XRCC3
HGNC:12830 · SaudiVarKB evidence summary derived from retained literature mentions.
18Gene mentions
18Publications
8Linked variants
5Associated phenotypes
Associated phenotypes
Co-mentioned in XRCC3 publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| breast cancer | — | 4 | 4 |
| thyroid cancer | — | 1 | 1 |
| inflammatory bowel disease | — | 1 | 1 |
| ulcerative colitis | — | 1 | 1 |
| lung cancer | — | 1 | 1 |
Linked variants
Variants normalized to XRCC3| Variant | HGVS / rsID | Articles | Mentions |
|---|---|---|---|
| rs1799794 | rs1799794 | 2 | 2 |
| rs861539 | rs861539 | 2 | 2 |
| M241T | — | 1 | 1 |
| rs1801321 | rs1801321 | 1 | 1 |
| rs543072564 | rs543072564 | 1 | 1 |
| rs369703243 | rs369703243 | 1 | 1 |
| rs1799796 | rs1799796 | 1 | 1 |
| C18067T | — | 1 | 1 |
Population context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | — | 2 |
| Not specified | — | 155 | 2 |
| Saudi Arabia | — | 229 | 1 |
| Not specified | — | 26 | 1 |
| Not specified | — | 31 | 1 |
| Not specified | — | 60 | 1 |
| Saudi Arabia | — | 407 | 1 |
| Saudi Arabia | — | 134 | 1 |
| Saudi Arabia | — | 145 | 1 |
| Saudi Arabia | — | 50 | 1 |
| Not specified | — | 186 | 1 |
| Saudi Arabia | — | 232 | 1 |
| Saudi Arabia | — | 386 | 1 |
| Not specified | — | 171 | 1 |
Supporting publications
18 records- 2023The Curcumin Analog PAC Is a Potential Solution for the Treatment of Triple-Negative Breast Cancer by Modulating the Gene Expression of DNA Repair Pathways.International journal of molecular sciencesPubMed ↗
- 2022Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population.Nucleosides, nucleotides & nucleic acidsPubMed ↗
- 2017Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.The International journal of biological markersPubMed ↗
- 2017Genetic Predisposition to Cervical Cancer and the Association With XRCC1 and TGFB1 Polymorphisms.International journal of gynecological cancer : official journal of the International Gynecological Cancer SocietyPubMed ↗
- 2016Polymorphisms in DNA Repair Gene XRCC3 and Susceptibility to Breast Cancer in Saudi Females.BioMed research internationalPubMed ↗
- 2015X-ray repair cross-complementing protein 1 and 3 polymorphisms and susceptibility of breast cancer in a Jordanian population.Saudi medical journalPubMed ↗
- 2014Haplotype analyses of DNA repair gene polymorphisms and their role in ulcerative colitis.PloS onePubMed ↗
- 2014Among 45 variants in 11 genes, HDM2 promoter polymorphisms emerge as new candidate biomarker associated with radiation toxicity.3 BiotechPubMed ↗
- 2013HPV prevalence and genetic predisposition to cervical cancer in Saudi Arabia.Infectious agents and cancerPubMed ↗
- 2013SNPs in genes implicated in radiation response are associated with radiotoxicity and evoke roles as predictive and prognostic biomarkers.Radiation oncology (London, England)PubMed ↗
- 2013DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia.Biological researchPubMed ↗
- 2013Genetic variation in a DNA double strand break repair gene in saudi population: a comparative study with worldwide ethnic groups.Asian Pacific journal of cancer prevention : APJCPPubMed ↗
- 2012Involvement of single-nucleotide polymorphisms in predisposition to head and neck cancer in Saudi Arabia.Genetic testing and molecular biomarkersPubMed ↗
- 2012DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the hyderabad population of India.Asian Pacific journal of cancer prevention : APJCPPubMed ↗
- 2010Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes.Radiation researchPubMed ↗
- 2008RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.Journal of endocrinological investigationPubMed ↗
- 2008Association between XRCC1 G399A Polymorphism and Late Complications to Radiotherapy in Saudi Head and Neck Cancer Patients.Journal of the Egyptian National Cancer InstitutePubMed ↗
- 2007Radiosensitivity of human fibroblasts is associated with amino acid substitution variants in susceptible genes and correlates with the number of risk alleles.International journal of radiation oncology, biology, physicsPubMed ↗