IL10
HGNC:5962 · 29 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | IL10 | “PT does exhibit significant hypoglycemia, hyperketonemia, elevated liver and kidney function biomarkers, dyslipidemia, oxidative stress (↑ MDA, ↓ GSH, GPx, SOD, CAT), increased pro-inflammatory cytokines (IL1α, IL1β, IL6, TNFα), and reduced IL10.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “This study identifies several significant genetic variants associated with autoimmune diseases, including PTPN22, HLA-DRB1, HLA-DQA1, IRF5, IL10, and other immune-regulatory genes.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “ALA downregulated the expression of pro-inflammatory genes (IL17F, TNF) and upregulated the expression of the anti-inflammatory cytokine IL10 gene in the joint tissues.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “In contrast, the values of IL10, PRDX6, ATG7, and NDUFS6 were in the opposite range.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Infection also heightened gene expression of inflammatory cytokines including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), interleukin 1β (IL1β), and interleukin 10 (IL10).” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The rare variant analysis prioritized NOD2, IL23, IL10, IL27, and TRAF1 genes in non-responders.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “In contrast to the untreated group, animals given PZQ and/or DLE exhibited an enhanced immunological response, as indicated by increased serum IFNγ, TNFα, IL4 and IL10 levels, increased numbers of CD4 + and CD25 + cells in blood and spleen and altered expression of apoptosis-related genes (low Bax and caspase3 and high Bcl2) in the spleen.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “RESULTS: We identified eight hub genes highly expressed in the case of PE, namely, PTGS2, ENG, KIT, MME, CGA, GAPDH, GPX3, and P4HA1, and the network of the PE + IUGR gene set demonstrated that nine hub genes were overexpressed, namely, PTGS2, FGF7, FGF10, IL10, SPP1, MPO, THBS1, CYBB, and PF4.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Significant variations in testicular parameters, apoptotic genes (Bcl-2, P53, and Caspase3), inflammatory and anti-inflammatory cytokines (IL1β, IL10), male sex hormones follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and sperm quality were also observed.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “In this in silico study, berberine chloride greatly modulated several potent CVDs-related targets, including SIGMAR1, GRP78, CASP3, BECN1, PIK3C3, SQSTM1/p62, LC3B, GLUT3, INSR, LDLR, LXRα, PPARγ, IL1β, IFNγ, iNOS, COX-2, MCP-1, IL10, GPx1, and SOD3.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Nucleotide sequence variations between healthy and endometritis-affected cows were revealed using PCR-DNA sequencing for immune (TLR4, TLR7, TNF-α, IL10, NCF4, and LITAF), antioxidant (ATOX1, GST, and OXSR1), and erythritol-related (TKT, RPIA, and AMPD1) genes.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “In the present rats-established UC, the therapeutic roles of oral probiotics (60 billion probiotic bacteria per kg per day) and azithromycin (40 mg per kg per day) regimens were evaluated by measuring changes in disease activity index, macroscopic damage index, oxidative stress markers, TLR4, p-38 MAPK, NF-κB signaling pathway in addition to their molecular downstream; tumor necrosis factor alpha (TNFα), interleukin (IL)1β, IL6, IL10 and inducible nitric oxide synthase (iNOS).” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The main targets of toxicity were casp3, TNF, IL10, IL1B, BAG3, CCNB1, CCNE1, and CDC25A, and the biological pathways implicated were signal transduction involved in DNA damage checkpoints, cellular and chemical responses to oxidative stress, DNA damage response signal transduction by P53, stress-activated protein kinase signaling cascade, netrin-UNC5B signaling, PTEN gene regulation, and immune response.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Following IBDV infection, Vac1 resulted in a noteworthy increase in the expression of IL2 and IFN-γ, Vac2 showed a significant upregulation in TNF-α and granzyme, and both Vac1 and Vac3 exhibited increased levels of IL1β and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “We examined the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, IL10, and leptin in pancreatic tissues and serum.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Oleanolic acid interacted with the proteins AKR1B10, CASP3, CASP8, CYP1A2, CYP1A2, HMGB1, NAMPT, NFE2L2, NQO1, PPARA, PTGIR, TOP1, TOP2A, UGT2B10, and UGT2B11 and stigmasterol with ABCA1, ABCG5, ABCG8, CTSE, HMGCR, IL10, CXCL8, NR1H2, NR1H3, SLCO1B1, SREBF2, and TNF.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Specifically in L-PRF, IL8, IL2, IL6, and IL1A were expressed abundantly, whereas IL4, IL10, and IL6 were significantly high in i-PRF.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Association of IL28 B and IL10 Polymorphism with HCV Infection and Direct Antiviral Treatment.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The objectives of this study were to investigate polymorphisms and changes in expression patterns of the genes FGF5, PGAM2, TLR2 and IL10 in V-line, Baladi Black and Baladi Red rabbits.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Interestingly, DCs increased in all lymphatic organs of mice vaccinated with oral live Salmonella-based vaccine expressing preproinsulin (PPI), in combination with TGFβ, IL10, and subtherapeutic-doses of anti-CD3 mAb compared with vehicle-treated mice.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Current concepts in pediatric inflammatory bowel disease; IL10/IL10R colitis as a model disease.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Interestingly, group 1012 B showed down-regulated expression of TLR2, IL10, and IL4 genes but up-regulated expression of IFNγ, compared to group 108 B and to the control.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Coherently, the lipid peroxidation marker (MDA) and pro-inflammatory cytokines (IL1β, IL6, IL17A, IFN-γ & TNF-α) augmented significantly, while the anti-oxidative markers (GSH, GPx & CAT) and anti-inflammatory cytokines (IL10 & IL22) diminished substantially, in the PC hepatorenal tissues.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The obtained results revealed notable improvement in RIRI following all treatment (MSCs, Exo, and Exo + Mel) with best improvement in Exo + Mel group as evidenced by: 1) decreased kidney injury histopathological score; 2) reduced blood levels of kidney damage markers [blood urea nitrogen (BUN) and creatinine]; 3) declined oxidative stress status (MDA level, HIF1α gene, and NOX2 protein); 4) increased anti-oxidant status (HO1 gene, and SOD, CAT, GPX activities); 5) declined apoptosis (caspase 3 activity and mRNA, and PARP1, Bax genes), 6) induced anti-apoptotic effect (Bcl2 gene); 7) inhibition of inflammation (decreased MPO activity and ICAM1, IL1B, NFkB genes and increased IL10 genes); 8) improved regeneration (bFGF, HGF and SOX9 proteins); and 9) enhanced angiogenesis (VEGF gene).” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “CD4+CD25high Foxp3+ T cells secreting IL10 were lower in H. pylori positive patients.CD4+CD25-Fox3+T cells were also higher in patients than controls and more in those negative for H. pylori.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “Our three-dimensional protein modeling assays showed that the point mutations cause major drifts in the structural plasticity of IL10 RA molecule and negatively influence its stability.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “The present study concerned novel variants and other genetic polymorphisms of the promoter and exonic regions of the IL10 gene in patients with moderate to severe psoriasis and potential differences in genotype compared to a group of healthy volunteers.” | 0.98 | hgnc_dict_v1 |
| gene | IL10 | “CONCLUSION: Genetic polymorphisms related to the IL6, IL10, and TNF-alpha genes showed a particular pattern of association with psoriasis that may have a potential impact on disease counseling and management.” | 0.98 | hgnc_dict_v1 |