VEGFA
HGNC:12680 · 31 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | VEGFA | “RESULTS: The findings revealed that the FOS gene was highly acidic with an isoelectric point (pI = 4.77); however, the VEGFA gene was greatly basic with an isoelectric point (pI = 9.24) as compared to the chosen genes in H. sapiens.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “The expression of apoptosis-related markers, including caspase 3, caspase 9, caspase 8, Bax, and Bcl2, and metastasis markers, including E-cadherin, N-cadherin, vimentin, fibronectin 1, and VEGFA, was quantified at the mRNA and protein levels via quantitative real-time PCR (qRT-PCR) and Western blotting, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “These miRNAs influence key genes, including FOXO3, NFAT3, PTEN, RHOA, VEGFA, SMAD7, and CDK2, playing significant roles in both tumor suppression and oncogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Inhibitory effects of Gracilaria edulis and Gracilaria salicornia against the MGMT and VEGFA biomarkers involved in the onset and advancement of glioblastoma using in silico and in vitro approaches.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Illuminating the role of VEGFA and EGFR in head and neck squamous cell carcinoma through the multi-omics data integration.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “We identified four significant subnetworks revealing potentially important hub genes, including VEGFA, KIF4A, ZWINT, PTPRU, IKBKE, STYK1, CENPO, and UBE2C.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “A number of pathways, including PLP2/Notch, VEGFA/Akt1, PDX1, KLK4, RUNX2, DPF3, EMP3, APE1, ERK/EMT axis, and others, are impacted by the inclusion of miR-765 in their analysis.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Top hub genes identified were TLR4, MMP9, MAPK14, AKT1, VEGFA and HSP90AA1 with their respective associates.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Following that, a compound-target protein-pathway network was constructed, which uncovered that, namely, hispidulin, stigmasterol, ascorbic acid, octopamine, cyperene, kaempferol, pungenin, citric acid, d-tartaric acid, beta-sitosterol, (-)-epicatechin gallate, and (+)-catechin demonstrably influence cell proliferation and growth by impacting the AKT1 and VEGFA proteins.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Meanwhile, TP-NP could enhance the expressions of transforming growth factor beta1 (TGF-β1), in addition to the angiogenic markers; vascular endothelia growth factor A (VEGFA) and platelet-derived growth factor receptor alpha (PDGFRα).” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “In summary, we proposed that quercetin, luteolin, apigenin, catechin, epicatechin, stigmasterol, beta-sitosterol, celastrol, and betulic acid inhibit tumor growth by affecting tumor protein 53 (TP53), interleukin 6 (IL6), RAC-alpha serine/threonine protein kinases 1 (AKT1), caspase-3 (CASP3), tumor necrosis factor (TNF), jun proto-oncogene (JUN), heat shot protein 90 AA1 (HSP90AA1), vascular endothelial growth factor A (VEGFA), epidermal growth factor receptor (EGFR), and SRC proto-oncogene (SRC).” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “RESULTS: The quantitative bpMR imaging textural features, including the histogram and grey level co-occurrence matrix (GLCM), correlated with three hypoxia-related genes (ANGPTL4, VEGFA, and P4HA1) based on RNA sequencing using the TempO-Seq method.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Among these genes, HNF4A, PPARA, VEGFA, TCF7L2, HLA-DRB1, PPARG, NOS3, KCNJ11, PRKAA2, and HNF1A were mentioned in more than 200 articles.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “The key genes, including EGFR, MYC, VEGFA, and PTEN, are targeted by TF such as AR, Sp1, TP53, NF-KB1, STAT3, RELA.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Real-time polymerase chain reaction (RT-PCR) was performed for SYCP3, VEGFA and WT1 genes.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Further analysis of the possible impact of the poly-Q mutation present in the NCOA3 gene indicated associated deregulation of 15 genes, including the up-regulation of the stem cell related SEMA3D gene and the angiogenesis related VEGFA gene.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Chemopreventive effects were accompanied by decreased VEGFA expression, ablated IL6, COX-2, and p-NF-κB, and decreased pulmonary M2 macrophages and myeloid-derived suppressor cells.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “AIM: Previous studies have shown that vascular endothelial growth factor (VEGFA) gene variants were associated with breast cancer risk.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Genetic variations in VEGFA gene were suggested to contribute alterations in VEGF secretion and PCOS.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Deletion of FOXO1 in chondrocytes in vivo suppressed the expression of vascular endothelial growth factor-A (VEGFA) at both the protein and mRNA levels.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Association of VEGFA variants with altered VEGF secretion and type 2 diabetes: A case-control study.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Signal transduction networks originated by VEGFA/VEGFR2, (a notable ligand-receptor complex in the VEGF system) leads to major angiogenesis events ranging from endothelial cell proliferation, to new vessel formation, Furthermore, differential expression of VEGF-VEGFR mRNA also found in different types of RCC.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Quantitative real-time PCR for miR-34a and its targets; MET oncogene; gene-regulating apoptosis (TP53INP2 and DFFA); cell proliferation (E2F3); and cell differentiation (SOX2 and TGFB3) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Metformin improves the angiogenic potential of human CD34⁺ cells co-incident with downregulating CXCL10 and TIMP1 gene expression and increasing VEGFA under hyperglycemia and hypoxia within a therapeutic window for myocardial infarction.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Indeed, we demonstrate in two multiplex consanguineous families that we are able to map TA to regions of autozygosity in which whole-exome sequencing revealed homozygous truncating mutations in PRKD1 (encoding a kinase derepressor of MAF2) and NRP1 (encoding a coreceptor of vascular endothelial growth factor (VEGFA)).” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “These included genetic variants within or near VEGFA, CCR5, CCL2, IL-1, MMP9, EPO, IL-8, ADIPOQ and IL-10. rs1800871 (T) genetic variant in IL-10 showed protective effect for DN.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “Impact of VEGFA -583C > T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “We investigated an association between single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor A (VEGFA) gene region and KSHV viremia in kidney transplant recipients (KTR) in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | VEGFA | “OBJECTIVE: The association of vascular endothelial growth factor (VEGFA) variants and VEGF secretion with sickle cell disease (SCD) vasoocclusive crisis (VOC) was investigated in 210 VOC patients and 114 pain-free control patients.” | 0.98 | hgnc_dict_v1 |