (Factor V Leiden, Prothrombin A20210G, MTHFR C677T) were performed using PCR-RFLP (restriction fragment length polymorphism) and gel electrophoresis.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Impact of MTHFR (C677T) gene polymorphism on antiepileptic drug monotherapy in North Indian epileptic population.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Evaluation of Gestational Diabetes Mellitus Risk in South Indian Women Based on MTHFR (C677T) and FVL (G1691A) Mutations.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Genetic testing revealed the subject to be heterozygous for both the factor V leiden and MTHFR C677T polymorphisms.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Association of MTHFR C677T and A1298C gene polymorphisms with hypertension.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “In addition, inherited prothrombotic defects, such as protein C, protein S, and antithrombin deficiencies, and genetic mutations for FV Leiden, prothrombin gene G20210A (FII G20210A), and methyltetrahydrofolate reductase C677T (MTHFR C677T) were studied.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “The association of factor V-Leiden and methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C mutations with stroke was investigated in 118 patients with stroke and 120 control subjects.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Although allele frequency of C677T of MTHFR was statistically similar in the hemodialysis patients and in the control group, the homozygotes T allele genotype was over represented in the hemodialysis group compared to normal.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Traditional risk factors of CAD and protein C, S, antithrombin III deficiencies, factor V Leiden (FV Leiden), prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T mutations were investigated.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Two common variants in the MTHFR gene (C677T and A1298C) have been associated with reduced enzyme activity, thereby making MTHFR polymorphisms a potential candidate as a cancer-predisposing factor.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Factor V-Leiden, prothrombin G20210A, and MTHFR C677T mutations among patients with sickle cell disease in Eastern Saudi Arabia.” | 0.82 | literature_variant_regex_v2 |
| variant | C677T | “Factor V G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase [MTHFR] C677T gene polymorphism in angiographically documented coronary artery disease.” | 0.82 | literature_variant_regex_v2 |