TYK2
HGNC:12440 · SaudiVarKB evidence summary derived from retained literature mentions.
14Gene mentions
14Publications
6Linked variants
8Associated phenotypes
Associated phenotypes
Co-mentioned in TYK2 publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| rheumatoid arthritis | — | 2 | 2 |
| atopic dermatitis | — | 2 | 2 |
| inflammatory bowel disease | — | 2 | 2 |
| diabetes mellitus | — | 1 | 1 |
| COVID-19 | — | 1 | 1 |
| Crohn disease | — | 1 | 1 |
| ulcerative colitis | — | 1 | 1 |
| tuberculosis | — | 1 | 1 |
Linked variants
Variants normalized to TYK2Population context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | — | 1 |
| Not specified | — | — | 1 |
| Not specified | — | 19 | 1 |
| Saudi Arabia | — | 884 | 1 |
| Saudi Arabia | — | 16 | 1 |
Supporting publications
14 records- 2026Emerging synthetic drugs for the management of hidradenitis suppurativa: a comprehensive update.Expert opinion on pharmacotherapyPubMed ↗
- 2025High-Throughput Whole-Exome Sequencing and Large-Scale Computational Analysis to Identify the Genetic Biomarkers to Predict the Vedolizumab Response Status in Inflammatory Bowel Disease Patients from Saudi Arabia.BiomedicinesPubMed ↗
- 2025Defects in Innate and Intrinsic Immunity in Morocco: A Retrospective Analysis of the Genetic Landscape and Clinical Correlations.Pathogens & immunityPubMed ↗
- 2024Consanguineous marriages increase the incidence of recurrent tuberculosis: Evidence from whole exome sequencing.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesPubMed ↗
- 2024Exploring the Antiviral Potential of Artemisia annua Through JAK-STAT Pathway Targeting: A Network Pharmacology Approach.Pharmaceuticals (Basel, Switzerland)PubMed ↗
- 2023Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.Genome medicinePubMed ↗
- 2023Docking and Selectivity Studies of Covalently Bound Janus Kinase 3 Inhibitors.International journal of molecular sciencesPubMed ↗
- 2023Genome-Wide Identification of lncRNA and mRNA for Diagnosing Type 2 Diabetes in Saudi Arabia.Pharmacogenomics and personalized medicinePubMed ↗
- 2022Impaired IL-23-dependent induction of IFN-γ underlies mycobacterial disease in patients with inherited TYK2 deficiency.The Journal of experimental medicinePubMed ↗
- 2021Characterization of Rheumatoid Arthritis Risk-Associated SNPs and Identification of Novel Therapeutic Sites Using an In-Silico Approach.BiologyPubMed ↗
- 2019An Update on JAK Inhibitors.Current medicinal chemistryPubMed ↗
- 2019Computational Molecular Phenotypic Analysis of PTPN22 (W620R), IL6R (D358A), and TYK2 (P1104A) Gene Mutations of Rheumatoid Arthritis.Frontiers in geneticsPubMed ↗
- 2015Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome.The Journal of experimental medicinePubMed ↗
- 2013Clinical, immunological and molecular characterization of DOCK8 and DOCK8-like deficient patients: single center experience of twenty-five patients.Journal of clinical immunologyPubMed ↗