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gene

BDNF

HGNC:1033 · 86 retained evidence mentions

Supporting evidence

TypeEntitySource evidenceConfidenceExtractor
geneBDNF“The effect of PSB on 3-NPA induced alterations on lipid peroxidation and oxidative stress markers (malondialdehyde, superoxide dismutase, reduced glutathione, and catalase), neurotransmitter levels (dopamine serotonin, glutamate, and GABA), Complex I (ATP generation) and Complex II (succinate dehydrogenase) cytokines levels (tumour necrosis factor-α, interleukin-1β, and IL-6), programmed cell-death marker levels (Caspase-3 and Caspase-9), and brain-derived neurotrophic factor (BDNF) was assessed by brain striatum homogenate.”0.98hgnc_dict_v1
geneBDNF“Common molecular signatures: the role of BDNF, melatonin, and orexin in the ASD-schizophrenia continuum.”0.98hgnc_dict_v1
geneBDNF“BDNF Val66Met Variant as a Genetic Risk Factor for Major Depressive Disorder in Saudis.”0.98hgnc_dict_v1
geneBDNF“Increasing evidence indicates that activation of the Sonic Hedgehog (Shh) signaling could enhance neurotrophic and prosurvival signaling, particularly through modulation of the brain-derived neurotrophic factor (BDNF)/protein kinase B (Akt)/glycogen synthase kinase-3β (GSK-3β) cascade.”0.98hgnc_dict_v1
geneBDNF“These include dysregulation of the dopaminergic, serotonergic, glutamatergic, GABAergic, and acetylcholinergic systems; changes in BDNF signaling; histamine dysregulation; microglial activation; neuroinflammation; complement-mediated synapse elimination; gut-brain axis signaling; and endocannabinoid system dysfunction.”0.98hgnc_dict_v1
geneBDNF“Hippocampal mRNA expression of Wnt pathway components and brain-derived neurotrophic factor (BDNF) was quantified by RT-qPCR using the 2-ΔΔCt method.”0.98hgnc_dict_v1
geneBDNF“Gene expression investigations revealed downregulation of NF-κB, COX-2, and TNF-α, and overexpression of BDNF.”0.98hgnc_dict_v1
geneBDNF“Similarly, ANZ administration showed marked reductions in the levels of BDNF, NGF, GDNF PSD-95, and synaptophysin while increasing the levels of NF-κB, COX-2, TNF-α, IL-1β, and IL-6.”0.98hgnc_dict_v1
geneBDNF“This study investigated the effects of Dex on microglial activation, neuroinflammation, and apoptosis, and the role of Api in hippocampal neurogenesis, along with its combined effects via the miR-15a/ROCK-1/ERK1/2/CREB/BDNF signaling cascade.”0.98hgnc_dict_v1
geneBDNF“SI rats showed marked reductions in locomotion, sucrose preference, social interaction, antioxidant capacity (Nrf2, SOD, CAT, GSH), neurotransmitters (serotonin, dopamine, GABA, glycine), and BDNF, alongside significant increases in oxidative stress markers (8-OHdG, MDA, NO), inflammatory cytokines (TNF-α, IL-1β, NF-κB), apoptotic mediators (Bax and Caspase-3), GFAP, and histological degeneration (P < 0.05).”0.98hgnc_dict_v1
geneBDNF“Aloe Polysaccharides against 3-Nitropropionic acid-induced Huntington's disease-like symptoms: Role of BDNF/NF-κB/Nrf2 signaling pathways.”0.98hgnc_dict_v1
geneBDNF“Acute or transient (short-term) A₂AR activation, on the other hand, increases the production of anti-inflammatory cytokines like IL-10 and enhances neurotrophic support through BDNF.”0.98hgnc_dict_v1
geneBDNF“Taurine Mitigates Microplastic-Induced Neurotoxicity Through Modulation of Neurobehavior, Neurotransmitters, Oxidative Stress, and AKT-1/CREB-1/BDNF Signaling in Mice.”0.98hgnc_dict_v1
geneBDNF“24 male rats were allocated to control, fasting lean group, obese (HFD-fed), and obese fasting groups; behavioral tests, biochemical assays, and molecular analyses (inflammatory markers, BDNF, and autophagy-related genes) were conducted to assess cognitive function and underlying mechanisms.”0.98hgnc_dict_v1
geneBDNF“The mice were tested for anxiety, cognition and depression in an array of behavioral experiments, followed by analyzing the oxidative markers, morphological changes and mRNA expression of GFAP, BDNF and TrkB in isolated hippocampi.”0.98hgnc_dict_v1
geneBDNF“Dysregulation of miR-124, miR-135, and miR-16 affects neurotransmitter signaling and neurotrophic support, particularly serotonin, dopamine, and brain-derived neurotrophic factor (BDNF), and increases neuroinflammation.”0.98hgnc_dict_v1
geneBDNF“Additionally, barbigerone effectively attenuated the 3-NPA-induced elevation of caspase-3 and caspase-9, while upregulating brain-derived neurotrophic factor (BDNF), which is crucial for neuronal survival and cognitive function.”0.98hgnc_dict_v1
geneBDNF“Additionally, the expression levels of neurotrophic factors (BDNF), antioxidant (GSH), and glutamine synthase (GS) were lower in diabetic retinas compared to controls.”0.98hgnc_dict_v1
geneBDNF“Molecular Crosstalk of Vitamin D3 with cGAS-STING and BDNF Pathways in a Rat Model of Chronic Stress.”0.98hgnc_dict_v1
geneBDNF“Rufinamide Mitigates Seizures and Behavioural Deficits via BDNF/TrkB Modulation and Oxidative Stress Reduction in Pentylenetetrazole-Kindled Mice.”0.98hgnc_dict_v1
geneBDNF“Moreover, brain health was compromised after TiO2-NPs exposure which is evident by reduced concentrations of Nerve growth factor (NGF) (58 %), Synaptophysin (63 %), Glial cell line derived neurotrophic factor (GDNF) (54 %), Postsynaptic density 95 (PSD-95) (49 %), and Brain-derived neurotrophic factor (BDNF) (61 %).”0.98hgnc_dict_v1
geneBDNF“Moreover, MSG altered cerebellar histological structure and significantly (p < 0.05) decreased antioxidant system activity and protein levels of phosphorylated phosphoinositide 3-kinases (p-PI3K), phosphorylated protein kinase B (p-AKT), and brain-derived neurotrophic factor (BDNF).”0.98hgnc_dict_v1
geneBDNF“The results showed that when SH-SY5Y cells are exposed to MG (2400 μM) + taurine (1.5 mg/mL), genes SHH, BMP2, ERBB2, NEUROG2, BDNF, POU3F3, PARD3, PAX3, NR2E3, NRP2, CXCL1, and EGF had a significant increase (p < 0.005).”0.98hgnc_dict_v1
geneBDNF“Brain-derived neurotrophic factor (BDNF), an autocrine/paracrine regulator of basic ovarian functions and antagonist of kisspeptin.”0.98hgnc_dict_v1
geneBDNF“Serotoninergic modulation in the brainstem and hypothalamus of female overnourished rats: impact on mitochondrial markers, oxidative stress and BDNF mRNA levels.”0.98hgnc_dict_v1
geneBDNF“Additionally, CdCl2 impaired spatial, short-term, and recognition memory, decreased granular cell density in the dentate gyrus (DG), and reduced levels of neuroprotective factors, including Nrf2, brain-derived neurotrophic factor (BDNF), acetylcholine (ACh), and several antioxidant enzymes including heme-oxygenase-1 (HO-1) and superoxide dismutase (SOD), as well as reduced glutathione (GSH).”0.98hgnc_dict_v1
geneBDNF“Using quantitative real-time PCR (qRT-PCR), the expression of the Brain-Derived Neurotrophic Factor (BDNF) gene was examined in prefrontal cortex (PFC) samples.”0.98hgnc_dict_v1
geneBDNF“This study examines primary molecular markers commonly assessed in GBM patients, including brain-derived neurotrophic factor (BDNF), platelet-derived growth factor receptor A (PDGFRA), O6-methylguanine DNA methyltransferase (MGMT), epidermal growth factor receptor (EGFR), and vascular endothelial growth factor A (VEGFA) using computational approaches.”0.98hgnc_dict_v1
geneBDNF“Herbs such as curcumin, ginkgo biloba, panax ginseng, bacopa monnieri, ashwagandha, and rhodiola rosea influence the BDNF pathway through various mechanisms.”0.98hgnc_dict_v1
geneBDNF“Therapeutic effects of Lactobacillus rhamnosus, thymol and their combination against neurotoxicity in propionic acid (PA)-induced autistic rats: insights into the role of the Nrf2/HO-1, Wnt3/β-catenin/GSK3β BDNF/p-TrkB/CREB, pI3K/Akt/mTOR, AMPK/SIRT-1, and PERK/CHOP/Bcl-2 pathways.”0.98hgnc_dict_v1
geneBDNF“In vivo, in silico effects of sakuranetin as a multi-target nutraceutical against PTZ-induced seizures via GABA restoration and BDNF/TrkB activation.”0.98hgnc_dict_v1
geneBDNF“Accumulating evidence indicates that NSs, including Allopregnanolone, brexanolone, and ganaxolone, may exert neuroprotective and anti-epileptogenic effects through both direct GABAergic modulation and indirect regulation of mTORC1, AMPK, and BDNF signaling pathways, as well as autophagy activation.”0.98hgnc_dict_v1
geneBDNF“RT-PCR confirmed substantial downregulation of proinflammatory and excitatory markers, including BDNF, TrkB, and TNF-α, indicating suppression of neuroinflammation and excitotoxicity in combination-treated group.”0.98hgnc_dict_v1
geneBDNF“Assessments included oxidative stress markers (8-OHdG, MDA, NO), antioxidant (GSH, GST, GPX, SOD, CAT), cholinergic function (AChE), epigenetic markers (DNA methylation, BDNF promoter methylation, miR-34a, miR-29b), neurodegeneration-associated proteins (Aβ1-42, Tau), survival/inflammatory signaling pathways (p-Akt, PI3K mRNA, ERK, Bcl-2, COX2, IL-1β, TNF-α, IL-2, TGF-β), apoptosis (Caspase-3), BDNF mRNA, and brain histology.”0.98hgnc_dict_v1
geneBDNF“Bcl-2, BDNF, IL-1β and Caspase showed high binding affinities with docking score of 7.8 kcal/mol, 7.7. kcal/mol.”0.98hgnc_dict_v1
geneBDNF“All treatments remarkably improved MSG-induced abnormalities in neurotransmitters' levels; biochemical markers; along with histological findings, via modulating HMGB1/RAGE/JAK-2/STAT-3, PI3K/AKT/CREB/BDNF, AMPK/SIRT-1 and PERK/CHOP pathways.”0.98hgnc_dict_v1
geneBDNF“Interestingly, ketamine enhanced hippocampal expression of brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB), phosphorylated protein kinase B (p-Akt), phosphorylated glycogen synthase kinase-3β (p-GSK-3β), phosphorylated mechanistic target of rapamycin (p-mTOR), deactivated Unc-51-like autophagy activating kinase 1 (ULK1), and synapsin I, while decreasing phosphorylated eukaryotic elongation factor 2 (p-eEF2), autophagy markers (Beclin-1 and LC3), caspase-3, p-tau, and oxidative/nitrosative stress markers, reflecting the amendment of the CUS-induced disturbed synaptogenesis, autophagy, and tauopathy.”0.98hgnc_dict_v1
geneBDNF“Conversely, they also support repair through neurotrophic factor release (e.g., BDNF, CNTF) and remyelination.”0.98hgnc_dict_v1
geneBDNF“Biochemical tests promoting oxidative stress were evaluated [superoxide dismutase (SOD), reduced glutathione (GSH), catalase (CAT) and malondialdehyde (MDA)], including changes to neurotransmitters serotonin (5-HT), dopamine (DA), norepinephrine (NE), homovanillic acid (HVA), (3,4-dihydroxyphenylacetic acid (DOPAC), γ-aminobutyric acid (GABA), and 5-hydroxy indole acetic acid (5-HIAA), nuclear factor kappa-B (NF-κB), tumor necrosis factor-α (TNF-α), interleukins-1β (IL-1β), IL-6, brain-derived neurotrophic factor (BDNF), and nuclear factor erythroid 2-related factor 2 (Nrf2).”0.98hgnc_dict_v1
geneBDNF“Gene expression analysis revealed downregulation of SOD1 and CAT genes, upregulation of inflammatory genes TNF-α and IL-1β, and increased expression of the apoptotic gene p53 with decreased expression of Bcl-2 and BDNF.”0.98hgnc_dict_v1
geneBDNF“Gene expressions of SIRT1, BDNF, and RAGE were assessed.”0.98hgnc_dict_v1
geneBDNF“In silico energetic and molecular dynamic simulations studies demonstrate potential effect of the point mutations with implications for protein engineering in BDNF.”0.98hgnc_dict_v1
geneBDNF“In vitro, MNCs subjected to TNFα and/or IFNγ displayed both pro- and anti-inflammatory characteristics indicated by changes in cytokine (IL-18 & IL-10) and growth factor (BDNF & VEGF) gene and protein expression compared to controls.”0.98hgnc_dict_v1
geneBDNF“Quercetin modulates expression of serum exosomal long noncoding RNA NEAT1 to regulate the miR-129-5p/BDNF axis and attenuate cognitive impairment in diabetic mice.”0.98hgnc_dict_v1
geneBDNF“Distinctive mesenchymal-like neurofibroma stem cells shape NF1 clinical phenotypes controlled by BDNF microenvironment.”0.98hgnc_dict_v1
geneBDNF“Mimosa pudica L. aqueous extract protects mice against pilocarpine-picrotoxin kindling-induced temporal lobe epilepsy, oxidative stress, and alteration in GABAergic/cholinergic pathways and BDNF expression.”0.98hgnc_dict_v1
geneBDNF“Ger mitigated MDA, NO, IL-1β, IL-6, TNF-α and IFN-γ, GFAP, caspase-3, and -9 levels and Bax gene expression and escalated GSH, SOD, catalase, BDNF and Bcl2 gene expression.”0.98hgnc_dict_v1
geneBDNF“Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4/NFκB-Nrf2/HO-1 and BDNF/VEGF signaling in stress-intensified PTZ induced epilepsy in mice.”0.98hgnc_dict_v1
geneBDNF“Further, CGA pre-treatment caused significant increases in acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF) levels, along with marked increases in dopamine, norepinephrine, and serotonin levels.”0.98hgnc_dict_v1
geneBDNF“In addition, accumulation of α-Syn in epilepsy could be secondary to the different cellular alterations including oxidative stress, neuroinflammation, reduction of brain-derived neurotrophic factor (BDNF) and progranulin (PGN), and failure of the autophagy pathway.”0.98hgnc_dict_v1
geneBDNF“In conclusion, KD improves cognitive function and attenuates the progression of AD neuropathology by reducing oxidative stress, mitochondrial dysfunction, and enhancing neuronal autophagy and brain BDNF.”0.98hgnc_dict_v1
geneBDNF“In addition, Van reduced AChE activity, and elevated glial fibrillary acidic proteins (GFAP) increased neurotransmitter and brain-derived neurotrophic factors (BDNF).”0.98hgnc_dict_v1
geneBDNF“Perampanel increases seizure threshold in pentylenetetrazole-kindled mice and improves behavioral dysfunctions by modifying mRNA expression levels of BDNF/TrkB and inflammatory markers.”0.98hgnc_dict_v1
geneBDNF“Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy.”0.98hgnc_dict_v1
geneBDNF“Their regeneration role is conveyed by the different cells' resident in it and in its endoneurium (fibroblasts, microphages, vasculature associated cells, and Schwann cells) these cells secrete various growth factors (NGF, BDNF, GDNF, NT-3, and bFGF) that contribute to the regenerative phenotype.”0.98hgnc_dict_v1
geneBDNF“Further search in miRNAwalk and miRDB databases showed that certainly most of these dysregulated miRNAs identified target HSCR associated genes, such as RET, GDNF, BDNF, EDN3, EDNRB, ERBB, NRG1, SOX10; and other genes implied in neuronal migration and neurogenesis.”0.98hgnc_dict_v1
geneBDNF“Several biochemical parameters were assessed to support oxidative stress (GSH, SOD, CAT, LPO, GR, and GPx), alteration in neurotransmitters (DOPAC, HVA, 5-HIAA, norepinephrine, serotonin, GABA, and dopamine), alterations in BDNF and cleaved caspase (caspase 3) activity.”0.98hgnc_dict_v1
geneBDNF“Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family.”0.98hgnc_dict_v1
geneBDNF“Comparative Efficacy of Metformin and Glimepiride in Modulating Pharmacological Network to Increase BDNF Levels and Benefit Type 2 Diabetes-Related Cognitive Impairment.”0.98hgnc_dict_v1
geneBDNF“Moreover, cerebral gene expression analysis of S-100B, BDNF, TNF-α, IGF-1, IGF-1 R, IGFBP-2, IGFBP-5, Bax, Bcl-2, and caspase-3 was carried out.”0.98hgnc_dict_v1
geneBDNF“The levels of dopamine, BDNF, GSH, and TAC returned to normal values during the study.”0.98hgnc_dict_v1
geneBDNF“The major conclusion drawn from this systematic analysis states that there are 51 genes linked with the development of ADA; and 3 (BDNF, PERIOD2 and SLC6A4) of them are common to all the three aspects of ADA.”0.98hgnc_dict_v1
geneBDNF“In addition, NSCs secret diversity of mediators, including neurotrophic factors (e.g., BDNF, NGF, GDNF, CNTF, and NT-3), pro-angiogenic mediators (e.g., FGF-2 and VEGF), and anti-inflammatory biomolecules.”0.98hgnc_dict_v1
geneBDNF“Several studies indicate that APOE4 modulates critical factors for neuronal function, including brain-derived neurotrophic factor (BDNF) and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α).”0.98hgnc_dict_v1
geneBDNF“In addition, metformin improves the expression of brain-derived neurotrophic factor (BDNF) which has a neuroprotective effect.”0.98hgnc_dict_v1
geneBDNF“Tiagabine suppresses pentylenetetrazole-induced seizures in mice and improves behavioral and cognitive parameters by modulating BDNF/TrkB expression and neuroinflammatory markers.”0.98hgnc_dict_v1
geneBDNF“Anti-Huntington's Effect of Rosiridin via Oxidative Stress/AchE Inhibition and Modulation of Succinate Dehydrogenase, Nitrite, and BDNF Levels against 3-Nitropropionic Acid in Rodents.”0.98hgnc_dict_v1
geneBDNF“The observed viability in nicotine treated cells were due to elevated IL-6, IL-10 while in glucose was due to brain derived neurotropic factor (BDNF).”0.98hgnc_dict_v1
geneBDNF“The LightGBM model achieved an AUC 0.842 to diagnose the TMJ OA status with Headaches and Range of Mouth Opening Without Pain ranked as top features, and top interactions of VE-cadherin in Serum and Angiogenin in Saliva, TGF-β1 in Saliva and Headaches, Gender and Muscle Soreness, PA1 in Saliva and Range of Mouth Opening Without Pain, Lateral Condyle Grey Level Non-Uniformity and Lateral Fossa Short Run Emphasis, TGF-β1 in Serum and Lateral Fossa Trabeculae number, MMP3 in Serum and VEGF in Serum, Headaches and Lateral Fossa Trabecular spacing, Headaches and PA1 in Saliva, and Headaches and BDNF in Saliva.”0.98hgnc_dict_v1
geneBDNF“RESULTS: P021 treatment during early development prevented cognitive impairment and increased expressions of pCREB and BDNF that activated downstream various signaling cascades such as PLC/PKC, MEK/ERK and PI3K/Akt, and ameliorated synaptic protein deficit in 4-month-old 3xTg-AD mice.”0.98hgnc_dict_v1
geneBDNF“Groups were subjected to assessment of Tumor growth factor-1β (TGF-1β), hypoxia inducible factor-1α (HIF-1α), brain derived neurotrophic factor (BDNF) levels, histone deacetylase (HDAC) activity & neuronal restrictive silencing factor (NRSF) gene expression.”0.98hgnc_dict_v1
geneBDNF“Fecal Transplant and Bifidobacterium Treatments Modulate Gut Clostridium Bacteria and Rescue Social Impairment and Hippocampal BDNF Expression in a Rodent Model of Autism.”0.98hgnc_dict_v1
geneBDNF“Association between the Val66Met polymorphism (rs6265/G196A) of the BDNF gene and cognitive performance with SSRI use in Arab Alzheimer's disease patients.”0.98hgnc_dict_v1
geneBDNF“BDNF/Fractalkine/SPARC/Irisin/FGF21/Musclin/IL-6).”0.98hgnc_dict_v1
geneBDNF“Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.”0.98hgnc_dict_v1
geneBDNF“Finally, we explored the influence of a common brain-derived neurotrophic factor (BDNF) polymorphism on cTBS aftereffects in a subset of the ASD group.”0.98hgnc_dict_v1
geneBDNF“The histopathological changes in the hippocampus were studied using hematoxylin and eosin stain and immunohistochemical stain for brain-derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP), beclin-1, nuclear factor kappa-B (NF-κB) and Bcl-2-like protein 4 (BAX).”0.98hgnc_dict_v1
geneBDNF“The interaction of BDNF Val66Met, PTSD, and child abuse on psychophysiological reactivity and HPA axis function in a sample of Gulf War Veterans.”0.98hgnc_dict_v1
geneBDNF“Neuronal damage was also assessed by performing tissue staining by hematoxylin and eosin, estimating hippocampus level of glutamate, gamma-aminobutyric acid (GABA), glial fibrillary acidic protein (GFAP) and brain-derived neurotrophic factor (BDNF).”0.98hgnc_dict_v1
geneBDNF“Moreover, decreased levels of neuroprotective factors (Brain derived neurotrophic factor (BDNF)), tropomyosin related kinase B (TrkB) and synaptophysin in diabetic retina were augmented with naringenin treatments.”0.98hgnc_dict_v1
geneBDNF“We quantitated the expression levels of BDNF, NGF, TrkB, synaptophysin, Akt, Bcl-2, cytochrome c and caspase-3 using Western blotting techniques in the diabetic retina with and without quercetin treatments and compared with non-diabetic rats.”0.98hgnc_dict_v1
geneBDNF“Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine.”0.98hgnc_dict_v1
geneBDNF“Correlation Between Hedgehog (Hh) Protein Family and Brain-Derived Neurotrophic Factor (BDNF) in Autism Spectrum Disorder (ASD).”0.98hgnc_dict_v1
geneBDNF“We observed large effect sizes with obesity for rs10767664 (BDNF) (OR = 1.923, P = 0.00072) and rs3751812 (FTO) (OR = 1.523, P = 0.016) in our sample and, using weighted genetic risk scores, we found strong evidence of a cumulative effect using 11 SNPs taken predominantly from loci principally affecting appetite (OR = 2.57, P = 0.00092).”0.98hgnc_dict_v1
geneBDNF“Possible role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder: current status.”0.98hgnc_dict_v1
geneBDNF“We report here that the serum levels of Sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD.”0.98hgnc_dict_v1