CTNNB1
HGNC:2514 · 30 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | CTNNB1 | “77.9% MDACC and 79% TCGA, with a p-value of less than 0.001) and CTNNB1 mutations (0% vs.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Levodopa-Responsive Dystonia Secondary to CTNNB1 Neurodevelopmental Disorder.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “In Indigenous families, pathogenic variants were found in CTNNB1, SACS, SPG7, and SYNE1.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “RESULTS: Network pharmacology recognized 87 overlapping targets of Rhamnolipid and Surfactin with Alzheimer's disease, with hub genes involving CASP3, SRC, CTNNB1, HSP90AA1 and STAT3.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “RESULTS: The study identified 94 DEGs, of which 55 genes were remarkably upregulated, including CASP8, ZHX2, BCL2L1, CTNNB1, RB1, BAX, CD274, CCL20, FOXP3, and CCL18.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Additionally, nuclear staining of beta-catenin was detected while next generation sequencing revealed mutations in the CTNNB1 variant c.110 C > G p.(Ser37Cys) and the ARID1A variant c.4420 C > T p. (Gln1474*), respectively, at the high variant allele.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “RESULTS: Four hub genes (THBS2, CTNNB1, COL4A1, and E2F3) were identified as commonly upregulated in H. pylori-positive STAD samples and were further validated as highly expressed in STAD tissues and cell lines.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Notably, our findings reaffirm the relevance of lung cancer genes, such as CTNNB1, STAT3, HIF1A, HSP90AA1, and ERBB2, integral to various cellular processes and pivotal in cancer genesis and advancement.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Furthermore, network pharmacology analysis identified the top 10 hub genes, namely AKT1 (protein kinase B), CTNNB1 (catenin beta-1), SRC (proto-oncogene c-Src), TNF (tumor necrosis factor), EGFR (epidermal growth factor receptor), HSP90AA1 (heat shock protein 90α), MAPK3 (mitogen-activated protein kinase 3), STAT3 (signal transducer and activator of transcription 3), CASP3 (caspase protein), and ESR1 (estrogen receptor 1), which are responsible for hepatoprotective activity.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Among our findings, we have identified that ALK, VHL, CTNNB1, EGFR, ERBB4, PDGFRA, KDR, SMO, ABL1, HRAS, ATM, HNF1A, FLT3, and RB1 mutations are common for psammomatous meningioma and angiomatous tumours.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “The PPIN analysis resulted in identifying four CPBs (namely RIOK2, AKT1, CTNNB1, and TNF) that commonly overlapped with one another in network parameters (degree, bottleneck and maximum neighbourhood component).” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “The study also revealed the presence of specific somatic aberrations, including TP53, PIK3CA, APOB, CTNNB1, DPYD, LRP1B, MYC, and NFE2L2, which were identified in two patients.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “INTRODUCTION: BRAFV600E mutations frequently occur in papillary thyroid cancer (PTC). β-catenin, encoded by CTNNB1, is a key downstream component of the canonical Wnt signaling pathway and is often overexpressed in PTC.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “We also find that ADCY8, MYC, PTK2, CTNNB1, TP53, RB1, PRKCA, TCF7L2, PAK1, ITPR2, CYP3A4, UGT1A6, GCK, and FGFR2/3 appear to be among the prominent genes based on the networks of genes and pathways based on the copy number alterations, mutations, and structural variants study.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Notably, CTNNB1 3' UTR splicing is the most consistently dysregulated event across cancers.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Definite genetic variants in ABCB1, ADIPOQ, CTNNB1, SFRP3, LRP6, CYP19A1, PARP-1, TDG genes exhibited significant protection against CRC development in Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Identification of DPP4/CTNNB1/MET as a Theranostic Signature of Thyroid Cancer and Evaluation of the Therapeutic Potential of Sitagliptin.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Genetic sequencing showed a point mutation in the CTNNB1 gene, with no mutations in the APC, BRCA1, and BRCA2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “PURPOSE: Several recent studies have documented CTNNB1 and BRAF mutations which are mutually exclusive for adamantinomatous craniopharyngioma (ACP) and papillary craniopharyngioma (PCP) tumors.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Screening and computational analysis of colorectal associated non-synonymous polymorphism in CTNNB1 gene in Pakistani population.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “PIK3CA and ARID1A mutation frequencies were higher in White and Asian patients compared with other ethnicities; TP53 and FAT1 mutation frequencies were higher in Black/African Americans; and CTNNB1 and RYR2 mutation frequencies were higher Native Hawaiians or Asian Natives.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Seventy-nine percent of invasive ductal carcinoma with reduced CDH1 mRNA expression showed elevated expression of E-cadherin transcription suppressors TWIST2, ZEB2, NFKB1, LLGL2, CTNNB1 (p < 0.01).” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “In addition to genes previously implicated in Wilms tumors (WT1, CTNNB1, AMER1, DROSHA, DGCR8, XPO5, DICER1, SIX1, SIX2, MLLT1, MYCN, and TP53), we identified mutations in genes not previously recognized as recurrently involved in Wilms tumors, the most frequent being BCOR, BCORL1, NONO, MAX, COL6A3, ASXL1, MAP3K4, and ARID1A.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “We observed recurrent BRAFV600E mutations in papillary craniopharyngiomas, CTNNB1 mutations in adamantinomatous craniopharyngiomas, and activating GNAS mutations in growth hormone-secreting adenomas.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “A de novo CTNNB1 nonsense mutation associated with syndromic atypical hyperekplexia, microcephaly and intellectual disability: a case report.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Following DNA quality assessment, mutation analysis of CTNNB1 and methylation profile of CDH1 were performed.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “β-Catenin accumulation and S33F mutation of CTNNB1 gene in colorectal cancer in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “These include WTX, (on chromosome X), CTNNB1 (chromosome 3), and TP53 (chromosome 17) among others.” | 0.98 | hgnc_dict_v1 |
| gene | CTNNB1 | “Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |