hepatocellular carcinoma
SaudiVarKB evidence summary derived from retained literature mentions.
298Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| STAT3 | HGNC:11364 | 9 | 9 |
| TP53 | HGNC:11998 | 8 | 8 |
| AFP | HGNC:317 | 7 | 7 |
| BCL2 | HGNC:990 | 6 | 6 |
| BAX | HGNC:959 | 6 | 6 |
| EGFR | HGNC:3236 | 4 | 4 |
| TLR4 | HGNC:11850 | 4 | 4 |
| MMP9 | HGNC:7176 | 4 | 4 |
| MYC | HGNC:7553 | 4 | 4 |
| AURKA | HGNC:11393 | 4 | 4 |
| CD4 | HGNC:1678 | 3 | 3 |
| CTNNB1 | HGNC:2514 | 3 | 3 |
| JAK2 | HGNC:6192 | 3 | 3 |
| TLR3 | HGNC:11849 | 3 | 3 |
| SMAD4 | HGNC:6770 | 3 | 3 |
| RB1 | HGNC:9884 | 3 | 3 |
| CASP3 | HGNC:1504 | 3 | 3 |
| CENPF | HGNC:1857 | 3 | 3 |
| NCAPG | HGNC:24304 | 3 | 3 |
| PNPLA3 | HGNC:18590 | 3 | 3 |
| MICA | HGNC:7090 | 3 | 3 |
| TNF | HGNC:11892 | 2 | 2 |
| GLI1 | HGNC:4317 | 2 | 2 |
| PTEN | HGNC:9588 | 2 | 2 |
| LDLR | HGNC:6547 | 2 | 2 |
| CYP3A4 | HGNC:2637 | 2 | 2 |
| AKT1 | HGNC:391 | 2 | 2 |
| VDR | HGNC:12679 | 2 | 2 |
| HFE | HGNC:4886 | 2 | 2 |
| RRM2 | HGNC:10452 | 2 | 2 |
| PIK3CA | HGNC:8975 | 2 | 2 |
| CD44 | HGNC:1681 | 2 | 2 |
| JAK1 | HGNC:6190 | 2 | 2 |
| APOB | HGNC:603 | 2 | 2 |
| HSP90AA1 | HGNC:5253 | 2 | 2 |
| TPMT | HGNC:12014 | 2 | 2 |
| MCM2 | HGNC:6944 | 2 | 2 |
| CEP55 | HGNC:1161 | 2 | 2 |
| HOTAIR | HGNC:33510 | 2 | 2 |
| CCNB1 | HGNC:1579 | 2 | 2 |
| MAPK3 | HGNC:6877 | 2 | 2 |
| ERBB2 | HGNC:3430 | 2 | 2 |
| TOP2A | HGNC:11989 | 2 | 2 |
| PRKCG | HGNC:9402 | 2 | 2 |
| NFE2L2 | HGNC:7782 | 2 | 2 |
| DEPDC5 | HGNC:18423 | 2 | 2 |
| PARP1 | HGNC:270 | 1 | 1 |
| PAH | HGNC:8582 | 1 | 1 |
| COL1A1 | HGNC:2197 | 1 | 1 |
| MCM4 | HGNC:6947 | 1 | 1 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| rs1331262028 | rs1331262028 | 2 | 2 |
| rs2596542 | rs2596542 | 2 | 2 |
| rs5743314 | rs5743314 | 2 | 2 |
| rs2856718 | rs2856718 | 2 | 2 |
| rs9275572 | rs9275572 | 2 | 2 |
| rs7453920 | rs7453920 | 2 | 2 |
| rs6505162 | rs6505162 | 1 | 1 |
| rs1544410 | rs1544410 | 1 | 1 |
| rs11614913 | rs11614913 | 1 | 1 |
| rs731236 | rs731236 | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| p.H166R | p.H166R | 1 | 1 |
| G894T | G894T | 1 | 1 |
| rs2228570 | rs2228570 | 1 | 1 |
| rs231775 | rs231775 | 1 | 1 |
| rs7975232 | rs7975232 | 1 | 1 |
| rs14095 | rs14095 | 1 | 1 |
| rs114416617 | rs114416617 | 1 | 1 |
| rs145795985 | rs145795985 | 1 | 1 |
| rs1951964 | rs1951964 | 1 | 1 |
| rs45582331 | rs45582331 | 1 | 1 |
| rs44582331 | rs44582331 | 1 | 1 |
| rs3742305 | rs3742305 | 1 | 1 |
| rs361525 | rs361525 | 1 | 1 |
| N103D | N103D | 1 | 1 |
| Q30K | Q30K | 1 | 1 |
| I208T | I208T | 1 | 1 |
| rs378117 | rs378117 | 1 | 1 |
| rs1329774 | rs1329774 | 1 | 1 |
| rs4745058 | rs4745058 | 1 | 1 |
| rs2427043 | rs2427043 | 1 | 1 |
| rs76228864 | rs76228864 | 1 | 1 |
| rs76754767 | rs76754767 | 1 | 1 |
| rs45593131 | rs45593131 | 1 | 1 |
| rs2792999 | rs2792999 | 1 | 1 |
| rs8038528 | rs8038528 | 1 | 1 |
| rs1998853 | rs1998853 | 1 | 1 |
| rs12440990 | rs12440990 | 1 | 1 |
| rs4774596 | rs4774596 | 1 | 1 |
| rs3787728 | rs3787728 | 1 | 1 |
| rs1005695 | rs1005695 | 1 | 1 |
| rs2243250 | rs2243250 | 1 | 1 |
| rs1800795 | rs1800795 | 1 | 1 |
| rs1162102190 | rs1162102190 | 1 | 1 |
| rs868127012 | rs868127012 | 1 | 1 |
| rs750830348 | rs750830348 | 1 | 1 |
| rs768619375 | rs768619375 | 1 | 1 |
| rs752329416 | rs752329416 | 1 | 1 |
| rs2910164 | rs2910164 | 1 | 1 |
| rs1199520604 | rs1199520604 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Phytochemical Profiling and Anticancer Potential of Fagonia cretica L. Extracts on Liver Cancer (HepG2) Cells using In vitro and In silico Approaches.Anti-cancer agents in medicinal chemistry1 mentions
- 2026Citrate-capped AuNPs-induced redox reprogramming modulates the TP53-BAX/BCL2-CASP3 Axis, reinforcing antioxidant defense and promoting apoptotic signaling in liver Cancer.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy1 mentions
- 2026Bacterial-extract mediated gold nanoparticles: Enhanced uptake, oxidative stress, and cytotoxicity in HepG2 cells with biofilm inhibition and antibiotic synergy.Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy1 mentions
- 2026In silico identification of a prognostic gene signature and virtual screening for hepatocellular carcinoma.Computational biology and chemistry1 mentions
- 2026Intermittent fasting and liver disease: Insights from the Ramadan model.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association1 mentions
- 2026Nanoparticle-based approaches for doxorubicin delivery in hepatocellular carcinoma: Current strategies and emerging innovations.Seminars in oncology1 mentions
- 2026MicroRNA-mediated metabolic control in HCC: From molecular networks to therapy.Experimental cell research1 mentions
- 2026Integrative analysis of tissue and circulating miRNAs as biomarkers for progression and survival in hepatocellular carcinoma.Non-coding RNA research1 mentions
- 2026Unraveling risk factors and transcriptomic signatures in liver cancer progression and mortality through machine learning and bioinformatics.Briefings in functional genomics1 mentions
- 2026Association between elevated PRIM1 expression and poor prognosis in human urothelial carcinoma.Journal of Taibah University Medical Sciences1 mentions
- 2026Clinical biomarkers and biosensors for early detection of metabolic dysfunction-associated steatohepatitis (MASH): a translational perspective.Frontiers in bioengineering and biotechnology1 mentions
- 2026Carriage of rare APOB variants predisposes to severe steatotic liver disease and hepatocellular carcinoma.The Journal of clinical investigation1 mentions
- 2026Genetic insights into hepatocellular carcinoma: the role of VDR FokI (rs2228570) and TaqI (rs731236) polymorphisms in Egyptian patients.BMC medical genomics1 mentions
- 2026Comprehensive multi-omics analysis reveals RUNX1's prognostic value, immune associations, and MUC13-Mediated mechanistic role in hepatocellular carcinoma pathogenesis.Biochemistry and biophysics reports1 mentions
- 2026Identification of potential key genes and molecular mechanisms of oral squamous cell carcinoma based on integrated bioinformatics approach.Journal, genetic engineering & biotechnology1 mentions
- 2026Engineering CAR-based cellular immunotherapy for hepatocellular carcinoma: Current barriers, innovative strategies, and future directions.Critical reviews in oncology/hematology1 mentions
- 2026Single-Cell Transcriptomic Integration Identifies LTA4H as an Immune-Associated Therapeutic Target in Hepatocellular Carcinoma.Cell biochemistry and biophysics1 mentions
- 2026FedLiverNet: a federated learning framework for privacy-preserving and efficient liver cancer detection.Scientific reports1 mentions
- 2026Beyond silencing: integrative multi-omics and spatial profiling unravel the systems-level role of piRNAs in HBV-driven Hepatocarcinogenesis.Molecular biology reports1 mentions
- 2026Liver transplantation for Wilson disease: a spectrum from acute liver failure to Neuro-Wilson.BMC gastroenterology1 mentions
- 2026Breaking the serologic rule: chronic hepatitis B with simultaneous HBsAg and anti-HBs positivity-a case report.Journal of medical case reports1 mentions
- 2026Green synthesis of Ginkgo biloba-mediated magnetite (Fe3O4) nanoparticles: multifunctional antimicrobial, anticancer, and antioxidant activities with molecular mechanistic insights.Bioprocess and biosystems engineering1 mentions
- 2026Development and Characterization of PEGylated β-Carotene-Loaded Liposomes as Radiosensitizers in HepG2 Hepatocellular Carcinoma Cells: In Vitro and In Silico Studies.Anti-cancer agents in medicinal chemistry1 mentions
- 2026AI in multi-omics analysis of liver diseases.Progress in molecular biology and translational science1 mentions
- 2026Uncovering Prognostic Biomarkers Underlying Hepatocellular Carcinoma Through Integrative Multi-Omics and a Network-Based Approach.International journal of molecular sciences1 mentions
- 2026Hepatitis B virus-induced hepatocellular carcinoma: HBx-associated epigenetic mechanisms and therapeutic opportunities.Cancer gene therapy1 mentions
- 2026Peri-transplant use of immune checkpoint inhibitors in hepatocellular carcinoma: a transplant oncology perspective on safety, timing, post-transplant management, and future directions.Frontiers in oncology1 mentions
- 2026Novel Monoazo Dispersion Dyes Incorporating a 4-thiazolidinone Moiety: Synthesis, Structural Characterization, Molecular Docking, and Anticancer Investigations.Current medicinal chemistry1 mentions
- 2026Synthesis and multilevel evaluation of benzimidazole-based anticancer compounds: DNA/serum albumin interaction, and in-depth theoretical insights.Molecular and cellular biochemistry1 mentions
- 2025A Saffron-based Polyherbal Formulation DuK Prevents Hepatocellular Carcinoma in Male Wistar Rats.Current cancer drug targets1 mentions
- 2025Network-base approaches to identify therapeutic biomarkers in hepatocellular carcinoma and search for drug hunting utilizing molecular dynamics simulations.Journal of biomolecular structure & dynamics1 mentions
- 2025MicroRNA as Key Players in Hepatocellular Carcinoma: Insights into Their Role in Metastasis.Biochemical genetics1 mentions
- 2025Phosphoinositide 3-Kinase Inhibitors from Gladiolus Segetum Ker-Gawl Corms Supported by Network Pharmacology.Chemistry & biodiversity1 mentions
- 2025FGF21 affects the glycolysis process via mTOR-HIF1α axis in hepatocellular carcinoma.Cellular signalling1 mentions
- 2025Current advances in nanoparticle-based approaches for the hepatocellular carcinoma treatment.Clinics and research in hepatology and gastroenterology1 mentions
- 2025Pathological roles of lncRNA HOTAIR in liver cancer: An updated review.Gene1 mentions
- 2025A Comprehensive Review Highlighting the Prospects of Phytonutrient Berberine as an Anticancer Agent.Journal of biochemical and molecular toxicology1 mentions
- 2025Aloe arborescens Standardized Glycosidic Fraction Suppresses Hepatocarcinoma by Modulating TIMP1, MMP9 Genes Expression, and Inflammation/Ki67/TGFβ1 Pathway.Phytotherapy research : PTR1 mentions
- 2025Personalized treatment approaches in hepatocellular carcinoma.Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology1 mentions
- 2025HCV and HBV genotypes: vital in the progression of HCV/ HBV co-infection.BMC gastroenterology1 mentions
- 2025Insights into the cytotoxicity of photoactivatable Ru(II) carbonyl complexes towards human liver carcinoma cells.Bioorganic chemistry1 mentions
- 2025Unveiling NLR pathway signatures: EP300 and CPN60 markers integrated with clinical data and machine learning for precision NASH diagnosis.Cytokine1 mentions
- 2025Novel triazoloquinazoline derivatives as VEGFR inhibitors: synthesis, cytotoxic evaluation and in silico studies.Future medicinal chemistry1 mentions
- 2025Antimicrobial and cytotoxic activities of natural (Z)-13-docosenamide derived from Penicillium chrysogenum.Frontiers in cellular and infection microbiology1 mentions
- 2025The role of Prolyl 3-Hydroxylase 1 (P3H1) in tumor development and prognosis: a pan-cancer analysis with validation in colonic adenocarcinoma.American journal of translational research1 mentions
- 2025Sirtuins and Gut Microbiota: Dynamics in Health and a Journey from Metabolic Dysfunction to Hepatocellular Carcinoma.Cells1 mentions
- 2025Differentially expressed and alternately spliced genes as a novel tool for genotoxicity: a computerized study in ATT-myc transgenic mice for the recognition of genotoxic and non-genotoxic chemical.Frontiers in genetics1 mentions
- 2025Therapeutic potential of Bacopa monnieri extracts against hepatocellular carcinoma through in-vitro and computational studies.PloS one1 mentions
- 2025Chronic active and chronic inactive hepatitis B virus infection: Comparative study of genetic polymorphism and blood profile measures.PloS one1 mentions
- 2025Anthocyanins: From Natural Colorants to Potent Anticancer Agents.Food science & nutrition1 mentions
- 2025Deciphering cGAS-STING signaling: implications for tumor immunity and hepatocellular carcinoma.Naunyn-Schmiedeberg's archives of pharmacology1 mentions
- 2025Hepatobiliary Cancers in Saudi Arabia From 2000 to 2025.Cureus1 mentions
- 2025Enhancing hepatocellular carcinoma treatment: synergistic cytotoxicity and mechanistic insights of Ramucirumab and 5-Azacytidine combination therapy.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2025The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele-Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma Receiving Doxorubicin via Transarterial Chemoembolization.Pharmacology research & perspectives1 mentions
- 2025In vivo and in vitro therapeutic evaluation of bone marrow-derived mesenchymal stem cells in liver cancer treatment.Frontiers in cell and developmental biology1 mentions
- 2025Preliminary Evaluation of Plasma circ_0009910, circ_0027478, and miR-1236-3p as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma.International journal of molecular sciences1 mentions
- 2025Anticancer Effects of Monacolin X Against Human Liver Cancer Cell Line: Exploring the Apoptosis Using AO/EB and DCFHDA Fluorescent Staining.Luminescence : the journal of biological and chemical luminescence1 mentions
- 2025Imiquimod-Loaded Phospholipid-Free Small Unilamellar Vesicles Activate the Tumor Immune Microenvironment to Treat Liver Cancer and Liver Metastases.Advanced healthcare materials1 mentions
- 2025Genetic polymorphisms as predictors of the response of hepatocellular carcinoma patients to doxorubicin chemotherapy: a genome-wide association study.Frontiers in pharmacology1 mentions
- 2025Mutational landscape of the surface antigen of hepatitis B virus in patients with hepatocellular carcinoma.Gut pathogens1 mentions
- 2025Endophytic Trichoderma asperellum WNZ-21 produces novel bioactives with anticancer, anti-inflammatory, and hemoprotective properties from fermented bean biomass.Frontiers in microbiology1 mentions
- 2025Non-coding RNAs as key regulators in hepatitis B virus-related hepatocellular carcinoma.Frontiers in immunology1 mentions
- 2025Role of Liquid Biopsy for Early Detection, Prognosis, and Therapeutic Monitoring of Hepatocellular Carcinoma.Diagnostics (Basel, Switzerland)1 mentions
- 2025A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy.Food science & nutrition1 mentions
- 2025Shallow whole-genome sequencing of circulating tumour DNA predicts clinical outcomes to systemic therapy in advanced hepatocellular carcinoma.European journal of cancer (Oxford, England : 1990)1 mentions
- 2025Revolutionizing cancer treatment with Halomonas Aquamarina L-Glutaminase: insights from in vitro and computational studies.Scientific reports1 mentions
- 2025Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression.Discover oncology1 mentions
- 2025Reprogramming the hepatic immune microenvironment with mirtazapine in early neoplastic transformation: Evidence from a diethylnitrosamine-induced rat model.Chemico-biological interactions1 mentions
- 2025Resveratrol Alleviates Aflatoxin B1-induced Renal Cortex Oxidative Stress and Apoptosis in Adult Male Albino Rats.International journal of applied & basic medical research1 mentions
- 2025Green algae-derived sulfated polysaccharide-capped AgNPs with Decanoic and 9-Octadecenoic acid derivatives induce cytotoxicity via PI3Kα/mTOR pathway in HepG2 cell line.International journal of biological macromolecules1 mentions
- 2025Folate- and chitosan-functionalized lipid nanoparticles for co-delivery of pioglitazone and simvastatin to enhance hepatic cancer therapy: effects on IL-1β, IL-6, BCL2/BAX gene expression, and GPX4, COX-2, and MMP-9 activities.Molecular biology reports1 mentions
- 2025Estimating high mobility group box protein 1 (HMGB1) single nucleotide polymorphisms among hepatitis B virus infected patients of Pakistan origin.Brazilian journal of biology = Revista brasleira de biologia1 mentions
- 2025DC09, Derivative of 3-(2-hydroxy-5-methoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one Attenuates Nonalcoholic Fatty Liver Disease by Targeting PI3K/Akt Pathway: Insights From In-Vivo Zebrafish Model and In-Vitro HepG2 Cell.Journal of biochemical and molecular toxicology1 mentions
- 2025Oncogenic EME1 promotes tumor progression and immune modulation in human cancers with therapeutic targeting potential.Discover oncology1 mentions
- 2025Selective Angiographic Roadmap Analysis (SARA) of Hepatocellular Carcinoma Feeding Arteries for Transarterial Chemoembolization.Diagnostics (Basel, Switzerland)1 mentions
- 2025Investigating the Roles of MAPKs as Precision Oncology Targets: A Multi-cancer Expression and Survival Study.Cancer genomics & proteomics1 mentions
- 2025Budd-Chiari syndrome: Prognostic scores, special populations, and management challenges.World journal of gastroenterology1 mentions
- 2025ASK1 Signaling in Cancer: Pathogenic Driver or Therapeutic Target?Journal of biochemical and molecular toxicology1 mentions
- 2025Proton beam therapy indications in the Kingdom of Saudi Arabia: A SARO clinical practice guideline.Saudi medical journal1 mentions
- 2025Investigating the pathogenic potential of PKC-eta UTR variants in cancer progression.Computers in biology and medicine1 mentions
- 2025Association of vitamin D receptor gene polymorphisms ApaI (rs7975232) and BsmI (rs1544410) with hepatocellular carcinoma susceptibility in Egyptian patients.Molecular biology reports1 mentions
- 2024Utility of a microRNA panel in diagnosis and prognosis of hepatitis C-associated hepatocellular carcinoma.Laboratory medicine1 mentions
- 2024Leonurine ameliorates the STAT3 pathway through the upregulation of SHP-1 to retard the growth of hepatocellular carcinoma cells.Cellular signalling1 mentions
- 2024Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach.Pathology, research and practice1 mentions
- 2024Extracellular vesicles as tools and targets in therapy for diseases.Signal transduction and targeted therapy1 mentions
- 2024The role of TAOK3 in cancer progression and development as a prognostic marker: A pan-cancer analysis study.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society1 mentions
- 2024Unlocking the diagnostic, prognostic roles, and immune implications of BAX gene expression in pan-cancer analysis.American journal of translational research1 mentions
- 2024Harnessing the supremacy of MEG3 LncRNA to defeat gastrointestinal malignancies.Pathology, research and practice1 mentions
- 2024Echinacoside ameliorates hepatic fibrosis and tumor invasion in rats with thioacetamide-induced hepatocellular carcinoma.Biomolecules & biomedicine1 mentions
- 2024Multi-objective liver cancer algorithm: A novel algorithm for solving engineering design problems.Heliyon1 mentions
- 2024c-MET pathway in human malignancies and its targeting by natural compounds for cancer therapy.Phytomedicine : international journal of phytotherapy and phytopharmacology1 mentions
- 2024Thorough examination of the potential biological implications of the cuproptosis-related gene LIPT2 in the prognosis and immunotherapy in pan-cancer.American journal of translational research1 mentions
- 2024Decoding the DSCC1 gene as a pan-cancer biomarker in human cancers via comprehensive multi-omics analyses.American journal of translational research1 mentions
- 2024In silico design of a novel multi-epitope vaccine against HCV infection through immunoinformatics approaches.International journal of biological macromolecules1 mentions
- 2024RETRACTED: Potential Antitumor Activity of Combined Lycopene and Sorafenib against Solid Ehrlich Carcinoma via Targeting Autophagy and Apoptosis and Suppressing Proliferation.Pharmaceuticals (Basel, Switzerland)1 mentions
- 2024Non-coding RNA mediated regulation of PI3K/Akt pathway in hepatocellular carcinoma: Therapeutic perspectives.Pathology, research and practice1 mentions
- 2024Determination of hepatitis C virus subtype prevalent in Sindh, Pakistan: a phylogenetic analysis.Scientific reports1 mentions
- 2024Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma.Biosensors1 mentions
- 2024Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation Analysis Reveal Insights into the Molecular Mechanism of Cordia myxa in the Treatment of Liver Cancer.Biology1 mentions
- 2024MAFLD: an ideal framework for understanding disease phenotype in individuals of normal weight.Therapeutic advances in endocrinology and metabolism1 mentions