HLA-B
HGNC:4932 · 43 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | HLA-B | “Molecular docking studies showed very high-grade interactions between the vaccine and the immune receptors, with HLA-B showing the most stable complex.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Identification of the Novel HLA-B*42:38 Allele by Sequencing-Based Typing.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Identification of the Novel Allele, HLA-B*08:337, in a Saudi Individual Using Next-Generation Sequencing.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The Novel Allele, HLA-B*41:92, Identified by Next-Generation Sequencing in a Saudi Individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Deficiency of Adenosine Deaminase 2 Masquerading as Behçet's Disease: Phenotypic Mimicry with HLA-B*51 Positivity.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The gene with the highest number of variants was HLA-DRB1, followed by HLA-B, ABO, HPS4, and SP110 displaying both common polymorphisms and rare variants.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Association of HLA-B gene polymorphism and blood groups with COVID-19 susceptibility and severity.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The protein-protein interaction (PPI) network revealed five key hub proteins (ITGAX, IRF7, MX1, HLA-B, and IRF1).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Identification of the Novel HLA-B*49:01:01:23 Allele by Sequencing-Based Typing.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Our findings indicate that, based on alteration patterns, survivability, differential gene and protein level expressions, the genes ERBB3, ERBB4, HLA-B, AKT1, GNAS, FGFR4, PIK3R3 and AXIN2 emerge as primary risk factors in TNBC.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “OBJECTIVES: This study aimed to determine the diverse inborn and adventitious variables that contribute to the rise of Ankylosing Spondylitis (AS) and to elucidate the genotypic study of HLA-B*27 alleles along with sub-alleles and in-silico inhibition of their respective abnormal receptor proteins by natural compounds.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Gender, HLA-B*27 and/or HLA-B*51 positivity, and ethnicity did not show any significant impact on the prevalence of ME (p = 0.635, p = 0.372, p = 0.193, respectively).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “HLA-B* 51:01:01 G was protective from severe disease while HLA-B* 50:01:01 G, HLA-C* 06:02:01 G and HLA-DRB1 * 07:01:01 G were associated with risk to severe disease as well as the total COVID-19 cohort.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “It specifically highlights genes associated with antigen processing and presentation, such as HLA-B, HLA-A and HLA-DRB1 and their possible effects on tumour progression and immune evasion.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Identification of the novel HLA-B*53:69 allele by sequencing-based typing.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Prevalence of the HLA-B*5701 Allele and Abacavir Hypersensitivity in Saudi HIV Patients: A Multicenter Study.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “We identified 17 HLA-A, 28 HLA-B, 14 HLA-C, 13 HLA-DRB1, and 5 HLA-DQB1 alleles, of which HLA-A*02 (22.2%), -B*51 (19.5%), -C*07 (20.0%), -DRB1*03 (22.2%), and -DQB1*02 (32.8%) were the most frequent allele lineages.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The selected CTL epitopes showed high affinity and stable binding with the binding groove of common human HLA class I molecules (HLA-A*02:01 and HLA-B*44:02) and mouse major histocompatibility complex class I molecules.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “We were able to identify 15 HLA-A, 20 HLA-B, 11 HLA-C, 13 HLA-DRB1, and five HLA-DQB1 homozygous alleles demonstrating a very low genetic diversity in the Saudi population.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “We analysed frequencies for 24 HLA-A alleles (3 alleles for HLA-A∗26 at four digits), 50 HLA-B alleles (11 alleles for HLA-B∗51 at four digits), 15 HLA-C alleles, 16 HLA-DRB1 alleles, 6 HLA-DQB1 alleles, and 15 HLA-DPB1 alleles.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Association of HLA-B Gene Polymorphisms with Type 2 Diabetes in Pashtun Ethnic Population of Khyber Pakhtunkhwa, Pakistan.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “No independent effects of HLA-B allele associations were observed in T1D w/CD.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Identification of a novel HLA-B*18 variant, HLA-B*18:01:01:52, in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The frequency of HLA-B*51 was significantly higher among patients in the fatal group than among those in the mild infection group (15% vs.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Human leukocyte antigen (HLA)-B*57:01, HLA-B*15:02, HLA-A*31:01, and HLA-B*58:01 constitute established risk factors and preemptive genotyping of these HLA alleles in patients prior to the initiation of abacavir, carbamazepine, and allopurinol-based therapies can prevent toxicity and improve patient outcomes.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Novel HLA-B*50:66 allele, identified by next-generation sequencing in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The novel HLA-B*07:387 allele, identified by next-generation sequencing in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “HLA-B*57:01 is an established genetic risk factor for flucloxacillin DILI.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “A novel HLA-B allele, HLA-B*44:03:01:19, identified by next-generation sequencing in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “A novel HLA-B allele, HLA-B*08:242, identified by next-generation sequencing in a Saudi individual.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Association of serum 25-hydroxyvitamin D concentration with HLA-B, -DRB1 and -DQB1 genetic polymorphisms.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Ten alleles accounted for 70% of HLA-B alleles.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “These included SNPs within nuclear factor I A (NFIA), serologically defined colon cancer antigen 8 (SDCCAG8), lysosomal associated membrane protein 3 (LAMP3), nuclear factor kappa B subunit 1 (NFKB1), major histocompatibility complex, class I, B (HLA-B) and 5'-nucleotidase, cytosolic II (NT5C2) and SNPs within intragenic regions microRNA 6828 (MIR6828)-solute carrier family 7 member 14 (SLC7A14) and sonic hedgehog (SHH)-long intergenic non-protein coding RNA 1006 (LINC01006).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Ankylosing spondylitis (AS) is a common, highly heritable, inflammatory arthritis for which HLA-B*27 is the major genetic risk factor, although its role in the aetiology of AS remains elusive.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “In class I the HLA-A*01 (P = 0.03, OR 2.68), A*02 (P = 0.001, OR 3.02) and HLA-B*07 (P = 0.01, OR 3.27), were significantly associated with autism.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The alleles positively associated to the ESRD were: HLA-B*15, B*18, B*49 - DRB1*03, negatively associated alleles were A*26, HLA-B*39, B*50.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The most frequently observed allele for HLA-A was HLA-A*02:01:01:01 (13.6%); for HLA-B, HLA-B*50:01:01 (15.8%); for HLA-C, HLA-C*06:02:01:01 (18.7%); for HLA-DRB1, HLA-DRB1*07:01:01:01 (26.6%); and for HLA-DQB1, HLA-DQB1*02:01:01 (20.3%).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “AIMS: Being one of the most polymorphic genetic systems , the Human Leukocyte Antigen system is divided into class I (HLA-A, HLA-B and HLA-C) and class II (HLA-DP, -DQ and -DR).” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Class I HLA, HLA-A, HLA-B and HLA-C, and Class II HLA, HLA-DR and HLA-DQ, were typed for each patient and their partner.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “The strongest association was with HLA-B*08, which was associated with young age at onset and female gender.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “We observed no significant difference between patients and controls in HLA-B and HLA-C allele frequency.” | 0.98 | hgnc_dict_v1 |
| gene | HLA-B | “Identification of a novel HLA-B allele (B*4202) in a Saudi Arabian family with Behçet's disease.” | 0.98 | hgnc_dict_v1 |