KRAS
HGNC:6407 · 112 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | KRAS | “This assay enables highly sensitive detection of KRAS G12D ctDNA at the femtomolar level and effectively discriminates target mutants from wild-type sequences.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “RESULTS: Tumors from Saudi patients have a significantly lower frequency of KRAS mutations (6.5% vs.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Sotorasib in Advanced KRAS G12C-Mutated NSCLC: Results From the Global Expanded Access Program, Including Patients With Poor Performance Status and a History of CNS Metastases.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “KRAS Variant Frequency and Colorectal Cancer-Specific Survival by Race and Ethnicity.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Pathogenic KRAS variants disrupt structure and dynamics: Insights from integrated computational analyses.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “CEACAM5 expression did not significantly correlate with tumor stage, PD-L1 expression, tumor mutation burden, and EGFR or KRAS mutations.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “BACKGROUND: Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related mortality worldwide, with activating KRAS mutations representing a key oncogenic driver.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Mutations in MAPK/ERK pathway genes, such as KRAS and MAP2K1, have been observed in up to 33% of cases.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The RAS family of oncoproteins (KRAS, HRAS, and NRAS) drive aggressive cancers like pancreatic ductal adenocarcinoma (PDAC) and non-small cell lung cancer (NSCLC), yet targeting mutant RAS has historically been challenging due to its "undruggable" structure.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “METHODS: In the current study, we examined the therapeutic potential of these DPP-4 inhibitors in proliferation, wound healing, and colony formation, ROS induction, DNA fragmentation, apoptosis induction, and regulation of gene expression in KRAS G12C-mutated MIA PaCa-2 & KRAS G12D-mutated PANC-1 PDAC cells.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “This study aims to investigate the prevalence of ALK, EGFR, KRAS, ROS1, MET, BRAF, and HER2 mutations in patients with NSCLC within the Middle East and North Africa (MENA) region and to assess the current state of molecular testing and targeted treatments in the Gulf Cooperation Council (GCC) region.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “ADMET-Guided Docking and GROMACS Molecular Dynamics of Ziziphus lotus Phytochemicals Uncover Mutation-Agnostic Allosteric Stabilisers of the KRAS Switch-I/II Groove.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Computational screening of phytochemicals targeting mutant KRAS in colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “BACKGROUND: Sotorasib (AMG510) is a first-in-class irreversible, covalent, and selective KRAS G12C inhibitor.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “In silico docking studies, the favorable binding of orientin was identified with the key oncogenic targets (EGFR, ALK, KRAS, NTRK).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Ten hub genes were obtained based on maximum clique centrality (MCC), maximum neighborhood component (MNC), degree, closeness and betweenness using cytoHubba which included ACTB, ATM, ESR1, GAPDH, HNRNPK, KRAS, MDM2, SIRT1, TP53, and H3F3C (H3-5).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “It has prominent levels of mutated genes such as TP53, KRAS, MET, and EGFR.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Notably, KRAS, CUL3, TP53, ESR1, and PARP1 were influenced by both upregulated and downregulated miRNAs.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “This study investigates eight key genes (BRAF, EIF1 AX, FOXE1, KRAS, PDGFRA, PIK3 CA, PTEN, and TERT) that are deregulated in Hashimoto's Thyroiditis and their roles in thyroid cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Biomarkers, such as cancer antigen 19-9, KRAS mutations, and inflammatory markers, provide crucial insights into disease progression and treatment responses.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “RNA sequencing technology based on TEP demonstrates excellent diagnostic power by correctly identifying LC patients alongside their oncogenic alterations of EGFR, KRAS, and ALK.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Evolution of computational techniques against various KRAS mutants in search for therapeutic drugs: a review article.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The three isoforms of the RAS gene are HRAS, NRAS, and KRAS.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Genetic biomarkers such as BRAF, KRAS, and NRAS may provide early precision treatment options that are crucial for patient survival and well-being.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Additionally, using previously published data on KRAS codon 12 mutations for this cohort, we investigated associations between variables in the primary and secondary analyses and acquiring two or more somatic events (PTEN loss, ARID1A loss, or KRAS mutation) in this cohort.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “RESULTS: In the pan-cancer group, TP53 (58.5%), EGFR (20.4%), and KRAS (18.9%) were the most frequently mutated genes.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Computational insights into KRAS G12C inhibition: exploring possible repurposing of Azacitidine and Ribavirin.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “QSAR-guided discovery of novel KRAS inhibitors for lung cancer therapy.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Targeted next-generation sequencing (NGS) was used to detect BRAF, NRAS, KRAS, HRAS, RET/PTC fusions, and TERT promoter mutations.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “While somatic mutations such as KRAS and EGFR were commonly reported in tumor studies, our primary focus is on germline PSVs that may indicate population-specific genetic risks, including BRCA1 exon 11 mutations in breast cancer and p.Gly12Asp in KRAS for colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “In lung cancer, KRAS mutations, especially the G12C, favor aggressive tumor growth and resistance to standard therapies.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Unique to this case was the process of undergoing targeted genetic sequencing via the Find ITTM Panel Version 3.4 on the ACUM, looking for mutations in KRAS, PIK3CA, and FGFR2.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Exploring somatic mutations in BRAF, KRAS, and NRAS as therapeutic targets in Saudi colorectal cancer patients through massive parallel sequencing and variant classification.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The Kirsten Rat Sarcoma (KRAS) G12D mutant protein is a primary driver of pancreatic ductal adenocarcinoma, necessitating the identification of targeted drug molecules.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Single-point mutations in the Kirsten rat sarcoma (KRAS) viral proto-oncogene are the most common cause of human cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Molecular docking analysis revealed that N-[Carboxymethyl] maleamic acid is the leading molecule responsible for protein denaturation inhibition, having the highest binding affinity of 6.8 kJ/mol among all other compounds with KRAS inflammatory proteins.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Prospective virtual screening combined with bio-molecular simulation enabled identification of new inhibitors for the KRAS drug target.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Circular RNAs in the KRAS pathway: Emerging players in cancer progression.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Despite the lack of successful Ras signaling inhibitors, recent research has identified PDEδ, a KRAS transporter, as a potential target for inhibiting the oncogenic KRAS signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Critical molecular pathways driving pancreatic cancer development, including KRAS, Notch, and Hedgehog, are discussed.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Flavonoids as potential KRAS inhibitors: DFT, molecular docking, molecular dynamics simulation and ADMET analyses.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “NRAS mutations predominated at 67 % compared to HRAS (24 %) and KRAS (12 %).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Investigating the Feasibility of Predicting KRAS Status, Tumor Staging, and Extramural Venous Invasion in Colorectal Cancer Using Inter-Platform Magnetic Resonance Imaging Radiomic Features. (1) Background: Colorectal cancer is the third most common type of cancer with a high mortality rate and poor prognosis.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “After comprehensively analyzing these 233 ferroptosis driver genes by various TCGA databases, RNA-sequencing (RNA-seq), and Reverse Transcription Quantitative Real-Time Polymerase Chain Reaction (RT-qPCR) techniques, TP53 (tumor protein 53), PTEN (Phosphatase and TENsin homolog deleted on chromosome 10), KRAS (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog), and HRAS (Harvey Rat sarcoma virus) were identified as differentially expressed hub genes.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “In KRAS, mutations of G12D and G12C are common.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Additionally, the PI3K-Akt, p53, Ras, and Rap1 signaling pathways were demonstrated to be the key pathways, whereas CDK6, PIK3CB, and KRAS were found to be directly functional target genes.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “RESULTS: Three tumors were tested only by Sanger sequencing and were negative for BRAFV600E, HRAS, KRAS, NRAS, TERT promoter, PTEN, and PIK3CA mutations.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “METHODS: In total, 694 patients from the clinical trials COIN and COIN-B had MAPK-activated CRCs (assigned as KRAS, NRAS, or BRAF mutant).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Notch signaling, PTEN/Akt/mTOR axis, KRAS mutation, JAK/STAT signaling, P53, EGFR, and the VEGFs have all been linked to OC, and miRNAs have been shown to have a role in all of these.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “In addition, miRNAs have been found to have a role in various regulatory signaling pathways associated with MPM, such as the Notch signaling network, Wnt/β-catenin, mutation of KRAS, JAK/STAT signaling circuit, protein kinase B (AKT), and Hedgehog signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “LIMITATIONS: A study's drawback is the lack of data for a variety of risk variables linked to colorectal cancer incidence, such as the KRAS mutation and environmental risk factors including BMI and smoking.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The tumor was right-sided, and Kirsten rat sarcoma (KRAS) mutated based on that.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “For the early detection of CRC, the most common predictive biomarker found endogenously are KRAS and ctDNA/cfDNA along with SEPT9 methylated DNA.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Molecular abnormalities related to epidermal growth factor receptor (EGFR), v-Raf murine sarcoma viral oncogene homolog B1 (B-RAF) Kirsten rat sarcoma virus (KRAS) mutations, translocation of the anaplastic lymphoma kinase (ALK) gene, mesenchymal-epithelial transition factor (MET) amplification have been studied to overcome the resistance and to develop new therapies for non-small cell lung cancer (NSCLC).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Identification of potential inhibitor targeting KRAS mutation in Papillary Thyroid Carcinoma through molecular docking and dynamic simulation analysis.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Comparison of KRAS gene in circulating tumor DNA levels vs histological grading of colorectal cancer patients through liquid biopsy.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The Kirsten rat sarcoma (KRAS) oncoprotein has been on drug hunters list for decades now.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “KRAS G12C-Mutant Non-Small-Cell Lung Adenocarcinoma: First Documented Report in the Arabian Gulf.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Somatic hotspot mutations KRAS p.G12C and PIK3CA p.Q546K are associated with colorectal cancers from biallelic MUTYH carriers compared with non-carriers (p = 2 × 10-23 and p = 6 × 10-11, respectively).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “KRAS Mutations in Colorectal Cancer: Relationship With Clinicopathological Characteristics and Impact on Clinical Outcomes in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “We also detected mutations in other genes, including BRAF, EGFR, and KRAS.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Recurrent KRAS mutations are early events in the development of papillary renal neoplasm with reverse polarity.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “For a panel of 12 genes, 25% had the tumor protein 53 (TP53) gene mutation and 39% had the gene Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Oncogenic dependency on STAT3 serine phosphorylation in KRAS mutant lung cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “KRAS/NRAS/BRAF Mutation Rate in Saudi Academic Hospital Patients With Colorectal Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Here we show that NSD2, via H3K36me2 catalysis, cooperates with oncogenic KRAS signaling to drive lung adenocarcinoma (LUAD) pathogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The activated mutations in Neuroblastoma rat sarcoma viral oncogene homolog (NRAS) and Kirsten rat sarcoma viral oncogene homolog (KRAS) confers proliferative and survival signals, deliberating numerous effects on overall survival and progression free survival in AML patients.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “OBJECTIVES: KRAS, NRAS, and BRAF mutations are commonly present in colorectal cancer (CRC).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “851 cases of non-small cell lung cancer cases were profiled for the presence of biomarkers EGFR, KRAS, BRAF, and PIK3CA mutations by SNaPshot/sizing genotyping.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “OBJECTIVES: First, to determine the most important kinases and kinase pathways, and the amount of ABC transporters and KRAS in samples taken from Saudi CRC patients.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “833 samples of non-small cell lung cancer from 799 patients who received resection of their lung cancer, were selected for molecular analysis of six known mutations, including EGFR, KRAS, BRAF, PIK3CA, HER2 and ALK.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Chemopreventive effects were independent of the KRAS mutational status of the tumors.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “BACKGROUND: RAP1GDS1 (RAP1, GTP-GDP dissociation stimulator 1), also known as SmgGDS, is a guanine nucleotide exchange factor (GEF) that regulates small GTPases, including, RHOA, RAC1, and KRAS.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Other genetic alterations including EML4-NTRK1, EML4-ALK, NRAS, KRAS, PTEN, and CREBBP occurred once each.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “BRAF and KRAS mutations in papillary thyroid carcinoma in the United Arab Emirates.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “RESULTS: Synergy was observed between dacomitinib and fulvestrant in three human ERβ+ NSCLC models: 201T (wild-type EGFR), A549 (KRAS mutant), and HCC827 (EGFR 19 deletion) with combination indices of 0.1-0.6.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Screening of RAS (Kirsten rat sarcoma viral oncogene homolog (KRAS), neuro-blastoma RAS viral oncogene homolog (NRAS), and v-raf murine sarcoma viral oncogene homolog B1 (BRAF)) somatic mutations is necessary prior to considering anti-epidermal growth factor receptor (EGFR) therapies in CRC patients.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Utility of KRAS Gene and Clinicopathological Features in the Assessment of the Risk of Type 2 Diabetes in the Etiology of Colon Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “We evaluated variants in the following genes: BRAF, CBL, HRAS, KRAS, MAP2K1, MAP2K2, NF1, NRAS, PTPN11, RAF1, SHOC2, and SOS1.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “By Cox regression analysis, age at diagnosis, tumor stage, Kirsten Ras (KRAS) mutation, and lymphovascular invasion were signifcant prognostic factors for survival in CRC patients.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “BACKGROUND: Colorectal cancer (CRC) is categorized by alteration of vital pathways such as β-catenin (CTNNB1) mutations, WNT signaling activation, tumor protein 53 (TP53) inactivation, BRAF, Adenomatous polyposis coli (APC) inactivation, KRAS, dysregulation of epithelial to mesenchymal transition (EMT) genes, MYC amplification, etc.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Effect of KRAS mutational status on disease behavior and treatment outcome in patients with metastatic colorectal cancer: intratumor heterogeneity and mutational status.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Evaluation of the Idylla KRAS and NRAS mutation test in colorectal cancer tissue.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Different conventional DNA markers, such as microsatellite instability, CpG island methylator phenotype, chromosomal instability, and BRAF and KRAS mutations, have been used to classify colorectal cancer patients but have not yet shown promising prognostic values.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “However, this strategy is not useful in cancer cells with mutations in KRAS; a GTPase downstream of EGFR which constitutively activates the pathway without EGF stimulation.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “In this study, we studied epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), Kirsten rat sarcoma 2 viral oncogene homolog (KRAS), and Serine/Threonine Kinase 11 (STK11) to construct the ERSDM profile.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Mutated KRAS induces abnormalities in the regular function of these TFs which in turn cause abnormal cell growth and proliferation that leads to cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Prediction of potential targets for the identified miRNAs indicates the overexpression of KRAS, BCL2 and down-regulation of PTEN in PCa tumor tissues.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Recurrent somatic mutations in APC, TP53, and KRAS were frequently detected in highly heterogeneous colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Colonoscopy, CT/MRI, histopathology of tumor biopsies, and KRAS and BRAF testing were performed.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “This study comprehensively investigated a large series of pediatric DTC for single point mutations in BRAF, HRAS, KRAS, NRAS, PIK3CA, PTEN, and TERT.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “These tumours also acquire KRAS mutations during the development from precursor to primary disease, and primary testicular GCTs (TGCTs) are uniformly wild type for TP53.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The final two cases (MYH9 associated macrothrombocytopenia associated with multiple congenital anomalies; atypical juvenile myelomonocytic leukaemia associated with a KRAS mutation) highlight the utility of NGS where the diagnosis is less certain, or where there is an unusual phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “RESULTS: Targeted sequencing lead to the identification of frequent mutations in TP53 (65 %), APC (36 %), KRAS (35 %), PIK3CA (19 %), PTEN (13 %), EGFR (11 %), SMAD4 (11 %), and FBXW7 (7 %).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The KRAS/ K-RAS oncogene is crucially involved in human cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Moreover, we conducted a comparative study between isogenic derivatives cell lines of the normal HCECs in order to mimic the mutation of three major genes found in CRC genetic models: APC, KRAS, and TP53.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “The inactive orthlogues of the receptor tyrosine kinase Eph and MET, namely vab-1 and RB2088 respectively, the temperature sensitive constitutively active form of KRAS, SD551 (let-60; GA89) and the inactive c-CBL equivalent mutants in sli-1 (PS2728, PS1258, and MT13032) when subjected to chronic exposure of nicotine resulted in a significant loss in egg-laying capacity and fertility.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “We further demonstrated that SCRS data amplified by either MDA or MALBAC from a gastric cancer cell line could accurately detect gastric cancer CNVs with comparable sensitivity and specificity, including amplifications of 12p11.22 (KRAS) and 9p24.1 (JAK2, CD274, and PDCD1LG2).” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “METHODS: Molecular characterization of 770 CRC specimens was performed for microsatellite instability, BRAF, and KRAS by polymerase chain reaction and 500 cases for CpG island methylator phenotype (CIMP) high phenotype by MethyLight technology.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “METHODS: 770 CRC cases were analyzed for BRAF and KRAS mutations by direct DNA sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Novel KRAS gene mutations in sporadic colorectal cancer.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “PATIENTS AND METHODS: In the CAPRI-GOIM trial, 340 KRAS exon 2 wild-type mCRC patients received first-line FOLFIRI plus cetuximab.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Mutation in BRAF exon 15, KRAS, NRAS, and HRAS were studied by polymerase chain reaction (PCR)-sequencing of tumor DNA; RET/PTC rearrangement was determined by reverse transcription (RT)-PCR-sequencing of tumor cDNA.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Comprehensive survey of HRAS, KRAS, and NRAS mutations in proliferative thyroid lesions from an ethnically diverse population.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Prognostic significance of TRAIL death receptors in Middle Eastern colorectal carcinomas and their correlation to oncogenic KRAS alterations.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “KRAS and TP53 mutations in colorectal carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | KRAS | “PIK3CA amplification was seen in 54 of 152 (35.5%) EOC cases analyzed; PIK3CA gene mutations in 6/153 EOC (3.9%); KRAS mutations in 3/154 EOC (1.9%), BRAF mutations in 3/156 EOC (1.9%), p53 mutation in 50/154 EOC (32.5%), and loss of PTEN protein expression in 33/144 EOC (22.9%). p110 alpha overexpression was associated with increased phosphorylation of AKT-Ser 473 and with the proliferation marker Ki-67.” | 0.98 | hgnc_dict_v1 |