NLRP3
HGNC:16400 · 131 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | NLRP3 | “NLRs and preeclampsia: Advances in etiology, pathogenesis, and therapeutic targeting, highlighting NLRP3.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The endothelin-1/TLR4/NF-κB/NLRP3 inflammasome axis in preeclampsia: a review of a pathological feed-forward loop and therapeutic frontier.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Both experimental and human evidence support the association of proinflammatory myeloid reprogramming with the loss of ten-eleven translocation 2 (TET2)/DNA methyltransferase 3 alpha (DNMT3A), NOD-like receptor family pyrin domain-containing 3 (NLRP3), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6) signaling, as well as endothelial dysfunction and atherothrombosis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Biochemical parameters including acetylcholinesterase (AChE) activity, oxidative stress markers (MDA, SOD, CAT, GSH), and inflammatory biomarkers (NLRP3, TNF-α, IL-1β) were evaluated.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Dapansutrile alleviates sepsis-induced cardiac injury by modulating NF-кB-induced inflammatory response and TXNIP/NLRP3/ GSDMD-mediated pyroptosis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Association of NLRP3 rs10754558 polymorphism with inflammasome-related cytokine responses in chronic spontaneous urticaria.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “OBJECTIVE: This study aimed to evaluate the therapeutic effects of ethanolic propolis extract (PPL) against thioacetamide (ThA)-induced pulmonary injury in rats and elucidate the underlying mechanisms involving oxidative stress, inflammation, apoptosis, and the NF-κB/NLRP3 signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Dose-dependent neurotoxic effects of anastrozole via disrupting NLRP3 inflammasome and α-synuclein pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “This review comprehensively explores microbiota–virus interactions, including direct viral modulation by commensal bacteria and bacteriophages, metabolic reprogramming of host cells, and immunomodulation by microbial metabolites such as short-chain fatty acids (SCFAs) through the GPR43–NLRP3–MAVS axis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The beneficial effects of ivermectin to treat PF may be attributed to suppressing the NLRP3 inflammasome.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “In vivo investigations revealed improved skin appearance, restoration of epidermal thickness and collagen architecture, reduced levels of inflammatory cytokines (TNF-α, IL-1β, IL-6, NLRP3), reduced oxidative stress biomarkers (GSH, GPx, MDA, SOD), and genetic upregulation of VEGF, TGF-β1, and β-Catenin.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Interaction profiling confirmed stable binding through hydrogen bonding, hydrophobic, and π-interactions with BAX, ASC, GSDMD, KIM-1, JAK2, NLRP3, and miRNA-155.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Modulation of mTOR, NLRP3, and Nrf2/HO-1 signaling by atorvastatin and nitazoxanide in experimental ulcerative colitis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Association of NLRP3 Inflammasome rs10754558 Polymorphism with Type 2 Diabetes Mellitus and Its Complications: Clinical and Bioinformatics Study.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Hepatoprotection by Garlic Essential Oil Nanoemulsion Through Nrf2-Mediated Antioxidant Response and Inhibition of TLR4/NF-κB/NLRP3 Axis in High-Fat Diet-Fed Rats.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The collected samples were then analyzed for gene expression and protein levels of mTOR, STAT3, TGF-β, β-catenin, NFκB, TNF-α, TLR4, and NLRP3.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adipose Tissue.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Reprogramming lysosomal-purinergic crosstalk governs the synergistic attenuation of NLRP3 inflammasome activation by cyclodextrin-P2X7 blockade in diabetic rats.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “These oxidative changes were accompanied by increased pro-inflammatory cytokines (TNF-α, IL-1β) in both tissues, histopathological lesions in the heart and lungs, and upregulation of gene expressions of inflammatory and pyroptotic mediators (NLRP3, Caspase-1, ASC, GSDMD, NF-κB, COX-2, IL-1β, IL-18).” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Protective Effects of Herbacetin in Experimental Colitis: Targeting NF-κB and NLRP3 Pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Protective effect of obeticholic acid on cyclophosphamide-induced thyroid toxicity in rats by inhibiting TXNIP/NLRP3/ASC/caspase-1-dependent pyroptosis and p53/BAX/caspase-3-dependent apoptosis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The isoquinoline alkaloid berberine (BBR) is known to suppress pyroptosis and NLRP3 inflammasome activation, yet its impact on the broader process of PANoptosis remains undefined.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “AIMS: This study evaluates the ability of Rabeprazole (RAB) in counteracting cyclophosphamide (CP)-induced hepatotoxicity, focusing on its regulatory impact on key molecular signaling pathways, particularly AMPK/SIRT1, PI3K/Akt, TLR4/NF-κB, and MAPK, as well as its influence on NLRP3 inflammasome activation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Inflammasome and pyroptosis markers (NLRP3, cleaved-caspase-1, ASC, GSDMD-N, IL-1β, LDH) increased, mitophagy (PINK1, Parkin) decreased, and mitochondrial function (ROS up, ATP down) worsened in DCM group.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “By activating the AMP-activated protein kinase (AMPK) pathway, Metformin improves microvascular perfusion, enhances endothelial nitric oxide bioavailability, and inhibits oxidative stress and NLRP3 inflammasome activation, thereby reducing myocardial inflammation and injury.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Microbial-derived metabolites and immune mediators influence central nervous system (CNS) homeostasis by shaping microglial maturation and activation, regulating cytokine signaling networks, including IL-1β, IL-6, and TNF-α and modulating inflammasome pathways, such as NLRP3.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Trimetazidine is associated with suppression of endoplasmic reticulum stress-mediated NLRP3 inflammasome activation in type 1 diabetes-induced liver damage in rats.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “These structural improvements were accompanied by suppression of the colonic P2X7R/NF-κB/NLRP3/caspase-1 axis, reduced cytokine and oxidative injury, and improved barrier-function indices.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “We critically evaluate the preclinical efficacy of senolytics (eg, dasatinib + quercetin, navitoclax, fisetin), and senomorphics (eg, rapamycin, metformin, melatonin, NLRP3 inhibitors) in preserving ovarian reserve, mitigating SASP-driven inflammation and fibrosis, and extending reproductive lifespan.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Intratracheal Si instillation resulted in considerable pulmonary injury, characterized by increased hydroxyproline, oxidative stress (elevated MDA along with reduced GSH, SOD, and CAT), and the activation of inflammatory (TLR4/NF-κB/NLRP3/IL-1β/IL-6) and fibrogenic (TGF-β/Smad) responses.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “This review synthesizes evidence that weight regain (≥ 20% from nadir weight) reactivates obesity-driven kidney injury pathways, including glomerular hyperfiltration, lipotoxicity (toxic damage from lipid overload), and NOD-like receptor protein 3 (NLRP3) inflammasome activation (an immune complex driving inflammation).” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Outcomes included paw thickness, dysfunction and inflammation indices, serum uric acid, urea, creatinine, AST/ALT, cytokines (IL-1β, TNF-α, IL-6), oxidative stress markers (MDA, SOD, catalase, GSH), and NLRP3 immunoreactivity, supported by radiographic and histopathological analyses.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Blockade of NMDA-receptors mitigates autistic and cognitive behaviors via modulation of TLR-4/NLRP3 inflammasomes and microglia/astrocyte crosstalk in rat model of autism.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Molybdenum induces hepatic impairments via dysregulating NLRP3, JAK1/STAT3 and NF-κB pathways: A dose dependent toxicity assessment.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “PANoptosis exacerbates cytokine storms through ZBP1, NLRP3, and CASP8-mediated pathways, creating a pathological feedback loop that intensifies inflammation and promotes multi-organ damage.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Mechanistically, MDL811 enhanced hepatic SIRT6 activity and exerted anti-inflammatory effects by reducing acetylation of the inflammasome adaptor ASC, suppressing NLRP3 inflammasome activation, and decreasing nuclear NFκB p65 activity and downstream cytokine expression.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Neuroprotective potential of fortunellin against titanium dioxide nanoparticles induced neurotoxicity via regulating NLRP3, HMGB1/RAGE, and NF-κB pathway: A biochemical, histological and in-silico experimentation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Inflammation was reflected by increased NOD-Like Receptor family Pyrin domain-containing 3 inflammasome (NLRP3), Interleukin-6 (IL-6), and Interleukin-1 Beta (IL-1β), besides decreased Interleukin-10 (IL-10).” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Nifuroxazide attenuated 5-fluorouracil-induced cardiac intoxication by regulating NLRP3/STAT-3, PPAR-γ, and apoptosis signals.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Analysis of antioxidant levels, histopathological examinations, measurement of COX-2 & NLRP3 using ELISA, and gene expression analysis of TLR4, NFκB, IL-1β, TNF-α, Caspase-3, and Nrf-2, HO-1, and in hippocampus and cortex using RT-PCR, as well as DNA damage by comet assay, were carried out.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Furthermore, this molecule has a clear effect in reducing inflammation via inhibition of cyclooxygenases-2 (COX-2), tumor necrosis factor-α (TNF-α), and interleukins (IL-6, IL-1β), reduction of NLRP3, GSDMD, and caspase-1 expression, activation of the Nrf2 pathway, and suppression of the ERK/c-Fos/NFATc1 signaling axis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “SYR improves cardiac function via ER/SIRT1/NLRP3/GSDMD and has a protective effect against hypoxia/reoxygenation injury.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Gut microbiota and NLRP3 inflammasome activation in hemodialysis patients: exploring the link with systemic inflammation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Multiple signaling pathways have been implicated in the pathogenesis of ulcerative colitis (UC), including Sphingosine Kinase 1 (SPHK)/Sphingosine-1-Phosphate (S1P), AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/NLR family pyrin domain-containing 3 (NLRP3), zonula occludens-1 (ZO-1), and signal transducer and activator of transcription 3 (STAT3).” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Enhanced hepatoprotective efficacy of quercetin nanoparticles versus free quercetin against acrylamide-induced hepatotoxicity through modulation of MAPK/NF-κB/NLRP3 signaling pathways and molecular docking validation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “NLRP3 inflammasome-based therapies by natural products: a new development in the context of cancer therapy.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Subsiding of inflammatory markers (TNF-α, IL-18, IL-6, TRL-4, CD-8, NLRP3, and caspase 1) and upregulation of tight-junction-related genes (occludin and JAM) was detected in BBLNPs.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “We assessed paw thickness, arthritis indices, serum CRP, RF, OPG, RANKL, and gene expressions of synovial TLR4, NLRP3, caspase-1, GSDMD, Nrf-2, and HO, along with synovial histopathology and NF-κB immunoreactivity.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Cardioprotective potential of tectochrysin against vanadium induced heart damage via regulating NLRP3, JAK1/STAT3 and NF-κB pathway.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “After 48 h, an open field test was conducted, followed by brain tissues collection for measuring the expression of IGF-1, IL-1β and TREM2 and Immunohistochemistry (IHC) analysis for NLRP3 level.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Several prior studies have demonstrated that medications modulating neuroinflammation might lessen AD symptoms, mostly by controlling neuroinflammatory signaling pathways such as the NF-κB, MAPK, NLRP3, etc, and their respective signaling cascade.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The Association between the NLRP3 Inflammasome and Specific Long-Non Coding RNAs (lncRNAs) in Cancer; New Perspective and Summary of Recent Studies.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Nrf2, NF-κB, IL-1β, and NLRP3 mRNA expressions were measured from peripheral blood mononuclear cells (PBMC) using quantitative real-time polymerase chain reaction (qPCR).” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Computational Identification and Functional Analysis of Potentially Pathogenic nsSNPs in the NLRP3 Gene Linked to Alzheimer's Disease.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Testicular specimens were prepared for measurement of oxidative stress markers, and gene expression of NLRP3, caspase-3, and GSK-3b.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “This effect was mediated through the downregulation of pro-inflammatory and stress-related genes, including IL-6, COX-2, iNOS, TLR2, TLR4, NLRP3, CHOP, JNK, XBP1, and ATF6.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Evolocumab ameliorates myocardial fibrosis and improves metabolic syndrome-induced cardiac dysfunction in rats via inhibiting PCSK9/NLRP3 inflammasome and Caspase-1 / IL-1β pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Targeting of NF-κB/NLRP3 Axis in Gestational Diabetes Mellitus.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Targeting NLRP3 and AIM2 signaling pathways by Viscosol alleviates metabolic dysregulations induced inflammatory responses in diabetic neuro- and nephropathy: An in silico and in vivo study.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Therefore, we have developed chitosan-armored 1,2-dimyristoyl-sn-glycero-3-phosphoglycerol (DMPG) nanoliposomes amalgamated with synthesized beta-sitosterol-sinapic acid (Be-S) conjugate, further encapsulated with 3,4-methylenedioxy-β-nitrostyrene (MNS) as NLRP3 inhibitor, termed C@MN@DMBe-S, to overcome the limitation of free MNS and sinapic acid.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Multifunctional chrysin-loaded gallic acid-glycerol monostearate conjugate-based injectable hydrogel for targeted inhibition of hypoxia-induced NLRP3 inflammasome in ulcerative colitis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Chitosan-Based Intelligent Microneedles for Delivery of Amphotericin B Loaded Oleosomes: Antifungal Ocular Patch Targeting for Effective Against Fungal Keratitis Using Rabbit Model via TLR4/NLRP3 Pathway.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Thymoquinone Attenuates Aluminum Chloride-Induced Testicular Injury by Inhibiting NLRP3/Caspase 1/IL-1β Inflammasome Signaling and Polarizing the Macrophages Toward Anti-Inflammatory M2 Phenotype.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Evogliptin prevents ceramide-induced pyroptosis during calcification via modulation of NLRP3/GSDM-D mediated pathway in Vascular Smooth Muscle Cells.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Naftidrofuryl mitigates LPS-induced pulmonary injury through macrophage polarization and NLRP3/TLR4 regulation, an in vitro and in vivo perspective.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Association of polymorphism of NLRP3, ICAM-1, PTPN22, INS genes in childhood onset type 1 diabetes in a Pakistani population.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Corrigendum: Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study. [This corrects the article DOI: 10.3389/fphar.2024.1381523.].” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Effect of a high dose atorvastatin as added-on therapy on symptoms and serum AMPK/NLRP3 inflammasome and IL-6/STAT3 axes in patients with major depressive disorder: randomized controlled clinical study.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Adropin/Tirzepatide Combination Mitigates Cardiac Metabolic Aberrations in a Rat Model of Polycystic Ovarian Syndrome, Implicating the Role of the AKT/GSK3β/NF-κB/NLRP3 Pathway.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Ammonia Exposure-Induced Immunological Damage in Chicken Lymphoid Organs via TLR-7/MYD88/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Recent studies have revealed that ncRNAs can promote or inhibit pyroptosis by interacting with key molecular players such as NLRP3, GSDMD, and various transcription factors.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The production of cytokines, leukocyte recruitment, oxidative stress, and nucleotide-binding domain, leucinerich-containing family, pyrin domain-containing-3 (NLRP3)-inflammasome genes expressions were increased in positive arthritic mice and ameliorated significantly by SA administration.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “OBJECTIVES: We aimed to explore the potential therapeutic effects of Arctiin on rats with AD by evaluating the expression of TLR4, NLRP3, STAT3, TGF-β, cyclin D1, and CDK2.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Hesperetin protects against rotenone-induced motor disability and neurotoxicity via the regulation of SIRT1/NLRP3 signaling.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “NLRP3 (rs10754558) gene polymorphism and tumor necrosis factor alpha as predictors for disease activity and response to methotrexate and adalimumab in psoriasis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Alirocumab boosts antioxidant status and halts inflammation in rat model of sepsis-induced nephrotoxicity via modulation of Nrf2/HO-1, PCSK9/HMGB1/NF-ᴋB/NLRP3 and Fractalkine/CX3CR1 hubs.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Pinocembrin's protective effect against acute pancreatitis in a rat model: The correlation between TLR4/NF-κB/NLRP3 and miR-34a-5p/SIRT1/Nrf2/HO-1 pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Vitamin D regulates COVID-19 associated severity by suppressing the NLRP3 inflammasome pathway.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Fenpropathrin provoked kidney damage via controlling the NLRP3/Caspase-1/GSDMD-mediated pyroptosis: The palliative role of curcumin-loaded chitosan nanoparticles.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Furthermore, Zer reduced the caspase-1 activity without altering cytosolic NLRP3 content in challenged M2 BMDMs.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Targeting SIRT1, NLRP3 inflammasome, and Nrf2 signaling with chrysin alleviates the iron-triggered hepatotoxicity in rats.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Identification of novel NLRP3 inhibitors as therapeutic options for epilepsy by machine learning-based virtual screening, molecular docking and biomolecular simulation studies.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Pretreatment with either extract significantly reduced the seizure scores, partially reversed the histological changes in the cerebral cortex and exerted antioxidant/anti-inflammatory efficacy evinced by elevated hippocampal total antioxidant capacity and SOD and catalase activities, parallel to the decrement in MDA content, iNOS activity and the TXNIB/NLRP3 axis with a subsequent decrease in caspase 1 activation and a release of IL-1β and IL-18.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Methanolic extract in experimental rats: Role of APOE4/LRP1, TLR4/NF-κβ/NLRP3, Wnt 3/β-catenin/GSK-3β, autophagy and apoptotic cues.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Fenofibrate as an Adjunct Therapy for Ulcerative Colitis: Targeting Inflammation via SIRT1, NLRP3, and AMPK Pathways: A Randomized Controlled Pilot Study.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The recognition of NLRP3 inflammasome activation in the pathogenesis of UC has gained widespread acceptance.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Rosuvastatin and diosmetin inhibited the HSP70/TLR4 /NF-κB p65/NLRP3 signaling pathways and switched macrophage to M2 phenotype in a rat model of acute kidney injury induced by cisplatin.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “OBJECTIVE: In gout, hyperuricemia promotes urate crystal deposition, which stimulates the NLRP3 inflammasome and interleukin-1β (IL-1β)-mediated arthritis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The NLRP3 inflammasome rs35829419 C>A polymorphism is associated with type 2 diabetes mellitus in Saudi Arabia.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The Role of NLRP3 Inflammasome in Obesity and PCOS-A Systematic Review and Meta-Analysis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Furthermore, it relieved pyroptosis by negatively regulating the expression of the NLRP3, caspase-1, and IL-1β hepatic gene expression.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “γ-Mangostin abrogates AINT-induced cholestatic liver injury: Impact on Nrf2/NF-κB/NLRP3/Caspase-1/IL-1β/GSDMD signalling. γ-Mangostin (γ-MN) is one of the abundant xanthones separated from Garcinia mangostana (Clusiaceae) pericarps that has been reported to have varied bioactivities such as neuroprotective, cytotoxic, antihyperglycemic, antioxidant, and anti-inflammation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Additionally, ISO increased the levels of inflammatory markers (COX-2, NLRP3, and NF-кB) and apoptotic mediators such as p-JNK.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Besides, miRNAs are implicated in several modulatory signaling pathways of cardiovascular disorders including mitogen-activated protein kinase, nuclear factor kappa beta, protein kinase B (AKT), NOD-like receptor family pyrin domain-containing 3 (NLRP3), Jun N-terminal kinases (JNKs), Toll-like receptors (TLRs) and apoptotic protease-activating factor 1 (Apaf-1)/caspases.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Suppressing NLRP3 activation and PI3K/AKT/mTOR signaling ameliorates amiodarone-induced pulmonary fibrosis in rats: a possible protective role of nobiletin.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Nifuroxazide mitigates doxorubicin-induced cardiovascular injury: Insight into oxidative/NLRP3/GSDMD-mediated pyroptotic signaling modulation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Furthermore, indomethacin administration led to disturbed intestinal permeability, evidenced by the activation of the NLRP3 inflammasomes pathway and elevation of downstream biomarkers (TLR4, IL18, caspase 1).” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Importantly, both β-hydroxybutyrate and KD curbed the DSS-induced aberrant NLRP3 inflammasome activation as observed in mRNA and protein expression analysis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “These effects were attributed to inhibiting NFκB and NLRP3 inflammasome activation and restraining pyroptosis and apoptosis while enhancing autophagy as revealed by reduced p62 and increased BECN1.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Acute Glycemic Control in Prediabetes Individuals Favorably Alters Serum NLRP3 Inflammasome and Related Interleukins.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Consequently, the expression of NLRP3 and IL-1β is shown to be positively correlated with neutrophil recruitment and negatively correlated with airflow obstruction.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Furthermore, mRNA and immunohistochemistry (IHC) analysis revealed that STR ameliorates UA (uric acid)-associated renal inflammation, fibrosis, and EMT (epithelial-mesenchymal transition) via MMPS (matrix metalloproteinases), inhibiting NF-κB/NLRP3 activation by the AMPK/SIRT1 pathway and modulating the JAK2-STAT3 and Nrf2 signaling pathways.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Carvacrol Alleviates Hyperuricemia-Induced Oxidative Stress and Inflammation by Modulating the NLRP3/NF-κB Pathwayt.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “NIMA-related kinase7 (NEK7) plays a multifunctional role in cell division and NLRP3 inflammasone activation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “These involve interferons, which appear as a consensus function, immune signaling receptor NLRP3 (NLR family pyrin domain-containing 3) inflammasome, and inflammatory cytokines such as interleukin 1β (IL-1β) and are critical in COVID-19 pathology.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The dynamic interplay between AMPK/NFκB signaling and NLRP3 is a new therapeutic target in inflammation: Emerging role of dapagliflozin in overcoming lipopolysaccharide-mediated lung injury.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Topiramate Reprofiling for the Attenuation of Cadmium-Induced Testicular Impairment in Rats: Role of NLRP3 Inflammasome and AMPK/mTOR-Linked Autophagy.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Our results revealed that diacetylrhein targeted the NLRP3 and inhibited the inflammasome assembly.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Multi-Strain-Probiotic-Loaded Nanoparticles Reduced Colon Inflammation and Orchestrated the Expressions of Tight Junction, NLRP3 Inflammasome and Caspase-1 Genes in DSS-Induced Colitis Model.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Combining the HSP90 inhibitor TAS-116 with metformin effectively degrades the NLRP3 and attenuates inflammasome activation in rats: A new management paradigm for ulcerative colitis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “THP-1 monocytes were treated with MSU crystals ± rhPRG4 and cellular levels of NLRP3 protein, pro-IL-1β, secreted IL-1β, and activities of caspase-1 and protein phosphatase-2A (PP2A) were quantified.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Evaluation of NLRP3 (rs10754558) and PTPN22 (1858C/T) (rs2476601) Functional Polymorphisms in Psoriasis Susceptibility in Egypt.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Role of NLRP3 Inflammasome Activation in Obesity-Mediated Metabolic Disorders.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Interference With the AMPKα/mTOR/NLRP3 Signaling and the IL-23/IL-17 Axis Effectively Protects Against the Dextran Sulfate Sodium Intoxication in Rats: A New Paradigm in Empagliflozin and Metformin Reprofiling for the Management of Ulcerative Colitis.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “A Novel Combination Therapy Using Rosuvastatin and Lactobacillus Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome Composition.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “The Expression of Allele Changes in NLRP3 (rs35829419) and IL-1β (+3954) Gene Polymorphisms in Periodontitis and Coronary Artery Disease.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Genetic Polymorphisms of NLRP3 (rs4612666) and CARD8 (rs2043211) in Periodontitis and Cardiovascular Diseases.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Resident macrophages initiate inflammation in response to MSU mediated by NF-κB nuclear translocation and NLRP3 inflammasome activation.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Here we show that the polysaccharide galactosaminogalactan (GAG) of A. fumigatus is a PAMP that activates the NLRP3 inflammasome.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Expression of miRNA-223 and NLRP3 gene in IgA patients and intervention of traditional Chinese medicine.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Also, mechanistically, NLRP3 KO mice showed a significant decrease in the inflammation and NAFLD phenotype and resisted the metabolic changes such as insulin resistance and glucose metabolism in the liver.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “IL-1β is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1β.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Chicoric acid prevents methotrexate-induced kidney injury by suppressing NF-κB/NLRP3 inflammasome activation and up-regulating Nrf2/ARE/HO-1 signaling.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Toll-like receptor2 (TLR2) and Nod-like receptor protein 3 (NLRP3) Inflammasome are implicated in hepatic steatosis, inflammation and fibrosis; the histological landmark stages of NASH.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “A large number of variants has been described for the four genes associated with the best known HRF, namely MEFV, NLRP3, MVK, TNFRSF1A.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “RESULTS: Cross-sectional analyses showed that the LPS-induced expression of genes involved in inflammasome (NLRP3, caspase 5 and NAIP), Nod-like receptors (NLRX1 and NOD1), downstream signaling (P2RX7, RAGE, RIPk2, TIRAP and BIRC2) and effector molecules (IFN-γ, IL-12β, IL-1β, CCL2, CCL5, IL-6 and TNFα) was significantly increased in obese subjects at baseline as compared with normal weight controls.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Patients carrying NLRP3 variants and germline-mutation-negative patients were included.” | 0.98 | hgnc_dict_v1 |
| gene | NLRP3 | “Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis: the role of NLRP3 inflammasome activation.” | 0.98 | hgnc_dict_v1 |