ISG15
HGNC:4053 · SaudiVarKB evidence summary derived from retained literature mentions.
11Gene mentions
11Publications
0Linked variants
6Associated phenotypes
Associated phenotypes
Co-mentioned in ISG15 publications| Phenotype | Identifier | Articles | Mentions |
|---|---|---|---|
| systemic lupus erythematosus | — | 2 | 2 |
| hepatitis C | — | 2 | 2 |
| breast cancer | — | 2 | 2 |
| developmental delay | HP:0001263 | 1 | 1 |
| COVID-19 | — | 1 | 1 |
| MERS | — | 1 | 1 |
Linked variants
Variants normalized to ISG15| Variant | HGVS / rsID | Articles | Mentions |
|---|
No normalized variants are linked to this gene.
Population context
Reported in the same publications| Country / region | Group | Cohort | Articles |
|---|---|---|---|
| Saudi Arabia | — | 50 | 1 |
| Not specified | — | 39 | 1 |
| Saudi Arabia | — | 20 | 1 |
| Not specified | — | 132 | 1 |
Supporting publications
11 records- 2026ISG15 as a novel serum biomarker for breast Cancer: Diagnostic and prognostic significance, clinical laboratory applications, and multi-biomarker integration strategies.Clinica chimica acta; international journal of clinical chemistryPubMed ↗
- 2025SARS-CoV-2 S, M, and E Structural Glycoproteins Differentially Modulate Endoplasmic Reticulum Stress Responses.International journal of molecular sciencesPubMed ↗
- 2025Consanguinity and rare monogenic systemic autoinflammatory disorders: implications for prevalence and genetic variability.Pediatric rheumatology online journalPubMed ↗
- 2024Assessment of ubiquitin specific Peptidase-18 gene in peripheral blood of chronic hepatitis C patients treated with direct-acting antiviral drugs.HeliyonPubMed ↗
- 2024Monogenic interferon-mediated diseases: novel phenotype and genotype characteristics from a Saudi population.Clinical and experimental rheumatologyPubMed ↗
- 2024Elucidating the role of PPARG inhibition in enhancing MERS virus immune response: A network pharmacology and computational drug discovery.Journal of infection and public healthPubMed ↗
- 2021Lupus manifestations in children with primary immunodeficiency diseases: Comprehensive phenotypic and genetic features and outcome.Modern rheumatologyPubMed ↗
- 2021Autosomal Recessive ISG15 Deficiency Underlies Type I Interferonopathy with Systemic Lupus Erythematosus and Inflammatory Myositis.Journal of clinical immunologyPubMed ↗
- 2020Systemic Type I IFN Inflammation in Human ISG15 Deficiency Leads to Necrotizing Skin Lesions.Cell reportsPubMed ↗
- 2019Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray.BiomoleculesPubMed ↗
- 2016Cell-Intrinsic Adaptation Arising from Chronic Ablation of a Key Rho GTPase Regulator.Developmental cellPubMed ↗