CYP2C19
HGNC:2621 · 42 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CYP2C19 | “A preliminary effect of polymorphisms in CYP2C19, PRF1, and PRKAG2 on rivaroxaban outcome still needs validation.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Genetic variants of CYP2C19 and CYP2C18 and their clinical implications in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “We evaluated CYP2D6/CYP2C19 and three drug classes (opioids, selective serotonin reuptake inhibitors [SSRIs], proton pump inhibitors [PPIs]).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Regarding findings from individual studies and single gene-drug pairs, CYP2C19 loss-of-function alleles were strongly associated with clopidogrel non-response in the primary study on this topic (odds ratio: 3.43), and the CYP3A5 genotype was identified as a critical determinant of tacrolimus trough levels with a large effect size (Hedges' g = 1.59).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “The minor allele frequency of ARG2 (rs10483801), HBS1L-MYB (rs4895441), CYP2C19 (rs4986893) CYP2C19 (rs4244285), and OATP1B3 (rs3711358) gene was significantly higher in non-responders compared to responders.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Three compounds, namely, bicyclo[7.2.0]undec-4-ene, 4,11,11-trimethyl-8-methylene-,[1R-(1R∗,4Z,9S∗)], 2-methoxybenzoic acid, 2,3-dichlorophenyl ester, and (E)-3-butylidene-4,5-dihydroisobenzofuran-1(3H)-one, have the potential to modulate PTGS2, PLA2G4A, and CYP2C19 within metabolic signaling pathway, thus serving as promising therapeutic agents.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “This review synthesizes extensive clinical and preclinical evidence delineating mavacamten's mechanism of action, pharmacokinetics influenced by CYP2C19 genotype variability, and its demonstrated efficacy and long-term safety in improving functional capacity, symptom burden, and cardiac remodeling.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Comprehensive Molecular Evaluation of Transcription Factor 7-like 2, Long Noncoding RNA (ANRIL), and CYP2C19*17 Gene Variants and Their Association with Predisposition and Progression in Stroke Patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Platelet reactivity to adenosine diphosphate and CYP2C19 genotypes are linked with carotid plaques and may predict carotid plaque stability in acute ischemic stroke patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Before receiving AC therapy, venous blood was collected from female patients with BC for DNA extraction and the genotyping of four SNPs: rs2228100 in ALDH3A1 gene, rs12248560 in CYP2C19 gene, rs1045642 in ABCB1 gene, and rs6907567 in SLC22A16 gene.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Our docking analyses revealed L-arginine's strong interactions with diabetes-target genes (CYP1A2, CYP2C19, and NFKB), with multiple hydrogen bonds and binding energies ranging from - 7.2 to - 8.9 kcal/mol.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “We evaluated the inhibitory effect of STP on CLB and N-CLB metabolism, accounting for CYP2C19 phenotypes.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Those samples of 1-hexadecanol were found to be 1-hexadecanol (BBB 0.783), GI High, Pgp Substrate Yes, CYP2C19 Inhibitor Yes, CYP2D6 Yes, and HI -89.803.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “The ABCD-GENE score was developed to predict poor response to clopidogrel and includes Age, Body mass index, Chronic kidney disease (CKD; estimated glomerular filtration rate [eGFR] < 60 mL/min/1.73 m2), Diabetes, and CYP2C19 GENE variants; a score ≥ 10 is predictive of reduced clopidogrel effectiveness after percutaneous coronary intervention (PCI).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “We assessed the performance of seven sequence-based (SIFT, PolyPhen2, mutation accessor, FATHMM, PhD-SNP, MutPred2, and SNPs & Go) and five structure-based (mCSM, SDM, DDGun, CupSat, and MAESTROweb) tools in predicting the impact of 118 nsSNPs in the CYP2C19, CYP2C9, CYP2B6, CYP2D6, and DPYD genes with known function (24 normal, one increased, 42 decreased, and 51 no-function).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Differential Expression of Serum Proinflammatory Cytokine TNF-α and Genetic Determinants of TNF-α, CYP2C19*17, miR-423 Genes and Their Effect on Coronary Artery Disease Predisposition and Progression.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “In in silico ADME prediction, ALC was shown to have poor water solubility and high gastrointestinal absorption along with inhibition of some cytochrome P450s (CYP2C19 and CYP2C9) without inhibition of others (CYP1A2, CYP3A4, and CYP2D6) and P-glycoprotein substrate.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “The genetic association tests showed that VKORC1 (rs9923231, and rs61742245), CYP2C9 (rs98332238, rs9332172, rs1057910, rs9332230, rs1799853, rs1057911, and rs9332119), CYP2C19 (rs28399511, and rs3758581), and CYP2C8 (rs11572080 and rs10509681) were significantly associated with warfarin weekly dose.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “The cytochrome P450 genes (CYP2C9, CYP2C19, and CYP2D6) were estimated to impact responses of 54.3% (n = 1,156,113) of the used drugs (27.2% are possibly affected by CYP2C9, 12.8% by CYP2C19, and 14.3% by CYP2D6).” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “The frequency of major CYP2C19 genetic polymorphisms in women of Asian, Native Hawaiian and Pacific Islander subgroups.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “We mined next generation sequencing (NGS) data from 11,889 unrelated Saudi nationals, to determine the presence and frequencies of known functional SNP variants in 8 clinically relevant pharmacogenes (CYP2C9, CYP2C19, CYP3A5, CYP4F2, VKORC1, DPYD, TPMT and NUDT15), recommended by the Clinical Pharmacogenetics Implementation Consortium (CPIC), and collectively identified 82 such star alleles.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “It is commonly used to reduce the risk of blood coagulation in patients diagnosed with acute coronary syndrome, or ischemic stroke.Area covered: We reviewed published articles in PubMed and Google Scholar that focused on the mutations of CYP2C19, CYP3A4, CYP2C9, CYP2B6, and CYP1A2 genes related to clopidogrel clinical efficacy and safety.Expert opinion: Based on current pharmacogenetic studies, patients carrying CYP2C19*2, CYP2C19*3, CYP2C9*3, and CYP2B6*5 alleles may not respond to clopidogrel due to poor platelet inhibition efficacy revealed among them.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Mechanistic insights into the CYP2C19 genetic variants prevalent in the Indian population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “We aimed to summarize and investigate the current evidence regarding the frequency of CYP2D6, CYP2C9, CYP2C19, and MDR1 in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Association of CYP2C19, TNF-α, NOD1, NOD2, and PPARγ polymorphisms with peptic ulcer disease enhanced by Helicobacter pylori infection.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Prevalence of CYP2C19*2 carriers in Saudi ischemic stroke patients and the suitability of using genotyping to guide antiplatelet therapy in a university hospital setup.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Bedside testing of CYP2C19 vs. conventional clopidogrel treatment to guide antiplatelet therapy in ST-segment elevation myocardial infarction patients.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “The CYP2C19 genotypes and its effect on clopidogrel as an anti-platelet drug among the Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C9*3 and CYP2C19*3 Gene Variations With Type 2 Diabetes: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Besides, Kim-1, TIMP-1, and CYP2C19 mRNA expression levels were significantly downregulated, while other CYP isoforms showed no modulation, compared with CLZ-treated group.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Bedside testing of CYP2C19 gene for treatment of patients with PCI with antiplatelet therapy.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Therefore, this study aims to determine if there is any single nucleotide polymorphism (SNP) within CYP19A1, CYP2C19, CYP2C9, CYP1B1, CYP3A4, and CYP1A2 genes associated with BC in the Jordanian population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “In this review, we discuss some of the most clinically important CYPs isoforms (CYP2D6, CYP2A6, CYP2C19, CYP2C9, CYP1B1 and CYP1A2) with respect to gene polymorphisms and drug metabolism.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “This study examined an LSS using 2 estimation methods to determine apparent oral clearance (CL/F) and thus CYP2C19 activity.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Drinking Ethanol Has Few Acute Effects on CYP2C9, CYP2C19, NAT2, and P-Glycoprotein Activities but Somewhat Inhibits CYP1A2, CYP2D6, and Intestinal CYP3A: So What?” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “OBJECTIVES: Evaluate the impact of CYP2C19 allele *2 and allele *3 on PRU and the potential clinical consequences of such interaction.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Genotyping of CYP2C19 polymorphisms and its clinical validation in the ethnic Arab population.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “CYP2C19 genetic polymorphism in Saudi Arabians.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Genotype-phenotype analysis of CYP2C19 in healthy saudi individuals and its potential clinical implication in drug therapy.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Genotyping of cytochrome P450 enzymes CYP2B6, CYP2C9, CYP2C19, CYP3A5, aldehyde dehydrogenase (ALDH3A1), and glutathione S-transferase (GSTA1) was done either through RFLP or pyrosequencing.” | 0.98 | hgnc_dict_v1 |
| gene | CYP2C19 | “Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations.” | 0.98 | hgnc_dict_v1 |