Population record
Saudi Arabia · 54 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| population | Saudi Arabia | “METHODS: We conducted a retrospective multicentre study of 100 children with genetically confirmed monogenic lupus diagnosed before the age of 14 years. Patients were enrolled between 2000 and 2025 from centres in Saudi Arabia, Iran, Russia, Italy, Palestine and Oman.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “BACKGROUND: Ischemic stroke poses a notable global public health challenge, with the Kingdom of Saudi Arabia (KSA) being no exception. METHODS: In this study we included 100 stroke patients and 100-120 healthy controls from Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Genetic Polymorphisms of Vascular Endothelial Growth Factor and Their Impact on Recurrent Spontaneous Miscarriage in Saudi Women. This study investigated the impact of VEGF gene polymorphisms on RSM in Saudi women. Blood samples were collected from 200 Saudi women (100 cases with RSM and 100 controls). VEGF polymorphisms, along with reduced VEGF serum levels, are associated with an increased risk of RSM in Saudi women.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “MATERIALS AND METHODS: A descriptive anatomical study was performed using 100 dry adult human mandibles (200 sides) obtained from three different Saudi university museums; all mandibles are of Indian origin.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “We identified 100 cases of endometrial carcinoma, which were eventually classified using immunostains for mismatch repair (MMR) and p53 proteins, in addition to Sanger analysis for POLE gene (Ex, 9, 13, 14). This is the first study conducted in Saudi Arabia that investigated the prevalence and implications of these molecular subtypes in endometrial carcinoma.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “METHODS: This is a retrospective study; we collected the data of the last 100 pediatric patients under the age of 29 months who underwent a three-dimensional (3D) skull computed tomography (CT) for reasons of trauma. CONCLUSIONS: The current study provides valuable insights into the prevalence and characteristics of skull suture variations in the Saudi pediatric population under the age of one, based on 3D CT imaging data.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The Genetic Polymorphisms of CYP2C9 and VKORC1 in the Saudi Population and Their Impact on Anticoagulant Management. The current study aims to investigate the frequency of CYP2C9 and VKORC1 variant genotypes and determine the appropriate warfarin dosage for patients in Saudi Arabia. Materials and Methods: Blood samples were collected from 100 Saudi patients undergoing treatment with warfarin. Conclusions: The findings indicate that genetic variations influence drug metabolism and response in the Saudi population, aligned with global studies.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Two hundred neonates (100 IDMs, 100 controls) underwent standardized echocardiographic assessment within the first week of life. Integration of IDM cardiac screening into regional neonatal care policies should be considered in high-prevalence settings such as Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Involvement of Single Nucleotide Variants in the Klotho Gene Among Obesity Individuals with and without Type 2 Diabetes Mellitus in the Saudi Population. AIM: The aim of this study is to examine the possible effect of SNVs in Klotho on the obese population in Saudi Arabia using middle-aged participants with and without T2DM. METHODS: This study consists of 100 controls and 100 obesity patients, in which 50 had T2DM and the remaining 50 were obese without T2DM. CONCLUSION: This study concludes that rs1207568 and rs9527025 SNVs are associated with obesity in the Saudi population. SNVs in Klotho play a role in the Saudi population's susceptibility to obesity.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Role of NQO1 Gene Involvement and Susceptibility of T2DM Among Saudi Arabia Population. The study included 100 newly diagnosed T2DM cases and 100 healthy individuals as healthy controls.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The aim of this study is to explore the role of A4889G polymorphism in CYP1A1 gene in acute myeloid leukemia (AML) in the Saudi population. This study was designed as an experimental case-control study in which 100 AML cases and 100 controls were selected. In conclusion, we confirm that A4889G polymorphism is associated with AML in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Exploring quality of life, discrimination, and knowledge of parents of ADHD children in Saudi Arabia: A cross-sectional study. Study participants were recruited using a convenient sampling technique from patient records in 4 regions of Saudi Arabia. A total of 100 participants were recruited for this study.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Examining the Genetic Role of rs8192675 Variant in Saudi Women Diagnosed with Polycystic Ovary Syndrome. This study aimed to investigate the rs8192675 SNP in women diagnosed with PCOS on a molecular level and further for T2DM development in the Saudi women. In this case-control study, 100 PCOS women and 100 healthy controls were selected. This study confirms that the rs8192675 SNP is associated with women with PCOS and strongly associated with women with PCOS with developed T2DM in Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Factors influencing blood pressure fluctuation in pediatric patients with sickle cell disease in Saudi Arabia: A retrospective single-center cohort study. METHODS: A total of 100 pediatric patients with SCD who followed up in the pediatric outpatient clinic were recruited for this retrospective cohort study.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Toll-like Receptor 9 Gene in the Development of Type 2 Diabetes Mellitus in the Saudi Arabian Population. Diabetes, notably type 2 diabetes mellitus (T2DM), is becoming more common in Saudi Arabia as a result of obesity and an aging population. T2DM is classified as a noncommunicable disease, and its incidence in the Saudi population continues to grow as a consequence of socioeconomic changes. As a result, the purpose of this study was to investigate the relationship between rs187084, rs352140, and rs5743836 SNPs in the TLR9 gene among T2DM patients in the Saudi population. This was a case-control study that included 100 T2DM cases and 100 control subjects. This study concluded that rs187084 and rs5743836 were strongly associated with T2DM in Saudi Arabian patients. This study provides further evidence that SNPs in the TLR9 gene play a significant role in T2DM development in a Saudi community.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “AIM: In this case-control study, C481T (rs1799929) and G857A (rs1799931) polymorphism studies were investigated in diagnosed AML patients in the Saudi population. METHODS: This case-control study included 100 AML patients and 100 control subjects recruited in Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Evidence of Association between CTLA-4 Gene Polymorphisms and Colorectal Cancers in Saudi Patients. It is highly expressed in several types of autoimmune diseases and cancers including colorectal cancer (CRC). (1) Objective: To explore the association between CTLA-4 single nucleotide polymorphisms (SNP) and risk to (CRC) in the Saudi population. (2) Methods: In this case-control study, 100 patients with CRC and 100 matched healthy controls were genotyped for three CTLA-4 SNPs: rs11571317 (-658C > T), rs231775 (+49A > G) and rs3087243 (CT60 G > A), using TaqMan assay method. The CTLA-4 mRNA gene expression was found significantly higher in tumors compared to normal adjacent colon samples (p < 0.001). (4) Conclusions: Our findings support an association between the CTLA-4 rs231775 (+49A > G) and rs3087243 (CT60 G > A) polymorphisms and CRC risk in the Saudi population. Further validation in a larger cohort size is needed prior to utilizing these SNPs as a potential screening marker in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “AIM: The purpose of this study was to investigate the effects of -656 T > G and 1349 T > G single nucleotide polymorphisms (SNPs) in the APE1 gene in Saudi women with PCOS. METHODS: This study includes 100 PCOS women and 100 healthy controls were genotyped for -656 T > G and 1349 T > G SNPs using PCR-RFLP method. CONCLUSION: This study found that the 1349 T > G SNP was related with PCOS in Saudi women.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Contribution of genetic variant identified in HHEX gene in the overweight Saudi patients confirmed with type 2 diabetes mellitus. AIM: The aim of this study was to investigate the rs7932837 polymorphism in the HHEX gene in overweight patients diagnosed with T2DM in the Saudi Population. METHODS: In this case-control study, one hundred T2DM cases and 100 controls were selected based on inclusion and exclusion criteria.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Screening of V617F mutation in JAK2 gene with acute myeloid leukemia in the Saudi population. The aim of this study was to induce V617F mutation in the JAK2 gene in the AML patients diagnosed in the Saudi population. In this case-control study, 100 AML patients and 100 healthy controls were recruited. In conclusion, the V617F mutation showed the positive association in the AML patients diagnosed in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Rs10204525 Polymorphism of the Programmed Death (PD-1) Gene Is Associated with Increased Risk in a Saudi Arabian Population with Colorectal Cancer. In this study, we aimed to assess the association between single nucleotide polymorphisms (SNP) of PD-1 and the risk of colorectal cancer (CRC) in the Saudi population. For this case-control study, the TaqMan assay method was used for genotyping three SNPs in the PD-1 gene in 100 CRC patients and 100 healthy controls.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Angiogenin Levels and Their Association with Cardiometabolic Indices Following Vitamin D Status Correction in Saudi Adults. This interventional study in vitamin D-deficient Saudi adults was designed to investigate it. A total of 100 vitamin D-deficient Saudi adults aged 30-50 years were randomly selected to undergo 6-month vitamin D supplementation.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “METHODS: This web-based survey was performed in 2020 at an eye hospital in Saudi Arabia. RESULTS: Of the 100 participants, 72 were aware of assessing mental health of eye patients and 82 expressed about limited skills for such assessment. The PHQ-9 related score was significantly correlated to "30-39 years" age group (Kruskal Wallis p = 0.04) and non-Saudi professionals (Mann Whitney p = 0.005). The GAD-7 related score was significantly correlated to non-Saudi professionals (Mann Whitney p = 0.04).” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Genotypic and phylogenic analyses of cutaneous leishmaniasis in Al Ahsa, Eastern Saudi Arabia during the coronavirus disease 2019 pandemic: First cases of Leishmania tropica with the predominance of Leishmania major. During the coronavirus disease 2019 lockdown period, a surge in sandflies and cutaneous leishmaniasis (CL) cases was observed in Al-Ahsa, Saudi Arabia. Skin punch biopsies were obtained from 100 patients clinically diagnosed with CL in Al-Ahsa who had no travel history in the last 6 months.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The connection between ACE gene and vitiligo is connected through the auto immune diseases and there are no genetic polymorphism studies have been carried out with ACE gene with vitiligo in the Saudi population. This is a case-control study carried out in the Saudi population with 100 vitiligo cases and 100 healthy controls. In conclusion, in Saudi populations, the ACE gene I/D polymorphism was identified as being correlated with vitiligo. This is the first study in Saudi Arabia to report the risk factors of vitiligo with the ACE gene polymorphism.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Mutational spectrum of BRAF gene in colorectal cancer patients in Saudi Arabia. Colorectal cancer (CRC) is one of the topmost causes of death in males in Saudi Arabia. It is very important to determine the genetic causes of CRC in the Saudi population. In this study, we mapped the spectrum of BRAF mutations in 100 Saudi patients with CRC. These findings provide insights into the molecular etiology of CRC in general and to the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Genetic Variants of RPL5 and RPL9 Genes among Saudi Patients Diagnosed with Thrombosis. OBJECTIVE: The aim of this work was to assess genetic variants of RPL5 and RPL9 and thrombosis to characterize their role in the diagnosis of thrombosis among the Saudi population. METHODS: The cross-sectional study involved 100 Saudi patients diagnosed with thrombosis (arterial or venous) in 50 healthy individuals as controls in the same age and sex groups. New gene variants of RPL5 (5 SNPs) and RPL9 (9 SNPs) were detected in Saudi thrombotic patients. CONCLUSION: Mutations in RPL5 and RPL9 were reported in all thrombotic patients, represented by a new variant of the ribosomal protein gene and correlated with thrombosis in the Saudi population. These results may reflect an association between the ribosomal protein SNP gene and the incidence and progression of thrombosis in the Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Sudden unexpected death in epilepsy: Experience of neurologists in Saudi Arabia. OBJECTIVE: This study aimed to examine the understanding and practices of SUDEP by neurologists in Saudi Arabia. METHODS: An electronic web-based survey was sent to 125 neurologists using the mailing list of the Saudi Neurology Society. No association was found between how often SUDEP was discussed and other factors, including training in epilepsy, ≥10 years in practice, seeing ≥100 patients, and having SUDEP cases in the past two years. CONCLUSIONS: Neurologists in Saudi Arabia do not often discuss SUDEP with patients that have epilepsy.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Whole Exome Sequencing Identifies Three Novel Mutations in the ASPM Gene From Saudi Families Leading to Primary Microcephaly. We studied three different families having primary microcephaly from different regions of Saudi Arabia. The identified respective mutations were ruled out in 100 healthy control samples. In conclusion, we found three novel mutations in the ASPM gene in Saudi families that will help to establish a disease database for specified mutations in Saudi population and will further help to identify strategies to tackle primary microcephaly in the kingdom.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Whole exome sequencing of a Saudi family and systems biology analysis identifies CPED1 as a putative causative gene to Celiac Disease. Therefore, we studied a Saudi family with two CD affected siblings to discover the causal genetic defect. Saudi population specific minor allele frequency (MAF) analysis has confirmed its extremely rare prevalence in homozygous condition (MAF is 0.0004). The Sanger sequencing analysis confirmed the absence of this homozygous variant in 100 sporadic Saudi CD cases. In conclusion, by using WES and systems biology analysis, present study for the first-time reports CPED1 as a potential causative gene for CD in a Saudi family with potential implications to both disease diagnosis and genetic counseling.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Whole exome sequencing reveals a homozygous nonsense mutation in HEXA gene leading to Tay-Sachs disease in Saudi Family. OBJECTIVE: To study the causative variants in affected member of a Saudi family with Tay-Sachs disorder. This mutation was also studied in 100 unrelated healthy controls.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Identification of Genetic Variants Associated With Myocardial Infarction in Saudi Arabia. The genetic variants associated with various genetic disorders have not been identified decisively in Saudi Arabia. Among these variants, six known for their association with coronary artery disease or myocardial infarction (MI) were studied on Saudi patients. A total of 100 MI patients and 103 healthy control individuals participated in this study. The six variants (SNPs) were evaluated for the risk of developing MI in the Saudi patients. Analysis of allele frequencies indicated that A allele of rs11591147 variant can be a protective allele, thus, is associated with the decreased risk of MI in Saudi individuals. Rare allele of rs111245230 variant (e.g., C allele) was extremely reduced, while rare allele of rs3782886 variant (e.g., G allele) does not exist in the ethnic signature of the Saudi population. This study elucidates the possible prediction of risk factors associated with severe diseases in Saudi population utilizing SNapShot multiplex system.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Screening of common genetic variants in the APOB gene related to familial hypercholesterolemia in a Saudi population: A case-control study. The present study was conducted to investigate the association of APOB and patients with FH in a Saudi population.We genotyped 100 patients with FH and 100 controls for 2 polymorphisms in APOB using polymerase chain reaction-restriction fragment length polymorphism, followed by 3% agarose gel electrophoresis. There was also no correlation between clinical characteristics and the rs151009667 polymorphism.In conclusion, we confirmed the association between the rs151009667 polymorphism and FH in a Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “CD163 is a predictive biomarker for prognosis of classical Hodgkin's lymphoma in Saudi patients. The aim of the present retrospective case-control study was to establish a gene expression profile of a specific biomarker for classical HL (CHL) in order to predict the outcome and survival of CHL patients in Saudi Arabia. Genotyping of selected SNPs of this antigen was performed for 100 CHL cases and controls.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Overall survival of classical Hodgkins lymphoma in Saudi patients is affected by XPG repair gene polymorphism. The present study aimed to define an SNP molecular profile, based on DNA repair genes mutations, as predictive biomarkers for the prognostic outcome of patients with Classical HL (CHL) in Saudi Arabia. Genotyping of selected SNPs located in selected DNA repair genes was performed on 100 CHL cases and an equivalent number of healthy controls. The present study also provided valuable insights on the contribution of DNA repair genes in Saudi patients with CHL. To the best of our knowledge, we defined for the first time, a specific genetic pattern associated with CHL outcome was defined in the present study in Saudi patients.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Involvement of microRNA-423 Gene Variability in Breast Cancer Progression in Saudi Arabia. Therefore, we investigated the prevalence of microRNA-423 rs6505162C>T gene variation with breast cancer susceptibility in Saudi women. Methodology: This study was conducted on 100 breast cancer patients and 124 matched healthy individuals. Some 6.73 ,4.14 and 2.63 fold increased risk of developing breast cancer was associated with TT and CT genotypes and the T allele of microRNA-423 in the northwestern region of Saudi Arabia. Conclusion: Our findings indicate that the microRNA-423 TT genotype and the T allele are associated with an increased susceptibility, metastasis and advanced stage of breast cancer in Saudi Arabian patients.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “To date, less than 100 cases of valgus SCFE have been described in the literature. Herein, we report the case of an 11-year-old Saudi Arabian girl presented to clinic with a one-year history of bilateral hip pain and limping.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Genetic Influence in Developmental Dysplasia of the Hip in Saudi Arabian Children Due to GDF5 Polymorphism. Developmental dysplasia of the hip (DDH) is quite common among Saudi Arabian babies. We collected and analyzed for a functional single nucleotide polymorphism (SNP) in the 5'-untranslated region of the GDF5 gene (rs143383), 473 blood samples, (100 patients, 200 parents, 73 siblings and 100 healthy controls.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “CYP19A1 gene polymorphism and colorectal cancer etiology in Saudi population: case-control study. PATIENTS AND METHODS: Blood samples from 100 CRC patients and 100 healthy controls were drawn for DNA extractions.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Early detection of myocardial dysfunction in poorly treated pediatric thalassemia children and adolescents: Two Saudi centers experience. PATIENTS AND METHODS: 100 thalassemic patients below 18 years old and 100 healthy, age & sex matched controls were enrolled in our case-control study. Cases were selected from those attending outpatient clinics and inpatient wards, King Abdulaziz University hospital and Alhada Armed Forces Hospital, Saudi Arabia, between January 2014 and January 2015.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The significance and occurrence of TNF receptor polymorphisms in the Saudi population. Background and objective: On the basis that the inflammatory effects of TNF (tumour necrosis factor) are predominantly mediated through interaction with the TNF receptor-1 (TNFRSF1A), the current study was designed to establish the prevalence of the mutations, R92Q and P46L TNFRSF1A polymorphisms both in the general healthy Saudi population, and in Saudi patients carrying inflammatory diseases such as atherosclerosis or rheumatoid arthritis. We felt it important to report the frequency of the mutations, R92Q and P46L TNFRSF1A polymorphisms in healthy Saudi individuals, and those with inflammatory conditions, as well as to describe the pattern of immunological factors in individuals expressing R92Q or P46L TNFRSF1A. Patients and methods: We collected in PAX gene blood RNA tubes (for RT-PCR and sequencing) 500 blood samples from normal healthy individuals from the West and Center of Saudi Arabia, as well as 100 from patients with atherosclerosis, and 100 patients diagnosed with rheumatoid arthritis. Conclusion: Our findings reasonably anticipate the presence of TRAPS disease (low penetrance mutations) amongst the Saudi population although further studies are needed to confirm these results.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Association of Vitamin D Receptor Gene Polymorphisms with Colorectal Cancer in a Saudi Arabian Population. OBJECTIVE: To assess the association of VDR gene polymorphisms in relation with colorectal cancer (CRC) in a Saudi population. One hundred diagnosed CRC patients and 100 healthy control subjects that were age and gender matched were recruited. In addition, statistically significant differences were observed for the genotypic distributions of VDR-BsmI, ApaI and TaqI SNPs between Saudi Arabian population and several of the International HapMap project populations. These findings need further validation in larger cohorts prior to utilizing these SNPs as potential screening markers for colorectal cancers in Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “One hundred CRC patients and 100 controls were genotyped for TNF-α -308, -238, and -857 using TaqMan allelic discrimination assay. TNF-α -238A may be useful as a screening marker to identify individuals prior to their acquiring CRC in the Saudi population although, further validations in larger cohorts are needed.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “In this study, we evaluated the association between ACE polymorphism and the risk of MGH in a Saudi population. We conducted a case-control study in a population of 100 MGH patients and 100 control subjects. Our study suggests that ACE genotypes were not associated with ACE polymorphism in a Saudi population.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Analysis of the SOD1 Gene in Keratoconus Patients from Saudi Arabia. We investigated Saudi patients with familial and sporadic Keratoconus for mutations in the Superoxide dismutase 1, soluble (SOD1) gene. We sequenced the entire coding region, exon-intron boundaries and intron 2 encompassing a 7-bp deletion in clinically confirmed Keratoconus patients (n = 55) and 100 ethnically matched healthy controls.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “MATERIALS AND METHOD: A total of 100 sickle cell patients (SS), 50 sickle cell trait patients (AS) and 50 healthy control individuals were included in the present study. CONCLUSION: The presence of the Arab-Indian haplotype as the predominant haplotype might be suggestive of a gene flow to/from Saudi-Arabia or India and it was associated with higher HbF levels and a milder disease severity.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic population of Saudi Arabia, an emerging high-risk area. Saudi Arabia has witnessed an increase in occurrence of breast cancer in its unexplored ethnic populations over the past few years. TaqMan based Real Time Polymerase chain reaction genotyping assays were used to determine the frequency of single nucleotide polymorphisms in BRCA1 (rs799917) and BRCA2 (rs144848) in a group of 100 breast cancer patients and unaffected age matched controls of Saudi Arabian origin. The differences could be due to exposure to particular environmental carcinogens; different lifestyle, reproductive pattern; dietary or cultural practices of Saudi Arabian women that need further investigations.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Association of multiple drug resistance-1 gene polymorphism with multiple drug resistance in breast cancer patients from an ethnic Saudi Arabian population. Blood samples from 100 healthy individuals are used, as controls were also genotyped for the MDR1 gene. These findings demonstrate, for the first time, that the polymorphisms in (exon 12) 1236 codon of the MDR1 gene greatly influence the drug response in patients from the Arab population of Saudi Arabia.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “OBJECTIVES: We aimed to analyse INSR mutations in Saudi patients with severe insulin resistance. DESIGN: Ten patients with Type A insulin resistance syndrome from five unrelated Saudi families were investigated. The c.433 C>T (p.R118C) sequence variation was not found in 100 population controls. CONCLUSIONS: Biallelic c.433 C>T (p.R118C) mutation of INSR causes significant damage to insulin binding and insulin-mediated signal transduction. p.R118C is a founder mutation frequently present in the Saudi patients with severe insulin resistance.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Interleukin 17A and F and asthma in Saudi Arabia: gene polymorphisms and protein levels. PATIENTS AND METHODS: The study group included 100 asthma patients and 102 ethnically matched controls. Levels of IL17A and IL17F were positively and significantly correlated in the asthma patients CONCLUSION: Of all the SNPs analyzed, only rs17880588 showed a significant association with asthma in the Saudi population we studied.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “High rate of persistent/recurrent disease among patients with differentiated thyroid cancer in Saudi Arabia: factors affecting nonremission. METHODS: The study included 100 consecutively treated patients (20 males, 80 females; median age 36 years) diagnosed with DTC.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “The King Faisal Specialist Hospital and Research Centre in the Kingdom of Saudi Arabia treats approximately 100 new cases per month.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Hemoglobin H disease in the eastern region of Saudi Arabia. OBJECTIVE: Alpha-thalassemia is frequently encountered in eastern Saudi Arabia. We found 100 cases of Hemoglobin H disease, only one case was non-Saudi. The genetic studies to determine the exact alpha-thalassemia determinants producing Hb H disease in eastern Saudi Arabia are needed.” | 0.95 | saudi_context_rules_v1 |
| population | Saudi Arabia | “Sensorineural hearing loss in homozygous sickle cell disease in Qatif, Saudi Arabia. The control group consisted of 100 healthy individuals.” | 0.95 | saudi_context_rules_v1 |