BCL2
HGNC:990 · 66 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BCL2 | “Gene expression analysis revealed a significant upregulation of acetylcholinesterase, P53, BCL2, Mouse ICAM-1, PSEN, and BACE genes in the Alzheimer's disease group compared to controls.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Expression of cell cycle regulators (CCND1, CCND3, p21, and p27), apoptotic markers (BCL2, Bcl-2-associated X protein, cytochrome c, caspase-8, caspase-9, and caspase-3), and metabolic mediators (protein kinase B [Akt], mammalian target of rapamycin [mTOR], adenosine monophosphate-activated protein kinase [AMPK], and phosphatase and tensin homolog [PTEN]) was analyzed by quantitative reverse transcription-polymerase chain reaction.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Also, to elucidate the anticancer mechanism of compounds, pro-apoptotic BAX and BiD, anti-apoptotic BCL2 and BCL-xl, oxidant enzymes PRDX1 and SOD1 levels were examined by RT-qPCR.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “It also triggered hepatic inflammation via NF-κB/COX-2 signaling, increasing TNF-α, IL-1β, and IL-6, and promoted apoptosis by upregulating BAX, Caspase-3, Caspase-8, and downregulating BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Pro-apoptotic signaling (BAX, CASP3 upregulation; BCL2 downregulation) and mitochondrial dysfunction further compromise mammary epithelial viability.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Upregulation of P53 and BAX following PDT was greatly enhanced, and BCL2 expression was significantly reduced as compared to wild-type groups.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “In parallel, ETP-DNPs induced apoptosis by significantly upregulating Bax and increasing the Bax/BCL2 ratio, confirming activation of the intrinsic mitochondrial apoptotic pathway.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “In addition, ASX-CNPs significantly decreased apoptotic and necrotic spermatozoa, downregulated the pro-apoptotic genes Bax and Caspase-3, and upregulated the anti-apoptotic gene BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Effect of miR-1 and miR-126-5p in BCL2 and PIK3R2 regulation in apoptotic signaling during ST-elevation myocardial infarction.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Additionally, they significantly elevated B-cell lymphoma 2 (BCL2) and platelet-derived growth factor (PDGF) levels, indicating their potential to mitigate inflammation and promote tissue repair.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Gene expression analysis using qRT-PCR examined key apoptosis-related markers (TP53, BAX, BCL2, CASP3).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Tumor cells were reactive for STAT6, BCL2, and CD99, while CD34 was negative.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Atranorin treatment significantly increased the expression of caspase 3, caspase 9, and Bax in the HGC-27 cell line; conversely, no significant alterations were observed in the expression of caspase 8 and BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Gene expression studies showed significant down regulation of PD-L1, EGFR, STAT3, BCL2 and Ki-67, while the up regulation of Caspase-3, Caspase-9 and BAX (p < 0.0001).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “To explain the mode of molecular action of compounds on cells, we tested the mRNA levels of apoptotic and antiapoptotic genes such as BAX, BCL2, BCL2-xl, BiD, and caspase 3 by qRT-PCR.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Protein-protein interaction (PPI) analysis highlighted ten key genes-EGFR, ESR1, HIF1A, HSP90AA1, MAPK1, BCL2, STAT3, TP53, CASP3, and SRC-implicated in the progression of various cancers, including breast, colorectal, liver, and lung tumors.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Subsequently, protein-protein interaction (PPI) network analysis identified top hub genes including AKT1, CASP3, TNF, and BCL2 as central to disease modulation.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Folate- and chitosan-functionalized lipid nanoparticles for co-delivery of pioglitazone and simvastatin to enhance hepatic cancer therapy: effects on IL-1β, IL-6, BCL2/BAX gene expression, and GPX4, COX-2, and MMP-9 activities.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Gene expression analysis of SOD1, CAT, NF-κB, TNF-α, IL-1β, BCL2, BAX, MBP, and Syn2a provided molecular evidence of disrupted antioxidant defenses, impaired myelin formation, altered synaptic function in the brain, inflammatory responses, and increased apoptosis in the ovaries.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Colon samples were collected to evaluate gene and protein expression of various factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB), tumor necrosis factor alpha (TNF-α), sphingosine kinase 1 (SphK1), macrophage inflammatory protein 1-alpha (MIP-1α), B-cell lymphoma 2 (BCL2), and BCL2 associated X (BAX), as well as the activities of caspase-3/8/9.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “However, nebivolol demonstrated higher efficacy than metoprolol in suppressing the expression of the proapoptotic marker BNIP3, while upregulating the antioxidant defense system and anti-apoptotic BCL2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “We aimed to investigate the potential protective effects of genistein on epilepsy using rat models through behavior analysis and investigation of key pathways, including antioxidant activity (Nrf2 and HO-1), promoting mitochondrial biogenesis (TFAM), and reducing brain tissue apoptosis (BCL2, BAX, and caspases).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Using Machine Learning and Data Science, we exploit protein sequential data from commonly altered genes including BCL2, HSP90, PARP, and RB to make predictions for Chronic Myeloid Leukaemia (CML).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The most enriched cancer-linked target genes were PLCG1, BCL2, CYP1B1, NSD2, and ESR2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The topological screening of the PPI network revealed BCL2, TNF, NFKBIA, CREBBP and IL7R as potential hub targets.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “However, 5-FU/TQ/CQ10 triple therapy exhibited the most potent pro-apoptotic activity in all cell lines, portrayed by the lowest levels of oncogenes (CCND1, CCND3, BCL2, and survivin) and the highest upregulation of tumour suppressors (p21, p27, BAX, Cytochrome-C, and Caspase-3).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Apoptotic gene expression showed a significant downregulation of caspase-3 and BAX, with BCL2 upregulation.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Molecular docking studies showed the high affinity binding of IMT to critical proteins, including BCL2 (-6.637 kcal/mol), Caspase-6, and EGFR, which proved its potential therapeutic value.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Furthermore, expressions and concentrations of B-Cell Lymphoma 2 (BCL2), Nuclear Factor Erythroid 2-Related Factor-2 (Nrf2), nuclear factor κB (NFκB), BCL2-associated X (BAX), tumor necrosis factor-α (TNF-α), and Interleukin-1 β (IL-1β) in brain tissues were analyzed.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “We identified BCL2, IL6, and TNF as potential hub targets of PTX for liver injury treatment based on the construction of the PPI network.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Histopathological analysis revealed dense dermal lymphoid infiltrate with a non-germinal centre phenotype (CD20+, MUM1+, BCL2+, BCL6+, CD10-).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Significant genes involved are STAT3, BCL2, and MTOR, emphasizing the chemical hazards of ICS exposure.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The production of apoptotic markers including Caspase-3 (68.89 ± 2.67 U/g) and Bax (159.05 ± 6.50 pg/ml) was significantly elevated while decreasing the anti-apoptotic marker of BCL2 (0.42 ± 0.07 pg/ml).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “ZnO-PIP NPs showed dose-dependent anticancer activity on KB cells, upregulating apoptotic genes BCL2, BAX, and P53.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Moreover, the underlying molecular mechanisms were also evaluated by measuring Nrf2 and HO-1, which are involved in oxidative stress, NFκB and TNF-α, which are involved in inflammation, and BCL2, BAX, and caspase-3, which are involved in apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Ag NPs also upregulated the hepatic and renal genes involved in inflammation such as the interleukin-6 (il-6) and tumor necrosis factor-α (tnf-α), nuclear factor kappa B (nf-κβ), apoptosis such as the BCL2 associated X (bax), casp3, and other related to metabolism including asparagine synthetase (asns), suppressor of cytokine signaling 3 (socs3), MYC proto-oncogene (myc), and C-C motif chemokine ligand 2 (ccl2).” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Further, the nanoparticles induced apoptosis in cancer cells, as evidenced by the modulation of oncogenes (P21, P53, and BCL2), suggesting their therapeutic potential.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “METHODS: In the present study, we took up eleven genes (DAPK1, BECN1, PIK3C3 (VPS34), BCL2, MAPK8, BNIP3 L (NIX), PMAIP1, BAD, BID, BBC3, MCL1) that are part of molecular signaling mechanism prior to autophagy and apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Regarding gene expression, WJ-MSCs and VPA decreased BAX and TGF-β1, up-regulated Akt, PI3K, BCL2, SDF1α, and CXCR4 related to IRI.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Unraveling the intricate mechanism of apoptotic activity, ZnO-CU NPs orchestrated the upregulation of pivotal genes, including BCL2, BAX, and P53, within the KB cells.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “This study delves into the pan-cancer analysis of BCL2 Associated X (BAX) gene expression, seeking to unravel its significance in cancer development, prognosis, and potential therapeutic strategies.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Venetoclax is a selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (BCL2), as a targeted therapy for multiple myeloma (MM) patients.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Corrigendum to "Molecular hybridization design and synthesis of novel spirooxindole-based MDM2 inhibitors endowed with BCL2 signaling attenuation; a step towards the next generation p53 activators" [Bioorg.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Genetic investigations, led by high-throughput sequencing, have unveiled recurrent mutations in genes such as MYC, BCL2, and BCL6, casting light on the underlying genetic chaos propelling DLBCL's aggressiveness.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Green Synthesized Zinc Oxide Nanoparticles Attenuate Acrylamide-Induced Cardiac Injury via Controlling Endoplasmic Reticulum Stress-Associated Apoptosis Through ATF3/CHOP/BCL2 Signaling in Rats.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Colon samples were obtained to assess the gene and protein expression of nuclear factor erythroid 2-related factor-2 (Nrf2), heme oxygenase-1 (HO-1), peroxisome proliferator-activated receptor-gamma coactivator (PGC-1), mitochondrial transcription factor A (TFAM), B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3, caspase-8, and caspase-9.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Western blotting and immunohistochemical studies revealed increased levels of ILK, P-PI3K, P-AKT, and BCL2, as well as those of caspase 3, BAX, and P-PTEN, indicating mitigation of cardiomyocyte apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Gas5 enhances apoptosis by regulating apoptotic proteins, such as caspases and BCL2 family proteins, and the sensitivity of BCCs to chemotherapeutic agents.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “SN-CHM may also greatly upregulate the apoptotic gene BAX while considerably downregulating the anti-apoptotic genes BCL2 and BCL-Xl.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Specifically, apoptotic pathway proteins including BAD, BIK, BID, CASP8, MCL1, BCL2, and BAK1 were highly impacted by treatment with D. falcata plant extract.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Amy and Sor cotreatment resulted in the highest glutathione levels and induction of pro-autophagic genes AMPK, HGMB1, ATG5, Beclin 1, and LC3, suppressed the mTOR and BCL2 anti-apoptotic gene.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “All the flavonoids were predicted to be orally bioavailable, with more than 90% targets as enzymes, including kinases and lyases, and with common targets such as NOS2, CASP3, CASP9, CAT, BCL2, TNF, and HMOX1.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Studies of their effects on the apoptotic BAX and antiapoptotic BCL2 genes, molecular docking studies, and absorption, distribution, metabolism and excretion studies were conducted.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The regulation of apoptosis (the programmed cell death) is dependent on the crucial involvement of BCL2 and BAX.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “This autonomous thymic maintenance results in the development of self-renewing preleukemic stem cells (pre-LSCs) and subsequent leukemogenesis, both of which are profoundly inhibited by restoration of thymic competition or expression of the antiapoptotic factor BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Moreover, we measured gene and protein expression of B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), caspase-3/8/9, NF-κB, tumor necrosis factor (TNF)-α and IL-1β/4/6/10.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “We treated UC rats with 30 mg/kg cycloastragenol and assessed gene and protein expression levels of SphK, MIP-1α, B-cell lymphoma 2 (BCL2), BCL2-associated X (BAX), miR-143, NF-κB, tumour necrosis factor (TNF)-α and active caspase-3.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Furthermore, alteration in the immune-related genes expression (down-regulation of IL-10 and TGF-β and up-regulation of IL-1β, IL-6, IL-8, and TRL-4), hepato-renal dysfunction (elevated ALT, AST, urea, and creatinine), and high levels of serum stress indicators (cortisol and glucose) were markedly evident. sub-lethal Cu toxicity induced significant up-regulation of apoptosis biomarkers involving, nuclear factor-κβ (NF-κβ), Bcl-2 Associated X-protein (BAX), meanwhile, the expression of B-cell lymphoma 2 (BCL2) and Proliferating cell nuclear antigen (PCNA) was remarkably down-regulated.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The expression of the BCL2, MCL1, and Vimentin genes, on the other hand, was reduced.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Mechanisms of resistance to venetoclax include alterations involving the BH3-binding groove, BCL2 gene mutations affecting venetoclax binding, and activation of alternative anti-apoptotic pathways.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “The accumulation of ASK1, the cytoplasmic apoptosis regulators BAX and BCL2, and proliferating cell nuclear antigen (PCNA, a cell proliferation marker), as well as progesterone release, were evaluated by quantitative immunocytochemistry and radioimmunoassay.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Recently tested CNSTs biomarkers include VEGFR-2, EGFRvIII, IL2, PDGFR, MMPs, BRAF, STAT3, PTEN, TERT, AKT, NF2, and BCL2.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Prediction of potential targets for the identified miRNAs indicates the overexpression of KRAS, BCL2 and down-regulation of PTEN in PCa tumor tissues.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.” | 0.98 | hgnc_dict_v1 |
| gene | BCL2 | “Immunohistochemical (bcl2, bcl6, CD5, CD10, CD20, CD95, CD168, cyclin E, FOXP1, GCET, Ki-67, LMO2, MUM1p, pSTAT3) and in situ hybridization analyses (BCL2 break apart probe, C-MYC break apart probe and C-MYC/IGH double-fusion probe, and Epstein-Barr virus probe) were performed and correlated with the endpoints.” | 0.98 | hgnc_dict_v1 |