IL6
HGNC:6018 · 33 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IL6 | “We further identified 201 common upregulated hub genes (including MMP9, CDH1, HSP90AB1, SOX2, CDKN2A, SPP1, EZH2) and 224 common downregulated hub genes (such as IL6, TNF, IL1B, JUN, CCL2, TLR4, FOS, PTGS2).” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Hub genes such as TNF, IL6, CASP3, and GPX1 highlighted potential interactions among pathways affected by niclosamide.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “The present study aimed to evaluate the ethnoveterinary supplementation of banana peel extract powder (BPP) against Salmonella enterica subspecies enterica serovar Gallinarum biotype Gallinarum (Salmonella Gallinarum), focusing on two key immune-related genes (IL6 and MHC class IIβ), gut morphology, and growth performance of broiler chickens experimentally challenged with Salmonella Gallinarum.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Clinical evaluation, complete blood count, biochemical analysis, cytokine profiling, antioxidant assays, hepatic ultrasonography, quantitative real-time PCR of immune (IL6, IL8), antioxidant (SOD3, HMOX1), and lipogenic (ACACA, FASN) genes, and PCR-DNA sequencing were performed.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Network pharmacology analysis, integrating targets predicted via SwissTargetPrediction and disease-associated genes from GeneCards, identified PPARG, ESR1, and IL6 as key hub genes underlying OFSO's effects.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “In NT2/D1 cells, TG7 silencing using 20 nM DsiRNA3 led to a dose-dependent reduction in cell viability, with up to 48% inhibition observed at 200 nM (MTT assay, ****p < 0.0001). qRT-PCR analysis revealed significant upregulation of IL6 (3.2-fold), TNFα (2.8-fold), and CASP3 (2.5-fold) mRNA levels following TG7 knockdown (p < 0.0001), while p53 expression remained unchanged.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Ten hub genes were identified, with CXCR4, MMP9, CTLA4, CD80, and ICOS upregulated, and IL6, KIT, PPARG, SLC2A4, and CEBPA downregulated.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Transcriptomics analysis found that ABP enriched TNF and hematopoietic pathways, with IL6 and IL1β as key pro-inflammatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “EAC-induced renal and hepatic damage was accompanied by elevated expression of proinflammatory biomarkers (TGF-β, NFκB, and IL6 genes) and altered serum apoptotic signaling, including reduced p53, Bax, caspase-3, and cytochrome c levels, alongside increased Bcl-2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “In Group II, genes such as LIF, LBP, CSF3, IL6, CCL2, SAA1, CCL20, MMP9, CXCL10, and MMP1 were found to be involved in the transformation to adult glioblastoma.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “In silico results identified 112 inflammation-associated gene targets, whereas tumor necrosis factor (TNF), IL6, and AKT1 were identified as top hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Pioglitazone pre-treatment reduced the expression of pro-inflammatory cytokine genes (IL6 and TNF).” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “PARP-1 inhibition reduced HG-induced inflammatory response, including NF-kB, IL6, IL1β, TNFα, iNOS, and TGF-β expression, and HG-induced apoptosis response, such as Cas-3, Cas-9, BAK, BAX, and AIF expression.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Ten key genes were found to be significantly associated with bladder cancer: IL6, CCNA2, CCNB1, CDK1, PLK1, TOP2A, AURKA, AURKB, FOXM1, and CALML5.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “While, the proinflammatory genes expression (IL1B, IL6, IFNᵧ, and TNF) were down regulated (p ≤ 0.001) in the LGX200 compared to others.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Besides routine histology and immunocytochemistry detection (cytokeratin-7 [CK-7]), addition to biochemical evaluation of expression of various cytokines including tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), IL6, IL-1RA, IL-8, IL-10, and IL-13 was carried out.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “The healing of diabetic wounds was assessed by measuring wound closure, oxidative stress markers, immunohistochemical staining of NF-βB, VEGF, CD34, CD45, Ki-67, and eNOS, gene expression of MMP-9, TGF-β1, EGF-b1, FGF, and Col1A1, protein levels of TNFα, IL-1β, IL6, Ang II, and HIF-1α by ELISA assay, and histological examination with H & E and Masson's trichrome.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “In the framework of this study, we explored the active ingredient-target-pathway network and figured out that oleanolic acid, arjunolic acid, luteolin, kaempferol, cholesterol, ellagic acid 4-O-xylopyranoside 3,3'-dimethyl ether, and cyclohexyl (2,4-dimethyl phenyl) methanone contributed significantly to the development of CCF by affecting AKT1, MAPK14, TNF, IL6, ESR1, and HSP90AA1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “This study was designed to screen serum levels using an enzyme linked immunosorbent assay (ELISA) and genetic variants in the TNF-α and IL6 genes using polymerase chain reactions (PCR).” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “By combining the PARP inhibitor (PARPi), talazoparib, with radiation, senescence was enhanced in 4T1 and MDA-MB-231 triple-negative breast cancer cell lines (based on SA-β-gal upregulation, increased expression of CDKN1A and the senescence-associated secretory phenotype (SASP) marker, IL6).” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “For example, miRNAs can regulate STAT3 via targeting its upstream mediators such as IL6, IL9, and JAKs or directly binding to the STAT3 gene.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Montelukast was more effective in reducing serum levels of IL6 and iNOS, expression of TNF-α and IL-1β, and the upregulation of IL-10 expression.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Also, in the hippocampus, the expression of IL6 and Bcl-2 at the mRNA level and expression of Sirt-1, P53, caspase-3, GFAP, and NF-kB in CA3 hippocampal region by immunohistochemistry was investigated.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Fedratinib inhibited the expression of LIF, SOCS3, RRAD, NOTCH3, TNF, COMP, THBS2, and IL6, which are associated with various signalling pathways, including TGFβ signalling, insulin signalling, focal adhesion, Notch Signalling, IL-6 signalling, endochondral ossification, TNF-α, and cytokines and inflammatory response.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Chemopreventive effects were accompanied by decreased VEGFA expression, ablated IL6, COX-2, and p-NF-κB, and decreased pulmonary M2 macrophages and myeloid-derived suppressor cells.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Global gene expression profiling of BMS-833923-treated compared to vehicle-treated control cells, identified 348 upregulated and 540 downregulated genes with significant effects on multiple signaling pathways, including GPCR, endochondral ossification, RANK-RANKL, insulin, TNF alpha, IL6, and inflammatory response.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Global gene expression profiling of LY411575-treated cells revealed changes in multiple signaling pathways, including focal adhesion, insulin, TGFβ, IL6, and Notch signaling, and decreased the expression of genes associated with functional categories of tissue development.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Elevated gene expression was also evident from the level of these proteins in plasma, where the level of IL1α, IL-β were significantly higher in the serum of PTB patients compared to the controls, however, IL6 and TNF-α were significantly lower despite higher gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “IL-33 markedly stimulated expression of the IL1B, CCL2, IL6, CXCL2 and CSF3 genes, but there was no effect on ADIPOQ expression.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “DHA slightly countered the actions of IL-1β on CCL2, IL6 and ADIPOQ expression, though not on secretion of these adipokines.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “Our results showed that progressive CRCLM after PVE undergo gene expression changes that indicate activation of core cancer pathways (IL-17 (p = 5.94 × 10-03), PI3K (p = 8.71 × 10-03), IL6 and IGF-1 signaling pathways), consistent with changes driven by cytokines and growth factors.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “RESULTS: Suggestive relationships have been established between lipid plasma levels and total bilirubin and SNPs in CETP, MCP1, ABCC2, LEP and SLCO1B3 genes and between diarrhea and SNPs in IL6 gene.” | 0.98 | hgnc_dict_v1 |
| gene | IL6 | “CONCLUSION: Genetic polymorphisms related to the IL6, IL10, and TNF-alpha genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.” | 0.98 | hgnc_dict_v1 |