BRCA1
HGNC:1100 · 122 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | BRCA1 | “Poly(ADP-ribose) polymerase (PARP) inhibitors have made significant advances in the treatment of breast cancer, especially in tumors with homologous recombination deficiency such as BRCA1/2-mutated cancers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Prevalence of BRCA1 and BRCA2 Germline Mutations in Western Saudi Patients with Epithelial Tubo-Ovarian Carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Low Frequency of Pathogenic Variants in BRCA1 Exons 11/20 and BRCA2 Exon 11 Suggests Divergent Mutational Hotspots in Sudanese Breast Cancer Patients: A Case-Control Study.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “This review describes the role of BRCA1/2 in BC and OC, highlighting key discovery milestones and providing an overview of available PARP inhibitors (PARPi) at various stages of development.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The genes associated with tumor suppression (p53, BRCA1, and BRCA2), telomere length maintenance (TERT), DNA damage response (FGFR2), and DNA repair (CHD1) are recognized for their intricate function in tumor genesis and progression.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Eleven patients (4.5%) harbored germline PVs/LPVs in cancer susceptibility genes including STK11, TP53, BRCA1, BRCA2, FANCA, SLX4, RAD50, MSH6, POLD1 and NF1.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Awareness and attitudes toward BRCA1/2 genetic testing among at-risk women in Egypt.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “PALB2 plays a crucial role in DNA repair by interacting with BRCA1 and BRCA2.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Global prevalence and ethnic variation of pathogenic BRCA1/2 variants in breast cancer: a systematic review and meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “While BRCA1/2 explain part of the hereditary risk, the contribution of rare coding variants in Arab EOBC remains unclear.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Identification of BRCA1 and BRCA2 Germline Mutations in Female Breast Cancer Patients Using Next Generation Sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The status of the BRCA1 and BRCA2 genes was determined by DNA sequencing in all patients.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Poly (ADP-ribose) polymerase (PARP) inhibitors have appeared as a transformative class of anticancer agents, particularly for tumors with homologous recombination deficiencies such as BRCA1/2-mutated breast, ovarian, prostate, and pancreatic cancers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Single mutations were observed in BRCA1, LATS2, ATM, USP35, and CIC, associated with DNA repair, the ubiquitin proteasome pathway, and transcriptional regulation respectively.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Molecular Dynamics and Energetic Insights into Novel PARP15 Inhibitors: A Structural Approach for Targeting BRCA-Mutated Breast Cancer. <p> Introduction: Breast cancer remains a critical global health issue, particularly in patients with BRCA1/2 mutations, which lead to genomic instability and increased cancer susceptibility.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “High-risk genes, including BRCA1, BRCA2, PALB2, TP53 and PTEN, with germline pathogenic or likely pathogenic variants (PVs/LPVs), substantially increase the risk of breast cancer and other malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “In vitro, decitabine-induced growth inhibition, apoptosis, and re-expression of silenced genes (such as BRCA1 and CDH1).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Moreover, genotype TT in variant rs1575535582 was associated with BRCA1 positive status among the breast cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Moreover, it can inhibit inflammatory markers (IL-6, TNF-α, and IL-1β), downregulate oncogenes (Ras, HER2, MYC, and BCR/ABL1), and upregulate tumor suppressor genes (TSGs) such as TP53, PTEN, and BRCA1 and BRCA2 expression.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “PARP inhibitors (PARPi) were the first approved cancer treatments to target the DNA damage response in BRCA1/2-mutated breast and ovarian malignancies.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Genetic testing identified a BRCA1 mutation, leading to adjuvant maintenance therapy with Olaparib.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Overall, 34, 10, and 7 PV/LPV were identified in BRCA1, BRCA2, and other genes, respectively.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Moreover, anthocyanins downregulate oncogenes (Bcl-2, MYC, and HER2) and improve the activity of tumor suppressor genes (TP53, BRCA1, and RB1).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Breast Cancer Risk Modification in Women with Pathogenic Variants in BRCA1, BRCA2, ATM, CHEK2, and PALB2.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Besides, younger BC women are statistically more likely than older ones to have pathogenic germline variants in BC susceptibility genes (BRCA1/2, TP53, PALB2).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Risk-benefits assessment of tamoxifen or raloxifene as chemoprevention for risk reduction of breast cancer among BRCA1 and BRCA2 carriers: a meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Mutations in the BRCA1 and BRCA2 genes are well-established in hereditary breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “In patients with breast cancer, PIK3CA (35.3%), ESR1 (21.7%), and BRCA1/2 (13.3%) had the most prevalent alterations among NCCN-recommended genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Major risk factors include hormonal imbalance, radiation exposure, obesity, alcohol use, and Breast Cancer Gene 1 and 2 (BRCA1/2) mutations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Mutations of TP53 and BRCA1 genes have been associated with HGSC, which has been suggested as a subtype that arises from the fallopian tube lesion called serous tubal intraepithelial carcinoma (STIC).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “PURPOSE: The prognostic significance of BRCA1/2 mutation and RB1 alteration (Alt) in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor-2-negative (HER2-) breast cancer (BC) treated with endocrine therapy (ET) ± cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) remains unresolved.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “RAD51 facilitates homology search and strand invasion, while PALB2 links BRCA1 and BRCA2, stabilizing RAD51 filaments.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Breast, colorectal, and lung cancers were the most studied, with BRCA1/2 and TP53 among the most frequently mutated genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The molecular landscape of TNBC is covered in the first section, which keeps the focus on transcriptome and genomic profiling while highlighting key molecular targets like mutations in the BRCA1/2, PIK3CA, androgen receptors (AR), epidermal growth factor receptors (EGFR), and immunological checkpoint molecules.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “NGS already has the capacity to ameliorate genetic screening in families with previous histories of the high occurrence of various cancer-associated genes, including TP53, APC, BRCA2, and BRCA1.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Individuals with TP53 mutations also have an elevated probability of carrying mutations in BRCA1 and BRCA2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Notably, the BRCA1, BRCA2, and HOXB13 genes exhibited significant variants in 20% of the prostate cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Detection of genomic variants in BRCA1 and BRCA2 across gastric cancer patients using next generation sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Exploration of BRCA1 and BRCA2 mutations in gastric cancer patients through next generation sequencing: implications for diagnosis and therapy.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Various risk factors contributing to breast cancer include age, family history, genetic mutations (chiefly in BRCA1 and BRCA2 genes) along with hormonal imbalances (oestrogen, progesterone, HER2).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “RESULTS: Our study identified genetic mutations in BRCA1, BRCA2, TP53, and PMS2.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Breast Cancer Associated Susceptibility Proteins Type 1/2 (BRCA1/2) promote cellular functioning by modulating NRF2-mediated antioxidant signaling.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Newly synthesized chitosan nanoparticles loaded with caffeine/moringa leaf extracts Halt Her2, BRCA1, and BRCA2 expressions.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Sanger sequencing was used to analyze peripheral blood DNA from these individuals to detect disease-causing mutations in the BRCA1, BRCA2, PTEN, TP53, and ATM genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Breast and ovarian cancers are prevalent worldwide, with genetic factors such as BRCA1 and BRCA2 mutations playing a significant role.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Constitutional BRCA1 and MGMT Methylation Are Significant Risk Factors for Triple-Negative Breast Cancer and High-Grade Serous Ovarian Cancer in Saudi Women.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Preliminary insights on the mutational spectrum of BRCA1 and BRCA2 genes in Pakhtun ethnicity breast cancer patients from Khyber Pakhtunkhwa (KP), Pakistan.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “In our research, we conducted a comprehensive screening using HTVS, SP, and XP, followed by an MM/GBSA computation of human-approved drugs targeting HER2/neu, BRCA1, PIK3CA, and ESR1.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Exploring Citrus sinensis Phytochemicals as Potential Inhibitors for Breast Cancer Genes BRCA1 and BRCA2 Using Pharmacophore Modeling, Molecular Docking, MD Simulations, and DFT Analysis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Ki-67 was high in 19 cases (31.1%); six (9.8%) had BRCA1 mutations, and six (9.8%) had BRCA2 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “As we did not find other conclusive candidates, we then performed a candidate gene approach to identify other candidate variants in genes involved in the FANCI protein interactome in OC families negative for pathogenic variants in BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, and FANCI, which identified four candidate variants.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “However, the optimal sequencing of therapy remains an unanswered question for a subset of mTNBC patients who harbor germline breast cancer gene 1/2 (BRCA1/2; gBRCA1/2) mutation.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Breast cancer (BC) is the most prevalent malignancy among women worldwide with germline pathogenic variants/likely pathogenic variants (PVs/LPVs) in BRCA1/2 accounting for a large portion of hereditary cases.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The immunohistochemical staining process achieved positive staining outcomes for BRCA1 and 2.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Of the 310 subjects, 119 (38.4%) were carriers of pathogenic or likely pathogenic variants (PVs) affecting one or more of the following genes: TP53, ATM, CHEK2, CDH1, CDKN2A, BRCA1, BRCA2, PALB2, BRIP1, RAD51D, APC, MLH1, MSH2, MSH6, PMS2, PTEN, NBN/NBS1 and MUTYH.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “MicroRNA-155-5p, Reduced by Curcumin-Re-Expressed Hypermethylated BRCA1, Is a Molecular Biomarker for Cancer Risk in BRCA1-methylation Carriers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Triple-negative breast cancer (TNBC), accounting for 10-15% of all breast malignancies, is more prevalent in women under 40, particularly in those of African descent or carrying the BRCA1 mutation.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The present review discusses candidate genes such as HOXB13, BRCA1, BRCA2, ATM, MMR gene, RAD51C, CHECK2, etc., and family-based linkage studies which defined the location of loci on chromosomal regions like 1q24-25, 1q42-43, Xq27-28, 1p36, 20q13, 17q21.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non-carriers: results from a rapid autopsy programme.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Women with germline BRCA1 mutations (BRCA1+/mut) have increased risk for hereditary breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The MCPH1 gene, also known as BRCT-repeat inhibitor of hTERT expression (BRIT1), has three BRCA1 carboxyl-terminal domains which is an important regulator of DNA repair, cell cycle checkpoints and chromosome condensation.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Prostate cancer risk, screening and management in patients with germline BRCA1/2 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “A bibliometric analysis of the top 100 most cited papers and research trends in breast cancer related BRCA1 and BRCA2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Low BRCA1 and BRCA2 Germline Mutation Rates in a French-Canadian Population with a Diagnosis of Epithelial Tubo-Ovarian Carcinoma.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Structurally, BARD1 has homologous domains to BRCA1 that aid their heterodimer interaction to inhibit the progression of different cancers such as breast and ovarian cancers following the BRCA1-dependant pathway.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Case Review: Whole-Exome Sequencing Analyses Identify Carriers of a Known Likely Pathogenic Intronic BRCA1 Variant in Ovarian Cancer Cases Clinically Negative for Pathogenic BRCA1 and BRCA2 Variants.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The most common deleterious germline BRCA1 mutation was c.1140dupG (39%).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Comparing breast cancer imaging characteristics of CHEK2 with BRCA1 and BRCA2 gene mutation carriers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Consumption of reused vegetable oil intensifies BRCA1 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “All the patients carrying TP53 mutations were negative for BRCA1 and BRCA2 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BACKGROUND: Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Genetic sequencing showed a point mutation in the CTNNB1 gene, with no mutations in the APC, BRCA1, and BRCA2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Multiple carriers of a limited number of pathogenic variants in BRCA1 and BRCA2, the major risk genes for hereditary breast and/or ovarian cancer syndrome families, have been identified in French Canadians, which is in stark contrast to the array of over 2000 different pathogenic variants reported in each of these genes in other populations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Representing a complex and heterogeneous type of cancer, its occurrence is attributed by both genetic (gene mutations, e.g., BRCA1, BRCA2) and non-genetic (race, ethnicity, etc.) risk factors.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Among the genes analyzed, the highest mutation rates were found in PIK3CA (12.9%), BRCA2 (11.7%), BRCA1 (10.2%), TP53 (6.0%), MSH2 (3.8%), PMS2 (3.8%), BARD1 (3.8%), MLH1 (3.4%), CDH1 (3.0%), RAD50 (3.0%), MSH6 (3.0%), NF1 (2.6%), in addition to others.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Our data showed that high ASXL1 mRNA is interrelated with increased BRCA1 associated protein-1 (BAP1) and its target gene E2F Transcription Factor 1 (E2F1) expression.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Comprehensive study for BRCA1 and BRCA2 entire coding regions in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BRCA1 and BRCA2 genes mutations among high risk breast cancer patients in Jordan.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “We identified a total of 14 point mutations and one deletion in BRCA1, BRCA2, and RAD50 genes from the BRCA panel analysis of breast cancer samples.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Soon after the discovery of BRCA1 and BRCA2 over 20 years ago, it became apparent that not all hereditary breast and/or ovarian cancer syndrome families were explained by germline variants in these cancer predisposing genes, suggesting that other such genes have yet to be discovered.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Three patients with B-ALL had heterozygous pathogenic mutations in TP53, BRCA1, and BRCA2; one patient with B-ALL had homozygous pathogenic mutation in PMS2; and one patient with T-ALL had LP homozygous mutation in AK2 that was associated with reticular dysgenesis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BRCA1 and BRCA2 mutations have linked with an increased risk for breast, ovarian, and PCa.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The role of BRCA1/2 in hereditary and familial breast and ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BACKGROUND: To systematically assess the prevalence of BRCA1 and BRCA2 gene mutations in women with Hereditary Breast and/or Ovarian Cancer (HBOC) in Arab countries and to describe the variability in the BRCA gene mutations in different regions of the Arab world.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “METHODS: We have utilized a cost-effective targeted sequencing approach of high priority actionable BC genes (BRCA1, BRCA2, ERBB2 and TP53) in a homogeneous patient cohort from Bangladesh (n = 52) by using tumor and blood samples.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Novel Associations between BRCA1 Variants C.181 T>G (Rs28897672) and Ovarian Crisk in Saudi Females.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “This study aim to investigate the association of breast cancer risk and prognostic factors with single nucleotide variants of the BRCA1, BRCA2, DAPK1, MMP9, TOX3, and TP53 genes in Jordanian women.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The total number of OC patients captured was 802; of these, 53 and five families carry 22 mutations in BRCA1/2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The inheritance of mutated suppressor genes, such as BRCA1 and BRCA2, is acknowledged as an etiological factor in hereditary breast carcinoma (HBC).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The association of BRCA1 and BRCA2 mutations with prostate cancer risk, frequency, and mortality: A meta-analysis.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “CDH1 copy number was associated with copy number loss of TP53, ATM, BRCA1, and BRCA2 (p < 0.001).” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “AKR1C3, BRCA1, BRCA2, CHGA, CYP19A1, HOXB13, KLK3, and PTEN contained the highest number of 3'UTR, 5'UTR, CDs, Intergenic, and Intronic variants.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Prevalence of BRCA1 and BRCA2 Mutations Among High-Risk Saudi Patients With Breast Cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “High prevalence of deleterious BRCA1 and BRCA2 germline mutations in arab breast and ovarian cancer patients.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Breast cancer in the GCC countries: A focus on BRCA1/2 and non-BRCA1/2 genes.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Main implications related to the switch to BRCA1/2 tumor testing in ovarian cancer patients: a proposal of a consensus.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “A Germline Mutation in the BRCA1 3’UTR Variant Predicts Susceptibility to Breast Cancer in a Saudi Arabian Population.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The top canonical pathway was entitled, role of BRCA1 in DNA damage response.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “We also find that 18 VOUS BRCA1 and BRCA2 variants that are listed in BRCA Exchange are present at least once in the homozygous state in patients who lack features of Fanconi anemia.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Inhibitors of poly(ADP-ribose) polymerase (PARP) are clinically used as single-agent therapy for tumors with BRCA1 or BRCA2 mutations.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “A subset of cases of BC from patients with known BRCA1 germline mutations was included as a control group.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “ANN simulations revealed that increased folate might restore ER and PR expression and reduce the promoter CpG island methylation of extra cellular superoxide dismutase and BRCA1.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Discovering the significant contribution of BRCA1/2 mutations to breast cancer susceptibility allowed for the design of genetic tests that allows the medical practitioner to focus the care for those who need it most.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The method allows detection of single point mutations in peptides composing the BRCA1 protein.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “In the present study, breast tumor samples from Canadian and Saudi Arabian patients were screened for known and unknown mutations within BRCA1 and BRCA2 as well as 21 additional genes, including, ATM, BARD1, CDH1, P53, EPCAM, MSH6, and RAD50, which have been implicated in breast and ovarian cancer predisposition.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The molecular significance of methylated BRCA1 promoter in white blood cells of cancer-free females.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Abnormalities in the breast cancer tumor suppressor genes (BRCA1 and BRCA2) are associated with breast and ovarian cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “We integrated these data with known pathways using Ingenuity Pathway Analysis tool and found following common pathways associated with all three diseases to be most affected; epithelial adherens junction signaling, remodelling of epithelial adherens junctions, role of BRCA1 in DNA damage response, sphingomyelin metabolism, 3- phosphoinositide biosynthesis, acute myeloid leukemia signaling, type I diabetes mellitus signaling, agrin interactions at neuromuscular junction, role of IL-17A in arthritis, and antigen presentation pathways.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Lack of association of BRCA1 and BRCA2 variants with breast cancer in an ethnic population of Saudi Arabia, an emerging high-risk area.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Methylation-related mutations in the BRCA1 promoter in peripheral blood cells from cancer-free women.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “The BRCA2 mutation was observed in 4 cases (40%) while no patient presented with the BRCA1 mutation.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Penetrance of BRCA1/BRCA2 specific gene mutations in Iranian women with breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “Mutation analysis of the breast cancer gene BRCA1 among breast cancer Jordanian females.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BRCA1 and BRCA2 mutations in breast cancer patients from Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | BRCA1 | “BRCA1 and BRCA2 mutations in breast cancer patients from Saudi Arabia.” | 0.98 | hgnc_dict_v1 |