leukemia
SaudiVarKB evidence summary derived from retained literature mentions.
500Phenotype mentions
100Publications
50Associated gene records
50Associated variant records
Associated gene records
Co-mentioned in the same publications| Gene | Identifier / context | Articles | Mentions |
|---|---|---|---|
| FLT3 | HGNC:3765 | 36 | 36 |
| BCR | HGNC:1014 | 16 | 16 |
| RUNX1 | HGNC:10471 | 14 | 14 |
| IDH1 | HGNC:5382 | 13 | 13 |
| NPM1 | HGNC:7910 | 13 | 13 |
| ABL1 | HGNC:76 | 11 | 11 |
| TP53 | HGNC:11998 | 10 | 10 |
| JAK2 | HGNC:6192 | 10 | 10 |
| GSTT1 | HGNC:4641 | 8 | 8 |
| CD34 | HGNC:1662 | 7 | 7 |
| GSTM1 | HGNC:4632 | 7 | 7 |
| DNMT3A | HGNC:2978 | 6 | 6 |
| CD33 | HGNC:1659 | 6 | 6 |
| TET2 | HGNC:25941 | 5 | 5 |
| IDH2 | HGNC:5383 | 5 | 5 |
| CD19 | HGNC:1633 | 4 | 4 |
| BTK | HGNC:1133 | 4 | 4 |
| STAT3 | HGNC:11364 | 4 | 4 |
| BCL2 | HGNC:990 | 4 | 4 |
| MPL | HGNC:7217 | 4 | 4 |
| GSTP1 | HGNC:4638 | 4 | 4 |
| CD38 | HGNC:1667 | 4 | 4 |
| CD4 | HGNC:1678 | 3 | 3 |
| NF1 | HGNC:7765 | 3 | 3 |
| CDKN1A | HGNC:1784 | 3 | 3 |
| ABCB1 | HGNC:40 | 3 | 3 |
| BRCA1 | HGNC:1100 | 3 | 3 |
| GATA2 | HGNC:4171 | 3 | 3 |
| BRCA2 | HGNC:1101 | 3 | 3 |
| PTPN11 | HGNC:9644 | 3 | 3 |
| CCND1 | HGNC:1582 | 3 | 3 |
| EGFR | HGNC:3236 | 3 | 3 |
| TLR4 | HGNC:11850 | 3 | 3 |
| CALR | HGNC:1455 | 3 | 3 |
| ASXL1 | HGNC:18318 | 3 | 3 |
| MYC | HGNC:7553 | 3 | 3 |
| FANCD2 | HGNC:3585 | 3 | 3 |
| E2F1 | HGNC:3113 | 3 | 3 |
| NRAS | HGNC:7989 | 3 | 3 |
| CD68 | HGNC:1693 | 3 | 3 |
| CYP1A1 | HGNC:2595 | 3 | 3 |
| STMN1 | HGNC:6510 | 3 | 3 |
| SIRT1 | HGNC:14929 | 2 | 2 |
| TNF | HGNC:11892 | 2 | 2 |
| NAT2 | HGNC:7646 | 2 | 2 |
| CYP2D6 | HGNC:2625 | 2 | 2 |
| PTEN | HGNC:9588 | 2 | 2 |
| MTHFR | HGNC:7436 | 2 | 2 |
| LDLR | HGNC:6547 | 2 | 2 |
| CYP3A4 | HGNC:2637 | 2 | 2 |
Associated variant records
Co-mentioned in the same publications| Variant | Identifier / context | Articles | Mentions |
|---|---|---|---|
| V617F | V617F | 3 | 3 |
| rs1800896 | rs1800896 | 2 | 2 |
| rs1800629 | rs1800629 | 2 | 2 |
| T315I | T315I | 2 | 2 |
| V225I | V225I | 2 | 2 |
| C481T | C481T | 2 | 2 |
| G857A | G857A | 2 | 2 |
| C3435T | C3435T | 2 | 2 |
| G2677T | G2677T | 2 | 2 |
| rs2927488 | rs2927488 | 1 | 1 |
| rs11801299 | rs11801299 | 1 | 1 |
| rs972283 | rs972283 | 1 | 1 |
| rs2910164 | rs2910164 | 1 | 1 |
| C677T | C677T | 1 | 1 |
| A1298C | A1298C | 1 | 1 |
| R258H | R258H | 1 | 1 |
| c.-67T>C | c.-67T>C | 1 | 1 |
| rs2814778 | rs2814778 | 1 | 1 |
| p.W577C | p.W577C | 1 | 1 |
| G894T | G894T | 1 | 1 |
| p.Arg798* | p.Arg798* | 1 | 1 |
| p.Leu492Pro | p.Leu492Pro | 1 | 1 |
| c.637_643del | c.637_643del | 1 | 1 |
| p.Arg2336His | p.Arg2336His | 1 | 1 |
| c.3425del | c.3425del | 1 | 1 |
| I189F | I189F | 1 | 1 |
| H211P | H211P | 1 | 1 |
| c.268T>C | c.268T>C | 1 | 1 |
| p.R90* | p.R90* | 1 | 1 |
| rs33980500 | rs33980500 | 1 | 1 |
| rs13210247 | rs13210247 | 1 | 1 |
| rs1131877 | rs1131877 | 1 | 1 |
| rs4665765 | rs4665765 | 1 | 1 |
| rs12078864 | rs12078864 | 1 | 1 |
| rs12988876 | rs12988876 | 1 | 1 |
| rs79918355 | rs79918355 | 1 | 1 |
| rs231775 | rs231775 | 1 | 1 |
| c.315del | c.315del | 1 | 1 |
| c.941_946dupTGCTGG | c.941_946dupTGCTGG | 1 | 1 |
| T474M | T474M | 1 | 1 |
| C481S | C481S | 1 | 1 |
| T474I | T474I | 1 | 1 |
| rs93059 | rs93059 | 1 | 1 |
| rs1287 | rs1287 | 1 | 1 |
| rs1801 | rs1801 | 1 | 1 |
| rs1050851 | rs1050851 | 1 | 1 |
| rs1957106 | rs1957106 | 1 | 1 |
| rs3138054 | rs3138054 | 1 | 1 |
| rs708567 | rs708567 | 1 | 1 |
| rs76999397 | rs76999397 | 1 | 1 |
Associated population records
Co-mentioned in the same publicationsSupporting publications
100 records- 2026Investigating the effects of the ARG258HIS mutation on RAD51C in inherited Fanconi Anemia and cancer disease.Journal of biomolecular structure & dynamics1 mentions
- 2026Identification of new dasatinib analogues targeting mutated BCR-ABL1: virtual screening, molecular docking, and dynamics simulations studies.Molecular diversity1 mentions
- 2026Chronic lymphocytic leukaemia in the Middle East: a subgroup analysis from the CREEK study on treatment patterns and outcomes.Expert review of anticancer therapy1 mentions
- 2026The emerging role of immunotherapy in improving outcomes in Down syndrome - associated acute lymphoblastic leukemia: an insightful review.Leukemia & lymphoma1 mentions
- 2026"Upfront Use of Blinatumomab in Adolescents and Adults With Philadelphia Chromosome: Negative B-cell Acute Lymphoblastic Leukemia: A Systematic Review and Proportional Meta-Analysis".Clinical lymphoma, myeloma & leukemia1 mentions
- 2026Interplay between acute graft-versus-host disease and graft-versus-leukemia effect in pediatric acute myeloid leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: implications for relapse incidence and survival - an EBMT PDWP retrospective study.Bone marrow transplantation1 mentions
- 2026The impact of DNMT3A mutation on survival of AML patients receiving allotransplant in first remission depends on the karyotype and co-occurring mutations.Bone marrow transplantation1 mentions
- 2026Clinical characteristics, treatment pathway and resource utilisation for patients with chronic lymphocytic leukaemia: A multicentre retrospective study.Leukemia research1 mentions
- 2026Impact of Extramedullary Disease at Diagnosis on Outcomes Post Allogeneic Hematopoietic Cell Transplant in Children and Young Adults With Acute Myeloid Leukemia: A CIBMTR Report.Transplantation and cellular therapy1 mentions
- 2026Strong constitutive NF-κB signaling in B cells drives SLL/CLL-like lymphomagenesis and overcomes microenvironmental dependencies.Leukemia1 mentions
- 2026Correction: Microsecond simulations to investigate the structural mechanism of super-resistant double mutations in BTK to the covalent inhibitor ibrutinib in multiple leukemia.Scientific reports1 mentions
- 2026Common variation at 1q23.3, 2p23.3, 2q33.3, and 2p21 influences the risk of acute myeloid leukemia.Blood1 mentions
- 2026Genetic polymorphisms of tumor necrosis factor receptor-associated factor 3 and their association with acute lymphoblastic leukemia.Cancer genetics1 mentions
- 2026Allogeneic hematopoietic stem cell transplantation in ERCC6L2 disease.Blood advances1 mentions
- 2026Genomic analysis of coexisting β-lactamase plasmids in Klebsiella pneumoniae from an immunocompromised patient.Journal of global antimicrobial resistance1 mentions
- 2026American Society of Hematology 2026 guidelines for frontline management of acute lymphoblastic leukemia in adolescents and young adults.Blood advances1 mentions
- 2026Biomarkers and advances in AML-MRC: from bench to bedside.Annals of hematology1 mentions
- 2026Pharmacomicrobiomics in blood cancers: How the gut microbiome and its metabolites shape drug efficacy and toxicity.Critical reviews in oncology/hematology1 mentions
- 2026IDH enzyme inhibition in cancer therapy: mechanisms, mutational insights, and effects of IDH inhibitors in glioma, acute myeloid leukemia and chondrosarcoma.3 Biotech1 mentions
- 2026Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer.World journal of oncology1 mentions
- 2026Magnesium Oxide Nanoparticles Loaded with 6-Gingerol: A Bioinspired Approach to Anticancer, Anti-Inflammatory, and Antioxidant Therapy.International journal of nanomedicine1 mentions
- 2026Precision targeting of BTK in chronic lymphocytic leukemia: computational insights into structural dynamics and the influence of mutations on BTK inhibitors through QM and MM studies.Journal of biomolecular structure & dynamics1 mentions
- 2026Machine learning-based DNA microarray analysis for disease detection using the MICRO-AI framework.Science progress1 mentions
- 2026Targeting the Menin-KMT2A Interface: Medicinal Chemistry Rules Governing Reversible, Covalent, and Degrader Inhibitors.Chemical biology & drug design1 mentions
- 2026Integrating dual convolutional networks and BiLSTM for precision prediction of chronic myeloid leukemia from protein sequences.Frontiers in genetics1 mentions
- 2026Synchronous Bilateral Retinoblastoma and Precursor B-Cell Acute Lymphoblastic Leukemia in a Treatment-Naive Infant With a De Novo Germline RB1 Variant.Pediatric blood & cancer1 mentions
- 2026Management of tyrosine kinase inhibitors and donor lymphocyte infusions post transplantation for chronic myeloid leukemia: a survey of contemporary practice on behalf of the chronic malignancies working party of the EBMT.Bone marrow transplantation1 mentions
- 2026Effect of age and sex on cardiovascular outcomes among patients with chronic lymphocytic leukemia treated with Bruton tyrosine kinase inhibitors: a propensity matched analysis.Leukemia & lymphoma1 mentions
- 2026Experimental Validation and Computational Deconstruction of Downstream Mutations in MIR5195: Integrating Whole-Exome Sequencing, Structural Dynamics, and Molecular Docking to Decipher Transcriptional Reprogramming in CML.Cell biochemistry and biophysics1 mentions
- 2026A Novel CIP2A and BCL-XL Clinical Diagnostic Toolkit to Predict Disease Progression and Treatment-Free Remission in Chronic Myeloid Leukaemia.International journal of molecular sciences1 mentions
- 2026CRIP1 functions as an oncogene in acute myeloid leukemia by modulating glycolytic metabolic reprogramming.Scientific reports1 mentions
- 2026Coronary vasospasm in a patient with RUNX1 mutation in eosinophilic leukemia and hypereosinophilic syndrome: A case report.Journal of cardiology cases1 mentions
- 2026Outcomes of 544 Patients with t(6;9)/DEK::NUP214 acute myeloid leukemia undergoing allogeneic stem cell transplantation: an EBMT study on behalf of the acute leukemia working party (ALWP) and the pediatric diseases working party (PDWP).Bone marrow transplantation1 mentions
- 2026Asciminib in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Case Series and Review of Emerging Evidence.Hematology reports1 mentions
- 2026Association of MUC3A P258S mutation with advanced phase CML structural and in silico insights.Functional & integrative genomics1 mentions
- 2026HTLV-1-Driven Clonal Evolution and Immune Escape in Adult T-Cell Leukaemia: From Viral Persistence to Therapeutic Failure.Reviews in medical virology1 mentions
- 2026Allosteric and ATP-Pocket BCR::ABL1 Inhibition In Vitro, and Characterising Ex Vivo Thrombo-Inflammatory Biomarkers and Thrombin Generation in Asciminib-Treated CML Patients.International journal of molecular sciences1 mentions
- 2026Measurable Residual Disease in Adult Acute B-Lymphoblastic Leukemia: Methods, Guidelines, and Emerging Actionability at Ultra-Low-Level.Cancers1 mentions
- 2026Novel NSAID Analogs Exhibit Anti-Leukemic Activity Through Modulation of Apoptotic and Survival Pathways.International journal of molecular sciences1 mentions
- 2026Differential Expression and Target Gene Analysis of PBMC-Derived microRNAs as Prognostic Biomarkers in Acute Lymphoblastic Leukemia.International journal of molecular sciences1 mentions
- 2026Disrupting the CBFβ-SMMHC-RUNX1 oncogenic protein-protein interaction in inv(16) AML: from fusion biology to targeted therapy.Discover oncology1 mentions
- 2026SDHB-associated paraganglioma in Saudi Arabia: High metastatic risk linked to a likely founder mutation.Journal of the Endocrine Society1 mentions
- 2026Epigenetics and In Silico Transcriptome Analysis of Pediatric Acute Myeloid Leukemia.European journal of haematology1 mentions
- 2026Computational Analysis of SPI1 Missense Mutations and ADMET-Guided Molecular Docking of Cinnamic Acid Targeting the PU.1 ETS Domain: Implications for Hematopoietic Dysregulation and Leukemogenesis.International journal of molecular sciences1 mentions
- 2026Automated leukemia detection from microscopic images using deep transfer learning with explainable AI-based analysis.Scientific reports1 mentions
- 2026Mechanistic insights into the HuR-V225I mutation and its impact on PKCδ binding dynamics in adult T-cell leukemia.Journal of biomolecular structure & dynamics1 mentions
- 2026Clonal Metamorphosis: Deconstructing MPN Evolution with Single-Cell and Spatial Multi-Omics.Clinical and experimental medicine1 mentions
- 2026Anticancer potential of geranyl acetate through RelA gene downregulation in acute myeloid leukemia cells.Scientific reports1 mentions
- 2026Unveiling natural anti-inflammatory compounds for sinusitis treatments by modulating FOXP3, C5aR1, and LIF.Frontiers in immunology1 mentions
- 2026CBFβ-SMMHC in inv(16) AML: Fusion biology, RUNX1 dysregulation, and therapeutic targeting of a leukemogenic protein-protein interaction.Pathology, research and practice1 mentions
- 2026Immunophenotypic Profiling of Lymphocyte Subsets in Children and Adolescents With Acute Lymphoblastic Leukaemia: Immune Dysregulation Before and After Remission.Journal of immunology research1 mentions
- 2025Novel computational and drug design strategies for the inhibition of human T-cell leukemia virus 1-associated lymphoma by Astilbin derivatives.Journal of biomolecular structure & dynamics1 mentions
- 2025Molecular Analysis of Genes CEBPA, NPM1, IDH1, and RUNX1 Polymorphisms as Biomarker Potential in Leukemia Patients.Molecular carcinogenesis1 mentions
- 2025Prevalence of SPOP and IDH Gene Mutations in Prostate Cancer in a Jordanian Population.Biochemical genetics1 mentions
- 2025Identification of Potential Biomarkers and Pathways in Acute Myeloid Leukemia: Correlation Between the Calcineurin Signaling Pathway and Vascular Brittleness in Acute Myeloid Leukemia.International journal of laboratory hematology1 mentions
- 2025Unraveling the Prognostic Role of t(1:19) in Pediatric Pre-B Acute Lymphoblastic Leukemia: Insights from a Saudi Nationwide Cohort.Cancer genetics1 mentions
- 2025MicroRNAs and long non-coding RNAs In T-cell lymphoma: Mechanisms, pathway, therapeutic opportunities.Pathology, research and practice1 mentions
- 2025Visible-light-induced CO-releasing properties and cytotoxicity of a Ru(II) carbonyl complex containing 2-(pyridin-2-yl)-quinoxaline.Dalton transactions (Cambridge, England : 2003)1 mentions
- 2025Evaluation of circ_0002232 and circ-vimentin gene expressions as valuable biomarkers in acute myeloid leukemia patients.Molecular biology reports1 mentions
- 2025Association of killer immunoglobulin-like receptor genotypes and haplotypes with acute lymphoblastic leukemia risk.Innate immunity1 mentions
- 2025Eugenol Promotes Apoptosis in Leukemia Cells via Targeting the Mitochondrial Biogenesis PPRC1 Gene.Cells1 mentions
- 2025STR profiling in a cohort of Saudi patients with acute leukemia.Journal of Taibah University Medical Sciences1 mentions
- 2025piRNAs in leukemogenesis: Mechanisms, biomarkers, and therapeutic implications.Clinica chimica acta; international journal of clinical chemistry1 mentions
- 2025An innovative approach to development of new pyrazolylquinolin-2-one hybrids as dual EGFR and BRAFV600E inhibitors.Molecular diversity1 mentions
- 2025Identification of UBA7 expression downregulation in myelodysplastic neoplasm with SF3B1 mutations.Scientific reports1 mentions
- 2025Single-cell RNA Sequencing Contributes to the Treatment of Acute Myeloid Leukaemia With Hematopoietic Stem Cell Transplantation, Chemotherapy, and Immunotherapy.Journal of biochemical and molecular toxicology1 mentions
- 2025Molecular epidemiology of bovine leukemia virus in cattle and phylogenetic analysis for determining its prevailing genotype in Khyber Pukhtunkhwa, Pakistan.Animal biotechnology1 mentions
- 2025Autologous stem cell transplantation for adults with Philadelphia-negative acute lymphoblastic leukemia in first complete remission. A study by the Acute Leukemia Working Party of the EBMT.BMC cancer1 mentions
- 2025HOX-PBX Up-regulation Predicts Favorable Prognosis in NPM1-mutated Normal Cytogenetic AML via WNT Signaling.Anticancer research1 mentions
- 2025Cigarette smoke modulates methylation levels of LEF1-AS1 and impedes its expression: An experimental study.Tobacco induced diseases1 mentions
- 2025Deep learning based semantic segmentation of leukemia effected white blood cell.PloS one1 mentions
- 2025A Comparative Analysis of Cardiovascular Events Associated With Acalabrutinib Versus Ibrutinib in Chronic Lymphocytic Leukemia: Insights From a Global Federated Network.Pharmacology research & perspectives1 mentions
- 2025Deciphering the structural and dynamic effects of SHP2-E76 mutations: mechanistic insights into oncogenic activation.BMC chemistry1 mentions
- 2025Safety of Hydroxyurea in Pregnancy: A Systematic Review of the Literature.Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC1 mentions
- 2025Efficacy of Total-Body Irradiation-based Intensified Myeloablative Regimens for Acute Leukemia-An International Collaborative Study.EJHaem1 mentions
- 2025A Review Article: Evaluation of the Frequency of Genetic Mutations in Leukemia.Discovery medicine1 mentions
- 2025Machine learning driven dashboard for chronic myeloid leukemia prediction using protein sequences.PloS one1 mentions
- 2025Dismantling the epigenetic alliance: Emerging strategies to disrupt the PRMT5:MEP50 complex for cancer therapy.European journal of medicinal chemistry1 mentions
- 2025Myeloid Neoplasms With Oligomonocytosis Exhibit Heterogenous Pathologic and Genetic Features.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc1 mentions
- 2025Icariin mitigates experimental contrast-induced nephropathy: Mechanistic insights.Tissue & cell1 mentions
- 2025Repurposing Biomolecules from Aerva javanica Against DDX3X in LAML: A Computer-Aided Therapeutic Approach.International journal of molecular sciences1 mentions
- 2025Unveiling ortho-phenolic Mannich ciprofloxacin-chalcone conjugates with potential antineoplastic activity: synthesis, mechanistic study, in silico docking and molecular dynamic simulation.European journal of medicinal chemistry1 mentions
- 2025CYP3A4 and CYP3A5 Genes in Cyclophosphamide-treated Chronic Lymphocytic Leukemia Patients: A Pharmacogenetics Study.Frontiers in bioscience (Scholar edition)1 mentions
- 2025Epigenetic therapy meets targeted protein degradation: HDAC-PROTACs in cancer treatment.Future medicinal chemistry1 mentions
- 2025Catastrophic asparaginase-induced cerebral and systemic thrombosis in a young female with T-cell lymphoblastic lymphoma: A case report & literature review.Leukemia research reports1 mentions
- 2025Enhanced production of extracellular L-asparaginase in batch culture via nitrous acid-induced mutagenesis of Aspergillus oryzae.Microbial cell factories1 mentions
- 2025Impaired DNA damage responses and inflammatory signaling underpin hematopoietic stem cell defects in Gata2 haploinsufficiency.Stem cell reports1 mentions
- 2025Prognostic Factors and Real-World Outcomes in Adolescents and Young Adults (AYA) With Philadelphia-Negative Acute Lymphoblastic Leukemia (ALL) Treated With the AYA-15 Protocol: A Retrospective Cohort Study From a Tertiary Care Referral Center in the Middle East.Clinical lymphoma, myeloma & leukemia1 mentions
- 2025In silico analysis of CSF2RB from cancer genomic databases reveals a heterogeneous role in different breast cancer subtypes.Frontiers in bioinformatics1 mentions
- 2025Inflammatory cell death and leukemia treatment.Critical reviews in oncology/hematology1 mentions
- 2025Employing a drug repurposing strategy to identify B-cell lymphoma-2 (BCL-2) inhibitors with anticancer potential: An in silico and in vitro based study.Bioorganic & medicinal chemistry1 mentions
- 2025Pan-cancer analysis of PTPN6: prognostic significance and functional implications in tumor progression.Discover oncology1 mentions
- 2025Pristimerin Dampens Acetaminophen-Induced Hepatotoxicity; The Role of NF-κB/iNOS/COX-II/Cytokines, PI3K/AKT, and BAX/BCL-2/Caspase-3 Signaling Pathways.Pharmaceutics1 mentions
- 2025Ocotillo optimization-driven deep learning for bone marrow cytology classification.PloS one1 mentions
- 2025The Association of IL-17RC Polymorphisms rs708567 and rs76999397 With Acute Lymphoblastic Leukaemia.International journal of immunogenetics1 mentions
- 2025First case of primary CNS lymphoma in a patient with severe combined immunodeficiency carrying a novel ZAP70 mutation: a case report.Annals of medicine and surgery (2012)1 mentions
- 2025Epigenetic mechanisms and next-gen editing platforms in hematology: From molecular basis to therapeutic frontiers.Critical reviews in oncology/hematology1 mentions
- 2025TP53-mutated MDS and AML: immune dysregulation, tumor microenvironment, and emerging therapeutic strategies.Frontiers in oncology1 mentions
- 2025Machine Learning for Multi-Omics Characterization of Blood Cancers: A Systematic Review.Cells1 mentions
- 2025The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives.European journal of haematology1 mentions