PARP1
HGNC:270 · 30 retained evidence mentions
Source-grounded findings
Supporting evidence
| Type | Entity | Source evidence | Confidence | Extractor |
|---|---|---|---|---|
| gene | PARP1 | “This review clarifies the dual function of poly(ADP-ribose) polymerase 1 (PARP1) in AD pathogenesis, emphasizing its role in mediating parthanatos, a unique caspase-independent cell death mechanism.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Furthermore, recent discoveries regarding biomolecular condensates in DNA repair (e.g., PARP1, MRNIP phase separation) reveal previously unrecognized regulatory layers governing repair pathway choice and SV formation.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Network pharmacology and molecular docking identified AP9 as a lead chemical with high affinity for hub proteins: as AKT1, EGFR, ESR1, HIF1A, MTOR, and PARP1, implying an involvement in neurodegenerative disease pathways.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Real-time polymerase chain reaction assay suggested that anti-cancer effects of our developed system may be attributed to the downregulation of Polo-Like Kinase 1 (PLK1) and Poly (ADP-Ribose) Polymerase 1 (PARP1) genes.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Integrated in silico and in vitro evaluation of Genistein and Apigenin as dual inhibitors of PARP1 and ESR1 in breast cancer.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Gene expression analysis revealed decreased pro-inflammatory activity and changes in stress response indicators such as PTGS2, PARP1, STAT1, TNF-⍺, IL-1β, and NF-κB.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Acidic pH depletes intracellular NAD⁺, partly driven by PARP1 activation.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “To enhance the reliability and translational relevance of the computational predictions, experimentally validated inhibitors lanabecestat (APP inhibitor), GNE0877 (LRRK2 inhibitor), and olaparib (PARP1 inhibitor) were included as positive controls to benchmark the binding affinity and interaction stability of moringa metabolites.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Essential Role for XRCC1 and PARP1 in the Repair of Genotoxic Damage During Spermatogenesis.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “The identified compounds were subjected to ADME screening, molecular docking, MM-GBSA, 500 ns molecular dynamics simulations, per-residue energy decomposition, and metadynamics to evaluate their stability in binding with cancer-specific targets (PARP1, CDK2, and CCNB1).” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “While PARP inhibitors targeting PARP1 and PARP2 have shown clinical success through synthetic lethality, PARP15, a mono-ADP-ribosyltransferase involved in DNA repair and tumour progression, remains largely understudied. </p><p> Method: A structure-based virtual screening approach was applied to identify potential PARP15 inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Four constituents of A. alba-Avicenol B, Avicenol C, Avicequinone B, and Avicequinone C-were verified, leading to the identification of 10 hub genes (i.e., EGFR, PIK3CA, JAK2, MTOR, JUN, ERBB2, IGF2, SRC, MDM2, and PARP1) associated with CRC.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Notably, KRAS, CUL3, TP53, ESR1, and PARP1 were influenced by both upregulated and downregulated miRNAs.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Evaluating Bis-Phenacyl Bromide-Based Bis-Heterocyclic Templates as Anticancer Prototypes and Potential PARP1 Inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “This study investigates the potential of siRNA-mediated silencing of poly(ADP-ribose) polymerase 1 (PARP1) to alleviate DPN in a rat model.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Methods: Gene set enrichment analyses (GSEAs) and drug ontology enrichment analyses (DOEAs) of PARPi response gene sets were applied as the surrogates of PARPi response to two CRC cohorts in order to compare the predictive capacities of TP53 mutation status, MSI status, as well as PARP1 and PARP2 expression for PARP inhibition to those of a homologous repair deficiency surrogate, and large-scale state transition (LST).” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “The most frequently interacting genes were HMOX1, CAT, NFE2L2, CASP3, MAPK1, CXCL8, PARP1, TNF, and PYGM.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “High glucose stimulation of Neuro2a cells increased PARP1 expression, and with siRNA-ChNP (1:3000) treatment, significant inhibition of PARP1 expression is observed that consequently reversed the expression of regulatory genes like SIRT1, FOXO1, FOXO3, and p53.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “We identified three DNA-repair genes, ALKBH3, NHEJ1, and PARP1, that were upregulated in early relapsers compared to late relapsers (p < 0.05).” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “BBR's ability to modulate chemoresistance is attributed to its diverse mechanisms of action, including inducing DNA breaks, inhibition of drug efflux pumps, modulation of apoptosis and necroptosis, downregulating multidrug resistance genes, enhancing immune response, suppressing angiogenesis and targeting multiple pathways within cancer cells, including protein kinase B/mammalian target of rapamycin (Akt/mTOR), epidermal growth factor receptor (EGFR), mitogen-activated protein kinase (MAPK), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), poly(ADP-ribose) polymerase (PARP1), janus kinase/signal transducers and activators of transcription (JAK-STAT), Wnt/β-catenin etc.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “In this study, we show that PARP1/2-mediated poly(ADP)-ribosylation (PARylation) is instrumental in the pro-apoptotic function of HuR.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Combination of ligand and structure based virtual screening approaches for the discovery of potential PARP1 inhibitors.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “These drugs included Atazanavir, Remdesivir, Efavirenz, Ritonavir, and Dolutegravir, PARP1 inhibitors (Olaparib and CVL218 which is Mefuparib hydrochloride), Abacavir, Roflumilast, Almitrine, and Mesylate.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “We have protein expression profiled for MRN and a panel of DNA repair factors involved in double-strand break repair (BRCA1, BRCA2, ATM, CHK2, ATR, Chk1, pChk1, RAD51, γH2AX, RPA1, RPA2, DNA-PKcs), RECQ DNA helicases (BLM, WRN, RECQ1, RECQL4, RECQ5), nucleotide excision repair (ERCC1) and base excision repair (SMUG1, APE1, FEN1, PARP1, XRCC1, Pol β) in 1650 clinical breast cancers.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Targeting PARP1 [Poly(ADP-Ribose) Polymerase 1] for synthetic lethality is a new strategy for BRCA germ-line mutated or platinum sensitive ovarian cancers.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “TMPRSS2, including IFNβ, STAT1, and STAT2, has the PARP1 binding site near to TSS either up or downstream promoter region.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “The obtained results revealed notable improvement in RIRI following all treatment (MSCs, Exo, and Exo + Mel) with best improvement in Exo + Mel group as evidenced by: 1) decreased kidney injury histopathological score; 2) reduced blood levels of kidney damage markers [blood urea nitrogen (BUN) and creatinine]; 3) declined oxidative stress status (MDA level, HIF1α gene, and NOX2 protein); 4) increased anti-oxidant status (HO1 gene, and SOD, CAT, GPX activities); 5) declined apoptosis (caspase 3 activity and mRNA, and PARP1, Bax genes), 6) induced anti-apoptotic effect (Bcl2 gene); 7) inhibition of inflammation (decreased MPO activity and ICAM1, IL1B, NFkB genes and increased IL10 genes); 8) improved regeneration (bFGF, HGF and SOX9 proteins); and 9) enhanced angiogenesis (VEGF gene).” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “Aim of the following study was to analyze the genetic association of rs1136410 (Val762Ala) in PARP1 gene with the risk of breast cancer using genotypic assays and insilico structural predictions.” | 0.98 | hgnc_dict_v1 |
| gene | PARP1 | “The C allele of a synonymous SNP (rs1805414, Ala284Ala) in PARP1 is a risk factor for susceptibility to breast cancer in Saudi patients.” | 0.98 | hgnc_dict_v1 |