XRCC1
HGNC:12828 · 34 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | XRCC1 | “Genetic variants associated with overall survival and/or progression-free survival included XPD Lys751Gln, XPD Asp312Asn, ERCC1 C118T, and XRCC1 Arg399Gln.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Essential Role for XRCC1 and PARP1 in the Repair of Genotoxic Damage During Spermatogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Variations in DNA repair (PARP-1, XRCC1, TP53) and cellular protection/drug metabolism genes (ABCC1, MDR1, GSTM1) also modulated susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Key genetic markers investigated for polymorphisms included OGG1, APE1, and XRCC1.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “On the other hand, specific mutations in ABCC1, ADIPOQ, CYP1A1, KIR, IL-17A, MMP2, NOTCH3, PRNCR1, RETN, TDG, TLR2, BRAF, PARP-1, TLR4, TLR-9, TNF-α, TSLP and XRCC1 genes demonstrated a substantial augmented CRC risk development in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Association of genetic polymorphisms in DNA repair genes ERCC2 Asp312Asn (rs1799793), ERCC2 Lys 751 Gln (rs13181), XRCC1 Arg399 Gln (rs25487) and XRCC3 Thr 241Met (rs861539) with the susceptibility of lung cancer in Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “CONCLUSION: Genetic polymorphisms and single nucleotide polymorphisms in DNA repair gene (XRCC1, XPD) and drug-metabolizing gene (GSTM1 and GSTT1) could serve as genetic biomarkers in lung cancer patients treated with the above indicated chemotherapy.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Genetic Variant XRCC1 rs1799782 (C194T) and Risk of Cancer Susceptibility in Indian Population: A Meta-analysis of Case-Control Studies.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Age- and Gender-Independent Association of XRCC1 Arg399Gln Polymorphism with Chronic Myeloid Leukemia.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “FEN1 inhibitor-resistant PEO1R cells were generated, and these reactivated BRCA2 and overexpressed the key repair proteins, POLβ and XRCC1.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Genetic variants of XRCC1 and risk of hepatocellular carcinoma in chronic hepatitis C patients.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Frequency of XRCC1 Exon 9 G>A gene polymorphism in Saudi Arabian population: A comparative study with worldwide ethnic groups.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Genetic Predisposition to Cervical Cancer and the Association With XRCC1 and TGFB1 Polymorphisms.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “XRCC1 Gene Polymorphisms and miR-21 Expression in Patients with Colorectal Carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Polymorphisms and mutations in GSTP1, RAD51, XRCC1 and XRCC3 genes in breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Our aim was to evaluate the relation of genetic polymorphisms in 2 DNA repair genes, XPD Lys751Gln and XRCC1 (A399G), with colorectal cancer (CRC) susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Association of XRCC1 Trp194 allele with risk of breast cancer, and Ki67 protein status in breast tumor tissues.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “RESULTS: The wide variation in SF2 (0.12-0.50; mean=0.33) was significantly associated with 3 SNPs: TP53 G72C (P=0.007), XRCC1 G399A (P=0.002) and ATM G1853A (P=0.01).” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “RESULTS: The XRCC1 Arg399Gln genotype did not exhibit any significant correlation with the susceptibility of BC (odds ratio [OR]=1.45, 95% confidence interval [CI]: 0.60-3.51) (p=0.47).” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Eleven candidate genes (ATM, XRCC1, XRCC3, XRCC4, XRCC5, PRKDC, LIG4, TP53, HDM2, CDKN1A, TGFB1) were selected for their presumed influence on radiosensitivity.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “DNA Repair Genes XRCC1, XRCC3, XPD, and OGG1 Polymorphisms among the Central Region Population of Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Association of XRCC1 gene polymorphisms with breast cancer susceptibility in Saudi patients.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “A total of 45 SNPs in 11 candidate genes (ATM, XRCC1, XRCC3, XRCC4, XRCC5, PRKDC, LIG4, TP53, HDM2, CDKN1A, TGFB1) were genotyped by direct genomic DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Therefore, we investigated HPV prevalence and genotype distribution in cervical cancer as well as the association with 9 genetic single nucleotide polymorphisms (SNPs): CDKN1A (p21) C31A, TP53 C72G, ATM G1853A, HDM2 promoter T309G, HDM2 A110G, LIG4 A591G, XRCC1 G399A, XRCC3 C241T and TGFβ1 T10C, presumed to predispose to cancer.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the hyderabad population of India.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “The aim of this study was to investigate the association between 10 SNPs in genes involved in cell cycle control and DNA repair (p21 C31A, p53 G72C, ATM G1853A, XRCC1 G399A, XRCC3 C241T, Ku80 A2790G, DNA Ligase IV C9T, DNA-PKcs A3434G, TGF-beta T10C, MDM2 promoter T309G) and the risk to develop head and neck cancer.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Association between normal tissue complications after radiotherapy and polymorphic variations in TGFB1 and XRCC1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Two hundred and twenty-three incident papillary thyroid cancer cases and 229 controls recruited from Saudi Arabian population were analyzed for 21 loci in 8 selected DNA repair genes by PCR-restriction fragment length polymorphism including non-homologous end joining pathway genes LIGIV (LIGlV ASP62HIS, PRO231SER, TRP46TER), XRCC4 Splice 33243301G>A and XRCC7 ILE3434THR; homologous recombination pathway genes XRCC3 ARG94HIS and THR241MET, RAD51 UTR 15452658T>C, 15455419A>G, RAD52 2259 and GLN221GLU, conserved DNA damage response gene Tp53 PRO47SER, PRO72ARG, Tp53 UTR 7178189A>C and base excision repair gene XRCC1 ARG194TRP, ARG280HIS, ARG399GLN, ARG559GLN.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Association between XRCC1 G399A Polymorphism and Late Complications to Radiotherapy in Saudi Head and Neck Cancer Patients.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “Deoxy-ribonucleic acid repair genes XRCC1 and XPD polymorphisms and brain tumor risk.” | 0.98 | hgnc_dict_v1 |
| gene | XRCC1 | “METHODS AND MATERIALS: Six amino acid substitution variants (ATM 1853 Asp/Asn G>A, p53 72 Arg/Pro G>C, p21 31 Ser/Arg C>A, XRCC1 399 Arg/Gln G>A, XRCC3 241 Thr/Met C>T, and TGFbeta1 10 Leu/Pro T>C) were genotyped by direct sequencing in 54 fibroblast strains of different radiosensitivity.” | 0.98 | hgnc_dict_v1 |